CN108641104A - A kind of water base cross-linked polymer and its preparation method and application - Google Patents
A kind of water base cross-linked polymer and its preparation method and application Download PDFInfo
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- CN108641104A CN108641104A CN201810324571.9A CN201810324571A CN108641104A CN 108641104 A CN108641104 A CN 108641104A CN 201810324571 A CN201810324571 A CN 201810324571A CN 108641104 A CN108641104 A CN 108641104A
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- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/246—Intercrosslinking of at least two polymers
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
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- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0228—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof with belt or strap, e.g. with buckle
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- A61F2007/0261—Compresses or poultices for effecting heating or cooling medicated
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- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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Abstract
The present invention relates to a kind of water base cross-linked polymers and its preparation method and application.Processing raw material for water base cross-linked polymer includes the component of following parts by weight：20 30 parts of moisturizer, 5 15 parts of Sodium Polyacrylate, 1 20 parts of cross-linked polyacrylic resin, 4 20 parts of non-ionic polyacrylamide, 0.5 20 parts of crosslinking agent, 0.5 20 parts of pH adjusting agent, 2 20 parts of alcoholic solvent, 2.3 20 parts of menthol, 5 45 parts of deionized water.In addition, suitable preservative, colorant, Derma-Guard, antioxidant and/or swelling and pain relieving agent can also be added as needed.The water base cross-linked polymer advantage of the present invention is as follows：1. relative to traditional facial mask, there is elasticity and cold compress effect, elasticity can compact skin, cold compress is applied to the postoperative local coolings such as facial laser, swelling and pain relieving acts on；2. relative to traditional cold compress patch, the present invention can prevent pernio by adding Derma-Guard；3. relative to conventional bandages, self-adhesion can be achieved because having high viscosity in dressing of the invention after harassing and disturbing, be not necessarily to additional buckle.
Description
Technical field
The present invention relates to a kind of polymer and its preparation method and application, more particularly to a kind of water base cross-linked polymer
And its preparation method and application.
Background technology
Medical-use cold compress dressing structure traditional at present is simple, is to be directly anchored to sticking non-woven fabrics using by dressing
On, it is then directly covered on some position of human body, although easy to use, has the following disadvantages：1) due to nonwoven
Cloth generally uses square structure, therefore holds angle labor not easy to stick in use, is easy to fall off；2) since non-woven fabrics is using complete viscous
Structure, therefore entire non-woven fabrics is covered at human skin, and the gas permeability on dressing periphery can be made excessively poor, and it is logical to be unfavorable for dressing
Wind radiates；3) structure is bonded using complete due to non-woven fabrics, feeling of pain is had when removing dressing patch；4) itself do not have elasticity, stretch
Contracting performance and self-adhesion, the thickness limitation of cold compress dressing, typically not greater than 2mm, the volatilization time is short, does not have itself compressing
Property.
The Chinese invention patent of publication No. CN107714290A, date of publication on February 23rd, 2018 disclose a kind of Medical cold
Dressing is applied, including：Inviscid non-woven fabrics, the dressing groove being arranged on non-woven fabrics and the dressing being fixed in dressing groove,
It is provided with strength sticker in end edge on the inside of inviscid non-woven fabrics, the surface of strength sticker is outside relative to inviscid nonwoven surface
The height of protrusion and the flush of dressing, the interior recess formed between dressing and strength sticker are ventilating area, are covered ventilative
It is uniformly provided with ventilative through hole on inviscid non-woven fabrics in area.Its dressing is fibroin-chitosan plural gel, is had
Excellent mechanical performance and water retention property, heat dissipation effect are notable.And the Medical-use cold compress dressing knot being prepared using the dressing
Structure is simple, easy to operate, when dressing cold compress radiates or eases pain, can reinforce the air on cold compress dressing periphery by ventilating area
Circulation enhances heat dissipation effect, and then enhances this Medical-use cold compress dressing heat dissipation analgesic effect.There is still a need for non-woven fabrics as base for it
There are limitations, such as the cold compress dressing itself not to have elasticity, preferably telescopicing performance and self-adhesion for cloth, processing and use,
Present invention seek to address that this technical problem.
Invention content
It is an object of the present invention to solving the deficiencies in the prior art, a kind of water base cross-linked polymer is provided.
The second object of the present invention is to provide a kind of processing method of water base cross-linked polymer.
The third object of the present invention is to provide a kind of application of water base cross-linked polymer.
Water base cross-linked polymer, processing raw material for the water base cross-linked polymer include the component of following parts by weight：
20-30 parts of moisturizer
5-15 parts of Sodium Polyacrylate
1-20 parts of cross-linked polyacrylic resin
4-20 parts of non-ionic polyacrylamide
0.5-20 parts of crosslinking agent
0.5-20 parts of pH adjusting agent
2-20 parts of alcoholic solvent
2.3-20 parts of menthol
5-45 parts of deionized water.
Preferably, any one in the also component comprising following parts by weight that processes raw material of the water base cross-linked polymer
Or it is several：
0.3-20 parts of preservative
5-20 parts of colorant
2.4-20 parts of Derma-Guard
0.8-20 parts of antioxidant
1-5 parts of swelling and pain relieving agent.
Preferably, any one in the also component comprising following parts by weight that processes raw material of the water base cross-linked polymer
Or two kinds：
1-10 parts of glutathione
1-10 parts of water-soluble dextran.
It is found in present inventor's practice, adds suitable oxidized form of glutathione and water-soluble dextran, it can be with
The moisture holding capacity for significantly improving dressing makes the flexibility of dressing significantly improve, and achievees the purpose that prolong the service life, separately
It outside, can be with wound healing.
Preferably, the moisturizer is any one in glycerine, propylene glycol or sorbierite；
The crosslinking agent is Dihydroxyaluminum Aminoacetate；
The pH adjusting agent is any one in citric acid, lactic acid, tartaric acid, malic acid, sodium citrate and potassium citrate
Kind；
The preservative is sodium benzoate, sorbic acid or ethyl hydroxy benzoate；
The colorant is the brilliant blue of mass fraction 1%；
The alcoholic solvent is the ethyl alcohol of volume fraction 95%；
The Derma-Guard is wintergreen；
The antioxidant is tea polyphenols and/or vitamin E；
The swelling and pain relieving agent is camphor.
Preferably, the glutathione is handled through incomplete oxidation, and oxidized form of glutathione accounts for 30-60 parts after processing, remaining
Amount is reduced glutathione.
Preferably, the processing method of the glutathione incomplete oxidation processing is as follows：
S1, reduced glutathione is taken, in 40-45 DEG C of dissolving, obtains the reduced glutathione solution of 50-80g/L, surveys
Its pH value is A1；
S2, with barium hydroxide tune pH to A2,7.0≤A2≤7.1；
S3, a certain amount of hydrogen peroxide is added, it is stirring while adding, continue to be stirred to react 0.2-0.3h after adding；
A certain amount of manganese dioxide is added in S4, after reaction, stirs 5-10min, then fully filters off manganese dioxide；
S5, with sulphur acid for adjusting pH to A3, A1-0.05≤A3≤A1；
S6, barium sulfate precipitate is fully filtered off, be spray-dried, obtain incomplete oxidation treated glutathione.
Preferably, the mass concentration of hydrogen peroxide is 30% in step S3, and additive amount is 0.2-0.3ml/g reduced form gluathiones
Peptide；
The miillpore filter essence filtering of 0.2-0.45 μm of precision is all made of in step S4 and step S6.
The preparation method of the preparation method of water base cross-linked polymer, the water base cross-linked polymer is as follows：
S1：Aqueous materials in raw material are mixed by solvent of the deionized water of formula ratio, mixing time 1-2 is small
When, stand 2 to 3 hours after stirring；
S2：Oil phase material in raw material is mixed by solvent of the alcoholic solvent of formula ratio, is stirred 1-2 hours；
S3：The oil phase material mixed liquor of the aqueous materials mixed liquor of S1 and S2 is remixed, is mixed under vacuum condition
0.5-1 hours, vacuum degree -0.098MPa or less；
S4：De-bubble, removal are less than 2mm bubbles below；
S5：It using release film as carrier, is coated using coating machine, coating thickness 0.5-5mm；
S6：Cured after the completion of step S5 coatings, hardening time：24-28 hours, solidification temperature：25-30 DEG C, relatively
Humidity 60-70%, constant temperature and humidity in solidification process；
S7：Winding, inner packing, outer packing obtain water base cross-linked polymer finished product.
Preferably, it is mixed in step S1 and S2 and is stirred using speed change, speed is respectively V1 and V2, and V1 is the 1.2- of V2
It 1.5 times, is mixed respectively with the speed of V1 and V2, progress was alternated with 3-5 minutes.
The application of water base cross-linked polymer, the water base cross-linked polymer is for processing bandage, facial mask, application and eye sticker
Deng.
The water base cross-linked polymer of the present invention may replace presently commercially available facial mask, cold compress patch, bandage etc., have as follows
Advantage：
1. relative to traditional facial mask, there is water base cross-linked polymer of the invention elasticity and cold compress effect, elasticity can compact
Skin, cold compress are applied to the postoperative local coolings such as facial laser, swelling and pain relieving effect, and high-moisture characteristic Z can be continuously maintained skin
Skin moistens；
2. relative to traditional cold compress patch, water base cross-linked polymer of the invention passes through addition in addition to cold compress effect
Derma-Guard (wintergreen) can prevent pernio (having more creeping chill, and sticky higher than traditional cold compress patch)；
3. relative to conventional bandages, self-adhesion can be achieved because having high viscosity in water base cross-linked polymer of the invention after harassing and disturbing,
Without additional buckle；Elasticity with height and addition wintergreen, are applied to the preoperative cold compress physical therapy of orthopaedics, detumescence, analgesic, pressure
Compel wrapping, fixed protection.
The water base cross-linked polymer desired use of the present invention：For providing binding force to closed soft tissue, pass through compressing
Wrapping, cold compress and protective agent composition are realized cold compress physical therapy, swelling and pain relieving and the fixed protection at swelling pain position, are accelerated simultaneously
Cell repair reduces chronic inflammation.
The water base cross-linked polymer structures feature of the present invention：In band-like or tubular gelation elastic material.
The water base cross-linked polymer effect of the present invention or mechanism：By the liquid vaporization in product, human heat is taken away, it is real
Existing cold compress physical therapy；It, can be to closed soft tissue pressure dressing using the viscosity of product, elasticity；By adding protective agent composition, prevent
Only shell temperature reduces rapidly issuable pernio, keeps skin wet.
Water base cross-linked polymer use form, state, position, time limit and the method for the present invention：
1. selecting suitable specifications and models product according to concrete position；
2. opening outer packing, circular bandage is carried out centered on affected part or sticking, length can be cut as needed；
Body surface injury temperature can be made to reduce rapidly when 3. using, keep temperature plateau small up to 6-8 at 15 DEG C to 18 DEG C
When (promote tissue normal healing it is cold within the scope of)；
4. such as still needing to use after gel is completely dried, replace immediately；
5. unsuitable tension when wrapping, need to often observe affected part and whether surrounding tissue blood fortune is good, if there is allergic reaction.
If any discomfort, please stop using immediately；
6. open wound please don't be directly used in, if special circumstances need to use, waterproof application protection need to be given breakage
Rear can be used；
7. this product be disposable, model of instant use once to turn it on, using and it is easy to carry, be especially of crucial importance to injury gained in sports
Emergency measure, avoid a series of preparatory process when traditional cold compress；
8. this product X-ray permeability is good；
It is used 9. this product can also be used as the laying that other fix material；
10. this product is non-sterile product.
The water base crosslinked polymeric materials feature of the present invention is as follows：
1. Sodium Polyacrylate under the action of aluminium ion, is cross-linked to form the water storage of 3 D stereo, water conservation glue-line, after solidification
Form the hydrogel layer with viscosity, elasticity；
2. under the conditions of the coating technique of no base fabric, gel thicknesses can reach 0.2cm-0.5cm；
3. to prevent gel to be broken, number of bubbles is controlled in≤1/cm3。
Specific implementation mode
Below by specific embodiment, technical scheme of the present invention will be further explained in detail.
Embodiment 1：
The embodiment of the present invention 1 provides a kind of water base cross-linked polymer, and the water base cross-linked polymer is by following parts by weight
Raw material processing form：
20 parts of moisturizer
5 parts of Sodium Polyacrylate
1 part of cross-linked polyacrylic resin
4 parts of non-ionic polyacrylamide
0.5 part of crosslinking agent
0.5 part of pH adjusting agent
2 parts of alcoholic solvent
2.3 parts of menthol
5 parts of deionized water；
Specific to the present embodiment, the moisturizer is glycerine；
The crosslinking agent is Dihydroxyaluminum Aminoacetate；
The pH adjusting agent is tartaric acid；
The alcoholic solvent is the ethyl alcohol of volume fraction 95%；
The preparation method of the water base cross-linked polymer is as follows：
S1：Aqueous materials in raw material are mixed by solvent of deionized water, mixing time 1 hour, stirring terminates
Stand 2 hours afterwards；
S2：Oil phase material in raw material is mixed by solvent of 95% ethyl alcohol, is stirred 1 hour；
S3：The oil phase material mixed liquor of the aqueous materials mixed liquor of S1 and S2 is remixed, is mixed under vacuum condition
0.5 hour, vacuum degree：- 0.098MPa or less；
S4：De-bubble, removal are less than 2mm bubbles below；
S5：It using release film as carrier, is coated using coating machine, coating thickness 0.5mm；
S6：Cured after the completion of step S5 coatings, hardening time：24 hours, solidification temperature：25 DEG C, relative humidity
60%, constant temperature and humidity in solidification process；
S7：Winding, inner packing, outer packing obtain water base cross-linked polymer finished product.
It is mixed in the present embodiment, in step S1 and S2 and is stirred using speed change, speed is respectively V1 and V2, and V1 is V2's
It 1.2 times, is mixed respectively with the speed of V1 and V2, progress was alternated with 3 minutes.
Embodiment 2
The embodiment of the present invention 2 provides another water base cross-linked polymer, under the processing raw material and include of the cold compress dressing
The component of row parts by weight：
30 parts of moisturizer
15 parts of Sodium Polyacrylate
20 parts of cross-linked polyacrylic resin
20 parts of non-ionic polyacrylamide
20 parts of crosslinking agent
20 parts of pH adjusting agent
20 parts of alcoholic solvent
20 parts of menthol
45 parts of deionized water；
The moisturizer is glycerine；
The crosslinking agent is Dihydroxyaluminum Aminoacetate；
The pH adjusting agent is citric acid；
The alcoholic solvent is the ethyl alcohol of volume fraction 95%；
The preparation method is the same as that of Example 1 for 2 water base cross-linked polymer of embodiment.
Embodiment 3
On the basis of Examples 1 and 2, the present invention provides a kind of water base cross-linked polymerics with more additional functions
Object, the water base cross-linked polymer are added to colorant, Derma-Guard, antioxidant and swelling and pain relieving agent, certain face are presented
Color, specifically, the cold compress dressing are process by following raw materials according：
20 parts of moisturizer
5 parts of Sodium Polyacrylate
1 part of cross-linked polyacrylic resin
4 parts of non-ionic polyacrylamide
0.5 part of crosslinking agent
0.5 part of pH adjusting agent
2 parts of alcoholic solvent
2.3 parts of menthol
5 parts of deionized water
0.3 part of preservative
5 parts of colorant
2.4 parts of Derma-Guard
0.8 part of antioxidant
1 part of swelling and pain relieving agent；
The moisturizer is glycerine；
The crosslinking agent is Dihydroxyaluminum Aminoacetate；
The pH adjusting agent is tartaric acid；
The preservative is ethyl hydroxy benzoate；
The colorant is the brilliant blue of mass fraction 1%；
The alcoholic solvent is the ethyl alcohol of volume fraction 95%；
The Derma-Guard is wintergreen；
The antioxidant is the equal proportion mixture of tea polyphenols and vitamin E；
The swelling and pain relieving agent is camphor
The preparation method of the preparation method of water base cross-linked polymer, the water base cross-linked polymer is as follows：
S1：Aqueous materials in raw material are mixed by solvent of the deionized water of formula ratio, mixing time 1 hour,
2 hours are stood after stirring；
S2：Oil phase material in raw material is mixed by solvent of the alcoholic solvent of formula ratio, is stirred 1 hour；
S3：The oil phase material mixed liquor of the aqueous materials mixed liquor of S1 and S2 is remixed, is mixed under vacuum condition
0.5 hour, vacuum degree -0.098MPa or less；
S4：De-bubble, removal are less than 2mm bubbles below；
S5：It using release film as carrier, is coated using coating machine, coating thickness 0.5mm；
S6：Cured after the completion of step S5 coatings, hardening time：24 hours, solidification temperature：25 DEG C, relative humidity
60%, constant temperature and humidity in solidification process；
S7：Winding, inner packing, outer packing obtain cold compress dressing finished product.
It is mixed in the present embodiment, in step S1 and S2 and is stirred using speed change, speed is respectively V1 and V2, and V1 is V2's
It 1.2 times, is mixed respectively with the speed of V1 and V2, progress was alternated with 3 minutes.
Embodiment 4
On the basis of Examples 1 and 2, the present invention provides a kind of water base cross-linked polymerics with more additional functions
Object, specifically, the water base cross-linked polymer are process by following raw materials according：
30 parts of moisturizer
15 parts of Sodium Polyacrylate
20 parts of cross-linked polyacrylic resin
20 parts of non-ionic polyacrylamide
20 parts of crosslinking agent
20 parts of pH adjusting agent
20 parts of alcoholic solvent
20 parts of menthol
45 parts of deionized water
20 parts of preservative
20 parts of colorant
20 parts of Derma-Guard
20 parts of antioxidant
5 parts of swelling and pain relieving agent；
The moisturizer is glycerine；
The crosslinking agent is Dihydroxyaluminum Aminoacetate；
The pH adjusting agent is tartaric acid；
The preservative is ethyl hydroxy benzoate；
The colorant is the brilliant blue of mass fraction 1%；
The alcoholic solvent is the ethyl alcohol of volume fraction 95%；
The Derma-Guard is wintergreen；
The antioxidant is vitamin E；
The swelling and pain relieving agent is camphor；
The preparation method of the cold compress dressing is as follows：
S1：Aqueous materials in raw material are mixed by solvent of the deionized water of formula ratio, mixing time 2 hours,
3 hours are stood after stirring；
S2：Oil phase material in raw material is mixed by solvent of the alcoholic solvent of formula ratio, is stirred 2 hours；
S3：The oil phase material mixed liquor of the aqueous materials mixed liquor of S1 and S2 is remixed, 1 is mixed under vacuum condition
Hour, vacuum degree -0.098MPa or less；
S4：De-bubble, removal are less than 2mm bubbles below；
S5：It using release film as carrier, is coated using coating machine, coating thickness 5mm；
S6：Cured after the completion of step S5 coatings, hardening time：28 hours, solidification temperature：30 DEG C, relative humidity
70%, constant temperature and humidity in solidification process；
S7：Winding, inner packing, outer packing obtain cold compress dressing finished product.
It is mixed in the present invention, in step S1 and S2 and is stirred using speed change, speed is respectively V1 and V2, and V1 is V2's
It 1.5 times, is mixed respectively with the speed of V1 and V2, progress was alternated with 5 minutes.
Embodiment 5
The embodiment of the present invention 5 provides the water base cross-linked polymer of another technical solution, substantially composition and preparation side
Method with embodiment 3, the difference is that：It is described process raw material in also contain glutathione and each 1 part of water-soluble dextran,
The glutathione is handled through incomplete oxidation, and oxidized form of glutathione accounts for 30 parts after processing, and surplus is reduced form
The processing method of glutathione, the glutathione incomplete oxidation processing is as follows：
S1, reduced glutathione is taken, in 40 DEG C of dissolvings, obtains the reduced glutathione solution of 50g/L, survey its pH value
For A1；
S2, with barium hydroxide tune pH to A2,7.0≤A2≤7.1；
S3, a certain amount of hydrogen peroxide is added, it is stirring while adding, continue to be stirred to react 0.2h after adding；
A certain amount of manganese dioxide is added in S4, after reaction, stirs 5min, then fully filters off manganese dioxide；
S5, with sulphur acid for adjusting pH to A3, A1-0.05≤A3≤A1；
S6, barium sulfate precipitate is fully filtered off, be spray-dried, obtain incomplete oxidation treated glutathione.
The mass concentration of hydrogen peroxide is 30% in step S3, and additive amount is 0.2ml/g reduced glutathiones；Step S4 and
The miillpore filter essence filtering of 0.2-0.45 μm of precision is all made of in step S6；
The mass concentration of hydrogen peroxide is 30% in step S3, and additive amount is 0.2ml/g reduced glutathiones；Step S4 and
The miillpore filter essence filtering of 0.2 μm of precision is all made of in step S6.
Embodiment 6
The embodiment of the present invention 6 provides the water base cross-linked polymer of another technical solution, substantially composition and preparation side
Method with embodiment 4, the difference is that：It is described process raw material in also contain glutathione and each 10 parts of water-soluble dextran,
The glutathione is handled through incomplete oxidation, and oxidized form of glutathione accounts for 60 parts after processing, and surplus is reduced form
Glutathione, the processing method of the glutathione incomplete oxidation processing is the same as embodiment 5.
Water base cross-linked polymer made from 1-2 of the embodiment of the present invention is in water white transparency, implements the water base friendship that 2-6 is prepared
The water base cross-linked polymer coating of linked polymer, the aobvious blue of appearance, embodiment 1-6 is uniform, no starved phenomenon, unit gel weight
≥800g/m2, loss on drying >=50% of colloid, pH value 4.0-8.5.The elongation of cold compress dressing is not less than 50%, adherency
Power is 10~20N.
The peel strength for the water base cross-linked polymer that 1-6 of the embodiment of the present invention is prepared：The counterweight of 150 grams of suspension, 1 point
Product can fall off in clock.
The cold resistance for the water base cross-linked polymer that 1-6 of the embodiment of the present invention is prepared：At 0 DEG C ± 1 DEG C, cold compress dressing
It does not freeze.
The residue for the water base cross-linked polymer that 1-6 of the embodiment of the present invention is prepared：When product is taken off from plastic plate,
Without apparent residual colloidal substance.
The clump count for the water base cross-linked polymer that 1-6 of the embodiment of the present invention is prepared：Total plate count after effect product sterilization≤
100cfu/g。
The application of the water base cross-linked polymer of the present invention, the cold compress dressing is for processing bandage, facial mask, application and eye sticker
Deng.
Above-mentioned embodiment is only a preferred solution of the present invention, not the present invention is made in any form
Limitation, on the premise of not exceeding the technical scheme recorded in the claims also other variations and modifications.
Claims (10)
1. water base cross-linked polymer, it is characterised in that：The water base cross-linked polymer processes raw material comprising following parts by weight
Component：
20-30 parts of moisturizer
5-15 parts of Sodium Polyacrylate
1-20 parts of cross-linked polyacrylic resin
4-20 parts of non-ionic polyacrylamide
0.5-20 parts of crosslinking agent
0.5-20 parts of pH adjusting agent
2-20 parts of alcoholic solvent
2.3-20 parts of menthol
5-45 parts of deionized water.
2. water base cross-linked polymer according to claim 1, it is characterised in that：The processing of the water base cross-linked polymer is former
Material also includes any one or a few in the component of following parts by weight：
0.3-20 parts of preservative
5-20 parts of colorant
2.4-20 parts of Derma-Guard
0.8-20 parts of antioxidant
1-5 parts of swelling and pain relieving agent.
3. water base cross-linked polymer according to claim 2, it is characterised in that：The processing of the water base cross-linked polymer is former
Material also includes any one or two kinds in the component of following parts by weight：
1-10 parts of glutathione
1-10 parts of water-soluble dextran.
4. water base cross-linked polymer according to claim 1 or 2 or 3, it is characterised in that：
The moisturizer is any one in glycerine, propylene glycol or sorbierite；
The crosslinking agent is Dihydroxyaluminum Aminoacetate；
The pH adjusting agent is any one in citric acid, lactic acid, tartaric acid, malic acid, sodium citrate and potassium citrate；
The preservative is sodium benzoate, sorbic acid or ethyl hydroxy benzoate；
The colorant is the brilliant blue of mass fraction 1%；
The alcoholic solvent is the ethyl alcohol of volume fraction 95%；
The Derma-Guard is wintergreen；
The antioxidant is tea polyphenols and/or vitamin E；
The swelling and pain relieving agent is camphor.
5. water base cross-linked polymer according to claim 3, it is characterised in that：The glutathione through incomplete oxidation at
Reason, oxidized form of glutathione accounts for 30-60 parts after processing, and surplus is reduced glutathione.
6. water base cross-linked polymer according to claim 5, it is characterised in that：The glutathione incomplete oxidation processing
Processing method it is as follows：
S1, reduced glutathione is taken, in 40-45 DEG C of dissolving, obtains the reduced glutathione solution of 50-80g/L, survey its pH
Value is A1；
S2, with barium hydroxide tune pH to A2,7.0≤A2≤7.1；
S3, a certain amount of hydrogen peroxide is added, it is stirring while adding, continue to be stirred to react 0.2-0.3h after adding；
A certain amount of manganese dioxide is added in S4, after reaction, stirs 5-10min, then fully filters off manganese dioxide；
S5, with sulphur acid for adjusting pH to A3, A1-0.05≤A3≤A1；
S6, barium sulfate precipitate is fully filtered off, be spray-dried, obtain incomplete oxidation treated glutathione.
7. water base cross-linked polymer according to claim 6, it is characterised in that：The mass concentration of hydrogen peroxide is in step S3
30%, additive amount is 0.2-0.3ml/g reduced glutathiones；
The miillpore filter essence filtering of 0.2-0.45 μm of precision is all made of in step S4 and step S6.
8. the preparation method of the water base cross-linked polymer described in claim 1-7 any one, it is characterised in that：The water base friendship
The preparation method of linked polymer is as follows：
S1：Aqueous materials in raw material are mixed by solvent of the deionized water of formula ratio, mixing time 1-2 hours is stirred
2 to 3 hours are stood after mixing；
S2：Oil phase material in raw material is mixed by solvent of the alcoholic solvent of formula ratio, is stirred 1-2 hours；
S3：The oil phase material mixed liquor of the aqueous materials mixed liquor of S1 and S2 is remixed, 0.5-1 is mixed under vacuum condition
Hour, vacuum degree -0.098MPa or less；
S4：De-bubble, removal are less than 2mm bubbles below；
S5：It using release film as carrier, is coated using coating machine, coating thickness 0.5-5mm；
S6：Cured after the completion of step S5 coatings, hardening time：24-28 hours, solidification temperature：25-30 DEG C, relative humidity
60-70%, constant temperature and humidity in solidification process；
S7：Winding, inner packing, outer packing obtain water base cross-linked polymer finished product.
9. water base cross-linked polymer according to claim 8, it is characterised in that：It is mixed using change in step S1 and S2
Speed stirring, speed are respectively V1 and V2, and V1 is 1.2-1.5 times of V2, is mixed respectively with the speed of V1 and V2, with 3-5 points
Clock alternates progress.
10. the application of the water base cross-linked polymer described in claim 1-7 any one, which is characterized in that the water base crosslinking
Polymer is for processing bandage, facial mask, application and eye sticker.
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| CN111110907A (en) * | 2019-12-31 | 2020-05-08 | 中广核达胜加速器技术有限公司 | Hydrogel dressing with wound surface repairing function and preparation method thereof |
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