CN107137380A - Temperature adjustment bactericidal composition and preparation method thereof and bandage and preparation method thereof - Google Patents
Temperature adjustment bactericidal composition and preparation method thereof and bandage and preparation method thereof Download PDFInfo
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- CN107137380A CN107137380A CN201710436629.4A CN201710436629A CN107137380A CN 107137380 A CN107137380 A CN 107137380A CN 201710436629 A CN201710436629 A CN 201710436629A CN 107137380 A CN107137380 A CN 107137380A
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- temperature adjustment
- bactericidal composition
- bandage
- wound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Abstract
The present invention relates to topical agent field, and more particularly to a kind of temperature adjustment bactericidal composition and preparation method thereof and bandage and preparation method thereof.The temperature adjustment bactericidal composition is made up of plurality of raw materials.In parts by weight, above-mentioned plurality of raw materials includes 10 25 parts of gucosamine polymer, 13 25 parts of alginates, 20 30 parts of paraffin and 25 35 parts of polyvinyl alcohol.It can be according to human body temperature adjust automatically to wound protection, lifted protection effect.
Description
Technical field
The present invention relates to topical agent field, and more particularly to a kind of temperature adjustment bactericidal composition and preparation method thereof and wound
Patch and preparation method thereof.
Background technology
Bandage is a kind of surgical medicine the most frequently used during people live.Adhesive bandage (Woundplast) also known as benzene prick chlorine
Ammonium is pasted, and is commonly called as sterilizing elastic adhesive bandage, as its name suggests, and many people are sticked once there is wound.It is the most frequently used during people live
A kind of surgical medicine.Therefore " hemostasis plaster " is commonly called as, with hemostasis, shield creation is used.It is by an elongated adhesive plaster, centre
The sliver for being accompanied by the dipped medicine of a fritter is constituted.Due to the limitation of its structure, the wound that adhesive bandage is only used for fritter is met an urgent need
Treatment, so as to play temporary transient hemostasis, protects the effect of the surface of a wound.But existing bandage is isolated only with gauze
Insulation, and gauze easily absorbs water, and can not form good protection to wound on the contrary.
The content of the invention
It is an object of the invention to provide a kind of temperature adjustment bactericidal composition, it can be according to human body temperature adjust automatically to wound
Protection, lifted protection effect.
Another object of the present invention is to provide a kind of method for preparing temperature adjustment bactericidal composition, pass through the preparation method energy
Quickly prepare temperature adjustment bactericidal composition.
Another object of the present invention is to provide a kind of bandage, the bandage can have according to the temperature of wound, regulation
The state of the compound of sterilizing function, is protected wound formation well, and suitable temperature can be played to the healing of wound
Facilitation.
Another object of the present invention is to provide in a kind of preparation method of bandage, the bandage prepared using this method
Drug particles it is tiny and uniform, can to wound formation protect well.
The present invention is solved its technical problem and realized using following technical scheme：
The present invention proposes a kind of temperature adjustment bactericidal composition, and the temperature adjustment bactericidal composition is made up of plurality of raw materials.With parts by weight
Meter, above-mentioned plurality of raw materials includes 10-25 parts of gucosamine polymer, 13-25 parts of alginates, 20-30 parts of paraffin and 25-
35 parts of polyvinyl alcohol.
The present invention proposes a kind of bandage, and it is mainly prepared by above-mentioned temperature adjustment bactericidal composition.
The present invention proposes a kind of preparation method of bandage, is sprayed into above-mentioned temperature adjustment bactericidal composition using method of electrostatic spinning
Sticked to after thread in bandage matrix.
The present invention proposes a kind of method for preparing temperature adjustment bactericidal composition, comprises the following steps：In parts by weight, by 10-
It is PVA mixed with 20-30 parts of paraffin and 25-35 parts again after 25 parts of gucosamine polymer and 13-25 parts of alginate mixing
Obtained mixture is closed to be mixed.
The beneficial effect of temperature adjustment bactericidal composition of the present invention and preparation method thereof and bandage and preparation method thereof is：Temperature adjustment
Bactericidal composition is poly- using 10-25 parts of gucosamine polymer, 13-25 parts of alginates, 20-30 parts of paraffin and 25-35 parts
Vinyl alcohol is realized realizes freely converting for temperature adjustment bactericidal composition liquid and solid-state according to the temperature of the surface of a wound, can be according to the surface of a wound
Recovery situation is protected surface of a wound formation, accelerates the recovery of the surface of a wound, it is to avoid the superinfection of the surface of a wound.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, are the conventional production that can be obtained by commercially available purchase
Product.
In the description of the invention, it is necessary to which explanation, term " first ", " second " etc. are only used for distinguishing description, without
It is understood that to indicate or imply relative importance.
Temperature adjustment bactericidal composition of the embodiment of the present invention and preparation method thereof and bandage and preparation method thereof are entered below
Row is illustrated.
A kind of temperature adjustment bactericidal composition provided in an embodiment of the present invention, the temperature adjustment bactericidal composition is made up of plurality of raw materials.
In parts by weight, above-mentioned raw materials include 10-25 parts of gucosamine polymer, 13-25 parts of alginates, 20-30 parts of paraffin and
25-35 parts of polyvinyl alcohol.
When each raw material in temperature adjustment bactericidal composition uses aforementioned proportion, the synergy between each component can reach
To optimum efficiency, and the ratio recorded above or below the embodiment of the present invention, the effect or function of each component will drop
It is low, while the synergy between component will also decrease or even disappear.Paraffin and polyvinyl alcohol act synergistically to be formed can solid-state and
The paraffin that liquid is freely converted-polyvinyl alcohol wrappage, and the conversion between solid-state and liquid is temperature adjustment composition senses
The temperature of the surface of a wound and carry out, and appropriate adjustment can also be carried out to the temperature of the surface of a wound by being changed between solid-state and liquid,
Further speed up the recovery of the surface of a wound.And alginate and the formation of gucosamine interpolymer interaction can be sterilized and antibacterial bag
Thing is wrapped up in, the surface of a wound is carried out disinfection, antibacterial, the superinfection of the surface of a wound can be further prevented.While paraffin-polyvinyl alcohol wrappage
With alginate and the polymer synergy of gucosamine polymer formation, surface of a wound formation is protected.If temperature adjustment Bactericidal composite
Use ratio between the raw material of the thing corresponding wrappage that changes can not be then successfully generated, and then can not realize that its is corresponding
Function, then reduces temperature adjustment bactericidal composition temperature controllable, the function of sterilization.
Gucosamine polymer is the polymer as formed by monomer is gucosamine polymerization, and gucosamine also known as amino
Glucose, is commonly called as Viartril-S, Glucosamine can help to repair and safeguard cartilage, and can stimulate the growth of cartilage cell.And
Gucosamine polymer can suppress pathogen growth in embodiments of the present invention, and wound is protected.
It is further preferred that gucosamine polymer is acetyl glucosamine amine polymer, acetyl glucosamine amine polymer is
It is that acetylglucosamine passes through the polymer that polymerisation is obtained by monomer.Acetylglucosamine be shrimp and crab shells through deproteinized matter and
Go after mineral matter processing, then be made with special natural enzyme hydrolysis.Experiment finds to have increase skin hyaluronic acid containing content, slowed down
Arthralgia, the effect for improving diabetes and hepatitis symptom and enhancement immunocompetence.Acetyl grape in embodiments of the present invention
The mainly effect of glycosaminoglycan polymer is can to keep the humidity around wound, improves inflammation, bacteria growing inhibiting.
It is further preferred that acetyl glucosamine amine polymer is chitin, the base unit of chitin is acetyl glucosamine
Amine, chitin is that 4 glucoside chains, which are connected with each other, forms polymer by 1000~3000 acetyl glucoseamin residues by p1.First
Shell element has good biocompatibility, no biotoxicity, can accelerate human body wound healing.Chitin in embodiments of the present invention
Main function be to sterilize, accelerate speed of wound healing.
Alginate is also known as alginic acid glue, alginate or alginates, is the salt of alginic acid.By (1 → 4)-β-crosslinking
D-MANNOSE aldehydic acid and (1-4)-α-crosslinking guluronic acid constitute long-chain polymer.It is primarily present in the thin of brown alga
In cell wall and iuntercellular mucilage, exist in the bacteriums such as the pseudomonad and nitrogen-fixing bacteria of some production clayey pod membranes.In this hair
In bright embodiment the main function of alginate be can gel blockage then realize hemostasis, it can also mitigate pain and suppression
Bacterium, and in surface of a wound formation moist environment, wound healing.
Further one or more of the alginate in sodium alginate, potassium alginate and calcium alginate.Alginic acid
Sodium is that the accessory substance after iodine and mannitol is extracted from the sea-tangle or sargassum of brown algae, and its molecule is by beta-D-mannuronic acid
(β-D-mannuronic, M) and α-L- guluronic acids (α-L-guluronic, G) are pressed (1-4) key and are formed by connecting, and are a kind of
Natural polysaccharide, with the stability needed for pharmaceutical preparation auxiliary material, dissolubility, viscosity and security.It is extra large in embodiments of the present invention
The main function of mosanom be can stop blooding, the neighbouring wettability of skin and antibacterial of moisturizing wound.
Potassium alginate is white to slightly yellow threadiness or particulate powder, and almost odorless, tasteless, is dissolved in water, does not dissolve in
Second, ether or chloroform etc..The effect of potassium alginate is hemostasis and antibacterial in embodiments of the present invention.
Calcium alginate is powdered, and white is to light yellow indefinite, and odorless, tasteless is water insoluble.Its moisture content is high, with good
Good biological degradability and biocompatibility, in embodiments of the present invention its can stop blooding, the moistening of the neighbouring skin of moisturizing wound
Degree and bacteria growing inhibiting.
Further, temperature adjustment bactericidal composition is capsule shape, and the housing of temperature adjustment bactericidal composition is mainly by gucosamine
The shell that polymer and alginate are made, the inner core of the temperature adjustment bactericidal composition is mainly by paraffin and polyvinyl alcohol system
Into core body.Gucosamine polymer has the function of sterilization with the shell that alginate is made, and it is contacted with wound first, and
Skin around wound and wound is sterilized, stopped blooding simultaneously.During Wound healing, peripheral cell is active, around wound
Skin temperature is higher, and then temperature adjustment bactericidal composition is experienced after the temperature of wound and wound surrounding skin, paraffin and poly- second
The core body that enol is made melts to be wrapped up the surface of a wound for liquid, and wound temperature is reduced after parcel, and then core body condenses change once again
For solid, stick on the surface of a wound, can prevent the oxygen in air and bacterium from being acted on wound, effectively the surface of a wound can be carried out
Protection, promotes surface of a wound import healing.Meanwhile, the temperature for the regulation surface of a wound that the inner core that paraffin and polyethylene are made can also be suitably, energy
It is enough effectively to prevent the liquid such as wound and water from contacting, it is to avoid wound because of water and air effect and inflammation
Further, capsule shape temperature adjustment bactericidal composition particle diameter be 50-60 microns, the particle diameter of temperature adjustment bactericidal composition
It is small, and then good protection can be formed to the surface of a wound with the contact of the surface of a wound well.
The present invention also provides a kind of method for preparing temperature adjustment bactericidal composition：
After 10-25 parts of gucosamine polymer and 13-25 parts of alginates are mixed again with 20-30 parts of paraffin and 25-
The mixture that 35 parts of polyvinyl alcohols are obtained is mixed.
Specifically, the paraffin after thawing is mixed with polyvinyl alcohol stirring in the environment of 85-120 DEG C, specifically, mixed
Polyvinyl alcohol progress is dissolved before conjunction and obtains corresponding poly-vinyl alcohol solution.Paraffin and polyethylene during being stirred continuously
Alcohol can form paraffin-polyvinyl alcohol wrappage, specifically wrap up paraffin for polyvinyl alcohol.Stirring uses mechanical agitation and super
Sound stirring is combined.Mechanical agitation has higher mixing speed, can be mixed larger molecule, but for tiny
The mixing of molecule is then unfavorable.And ultrasonic agitation is to enable to paraffin molecule and polyvinyl alcohol molecule to obtain larger using ultrasonic wave
Energy, moved beneficial to paraffin molecule and polyvinyl alcohol molecule so that polyvinyl alcohol molecule parcel paraffin molecule then forms poly-
Vinyl alcohol-parafilm wrap thing.Now, the churned mechanically rotating speed of use is 200-400 revs/min, the stirring frequency of ultrasonic agitation
Rate is 30-40 KHzs, and the time of stirring is 3-5 hours.
Meanwhile, gucosamine polymer and alginate are configured to solution respectively, then in the environment of 85-120 DEG C
Gucosamine polymer solution and alginate solution are carried out being mixed to get alginate-gucosamine polymeric wrap.
Similarly use be also mechanical agitation and ultrasonic agitation to combination, ultrasound can be gucosamine polymer molecule and alginate
Molecule provides enough energy, is easy to the formation of wrappage, and mechanical agitation is beneficial to gucosamine polymer and alginate is mixed
Close uniform, further ensure wrappage and uniformly formed.Now, the churned mechanically rotating speed of use is 200-400 revs/min
Clock, the stirring frequency of ultrasonic agitation is 30-40 KHzs, and the time of stirring is 4-7 hours.
Finally, alginate-gucosamine polymer is added to paraffin-polyvinyl alcohol in the environment of 85-120 DEG C
In mixed solution, proceed stirring.Now, stirring is similarly the agitating mode that mechanical agitation and ultrasonic agitation are combined.This
When, the outside arrived of stirring reaction is alginate-gucosamine polymer, and inner core is the wrappage of paraffin-polyvinyl alcohol.It is super
Sound stirs provides sufficient power for the parcel of paraffin-polyvinyl alcohol-alginate-gucosamine polymer, it is ensured that wrappage
Can normally it be formed.Now, the churned mechanically rotating speed of use is 300-400 revs/min, the stirring frequency of ultrasonic agitation
It is 50-60 KHzs, the time of stirring is 3-8 hours.
The present invention also provides a kind of bandage, and it is mainly prepared by above-mentioned temperature adjustment bactericidal composition.The bandage
Sterilizing is carried out to the surface of a wound using above-mentioned temperature adjustment bactericidal composition and forms protection, when particularly this uses the bandage, the tune
The alginate of the outer surface of warm bactericidal composition-gucosamine polymer carries out disinfection to the skin near the surface of a wound and the surface of a wound
Sterilizing, then the surface of a wound is repaired automatically, now, accelerated cell division, propagation near the surface of a wound and the surface of a wound, or is gulped down
Bite, then cause cellular activity near the surface of a wound and the surface of a wound more enthusiastically, further such that the skin near the surface of a wound and the surface of a wound
Skin temperature is raised, and paraffin-polyvinyl alcohol is changed into liquid by the effect of the surface of a wound with higher-energy in temperature adjustment bactericidal composition
Body, is wrapped up the surface of a wound, then the temperature reduction of the surface of a wound, and paraffin-polyvinyl alcohol is changed into solid formation and further protected, prevents
Only the surface of a wound and water, air etc. are contacted.If the temperature of the surface of a wound is raised again, paraffin-polyvinyl alcohol is changed into liquid from solid once again, if
Temperature reduction paraffin-polyvinyl alcohol is changed into solid from liquid so that the bandage can be according to the recovery situation of the surface of a wound to the surface of a wound
Protected.
The present invention also provides a kind of preparation method of bandage, is sprayed above-mentioned temperature adjustment bactericidal composition using method of electrostatic spinning
Into sticking in bandage matrix after thread.The particle diameter of temperature adjustment bactericidal composition is smaller, is difficult to lay in bandage matrix
It is even, and then cause it to form good protection to the surface of a wound.Therefore the present invention using method of electrostatic spinning to the tune that has prepared
Warm bactericidal composition is sprayed.
Electrostatic spinning is exactly the special shape of polymeric fluid electrostatic atomization, and it is not small that now the material is divided in atomization
Drop, but the small jet of polymer, can run considerably long distance, finally be solidified into fiber.Specifically, it is quiet in high pressure
In the presence of electric field, the capillary spinning head of electrostatic spinning apparatus and earthing pole moment produce a potential difference so that in capillary
Solution overcome the surface tension and viscoplasticity power of itself, hemispherical drop is presented in spinning head end, then with electric field
The increase of intensity, drop is drawn as coniform i.e. Taylor cones.After electric-field intensity exceedes critical value, the surface of drop is overcome
Power formation jet, is further speeded up, diameter reduces in the electric field, and stretching is bent to after certain distance in line, and Posterior circle,
And the cooling and solidifying of the volatilization and molten mass along with solvent, you can obtain required material.
And the present invention uses electrostatic spinning, being can be using the effect of electrostatic spinning by the smaller temperature adjustment Bactericidal composite of particle diameter
Thing is uniformly injected in bandage matrix, it is ensured that the therapeutic effect of temperature adjustment bactericidal composition.Meanwhile, by being obtained after electrostatic spinning
The particle diameter of the temperature adjustment bactericidal composition arrived is 5-10 microns.The smaller temperature adjustment bactericidal composition of particle diameter is obtained by physical change,
Utilized so that it is more easy to be adsorbed by human body, increase and the contact area of the surface of a wound.
Specifically, the voltage that electrostatic spinning is used is 20-30Kv, when the voltage of electrostatic spinning is less than the voltage of the scope
When, temperature adjustment bactericidal composition can not be pulled into Taylor cones by electrostatic spinning apparatus, and then can not realize injection, i.e., can not carry out
The preparation of bandage.And if electrostatic spinning use overtension, obtained effluxvelocity can be caused too fast, temperature adjustment sterilization group
Compound is accumulated on a certain region of bandage matrix, and can not be well disperse, and reduces its therapeutic effect.
Temperature adjustment bactericidal composition of the present invention and preparation method thereof and bandage and preparation method thereof, temperature adjustment bactericidal composition
Solid-liquid metamorphosis paraffin-polyvinyl alcohol wrappage is formed according to temperature change using paraffin and polyvinyl alcohol, marine alga is utilized
Hydrochlorate and the formation of gucosamine polymer can be sterilized and antibacterial alginate-gucosamine polymeric wrap, and paraffin-poly-
Vinyl alcohol wrappage and the temperature adjustment bactericidal composition of alginate-gucosamine polymeric wrap formation can be according to the surface of a wound
Temperature realizes freely converting for temperature adjustment bactericidal composition liquid and solid-state, can form anti-to the surface of a wound according to the recovery situation of the surface of a wound
Shield, accelerates the recovery of the surface of a wound, it is to avoid superinfection of the surface of a wound etc..
The feature and performance to the present invention are described in further detail with reference to embodiments.
Embodiment 1
The temperature adjustment bactericidal composition that the present embodiment is provided is made up of plurality of raw materials.Plurality of raw materials includes 10g chitins, 20g
Sodium alginate, 20g paraffin and 25g polyvinyl alcohol.And the particle diameter of the temperature adjustment bactericidal composition is 55 microns.
The present embodiment also provides a kind of method for preparing temperature adjustment bactericidal composition：
10g chitins, 20g sodium alginates are dissolved in water wiring solution-forming respectively, it is then under the conditions of 85 DEG C, chitin is molten
Liquid and sodium alginate soln stirring are mixed to get sodium alginate-chitin wrappage.Wherein, the stirring mixing be mechanical agitation and
The agitating mode that ultrasonic agitation is combined, and churned mechanically rotating speed is 300 revs/min, the stirring frequency of ultrasonic agitation is 40
KHz, the time of stirring is 5 hours.
Under the conditions of 85 DEG C, the 25g polyvinyl alcohol after dissolving and the stirring of 20g paraffin are mixed to get polyvinyl alcohol-paraffin
Wrappage.Wherein, stirring mixing is the agitating mode that mechanical agitation and ultrasonic agitation are combined, and churned mechanically rotating speed is
250 revs/min, the stirring frequency of ultrasonic agitation is 35 KHzs, and the time of stirring is 3 hours.
Under the conditions of 85 DEG C, polyvinyl alcohol-parafilm wrap thing is mixed to get with sodium alginate-chitin wrappage stirring
Temperature adjustment bactericidal composition.Wherein, stirring mixing is the agitating mode that mechanical agitation and ultrasonic agitation are combined, and mechanical agitation
Rotating speed be 300 revs/min, the stirring frequency of ultrasonic agitation is 50 KHzs, and the time of stirring is 3 hours.
The present embodiment also provides a kind of bandage, and it is mainly prepared by above-mentioned temperature adjustment bactericidal composition.
The present embodiment also provides a kind of preparation method of bandage, using method of electrostatic spinning by above-mentioned temperature adjustment bactericidal composition
Be sprayed into it is thread after stick in bandage matrix.Specifically, the voltage that electrostatic spinning is used is 25Kv, and now, above-mentioned temperature adjustment is killed
The particle diameter of bacteria composition is 5 microns.
Embodiment 2
The temperature adjustment bactericidal composition that the present embodiment is provided is made up of plurality of raw materials.Plurality of raw materials includes 20g chitins, 13g
Potassium alginate, 25g paraffin and 35g polyvinyl alcohol.And the particle diameter of the temperature adjustment bactericidal composition is 60 microns.
The present embodiment also provides a kind of method for preparing temperature adjustment bactericidal composition：
20g chitins, 13g potassium alginates are dissolved in water wiring solution-forming respectively, then under the conditions of 100 DEG C, by chitin
Solution and the stirring of potassium alginate solution are mixed to get potassium alginate-chitin wrappage.Wherein, stirring mixing is mechanical agitation
The agitating mode being combined with ultrasonic agitation, and churned mechanically rotating speed is 400 revs/min, the stirring frequency of ultrasonic agitation is
35 KHzs, the time of stirring is 4 hours.
Under the conditions of 120 DEG C, the 35g polyvinyl alcohol after dissolving and the stirring of 25g paraffin are mixed to get polyvinyl alcohol-paraffin
Wrappage.Wherein, stirring mixing is the agitating mode that mechanical agitation and ultrasonic agitation are combined, and churned mechanically rotating speed is
400 revs/min, the stirring frequency of ultrasonic agitation is 40 KHzs, and the time of stirring is 4 hours.
Under the conditions of 100 DEG C, polyvinyl alcohol-parafilm wrap thing is mixed with potassium alginate-chitin wrappage stirring
To temperature adjustment bactericidal composition.Wherein, stirring mixing is the agitating mode that mechanical agitation and ultrasonic agitation are combined, and machinery is stirred
The rotating speed mixed is 350 revs/min, and the stirring frequency of ultrasonic agitation is 60 KHzs, and the time of stirring is 5 hours.
The present embodiment also provides a kind of bandage, and it is mainly prepared by above-mentioned temperature adjustment bactericidal composition.
The present embodiment also provides a kind of preparation method of bandage, using method of electrostatic spinning by above-mentioned temperature adjustment bactericidal composition
Be sprayed into it is thread after stick in bandage matrix.Specifically, the voltage that electrostatic spinning is used is 22Kv, and now, above-mentioned temperature adjustment is killed
The particle diameter of bacteria composition is 7 microns.
Embodiment 3
The temperature adjustment bactericidal composition that the present embodiment is provided is made up of plurality of raw materials.Plurality of raw materials includes 25g chitins, 25g
Calcium alginate, 30g paraffin and 30g polyvinyl alcohol.And the particle diameter of the temperature adjustment bactericidal composition is 50 microns.
The present embodiment also provides a kind of method for preparing temperature adjustment bactericidal composition：
25g chitins, 25g calcium alginates are dissolved in water wiring solution-forming respectively, then under the conditions of 120 DEG C, by chitin
Solution and the stirring of calcium alginate solution are mixed to get calcium alginate-chitin wrappage.Wherein, stirring mixing is mechanical agitation
The agitating mode being combined with ultrasonic agitation, and churned mechanically rotating speed is 200 revs/min, the stirring frequency of ultrasonic agitation is
30 KHzs, the time of stirring is 7 hours.
Under the conditions of 100 DEG C, the 25g polyvinyl alcohol after dissolving and the stirring of 25g paraffin are mixed to get polyvinyl alcohol-paraffin
Wrappage.Wherein, stirring mixing is the agitating mode that mechanical agitation and ultrasonic agitation are combined, and churned mechanically rotating speed is
300 revs/min, the stirring frequency of ultrasonic agitation is 30 KHzs, and the time of stirring is 5 hours.
Under the conditions of 100 DEG C, polyvinyl alcohol-parafilm wrap thing is mixed with calcium alginate-chitin wrappage stirring
To temperature adjustment bactericidal composition.Wherein, stirring mixing is the agitating mode that mechanical agitation and ultrasonic agitation are combined, and machinery is stirred
The rotating speed mixed is 400 revs/min, and the stirring frequency of ultrasonic agitation is 55 KHzs, and the time of stirring is 8 hours.
The present embodiment also provides a kind of bandage, and it is mainly prepared by above-mentioned temperature adjustment bactericidal composition.
The present embodiment also provides a kind of preparation method of bandage, using method of electrostatic spinning by above-mentioned temperature adjustment bactericidal composition
Be sprayed into it is thread after stick in bandage matrix.Specifically, the voltage that electrostatic spinning is used is 30Kv, and now, above-mentioned temperature adjustment is killed
The particle diameter of bacteria composition is 10 microns.
Embodiment 4
The temperature adjustment bactericidal composition that the present embodiment is provided is made up of plurality of raw materials.Plurality of raw materials includes 15g chitins, 21g
Sodium alginate, 22g paraffin and 33g polyvinyl alcohol.And the particle diameter of the temperature adjustment bactericidal composition is 57 microns.
The present embodiment also provides a kind of method for preparing temperature adjustment bactericidal composition：
15g chitins, 21g sodium alginates are dissolved in water wiring solution-forming respectively, then under the conditions of 110 DEG C, by chitin
Solution and sodium alginate soln stirring are mixed to get sodium alginate-chitin wrappage.Wherein, stirring mixing is mechanical agitation
The agitating mode being combined with ultrasonic agitation, and churned mechanically rotating speed is 350 revs/min, the stirring frequency of ultrasonic agitation is
34 KHzs, the time of stirring is 6 hours.
Under the conditions of 120 DEG C, the 33g polyvinyl alcohol after dissolving and the stirring of 22g paraffin are mixed to get polyvinyl alcohol-paraffin
Wrappage.Wherein, stirring mixing is the agitating mode that mechanical agitation and ultrasonic agitation are combined, and churned mechanically rotating speed is
200 revs/min, the stirring frequency of ultrasonic agitation is 38 KHzs, and the time of stirring is 4 hours.
Under the conditions of 120 DEG C, polyvinyl alcohol-parafilm wrap thing is mixed with sodium alginate-chitin wrappage stirring
To temperature adjustment bactericidal composition.Wherein, stirring mixing is the agitating mode that mechanical agitation and ultrasonic agitation are combined, and machinery is stirred
The rotating speed mixed is 370 revs/min, and the stirring frequency of ultrasonic agitation is 57 KHzs, and the time of stirring is 7 hours.
The present embodiment also provides a kind of bandage, and it is mainly prepared by above-mentioned temperature adjustment bactericidal composition.
The present embodiment also provides a kind of preparation method of bandage, using method of electrostatic spinning by above-mentioned temperature adjustment bactericidal composition
Be sprayed into it is thread after stick in bandage matrix.Specifically, the voltage that electrostatic spinning is used is 25Kv, and now, above-mentioned temperature adjustment is killed
The particle diameter of bacteria composition is 8 microns.
Embodiment 5
The temperature adjustment bactericidal composition that the present embodiment is provided is made up of plurality of raw materials.Plurality of raw materials includes 18g chitins, 19g
Calcium alginate, 27g paraffin and 29g polyvinyl alcohol.And the particle diameter of the temperature adjustment bactericidal composition is 53 microns.
The present embodiment also provides a kind of method for preparing temperature adjustment bactericidal composition：
18g chitins, 19g calcium alginates are dissolved in wiring solution-forming after water respectively, then under the conditions of 95 DEG C, by chitin
Solution and the stirring of calcium alginate solution are mixed to get calcium alginate-chitin wrappage.Wherein, stirring mixing is mechanical agitation
The agitating mode being combined with ultrasonic agitation, and churned mechanically rotating speed is 250 revs/min, the stirring frequency of ultrasonic agitation is
38 KHzs, the time of stirring is 4 hours.
Under the conditions of 110 DEG C, the 29g polyvinyl alcohol after dissolving and the stirring of 27g paraffin are mixed to get polyvinyl alcohol-paraffin
Wrappage.Wherein, stirring mixing is the agitating mode that mechanical agitation and ultrasonic agitation are combined, and churned mechanically rotating speed is
350 revs/min, the stirring frequency of ultrasonic agitation is 32 KHzs, and the time of stirring is 3 hours.
Under the conditions of 110 DEG C, polyvinyl alcohol-parafilm wrap thing is mixed with calcium alginate-chitin wrappage stirring
To temperature adjustment bactericidal composition.Wherein, stirring mixing is the agitating mode that mechanical agitation and ultrasonic agitation are combined, and machinery is stirred
The rotating speed mixed is 380 revs/min, and the stirring frequency of ultrasonic agitation is 52 KHzs, and the time of stirring is 3 hours.
The present embodiment also provides a kind of bandage, and it is mainly prepared by above-mentioned temperature adjustment bactericidal composition.
The present embodiment also provides a kind of preparation method of bandage, using method of electrostatic spinning by above-mentioned temperature adjustment bactericidal composition
Be sprayed into it is thread after stick in bandage matrix.Specifically, the voltage that electrostatic spinning is used is 27Kv, and now, above-mentioned temperature adjustment is killed
The particle diameter of bacteria composition is 6 microns.
Comparative example 1：Commercially available bandage (benzalkonium chloride patch)
Experimental example 1
Select 60 hands that there is the patient slightly scratched, be divided into 6 groups, wherein 5 groups use embodiment 1- embodiments 5 respectively
The bandage prepared, another group of bandage using comparative example 1, then using same amount of water, with identical flow velocity pair
Elution 3 minutes is carried out to the position for posting bandage, the color of skin near the surface of a wound and the surface of a wound is observed after being then spaced 3 hours
And swelling degree, concrete outcome is shown in Table 1.
Change of skin near the surface of a wound of table 1 and the surface of a wound
It is poor using the bandage waterproof effect of comparative example 1 it can be seen from table 1, and the bandage of embodiment 1- embodiments 5
It itself can form separation layer to isolate water, good protection can be carried out to wound.And the wound of embodiment 1- embodiments 5
The fungistatic effect of patch is substantially better than the bandage of comparative example 1, so cause wound occur after getting wet swelling probability it is low.
In summary, each component mutually acts synergistically regulation temperature in 1-5 of embodiment of the present invention temperature adjustments bactericidal composition,
Bacteria growing inhibiting, forms good protection to the surface of a wound.Temperature adjustment bactericidal composition can realize that temperature adjustment is killed according to the temperature of the surface of a wound
Freely converting for bacteria composition liquid and solid-state, can protect surface of a wound formation according to the recovery situation of the surface of a wound, accelerate the surface of a wound
Recover, it is to avoid superinfection of the surface of a wound etc..
Embodiments described above is a part of embodiment of the invention, rather than whole embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of temperature adjustment bactericidal composition, it is characterised in that the temperature adjustment bactericidal composition is made up of plurality of raw materials, with parts by weight
Meter, the plurality of raw materials includes 10-25 parts of gucosamine polymer, 13-25 parts of alginates, 20-30 parts of paraffin and 25-35
Part polyvinyl alcohol.
2. temperature adjustment bactericidal composition according to claim 1, it is characterised in that the gucosamine polymer is acetyl Portugal
Grapes glucosamine polymer.
3. temperature adjustment bactericidal composition according to claim 2, it is characterised in that the acetyl glucosamine amine polymer is first
Shell element.
4. temperature adjustment bactericidal composition according to claim 1, it is characterised in that the alginate be selected from sodium alginate,
One or more in potassium alginate and calcium alginate.
5. temperature adjustment bactericidal composition according to claim 1, it is characterised in that the temperature adjustment bactericidal composition is capsule
Shape, the housing of the temperature adjustment bactericidal composition is mainly the shell being made up of gucosamine polymer and alginate, the tune
The inner core of warm bactericidal composition is mainly the core body being made up of paraffin and polyvinyl alcohol.
6. a kind of bandage, it is characterised in that the main temperature adjustment sterilization as described in claim 1-5 any one of the bandage
Composition is prepared.
7. a kind of preparation method of bandage, it is characterised in that using method of electrostatic spinning by described in claim 1-5 any one
Temperature adjustment bactericidal composition be sprayed into it is thread after stick in bandage matrix.
8. a kind of method for preparing temperature adjustment bactericidal composition, it is characterised in that comprise the following steps：In parts by weight, by 10-25
Part gucosamine polymer and 13-25 part alginates mix after again with 20-30 parts of paraffin and 25-35 parts of polyvinyl alcohols
Obtained mixture is mixed.
9. the method according to claim 8 for preparing temperature adjustment bactericidal composition, it is characterised in that the gucosamine polymerization
Thing, the alginate, the paraffin and the polyvinyl alcohol are mixed by the way of mixing, and mixing
The temperature of stirring is 85-120 DEG C, and mixing time is 10-20 hours.
10. the method according to claim 9 for preparing temperature adjustment bactericidal composition, it is characterised in that mixing is machinery
The agitating mode that stirring and ultrasonic agitation are combined.
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| CN201710436629.4A CN107137380B (en) | 2017-06-12 | 2017-06-12 | Temperature-regulating and sterilizing composition and preparation method thereof, and adhesive bandage and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710436629.4A CN107137380B (en) | 2017-06-12 | 2017-06-12 | Temperature-regulating and sterilizing composition and preparation method thereof, and adhesive bandage and preparation method thereof |
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| CN1962974A (en) * | 2006-11-04 | 2007-05-16 | 青岛大学 | Making process and use of phase-changing temperature-adjusting alginate fibers |
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| CN1962974A (en) * | 2006-11-04 | 2007-05-16 | 青岛大学 | Making process and use of phase-changing temperature-adjusting alginate fibers |
| CN101766585A (en) * | 2009-01-07 | 2010-07-07 | 吴天祥 | Medical paste film |
| CN104208741A (en) * | 2013-05-29 | 2014-12-17 | 陆建国 | Chitosan based adhesive bandage |
| CN106139239A (en) * | 2016-07-12 | 2016-11-23 | 东莞市万佳医疗科技有限公司 | Full-service fluid dressing and preparation method thereof |
| CN106400199A (en) * | 2016-08-31 | 2017-02-15 | 奥美医疗用品股份有限公司 | Phase change and temperature adjustment microcapsule material, preparation method thereof and prepared dressing |
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