CN110403760A - A kind of moisture absorption vapor-permeable type wound dressing patch - Google Patents
A kind of moisture absorption vapor-permeable type wound dressing patch Download PDFInfo
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- CN110403760A CN110403760A CN201910802976.3A CN201910802976A CN110403760A CN 110403760 A CN110403760 A CN 110403760A CN 201910802976 A CN201910802976 A CN 201910802976A CN 110403760 A CN110403760 A CN 110403760A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0203—Adhesive plasters or dressings having a fluid handling member
- A61F13/0213—Adhesive plasters or dressings having a fluid handling member the fluid handling member being a layer of hydrocoloid, gel forming material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0203—Adhesive plasters or dressings having a fluid handling member
- A61F13/0223—Adhesive plasters or dressings having a fluid handling member characterized by parametric properties of the fluid handling layer, e.g. absorbency, wicking capacity, liquid distribution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0246—Adhesive plasters or dressings characterised by the skin adhering layer
- A61F13/0253—Adhesive plasters or dressings characterised by the skin adhering layer characterized by the adhesive material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0038—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00463—Plasters use haemostatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00544—Plasters form or structure
- A61F2013/00604—Multilayer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00655—Plasters adhesive
- A61F2013/00676—Plasters adhesive hydrogel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/0091—Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/00927—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention belongs to medical material production technical fields, specifically disclose moisture absorption vapor-permeable type wound dressing patch, multilayer moisture absorption vapor-permeable type wound dressing patch of the invention, antibacterial layer is by chitosan, chitooligosaccharide-, oxidized sodium alginate, the gel of gelatin and purified water composition is made, it is short with onset time, long action time, with hemostasis, analgesia and the more equal multiple actions of rush, the liquid on skin can be absorbed in water absorption layer, keep the drying of wound, it is made of silica gel and hydroxy cellulose sodium, there is good gas permeability while moisture absorption, and waterproof layer can make vapor penetrating and be emitted into outside, further keep dry skin, suitable long-time is attached at human body surface, avoid skin allergy or discomfort.Dressing patch of the invention has high-hydroscopicity, gas permeability, penetrability and good biocompatibility, can wide hair in the wrapping, recovery and treatment of various wounds.
Description
The application is to be submitted to the entitled of State Intellectual Property Office of the People's Republic of China on December 24th, 2018
" a kind of moisture absorption vapor-permeable type wound dressing patch ", application No. is the divisional applications of the application for a patent for invention of " 201811583499.8 ".
Technical field
The present invention relates to a kind of medical dressing patch, specifically moisture absorption vapor-permeable type wound dressing is pasted.
Background technique
At the wrapping and emergency that dressing patch is widely used in various wounds due to the practicality is wide, using effect is good the advantages that
Reason, it is deep to be liked by many patients；Casting product is mainly traditional adhesive plaster, based on black plaster earlier, this product patient, which pastes, to be used
After be also easy to produce allergic phenomena, and tearing feeling of pain is had when removing；Dressing patch newer at present is with water soluble polymer
Material is matrix scaffold, is rich in 60% moisture content, reaches cold compress by the effective ingredients such as contained menthol and hydrogel physical action
Therapeutic effect can reduce joint tissue damage, eliminate swelling pain and reduce the concurrent of inflammation, though solve old-fashioned dressing patch
Unfavorable factor, but structure is still relatively simple, and the hemostasis moisture absorption for destructive wound is not it is obvious that when wound oozing of blood
Or body fluid it is more severe when, the using effect of dressing patch will have a greatly reduced quality.Wound healing is a dynamic process, so applying to wound
The requirement of material can be varied with recovery process.Effective wound dressing can not only make wound be isolated from the outside, and can
The diffusate for removing wound provides the moist microenvironment of a promotion wound healing, promotes tissue reconstruction.In recent years occur being permitted
Mostly with hydrogel wound dressings as main component, these materials include synthetic polymer polyurethane, polyethylene, polylactic acid, silicon
Ketone rubber etc. and natural polymer alginates, chitosan, gelatin etc..Wherein chitosan is obtained by chitin alkaline deacetylation
Polymer, have the characteristics that biocompatibility, degradable, styptic activity, it is anti-infective and accelerate wound healing.But merely by shell
The hydrogel bad mechanical strength of glycan preparation, limits its application in terms of wound dressing.Meanwhile the gas permeability of above-mentioned material
It is poor, it is unfavorable for the quick healing of wound.
It is a kind of with preferable moisture absorption and vapor-permeable type wound dressing patch therefore, it is necessary to develop.
Summary of the invention
The main purpose of the present invention is to provide a kind of moisture absorption vapor-permeable type wound dressing patches, with four-layer structure, including
What is be sequentially bonded sticks layer, antibacterial layer, water absorption layer and waterproof layer, can stick directly to human skin, absorbs from skin
Liquid, suitable long-time are attached at human body surface, keep skin dry and comfortable, and are avoided that the sense of discomfort or thorn of skin allergy or redness
Excitation.
Sticking layer has attaching and fixed effect, can directly stick and be fixed on skin, and wear the liquid on skin
Thoroughly.Antibacterial layer contains antipathogenic composition, can discharge antibacterial medicines, to have the function that sterilizing, avoids the secondary sense of wound
Dye, promotes the healing as early as possible of wound.Water absorption layer is absorbable from the liquid for sticking layer, so that wound is kept drying, avoids breeding
Bacterium.The waterproof film of waterproof layer is constituted, and the liquid that water absorption layer can be made to be absorbed penetrates waterproof layer after evaporating and is transmitted to outer
Portion keeps skin to be in more dry pleasant state.
Sticking layer can be made of acryl glue, PU glue, silica gel, hydrogel or artificial skin, and is sticked layer and further may be used
With perforation, netted or gap structure, to allow blood or tissue fluid to reach antibacterial layer and sticking layer and then reach suction
Water layer, and being absorbed by water absorption layer, in addition, the drug of antibacterial layer release can also by perforation, netted or gap structure to
Preferably reach wound, plays the effect of antibacterial disinfection.
Antibacterial layer is made of the gel that chitosan, chitooligosaccharide-, oxidized sodium alginate, gelatin and purified water form, above-mentioned
Gel can have a more wide in range proportion, in preferably every 100 milliliters of purified water containing 0.1 gram -3 grams chitosan, 0.1 gram -3
Gram chitooligosaccharide-, 1 gram -5 grams of oxidized sodium alginate, 0.1 gram -5 grams of gelatin.In more preferable every 100 milliliters of purified water
Contain 0.5 gram -2 grams of chitosans, 0.5 gram -2 grams of chitooligosaccharide-, 3 grams -5 grams of oxidized sodium alginate, 1 gram -3 grams bright
Glue；Contain 1 gram -1.5 grams of chitosan, 1 gram -1.5 grams of chitooligosaccharide-, 3 in still more preferably every 100 milliliters of purified water
Gram -4 grams of oxidized sodium alginate, 2 grams -3 grams of gelatin.
The above-mentioned antibacterial layer of gel is that a kind of onset time is short, long action time, can with promotion burn and scald, the wound such as acute and chronic
Mouth healing, and the new bio aerogel dressing that there is hemostasis, analgesia and rush to be cured triple role.The different molecular weight ladders used
Main raw material(s), that is, the chitosan and chitooligosaccharide- and oxidized sodium alginate of degree, wherein the molecular weight of chitosan is on 100,000 left sides
The right side, molecular weight is excessive, and intermolecular to make strand severity wrapped around one another with intramolecular hydrogen bond, solubility is too small, and degradation is very fast, no
The effect that product has dauer effect can be played；Chitooligosaccharide- molecular weight is between 2000-10000, middle-molecular-weihydroxyethyl 7000
It to be best, can either be directly dissolved in water, and the time that can guarantee that degradation plays a role is moderate.Alginic acid is one kind by brown alga
The polysaccharide of extraction is the statistic copolymer of beta-D-mannuronic acid (M unit) and α-L- guluronic acid (G unit).Oxygen
Changing sodium alginate has good biocompatibility, hypotoxicity, and molecular weight has preferable viscosity 14000 or more, can
Quick cross-linking simultaneously disperses drug, has good medicine releasability.These three substances are used in compounding to reach by successively gradually
The purpose for absorbing and persistently playing a role.
The gel can be prepared using following preparation methods, comprising the following steps:
(1) chitosan is added in purified water to be stirred until chitosan is completely dispersed in water；
(2) gelatin is added in the solution that step (1) obtains, is placed in 60 DEG C -70 DEG C of water-bath and is heated, until
Gelatin is completely dissolved；
(3) chitooligosaccharide- and oxidized sodium alginate are added in the solution that gelatin is completely dissolved, is stirred, makes it completely
It is dispersed in water to form gel, filling, sterilizing is carried out after standing defoaming, then carry out sterility test, after qualified.
Further, being stirred after addition chitosan in the step (1) is completely dispersed it, and the speed of stirring is 400-
500r/min。
Further, being added in the step (3) after chitooligosaccharide- and oxidized sodium alginate to be stirred is completely dispersed it,
The speed of stirring is 400-500r/min.
Preferably, oxidized sodium alginate takes following method to prepare: 4g sodium alginate being taken to be made into the water that mass fraction is 4%
Solution is added after 1.5g sodium metaperiodate is protected from light oxidation 8h and 2ml ethylene glycol termination oxidation reaction 30min is added, 2.5gNaCl is added
70ml ethyl alcohol is added after being sufficiently mixed makes its Precipitation, rotates, and with deionized water lysate, is cut with dialysis bag
The oxidized sodium alginate that molecular weight is greater than 14000 is left, every 6h changes a deionized water, after dialysis for 24 hours, then will precipitating with ethyl alcohol
It is precipitated, filters, be freeze-dried to obtain the final product.Larger using the oxidized sodium alginate molecular weight obtained after dialysis bag, product viscosity is bigger,
It can accelerate cross-linked speed.
Water absorption layer is made of silica gel and hydroxy cellulose sodium, and the two can have large range of quality proportioning, preferably silicon
Glue: for hydroxy cellulose sodium in the range of 100:10-100:30, silica gel has preferable hygroscopicity, can absorb wound
Blood and tissue fluid, but there is the shortcomings that poor air permeability in simple silica gel, certain hydroxyl fiber is added after absorption of liquid
Make water absorption layer that there is centainly poroid after plain sodium, it, can be better to reach so as to improve the gas permeability after moisture absorption
Liquid after absorption is evaporated and is kept the drying of wound.Mechanical mixture progress can be used in silica gel and hydroxy cellulose sodium
Film forming is squeezed to be prepared.
Waterproof layer can be made of waterproof membrane, the preferred polyethylene of waterproof membrane, can play dust-proof, waterproof, anti-gas-leak, antifouling
The effect of dye.
Further, layer, antibacterial layer and water absorption layer are sticked, staggered netted or circular hole channel is set.
Beneficial effect
Multilayer moisture absorption vapor-permeable type wound dressing patch of the invention, antibacterial layer is by chitosan, chitooligosaccharide-, oxidation alginic acid
The gel of sodium, gelatin and purified water composition is made, and has that onset time is short, long action time, has hemostasis, analgesia and promotees more etc.
The liquid on skin can be absorbed in multiple action, water absorption layer, keeps the drying of wound, by silica gel and hydroxy cellulose sodium group
At, there is good gas permeability while moisture absorption, and waterproof layer can make vapor penetrating and be emitted into outside, further keep
Dry skin, suitable long-time are attached at human body surface, avoid skin allergy or discomfort.Dressing patch of the invention has high water absorption
Property, gas permeability, penetrability and good biocompatibility, can be widely used in the wrapping, recovery and treatment of various wounds.
Specific embodiment
Principles and features of the present invention are described in following implementation, and the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the invention.
Embodiment 1: the preparation of antibacterial layer gel
It weighs 0.5 gram of chitosan to set in blender, 100 milliliters of purified waters is added, stir evenly, mixing speed 450r/min,
To being completely dispersed, 3 grams of gelatin are added in the solution, sets and is heated on 70 DEG C of water-bath, until gelatin is completely dissolved, then adds again
Entering 1.5 grams of chitooligosaccharide-s and 5 grams of oxidized sodium alginate stirrings is completely dispersed it, mixing speed 400r/min, stirring to shape
Gelled, finally, de-soak is stood, packing sterilizing, as finished product.
Embodiment 2: the preparation of antibacterial layer gel
It weighs 2 grams of chitosan to set in blender, 100 milliliters of purified waters is added, stir evenly, mixing speed 500r/min, until
It is completely dispersed, 5 grams of gelatin is added in the solution, sets and is heated on 70 DEG C of water-bath, until gelatin is completely dissolved, then added
2.0 grams of chitooligosaccharide-s and 3 grams of oxidized sodium alginate stirrings are completely dispersed it, mixing speed 450r/min, stirring to formation
Gel, finally, de-soak is stood, packing sterilizing, as finished product.
Embodiment 3: the preparation of antibacterial layer gel
It weighs 3 grams of chitosan to set in blender, 100 milliliters of purified waters is added, stir evenly, mixing speed 500r/min, until
It is completely dispersed, 2 grams of gelatin is added in the solution, sets and is heated on 60 DEG C of water-bath, until gelatin is completely dissolved, then added
1.0 grams of chitooligosaccharide-s and 4 grams of oxidized sodium alginate stirrings are completely dispersed it, mixing speed 500r/min, stirring to formation
Gel, finally, de-soak is stood, packing sterilizing, as finished product.
Embodiment 4: the preparation of multilayer moisture absorption vapor-permeable type wound dressing patch
It is coated with layer of polyethylene waterproof layer on substrate non-woven fabrics, is then coated with by silica gel and hydroxy cellulose sodium according to matter
The water absorption layer that the ratio that amount proportion is 100:10 is prepared, is then coated with the antibacterial layer gel being prepared by embodiment 1, most
Coating PU glue, which is used as, afterwards sticks layer.Above-mentioned material selects medical material.It finally does aseptic process and is packaged.
Embodiment 5
It is coated with layer of polyethylene waterproof layer on substrate non-woven fabrics, is then coated with by silica gel and hydroxy cellulose sodium according to matter
The water absorption layer that the ratio that amount proportion is 100:20 is prepared, is then coated with the antibacterial layer gel being prepared by embodiment 2, most
Coating PU glue, which is used as, afterwards sticks layer.Above-mentioned material selects medical material.It finally does aseptic process and is packaged.
Embodiment 6
It is coated with layer of polyethylene waterproof layer on substrate non-woven fabrics, is then coated with by silica gel and hydroxy cellulose sodium according to matter
The water absorption layer that the ratio that amount proportion is 100:30 is prepared, is then coated with the antibacterial layer gel being prepared by embodiment 3, most
Coating PU glue, which is used as, afterwards sticks layer.Above-mentioned material selects medical material.It finally does aseptic process and is packaged.
7 antibacterial test of embodiment
After Escherichia coli and staphylococcus aureus activation, strain is connected on inclined-plane, 37 DEG C of culture 12h, use is sterile
Bacterium solution on water washing inclined-plane surveys OD value, suitable with the strain amount for ensuring to be inoculated with every time, and the comparable bacterium solution of strain amount is taken to be coated on
On culture medium flat plate, the filter paper of diameter 0.6cm is placed in plate with tweezers, by tri- kinds of dressing patchs of embodiment 4-6, uses Oxford
Cup takes into the small cylinder hydrogel of same thickness, is placed on filter paper, and each gradient does 3 parallel, 37 DEG C of constant temperature incubations
12h is cultivated in case, measures the diameter of inhibition zone.
The anti-microbial property of 1 dressing of table compares
From table 1 it follows that these three dressing all have good antibacterial activity.
Embodiment 8 measures cytotoxicity
Using the cytotoxicity of 3 kinds of aerogel dressings patch in MTT colorimetric method for determining embodiment 4-6.Selected cell
For l cell (L929).
Cytotoxicity of the different dressing of table 2 to l cell (L929)
From Table 2, it can be seen that cell of the dressing patch that is prepared of embodiment 4-6 to l cell (L929)
Toxicity is lower, and the relative growth rate of cell is rated 0 grade (fancy grade) up to 100% or more, illustrates that dressing patch of the invention is available
Make bio-medical material.
Claims (7)
1. a kind of bacteriostatic gel, which is characterized in that the bacteriostatic gel is by chitosan, chitooligosaccharide-, oxidized sodium alginate, gelatin
It is made with the gel of purified water composition.
2. bacteriostatic gel according to claim 1, which is characterized in that bacteriostatic gel is included by every 100 milliliters of purified water
There are 0.1 gram -3 grams of chitosan, 0.1 gram -3 grams of chitooligosaccharide-, 1 gram of -5 grams of oxidized sodium alginate, 0.1 gram -5 grams of gelatin
It is prepared.
3. -2 described in any item bacteriostatic gels according to claim 1, which is characterized in that the gel of antibacterial layer is by every 100 milliliters
Purified water in contain 0.5 gram -2 grams of chitosan, 0.5 gram -2 grams of chitooligosaccharide-, 3 grams -5 grams of oxidized sodium alginate, 1
Grams -3 grams of gelatin is prepared.
4. bacteriostatic gel according to claim 1-3, which is characterized in that the gel of antibacterial layer is by every 100 milliliters
Purified water in contain 1 gram -1.5 grams of chitosan, 1 gram -1.5 grams of chitooligosaccharide-, 3 grams -4 grams of oxidized sodium alginate, 2
Grams -3 grams of gelatin is prepared.
5. the preparation method of bacteriostatic gel according to claim 1-4, which comprises the following steps:
(1) chitosan is added in purified water to be stirred until chitosan is completely dispersed in water；
(2) gelatin is added in the solution that step (1) obtains, is placed in 60 DEG C -70 DEG C of water-bath and is heated, until gelatin
It is completely dissolved；
(3) chitooligosaccharide- and oxidized sodium alginate are added in the solution that gelatin is completely dissolved, is stirred, is completely dispersed it
Gel is formed in water, filling, sterilizing is carried out after standing defoaming, then carry out sterility test, after qualified.
6. preparation method according to claim 5, which is characterized in that the speed stirred in the step (1) and (3) is 400-
500r/min。
7. preparation method according to claim 5, which is characterized in that the oxidized sodium alginate takes following method to prepare: taking
4g sodium alginate is made into the aqueous solution that mass fraction is 4%, is added after 1.5g sodium metaperiodate is protected from light oxidation 8h and 2ml ethylene glycol is added
Terminate oxidation reaction 30min, be added 2.5g NaCl be sufficiently mixed after be added 70ml ethyl alcohol make its Precipitation, rotate, spend from
Sub- water lysate retains the oxidized sodium alginate that lower molecular weight is greater than 14000 with dialysis bag, and every 6h changes a deionized water,
After dialysis for 24 hours, then with ethyl alcohol by Precipitation, suction filtration is freeze-dried to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910802976.3A CN110403760A (en) | 2018-12-24 | 2018-12-24 | A kind of moisture absorption vapor-permeable type wound dressing patch |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN115040682A (en) * | 2022-06-17 | 2022-09-13 | 水木山海科技(佛山)有限责任公司 | Multilayer cross-linked medical wound dressing and preparation method thereof |
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| CN109893342B (en) * | 2019-04-08 | 2020-10-27 | 佳木斯大学附属第一医院 | Dressing for craniocerebral trauma and preparation method thereof |
| CN113017989A (en) * | 2021-02-26 | 2021-06-25 | 福建省明辉机械制造有限公司 | Preparation method of ultrathin breathable sanitary towel |
| CN113062045A (en) * | 2021-03-25 | 2021-07-02 | 福建恒安集团有限公司 | Natural color surface layer sanitary towel |
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| CN101716366A (en) * | 2009-12-17 | 2010-06-02 | 天津大学 | Biocolloid hemostatic prepared by aldehyde-modified sodium alginate and amine-modified gelatine |
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| CN115040682B (en) * | 2022-06-17 | 2023-10-13 | 水木山海科技(佛山)有限责任公司 | Multilayer crosslinked medical wound dressing and preparation method thereof |
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| CN109481148A (en) | 2019-03-19 |
| CN109481148B (en) | 2019-08-16 |
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Application publication date: 20191105 |