CN101045123A - Cream for treating burns with preventing from scar and its producing process - Google Patents
Cream for treating burns with preventing from scar and its producing process Download PDFInfo
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- CN101045123A CN101045123A CN 200610018691 CN200610018691A CN101045123A CN 101045123 A CN101045123 A CN 101045123A CN 200610018691 CN200610018691 CN 200610018691 CN 200610018691 A CN200610018691 A CN 200610018691A CN 101045123 A CN101045123 A CN 101045123A
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Abstract
A medicine in the form of ointment for treating burn and scald without scar is prepared from the W/O matrix, freeze-dried powder of aloe gel, borneol, hexadecanol, vaseline, sodium laurylsulfate, glycerin, ethylparaben, and distilled water. Its preparing process is also disclosed.
Description
Affiliated technical field:
The invention belongs to a kind of burn medicine and production technology.
Background technology:
At present, be used for the treatment of burn medicine silver sulfadiazine, silver nitrate emulsifiable paste, moist expose burn ointment, compound recipe Crinis Carbonisatus ointment, silver pink ointment etc. are arranged.Silver sulfadiazine, silver nitrate emulsifiable paste belong to silver ion class medicine, and its shortcoming is that silver ion can combine with epithelial DNA, influences epithelization, even deepen wound surface, and wound healing is had a negative impact, and wound healing time is long, and more the back cicatrix is big and obvious.Moist expose burn ointment moist expose burn ointment, compound recipe Crinis Carbonisatus ointment, silver pink ointment also can't solve problems such as pain clinically, and all are oiliness ointment, and the coating and the breathability of the position plaster that is unfavorable for burning are poor.
Summary of the invention:
The object of the present invention is to provide a kind of healing time short, more the no cicatrix in back and treat in be easy to be coated with and good permeability, the production technology of the cream for treating burns with preventing from scar and the cream for treating burns with preventing from scar of pain relieving effect arranged.
Cream for treating burns with preventing from scar of the present invention, it is to be made by following proportion raw material: 10～50 parts of 1: 10～200 aloe vera dry jelly powders, described 1: 10～200 refer to 10～200 parts of aloe vera gel lyophilizations becomes 1 part of aloe vera dry jelly powder, (amount about aloe vera dry jelly powder among the present invention defines together than explaining also for this reason), 1～20 part of Borneolum Syntheticum, 140～160 parts of hexadecanol, 390～410 parts in vaseline, 5～20 parts of sodium lauryl sulphates, 40～60 parts of glycerol, ethyl hydroxybenzoate (5～10%, promptly 5～10g ethyl hydroxybenzoate is dissolved in the 100ml dehydrated alcohol) 10～30ml, 1000 parts of distilled water.The optimum ratio of each raw material is: 1: 100 aloe vera dry jelly powder 25g, and Borneolum Syntheticum 10g, hexadecanol 150g, vaseline 400g, sodium lauryl sulphate 10g, glycerol 50g, 10% ethyl hydroxybenzoate 20ml, distilled water is made 1000g.
The production technology of cream for treating burns with preventing from scar is:
1. oil phase preparation: get the formula ratio hexadecanol successively, vaseline is heated to fusing, and attemperation is incubated 10～30 minutes at 70～80 ℃.
2. water preparation: successively formula ratio glycerol, sodium lauryl sulphate are added in the distilled water, be heated to 70～80 ℃, add ethyl hydroxybenzoate,, be incubated 10～30 minutes with adding with stirring
3. the preparation of drug solution: get formula ratio Aloe gel lyophilized powder, add the water dissolution of 2～3 times of Aloe gel lyophilized powder formula ratios, stir.Get the formula ratio Borneolum Syntheticum, 5～10ml anhydrous alcohol solution.
4. emulsifying dosing: the oil phase prepared product is slowly added temperature under 70～80 ℃ of temperature be in 70～80 ℃ the water prepared product, with adding with stirring, when continuing to be stirred to temperature and being 40～45 ℃, add 1: 2～1: 3 aqueous solution of Aloe gel lyophilized powder still by same direction with adding with stirring, and continue to stir 2～10 minutes, subsequently, add Borneolum Syntheticum solution with adding with stirring, continue to stir 2～10 minutes, and room temperature is placed to condensation.The uviol lamp sterilization is 20～30 minutes after the packing, promptly gets cream for treating burns with preventing from scar.
Aloe gel is widely used in treating scald and incision and back preventing from scar more among the people; With Aloe gel local deep burn is treated, be 11.89 days the average time that Aloe gel heals a wound, and compared statistical significance (P＜0.05) with 18.19 days of vaseline group; With the wound of Aloe gel treatment diabetic mice model back, the result shows that Aloe can be by influencing inflammation, fibrous tissue formation, collagen protein synthesis and wound contraction and accelerating wound healing; Main saccharic composition is the 6-phosphomannose in the Aloe gel, and this composition has anti-inflammatory activity and can promote wound healing; Use Aloe or Aloe to mix use with other drug separately and handle the extensibility that wound all can increase wound, the delayed growth material that neutralization uses some drugs to produce because of the part, accelerating wound healing; Aloe can increase the content of collagen protein and hydroformylation thing in the granulation tissue, reduces the aldehyde dissolubility, and Aloe can increase the level of III collagen type, and topical application or oral aloetic effect are similar.Aloe can also be accelerated the biosynthesis and the degraded of collagen protein, increases new collagenogenic crosslinked and influence the agglutination of wound.In addition, Borneolum Syntheticum has antibiotic and pacifies neural effect.Above material explanation Aloe and Borneolum Syntheticum have treatment burn effect preferably.In the development of burn cream, be that main component does not add the preparation that Borneolum Syntheticum is made with the aloe vera dry jelly powder, it has facilitation preferably to wound healing in burn treating, but can not alleviate wound pain; And be that main component does not add the preparation that aloe vera dry jelly powder is made with the Borneolum Syntheticum, it can alleviate wound pain in burn treating, but not good enough to the wound healing facilitation.With aloe vera dry jelly powder and Borneolum Syntheticum as treatment burn key component, with hexadecanol, vaseline, sodium lauryl sulphate, glycerol, the w/o type ointment that the ethyl hydroxybenzoate ethanol solution is made as pharmaceutical adjunct, compare with existing burn cream on the market, cream for treating burns with preventing from scar of the present invention does not belong to the oiliness plaster, can produce facilitation preferably to wound healing, can alleviate the pain of burn wound again, good permeability is coated with being easy to, sufferer is easy to accept, and these advantages are that existing oiliness burn cream does not have.In addition, the burn cream of using clinically at present there is no with aloe frozen-dried powder and the Borneolum Syntheticum preparation as principal agent, cream for treating burns with preventing from scar of the present invention is that main pharmacodynamics becomes powder to make with aloe frozen-dried powder and Borneolum Syntheticum only, confirm that by pharmacological evaluation its treatment burn is respond well, and preparation reality is little, technology is simple, is easy to promote, and this also is one of innovation place of the present invention.
In a word, cream for treating burns with preventing from scar of the present invention has adopted preferred 1: 100 aloe vera dry jelly powder, and it contains the Aloe polysaccharide that wound healing is had remarkable facilitation, can suppress the fibroblastic undue growth of wound surface latter stage at wound healing, thereby prevent the generation of cicatrix; Cream for treating burns with preventing from scar of the present invention, adopted main loose strongly fragrant, can heat extraction, expedite the emergence of, property is walked and do not keep, also can granulation promoting analgesic Borneolum Syntheticum; In addition, cream for treating burns with preventing from scar of the present invention has adopted w/o type ointment substrate, has good permeability and is easy to advantage such as coating.To sum up, cream for treating burns with preventing from scar needed raw material of the present invention is few, cost is cheap, has effects such as reducing swelling and alleviating pain, granulation promoting, is used for each I, the II degree burns, scalds, burns, more the back preventing from scar.
1, the research of preparing process:
Substrate temperature is an object of study during with the dissolving water consumption of preparation technology's medicine and dosing, has carried out primary study, has determined a comparatively reasonably process route, situation such as following table 2:
1. investigate index: the accelerated stability with preparation serves as to investigate index.
2. substrate temperature when the dissolving water consumption of medicine and dosing
Table 2 amount of water and substrate temperature are to the influence of patent medicine stability
| The scheme numbering | Lyophilized powder: water (g/V) | Drug condition before mixing | The dosing substrate temperature (℃) | Centrifugal 30 minutes (3000r/nin) |
| Scheme 1 scheme 2 schemes 3 schemes 4 schemes 5 schemes 6 schemes 7 schemes 8 | 1∶0 1∶1 1∶2 1∶3 1∶0 1∶1 1∶2 1∶3 | White powder white pasty state white suspension white suspension white powder white pasty state white suspension white suspension | 40 40 40 40 45 45 45 45 | The serious water-oil separating of water-oil separating does not have water-oil separating and does not have the slight water-oil separating of water-oil separating water-oil separating and do not have water-oil separating and do not have water-oil separating |
Can find out the requirement of having only scheme 8 can satisfy the preparation accelerated stability from table 1, and when producing, the Aloe gel lyophilized powder is dissolved into liquid, helps the uniform mixing of itself and emulsion bases.Therefore, scheme 8 meets the preparation production requirement.
Manufacturing process and process conditions
1. oil phase preparation: get formula ratio hexadecanol vaseline successively and be heated to fusing, and attemperation is incubated 10～30 minutes at 70～80 ℃.
2. water preparation: successively formula ratio glycerol, sodium lauryl sulphate are added in the distilled water, be heated to 70～80 ℃, add ethyl hydroxybenzoate,, be incubated 10～30 minutes with adding with stirring
3. the preparation of drug solution: get formula ratio Aloe gel lyophilized powder, add 2～3 times of water gaging dissolvings, stir.Get the formula ratio Borneolum Syntheticum, 5～10ml anhydrous alcohol solution.
4. emulsifying dosing: under 70～80 ℃ of conditions, oil phase is slowly added aqueous phase,, continue to be stirred to 40～45 ℃ with adding with stirring.Add 1: 2～1: 3 aqueous solution of Aloe gel lyophilized powder still by same direction with adding with stirring, and continue to stir 2～10 minutes, subsequently, add Borneolum Syntheticum solution with adding with stirring, continue to stir 2～10 minutes, and room temperature is placed to condensation.The uviol lamp sterilization is 20～30 minutes after the packing, promptly gets cream for treating burns with preventing from scar.
2, pharmacological effect:
(1) the shallow II degree burn of Aloe cream for treating burns with preventing from scar treatment rat model
1) method
Scald device: the built-in 250ml conical flask of electric jacket, at the plate foam of taper bottleneck connection polrvinyl chloride, 1 * 1cm is dug in the centre
2The hole, the built-in distilled water of conical flask, heated and boiled during the burn modelling.
The making of model: rat back is used 8% Na in advance
2The depilation of S aqueous solution conformed after the depilation 1 day.Thereafter with rat with etherization after, on the scald device of making, scald with the steam of heated and boiled, scald time 6s, forming area is the shallow II degree scald of 1 * 1cm2.
The judgement that shallow II degree is scalded: the visible edge of wound of perusal forms tangible boundary around a white border line with normal skin around the wound surface, and wound surface is shallow white.Pathological section visible papillary layer of corium under light microscopic has obvious hyperemia, edema and leukocyte infiltration, collagen fiber swelling, discrete.
Experiment grouping: each is scalded rat, be divided into 5 groups at random, every group 10, be respectively dosage (containing Aloe gel lyophilized powder 25g/kg) group (B), Aloe cream for treating burns with preventing from scar low dosage (containing Aloe gel lyophilized powder 10g/kg) group (C), Sulfadiazine Silver Cream group (D) and blank matrix group (E) in Aloe cream for treating burns with preventing from scar high dose (containing Aloe gel lyophilized powder 50g/kg) group (A), the Aloe cream for treating burns with preventing from scar.
Medication: 5 groups of shallow II degree scalding model rats external are respectively respectively organized ointment, and thickness 0.5-1.0mm changes dressings 2 every day, clear up wound surface with normal saline before changing dressings.
Wound healing time: the wound surface incrustation comes off fully and is the standard of wound healing.
2) result
Wound healing time: A group is scalded back wound healing A average time group 11.4 days, B group 11.6 days, C group 13.8 days, D group 17.8 days, E group 17.4 days, A group, B group, C group and E group 17.4 days are compared with 17.8 days average healing times of D group all has significant statistical significance (P＜0.05); A group, B group and 13.8 days average healing times of C group are compared also all significant statistical significance (P＜0.05); A group and the no significant difference of B group.Knot high dose and middle dosage Aloe cream for treating burns with preventing from scar to burned rats after wound healing significant curative effect is arranged.See the following form 3:
Wound healing time after table 3 burned rats (n=10, x ± s)
| Group | A | B | C | D | E |
| Wound healing time (my god) | 11.4±2.2 | 11.6±1.7 | 13.8±3.0 | 17.8±1.6 | 17.4±2.9 |
Wound surface area: see the following form 3
Table 3 is hindered the back different time and is respectively formed the variation of face area (n=10, x ± s)
| Group | Wound surface area (cm 2) | |||
| 0d | 3d | 7d | 11d | |
| A B C D E | 0.95 0.95 0.95 0.95 0.95 | 0.95±0.23 0.90±0.30 0.93±0.21 0.99±0.10 1.13±0.52 | 0.86±0.52 0.66±0.54 1.11±0.62 1.22±0.26 1.23±0.32 | 0.30±0.44 0.20±0.30 0.59±0.80 0.83±0.38 0.92±0.52 |
Traumatic infection situation: see the following form 4
Table 4 is hindered the back different time and is respectively formed face infection conditions (n=10)
| Group | Traumatic infection (only) | ||
| 3d | 7d | 11d | |
| A B C D E | 0 0 3 0 5 | 2 1 2 0 9 | 0 0 0 0 3 |
More back cicatrix: A, B, C treat and saw wound surface on the 17th day and all heal, and blotchy surface is smooth, is as good as with the surrounding skin color, and all has thin big fine hair to grow.The treatment of D group was observed wound surface on the 20th day and is all healed, and blotchy surface has a small amount of projection injustice, compares with surrounding skin, and color is dark, the villus growth rareness.The treatment of E group was observed wound surface on the 20th day and is all healed, and blotchy surface is smooth, compares with surrounding skin, and color is as good as, the villus growth rareness.
(2) the rat hot plate method causes the pain test
(scalping, the threshold of pain＜30s) are divided into 3 groups (10 every group), matched group, Aloe cream for treating burns with preventing from scar group (25g/kg), silver sulfadiazine group at random with 30 of female rats.The administration group with warm water flush away ointment, is cleaned with dry cotton ball.Behind the medicine 1,1.5,2h drops into hot plate to the response time that metapedes occurs licking, the i.e. threshold of pain by literature method record rat.The result shows, the be significantly improved effect (seeing the following form 5) of the rat hot plate method threshold of pain of Aloe cream for treating burns with preventing from scar.
Table 5 Aloe cream for treating burns with preventing from scar is to the influence of the rat hot plate method threshold of pain (n=10, x ± s)
| Group | The preceding threshold of pain of medicine | Behind the medicine | ||
| 1h | 1.5h | 2h | ||
| Silver sulfadiazine group Aloe cream for treating burns with preventing from scar group blank group | 17.4±3.2 18.1±3.4 17.9±3.5 | 20.3±5.7 33.5±12.2 21.4±6.2 | 19.1±4.4 31.4±9.7 20.1±5.5 | 18.5±5.0 28.7±10.0 18.4±2.2 |
(3) conclusion by above test as can be known, the Aloe cream for treating burns with preventing from scar is scalded effective than other groups to the shallow II degree of rat, healing time is short, less thoughts dye existing, more after no speckle trace; And silver sulfadiazine treatment healing required time is obviously long partially, and healing back cicatrix is obvious, the blotchy surface injustice, and the colour of skin is dark, and the Aloe cream for treating burns with preventing from scar has significant analgesia role in addition.This test provides experimental basis for the clinical treatment minor burn.
Behind toxicological test rat and the Cavia porcellus external high and low dose Aloe cream for treating burns with preventing from scar, do not have any toxic reaction and anaphylaxis and occur, illustrate that the external of Aloe cream for treating burns with preventing from scar is safe and reliable.Main component is mainly Aloe gel lyophilized powder and Borneolum Syntheticum in the Aloe cream for treating burns with preventing from scar, does not contain the toxicity material, according to the document requirement, can not need carry out long term toxicity test.
Label and operation instructions sample manuscript
[nomenclature of drug] Aloe cream for treating burns with preventing from scar
[Chinese phonetic alphabet] Luhui fangba burns cream
[medicine composition] aloe vera dry jelly powder, Borneolum Syntheticum
[character] this product is an emulsion-type matrix white emulsifiable paste
[effect classification] this product is the burn and scald OTC (over-the-counter)
The external of [pharmacological action] this product is scalded the tissue experiment to the shallow II degree of rat local skin, has the promotion wound healing, the more not clear effect of back preventing from scar or cicatrix.
[function cures mainly] promoting blood circulation and detoxication, reducing swelling and alleviating pain, granulation promoting.Be used for various slight burnings, scald, burn.
[usage and dosage] external.Clear up wound surface with normal saline, the about 1mm thickness of coating this product was changed dressings once in every 6-8 hour.
[points for attention]
(1) this product is a medicine for external use, oral administration not, the careful usefulness of anemia of pregnant woman.
(2) this product is not done severe burn treatment research.
(3) scald local application and please note that the cleaning of wound surface is clean, exposure method is adopted in suggestion under cleaning ambient.
(4) during slight burn and scald treatment, wound surface has the pus tongue should remove hospital admission in the medication 1 day.
(5) use this medicine should note the whole body situation,, should in time remove hospital admission if any hyperpyrexia, when symptom such as shaking all over.
(6) the aloe juice allergy sufferers is forbidden.
[holding conditions] sealing, is put shady and cool dry place at shading.
[specification] every bag 10 gram
[packing]
[effect duration] 1 year
[date of manufacture] sees packing
Pharmaceutical college of [production unit] Medical University Of Fujian.
The specific embodiment:
Prescription 1:
1: 200 aloe vera dry jelly powder 10g; The 1g Borneolum Syntheticum; The 140g hexadecanol; 390g vaseline; The 5g sodium lauryl sulphate; 60g glycerol; 10% ethyl hydroxybenzoate 10ml; Distilled water is made 1000g.
Preparation method: 1. oil phase preparation: get formula ratio hexadecanol vaseline successively and be heated to fusing, and attemperation is incubated 10 minutes at 70 ℃; 2. water preparation: successively formula ratio glycerol, sodium lauryl sulphate are added in the distilled water, be heated to 70 ℃, add ethyl hydroxybenzoate,, be incubated 10 minutes with adding with stirring; 3. the preparation of drug solution: get formula ratio Aloe gel lyophilized powder, add 2 times of water gaging dissolvings, stir.Get the formula ratio Borneolum Syntheticum, the 5ml anhydrous alcohol solution; 4. emulsifying dosing: 70 ℃ of oil phases are slowly added 70 ℃ of aqueous phases,, continue to be stirred to 40 ℃ with adding with stirring.1: 2 aqueous solution of weight ratio that adds Aloe gel lyophilized powder and water still by same direction with adding with stirring, and continue to stir 2 minutes, subsequently, add Borneolum Syntheticum solution with adding with stirring, continue stirring 2 minutes, and room temperature is placed to cooling.The uviol lamp sterilization is 20 minutes after the packing, promptly gets cream for treating burns with preventing from scar.
Prescription 2:
1: 100 aloe vera dry jelly powder 20g; The 10g Borneolum Syntheticum; The 150g hexadecanol; 400g vaseline; The 10g sodium lauryl sulphate; 50g glycerol; 6% ethyl hydroxybenzoate 15ml; Distilled water is made 1000g.
Preparation method: 1. oil phase preparation: get formula ratio hexadecanol vaseline successively and be heated to fusing, and attemperation is incubated 20 minutes at 70 ℃; 2. water preparation: successively formula ratio glycerol, sodium lauryl sulphate are added in the distilled water, be heated to 70 ℃, add ethyl hydroxybenzoate,, be incubated 20 minutes with adding with stirring; 3. the preparation of drug solution: get formula ratio Aloe gel lyophilized powder, add 3 times of water gaging dissolvings, stir.Get the formula ratio Borneolum Syntheticum, the 10ml anhydrous alcohol solution; 4. emulsifying dosing: 70 ℃ of oil phases are slowly added 70 ℃ of aqueous phases,, continue to be stirred to 45 ℃ with adding with stirring.Add 1: 3 aqueous solution of Aloe gel lyophilized powder still by same direction with adding with stirring, and continue to stir 3 minutes, subsequently, add Borneolum Syntheticum solution with adding with stirring, continue to stir 3 minutes, and room temperature is placed to condensation.The uviol lamp sterilization is 25 minutes after the packing, promptly gets cream for treating burns with preventing from scar.
Prescription 3:
Aloe vera dry jelly powder 25g, 10g Borneolum Syntheticum, 150g hexadecanol, 400g vaseline, 10g sodium lauryl sulphate, 50g glycerol, 10% ethyl hydroxybenzoate 20ml, distilled water were made 1000g in 1: 100
Preparation method: 1. oil phase preparation: get formula ratio hexadecanol vaseline successively and be heated to fusing, and attemperation is incubated 30 minutes at 70 ℃; 2. water preparation: successively formula ratio glycerol, sodium lauryl sulphate are added in the distilled water, be heated to 70 ℃, add ethyl hydroxybenzoate,, be incubated 30 minutes with adding with stirring; 3. the preparation of drug solution: get formula ratio Aloe gel lyophilized powder, add 3 times of water gaging dissolvings, stir.Get the formula ratio Borneolum Syntheticum, the 10ml anhydrous alcohol solution; 4. emulsifying dosing: 70 ℃ of oil phases are slowly added 70 ℃ of aqueous phases,, continue to be stirred to 45 ℃ with adding with stirring.Add 1: 3 aqueous solution of Aloe gel lyophilized powder still by same direction with adding with stirring, and continue to stir 5 minutes, subsequently, add Borneolum Syntheticum solution with adding with stirring, continue to stir 5 minutes, and room temperature is placed to condensation.The uviol lamp sterilization is 30 minutes after the packing, promptly gets cream for treating burns with preventing from scar.
Prescription 4:
Aloe vera dry jelly powder 35g, 15g Borneolum Syntheticum, 160g hexadecanol, 390g vaseline, 15g sodium lauryl sulphate, 55g glycerol, 5% ethyl hydroxybenzoate 25ml, distilled water were made 1000g in 1: 10
Preparation method: 1. oil phase preparation: get formula ratio hexadecanol vaseline successively and be heated to fusing, and attemperation is incubated 30 minutes at 75 ℃; 2. water preparation: successively formula ratio glycerol, sodium lauryl sulphate are added in the distilled water, be heated to 70 ℃, add ethyl hydroxybenzoate,, be incubated 20 minutes with adding with stirring; 3. the preparation of drug solution: get formula ratio Aloe gel lyophilized powder, add 2 times of water gaging dissolvings, stir.Get the formula ratio Borneolum Syntheticum, the 20ml anhydrous alcohol solution; 4. emulsifying dosing: 70 ℃ of oil phases are slowly added 70 ℃ of aqueous phases,, continue to be stirred to 45 ℃ with adding with stirring.Add 1: 2 aqueous solution of Aloe gel lyophilized powder still by same direction with adding with stirring, and continue to stir 3 minutes, subsequently, add Borneolum Syntheticum solution with adding with stirring, continue to stir 3 minutes, and room temperature is placed to condensation.The uviol lamp sterilization is 25 minutes after the packing, promptly gets cream for treating burns with preventing from scar.
Prescription 5:
Aloe vera dry jelly powder 50g, 20g Borneolum Syntheticum, 150g hexadecanol, 410g vaseline, 20g sodium lauryl sulphate, 60g glycerol, 8% ethyl hydroxybenzoate 30ml, distilled water were made 1000g in 1: 10
Preparation method: 1. oil phase preparation: get formula ratio hexadecanol vaseline successively and be heated to fusing, and attemperation is incubated 30 minutes at 80 ℃; 2. water preparation: successively formula ratio glycerol, sodium lauryl sulphate are added in the distilled water, be heated to 80 ℃, add ethyl hydroxybenzoate,, be incubated 30 minutes with adding with stirring; 3. the preparation of drug solution: get formula ratio Aloe gel lyophilized powder, add 2 times of water gaging dissolvings, stir.Get the formula ratio Borneolum Syntheticum, the 20ml anhydrous alcohol solution; 4. emulsifying dosing: 80 ℃ of oil phases are slowly added 80 ℃ of aqueous phases,, continue to be stirred to 45 ℃ with adding with stirring.Add 1: 2 aqueous solution of Aloe gel lyophilized powder still by same direction with adding with stirring, and continue to stir 10 minutes, subsequently, add Borneolum Syntheticum solution with adding with stirring, continue to stir 10 minutes, and room temperature is placed to condensation.The uviol lamp sterilization is 30 minutes after the packing, promptly gets cream for treating burns with preventing from scar.
Claims (3)
1. cream for treating burns with preventing from scar, it is to be made by following proportion raw material:
1: 10～200 aloe vera dry jelly powders, 10～50 weight portions, Borneolum Syntheticum 1～20 weight portion, hexadecanol 140～160 weight portions, vaseline 390～410 weight portions, sodium lauryl sulphate 5～20 weight portions, glycerol 40～60 weight portions, 5～10% ethyl hydroxybenzoate ethanol solutions, 10～30ml, adding distil water to total formulation weight is 1000 weight portions.
2. cream for treating burns with preventing from scar according to claim 1 is characterized in that: each proportion of raw materials is:
1: 100 aloe vera dry jelly powder 25g, Borneolum Syntheticum 10g, hexadecanol 150g, vaseline 400g, sodium lauryl sulphate 10g, glycerol 50g, 5～10% ethyl hydroxybenzoate ethanol solution 20ml, adding distil water to total formulation weight is 1000g.
3. the production technology of the described cream for treating burns with preventing from scar of claim is characterized in that:
1. oil phase preparation: get formula ratio hexadecanol vaseline successively and be heated to fusing, and attemperation is incubated 10～30 minutes at 70～80 ℃;
2. water preparation: successively formula ratio glycerol, sodium lauryl sulphate are added in the distilled water, be heated to 70～80 ℃, add ethyl hydroxybenzoate,, be incubated 10～30 minutes with adding with stirring;
3. the preparation of drug solution: get formula ratio Aloe gel lyophilized powder, add 2～3 times of water gaging dissolvings, stir; Get the formula ratio Borneolum Syntheticum, 5～10ml anhydrous alcohol solution;
4. emulsifying dosing: under 70～80 ℃ of temperature, oil phase is slowly added aqueous phase, with adding with stirring, continue to be stirred to 40～45 ℃, add 1: 2～1: 3 aqueous solution of Aloe gel lyophilized powder still by same direction with adding with stirring, and continue to stir 2～10 minutes, subsequently, add Borneolum Syntheticum solution with adding, continue to stir 2～10 minutes, and room temperature is placed to cooling with stirring; The uviol lamp sterilization is 20～30 minutes after the packing, promptly gets cream for treating burns with preventing from scar.
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| CN101045123A true CN101045123A (en) | 2007-10-03 |
| CN101045123B CN101045123B (en) | 2010-09-15 |
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| CN108969508A (en) * | 2018-09-21 | 2018-12-11 | 珠海汉盈科技有限公司 | The spontaneous hotting mask of promotion burn wound reparation containing aloe extract |
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2006
- 2006-03-29 CN CN 200610018691 patent/CN101045123B/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107198776A (en) * | 2016-03-16 | 2017-09-26 | 上海医药工业研究院 | Pharmaceutical preparation for promoting body-surface rauma healing and preparation method thereof |
| CN107198776B (en) * | 2016-03-16 | 2020-11-24 | 上海医药工业研究院 | Pharmaceutical preparation for promoting body surface injury healing and preparation method thereof |
| CN105999213A (en) * | 2016-06-15 | 2016-10-12 | 通江县光泰科技发展有限责任公司 | Preparation method of giant salamander skin ointment for repairing human skin |
| CN107715093A (en) * | 2017-11-09 | 2018-02-23 | 山东农业大学 | A kind of ginger juice ointment for treating scald and preparation method thereof |
| CN107715093B (en) * | 2017-11-09 | 2020-12-04 | 山东农业大学 | Ginger juice scald ointment and preparation method thereof |
| CN108143895A (en) * | 2018-03-13 | 2018-06-12 | 宋永红 | Skin scar repairing paste |
| CN108969508A (en) * | 2018-09-21 | 2018-12-11 | 珠海汉盈科技有限公司 | The spontaneous hotting mask of promotion burn wound reparation containing aloe extract |
| CN115645474A (en) * | 2022-07-22 | 2023-01-31 | 河南稷道数字栽培研究院有限公司 | Preparation method of aloe gel burn external use medicine |
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