CN101491689B - Biodegradable composite superfine fiber medicine controlled-release felt and preparation technique thereof - Google Patents
Biodegradable composite superfine fiber medicine controlled-release felt and preparation technique thereof Download PDFInfo
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- CN101491689B CN101491689B CN 200910010540 CN200910010540A CN101491689B CN 101491689 B CN101491689 B CN 101491689B CN 200910010540 CN200910010540 CN 200910010540 CN 200910010540 A CN200910010540 A CN 200910010540A CN 101491689 B CN101491689 B CN 101491689B
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Abstract
The invention discloses a biodegradable composite ultrafine fibrous drug control release felt and preparation technology thereof. The release felt is designed to solve technical problems that the prior dressing membranes have poorer mechanical strength in different degrees, are difficult to keep wound surfaces moistened, have unobvious treatment effect on the wound surfaces, are more expensive, have certain antigenicity, are adverse to large-range application, and the like. The release felt is prepared from the following materials in percentage by weight: 0 to 50 percent of chitosan, 49.9 to 99.9 percent of PLA or PLGA, and 0.1 to 25 percent of anti-inflammatory and bactericidal drug. The preparation technology for the release felt comprises the steps of: firstly, dissolving the chitosan and the PLA or the PLGA into a cosolvent trifluoroacetic acid to prepare into an even solution; secondly, adding a drug ingredient into the solution, and ensuring that the drug is fully dissolved and dispersed into the solution through ultrasonic oscillation; thirdly, utilizing electrospinning technology to prepare the ultrafine fibrous drug control release felt. The release felt is characterized in that the release felt has moderate mechanical strength, good air permeability, good hemostatic effect, moderate degradation speed, good anti-inflammatory and bactericidal effect, and simple preparation technology, keeps the wound surfaces moistened, and can be widely used for wound surface treatment of burn and wound as well as postoperative wound recovery treatment.
Description
Technical field:
The present invention relates to a kind of medicine controlled-release felt and preparation technology thereof, relate in particular to a kind of Biodegradable composite superfine fiber medicine controlled-release felt and preparation technology thereof.Can be widely used in burning, the Wound treating of wound and resuming treatment of postoperative wound.
Background technology:
Skin is the organ of human body maximum, if skin is subject to large tracts of land damage, can cause even general problem of many parts, as metabolism aggravation, moisture and protein excessively scatter and disappear, immune system disorder etc., the serious entail dangers to life of going back.If wound surface covers suitable dressing, can effectively reduce the order of severity of patient's body superelevation metabolism, ease the pain, prevent that antibacterial from infecting, and accelerates wound healing.Therefore, people extensively explore the Wound dressing that can be used as skin barrier in recent years.Chinese patent [CN 1395968] discloses a kind of biological fluid dressing chitosan membrane and preparation method thereof.It is characterized in that through acidolysis, add the adjuvants such as gelatin, glycerol, then neutralize and filter through sodium bicarbonate.But this fluid dressing membrane mechanical strength is relatively poor, is not easy to keep wound surface moistening.Chinese patent [CN 1554448] discloses a kind of chitosan gelatine polyvinyl alcohol biological hemostatic dressing, is formulated by chitosan, gelatin, polyvinyl alcohol, glycerol.This dressing has hydrophilic, film property, tractive and haemostatic effect preferably, but wound surface is not had obvious therapeutical effect.Chinese patent [CN 1380109] discloses a kind of chitosan, collagen and sodium alginate compounded spongy biological dressing and preparation technology thereof.This dressing good biocompatibility, adhesiveness is strong, has the active function and the anastalsis that promote wound healing.But its NTx price used is comparatively expensive, and has certain antigenicity, is unfavorable for widespread adoption.
Summary of the invention:
The invention provides a kind of Biodegradable composite superfine fiber medicine controlled-release felt, Biodegradable composite superfine fiber medicine controlled-release felt and preparation technology thereof is characterized in that: discharge felt and prepare by following percentage by weight: chitosan 0%-40%, PLA or PLGA 49.9%-99.9% and anti-inflammation and sterilization medicine 0.1%-25%;
The preparation technology of Biodegradable composite superfine fiber medicine controlled-release felt, realize by following step: first chitosan and PLA or PLGA are dissolved in the cosolvent trifluoroacetic acid, be prepared into homogeneous solution, then add ingredient, through sonic oscillation, make medicine fully dissolve dispersion, the recycling Electrospinning is made composite superfine fiber medicine controlled-release felt.
Characteristics of the present invention and beneficial effect: composite superfine fiber medicine controlled-release felt of the present invention has that mechanical strength is moderate, good permeability, haemostatic effect is good, degradation speed is moderate and can keep wound surface moistening, obvious anti-inflammation and sterilization effect arranged, and preparation technology is simple, can be widely used in the treatment of burning, wound and wound surface and resuming treatment of postoperative wound.
The biodegradable blend film of chitosan and PLA or PLGA has good biocompatibility, degradability, toughness and breathability, has the protection wound surface, attracts the effects such as wound exudate, anti-inflammation and sterilization, hemostasis, analgesia, promotion wound healing and skin regeneration for large-area burns, wound.And being combined with each other, blend film and antibacterials improved its anti-inflammatory.
Adopting the Electrospinning preparation to discharge felt, realize spinning process or utilize high voltage electric field to realize spinning under electric field action, is a kind of specific form of electrostatic atomization (or electron spray), and method is simple, and is with low cost.Can satisfy medicine controlled-release felt adhesion and infiltrative requirement.
Description of drawings:
Fig. 1 contains the composite superfine fiber medicine controlled-release felt optical microscope photograph that 15% ring third kills star
Fig. 2 contains the release profiles that 15% ring third kills the composite superfine fiber medicine controlled-release felt of star
Fig. 3 contains the optical microscope photograph of the composite superfine fiber medicine controlled-release felt of 8% sulfadiazine
Fig. 4. contain the release profiles of the composite superfine fiber medicine controlled-release felt of 8% sulfadiazine
The specific embodiment:
Biodegradable composite superfine fiber medicine controlled-release felt and preparation technology thereof discharge felt and prepare by following percentage by weight: chitosan 0%-40%, PLA or PLGA 49.9%-99.9%% and anti-inflammation and sterilization medicine 0.1%-25%; Described chitosan is medicated chitin, and molecular weight is below 10000, and deacetylation is 75%～95%.Described PLA or PLGA, molecular weight be at 20,000-500, and 000.Described anti-inflammation and sterilization medicine is that oil-soluble or water miscible silver sulfadiazine, sulfadiazine, promise fluorine kill star or encircle third and kill the star medicine.
The preparation technology of Biodegradable composite superfine fiber medicine controlled-release felt, realize by following step: first chitosan and PLA or PLGA are dissolved in the cosolvent trifluoroacetic acid, be prepared into homogeneous solution, then add ingredient, through sonic oscillation, make medicine fully dissolve dispersion, the recycling Electrospinning is made composite superfine fiber medicine controlled-release felt.
A kind of spining technology that described Electrospinning refers to the spinning process under electric field action or utilizes high voltage electric field to realize is a kind of specific form of electrostatic atomization (or electron spray), and method is simple, and is with low cost.Electrospun equipment is made of several parts such as high tension generator, spinning liquid container, spinning nozzle and fiber receiving screens.The Electrospun process is as follows: with the spinning liquid spinning liquid container of packing into, and make chargedly, there is the competition of electrostatic repulsion and surface tension of liquid in the solution from spinning nozzle flows out.When electric field intensity is enough large, will overcome surface tension, fly out from the drop surface, form jet.In the process of comparative electrode flight, liquid stream constantly stretches, and solvent wherein volatilizees fast, namely discharges felt thereby obtain solid fiber on the collection screen of ground connection.
Chitosan is that occurring in nature is only second to cellulosic second largest biological polyoses, is also the alkaline polysaccharide of the unique a large amount of existence of occurring in nature simultaneously.Chitosan itself has biological activity and anastalsis, can stop formation, the hypertrophy of connective tissue cell and the synthesizing of collagen protein of fibrin element.The poly-'alpha '-hydroxy acids such as PLA or PLGA is the biodegradable polymer of synthetic, have the advantages such as good biocompatibility, mechanical strength be good, especially PLA by U.S. food and drug administration regard as can be applicable to clinical, as as operation suture thread and embedded material etc., and can prepare good intermingling material with chitosan.The mechanical strength that the poly-'alpha '-hydroxy acids such as PLA or PLGA is good can make up the defective of chitosan bad mechanical strength just.Therefore; chitosan and PLA or PLGA are made the composite ultrafine fiber felt have good biocompatibility, degradability, toughness, elasticity and breathability, have the protection wound surface, attract the effects such as wound exudate, anti-inflammation and sterilization, hemostasis, analgesia, promotion wound healing and skin regeneration for large-area burns, wound.And being combined with each other, composite ultrafine fiber felt and antibacterials improved its anti-inflammatory.
Embodiment 1. is 10 with medicated chitin 40%(molecular weight, 000) and PLA 45%(molecular weight be 100,000) be dissolved in trifluoroacetic acid, then add anti-inflammatory drug ring third to kill star 15%, sonic oscillation, make medicine fully dissolve dispersion, the recycling Electrospinning is prepared into composite superfine fiber medicine controlled-release felt.It is the optical microscope photograph of this composite superfine fiber medicine controlled-release felt referring to Fig. 1.Be the control release profiles of this composite superfine fiber medicine controlled-release felt in 37 ℃ of phosphate buffers referring to Fig. 2.
Embodiment 2. is 3000 with medicated chitin 30%(molecular weight) and PLGA 60%(molecular weight be 80,000) be dissolved in trifluoroacetic acid, then add anti-inflammatory drug ring third to kill star 10%, sonic oscillation, make medicine fully dissolve dispersion, the recycling Electrospinning is prepared into composite superfine fiber medicine controlled-release felt.
Embodiment 4. is 3000 with medicated chitin 10%(molecular weight) and PLGA 70%(molecular weight be 50,000) be dissolved in trifluoroacetic acid, then add anti-inflammatory drug sulfadiazine 20%, sonic oscillation, make medicine fully dissolve dispersion, the recycling Electrospinning is prepared into composite superfine fiber medicine controlled-release felt.
Embodiment 5. is 0 with medicated chitin 0%(molecular weight) and PLGA 99.9%(molecular weight be 40,000) be dissolved in trifluoroacetic acid, then add anti-inflammatory drug ring third to kill star 0.1%, sonic oscillation, make medicine fully dissolve dispersion, the recycling Electrospinning is prepared into composite superfine fiber medicine controlled-release felt.
Embodiment 6. is 6000 with medicated chitin 30%(molecular weight) and the PLGA45%(molecular weight be 300,000) be dissolved in trifluoroacetic acid, then add anti-inflammatory drug silver sulfadiazine 25%, sonic oscillation, make medicine fully dissolve dispersion, the recycling Electrospinning is prepared into composite superfine fiber medicine controlled-release felt.
The deacetylation of the medicated chitin described in above-described embodiment 1-7 is 75%～95%.The Electrospun equipment that adopts is made of several parts such as high tension generator, spinning liquid container, spinning nozzle and fiber receiving screens.
Claims (7)
1. the preparation technology of Biodegradable composite superfine fiber medicine controlled-release felt, is characterized in that: discharge felt and prepare by following percentage by weight: chitosan 0%-40%, PLA or PLGA49.9%-99.9% and anti-inflammation and sterilization medicine 0.1%-25%;
The preparation technology of Biodegradable composite superfine fiber medicine controlled-release felt, realize by following step: first chitosan and PLA or PLGA are dissolved in the cosolvent trifluoroacetic acid, be prepared into homogeneous solution, then add the anti-inflammation and sterilization ingredient, through sonic oscillation, make medicine fully dissolve dispersion, recycling Electrospinning equipment is made composite superfine fiber medicine controlled-release felt.
2. the preparation technology of Biodegradable composite superfine fiber medicine controlled-release felt according to claim 1 is characterized in that: described release felt is by the percentage by weight preparation of chitosan 30%, PLGA 60% and anti-inflammation and sterilization medicine 10%.
3. the preparation technology of Biodegradable composite superfine fiber medicine controlled-release felt according to claim 1 is characterized in that: described release felt is by the percentage by weight preparation of chitosan 20%, PLA 72% and anti-inflammation and sterilization medicine 8%.
4. the preparation technology of Biodegradable composite superfine fiber medicine controlled-release felt according to claim 1 is characterized in that: described release felt is by the percentage by weight preparation of chitosan 10%, PLGA 70% and anti-inflammation and sterilization medicine 20%.
5. the preparation technology of the Biodegradable composite superfine fiber medicine controlled-release felt described according to claim 1-4 any one, it is characterized in that: described chitosan is medicated chitin, and molecular weight is below 10000, and deacetylation is 75%-95%.
6. the preparation technology of the Biodegradable composite superfine fiber medicine controlled-release felt described according to claim 1-4 any one is characterized in that: described PLA or PLGA, molecular weight be at 20,000-500, and 000.
7. the preparation technology of the Biodegradable composite superfine fiber medicine controlled-release felt described according to claim 1-4 any one is characterized in that: described anti-inflammation and sterilization medicine is that oil-soluble or water miscible silver sulfadiazine, sulfadiazine, promise fluorine kill star or encircle third and kill star.
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| CN102641520A (en) * | 2012-05-07 | 2012-08-22 | 吉林大学 | Preparation method of biological repair nano dressing containing wood frog skin polypeptide and being used for wounds and burn |
| CN103611187A (en) * | 2013-11-15 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Preparation method of tissue engineering scaffold for realizing time-ordered release of medicine |
| CN104452106A (en) * | 2014-11-20 | 2015-03-25 | 东华大学 | Preparing method for nanofiber membrane of composite silica-based drug-carrying nano particles |
| CN109289082A (en) * | 2018-11-22 | 2019-02-01 | 李忠 | A kind of absorbability medical hemostatic bibre material and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857236A (en) * | 2006-03-08 | 2006-11-08 | 曾敬 | Compound medicine release controlling film of chitosan, sodium alginate and gelatin and its preparing process |
| CN101336892A (en) * | 2008-06-19 | 2009-01-07 | 济南基福医药科技有限公司 | Gel injection of sustained-released topology enzyme inhibitor and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1857236A (en) * | 2006-03-08 | 2006-11-08 | 曾敬 | Compound medicine release controlling film of chitosan, sodium alginate and gelatin and its preparing process |
| CN101336892A (en) * | 2008-06-19 | 2009-01-07 | 济南基福医药科技有限公司 | Gel injection of sustained-released topology enzyme inhibitor and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 曾敬.可生物降解电纺丝超细纤维.《中国科学院博士学位研究生学位论文》.2006,文章第2-4页. * |
| 杨华等.聚乳酸/壳聚糖互穿网络薄膜的合成及药物释放.《暨南大学学报》.2007,第28卷(第5期),文章第495页1.3部分. * |
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