CN1771981A - Pile ointment - Google Patents
Pile ointment Download PDFInfo
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- CN1771981A CN1771981A CN 200510094953 CN200510094953A CN1771981A CN 1771981 A CN1771981 A CN 1771981A CN 200510094953 CN200510094953 CN 200510094953 CN 200510094953 A CN200510094953 A CN 200510094953A CN 1771981 A CN1771981 A CN 1771981A
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- aescine
- gelatin
- liquid paraffin
- polyvinyl alcohol
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Abstract
The pile ointment is one kind of medicine preparation comprising ointment matrix of hydrophilic high molecular compound in 30-80 wt%; active medicine component aescin in 0.5-10 wt%; and oily solvent liquid paraffin the rest amount. The hydrophilic high molecular compound is one or two selected from gelatin, sodium carboxymethyl cellulose, PVA, starch, alginate jelly, carboxypropyl cellulose and carboxyethyl propyl cellulose. The present invention features that the pile ointment can form one protecting film on the surface of the rectum mucous membrane to release medicine component and protect rectum in the time period as long as 12 hr. The preparation has convenient use and high healing effect.
Description
Technical field
The present invention relates to a kind of medical field, be specifically related to a kind of plaster for the treatment of hemorrhoid.It is carrier that this ZHICHUANG GAO adopts macromolecule polymer material, does solvent with oil medium, includes medicines such as aescine.Said preparation can form one deck at the anorectal region mucomembranous surface and reach protecting film more than 12 hours, and can be in the part the long-time medicine that slowly discharges, hemorrhoid are had curative effect preferably, be a kind of comparatively ideal treatment hemorrhoid preparation.
Background technology
Hemorrhoid are common anal and intestinal diseases, up to 46.3%, the saying of " ten people, nine hemorrhoid " therefore, are arranged at China's sickness rate.Hemorrhoid are agglomerates that loose displacement of anus pad pathologic and crissum veins beneath the skin clump stasis of blood stream form, and main clinical manifestation is hemorrhage, local discomfort, secretions increase, pruritus and deviates from.Do not have the hemorrhoid of clinical symptoms and sign not need treatment, the hemorrhoid that need treat focus on and alleviate the elimination cardinal symptom, but not radical cure, unnecessary expansion range of operation is worthless, so non-operative treatment is subjected to anorectal surgical doctor's attention day by day.The non-operative treatment of hemorrhoid mainly contains endo-medicine method, external used medicine method, injection treatment, acupuncture method and physiotherapy etc.The most frequently used is the external used medicine method, and external application, anus thromboembolism, fumigation and wash method demibain by medicine reach therapeutic effect, and medicine commonly used has Rongchang County anus Thailand, MAYINGLONGZHICHUANGGAO, ZHICHUANGNING SAN, suppository of wild chrysanthemum flower etc.These medicines have certain curative effect to hemorrhoid really, but the pharmaceutically-active performance of the normal influence of the existence of enteral feces and chemical irritant is unfavorable for the healing of mucosa, have caused the vicious cycle of hemorrhoid to a certain extent and have crossed to prolong and do not healed.In order to address the aforementioned drawbacks, the invention provides a kind of novel ZHICHUANG GAO.Said preparation is easy to use, and curative effect is more satisfactory.
Summary of the invention
The object of the invention provides and a kind ofly can form protecting film for a long time at the anorectal region mucomembranous surface, and can be in the part the long-time ZHICHUANG GAO that slowly discharges medicine, to improve the effect of treatment hemorrhoid.
For achieving the above object, the technical solution used in the present invention is: a kind of ZHICHUANG GAO, and the effective ingredient of pharmaceutical preparation mainly is made up of following prescription:
Mastic substrate: hydrophilic high molecular polymer 30%～80% weight;
Active constituents of medicine: aescine 0.5%～10% weight;
Oil medium solvent: liquid paraffin surplus;
Described hydrophilic high molecular polymer is selected one of following material or both and both above combinations:
Gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol, starch, alginate jelly, carboxy-propyl cellulose, carboxyethyl propyl cellulose.
Related content in the technique scheme is explained as follows:
1, in the such scheme, the effective ingredient of pharmaceutical preparation is made up of following prescription preferably:
Gelatin 5%～50% weight;
Sodium carboxymethyl cellulose 5%～50% weight;
Polyvinyl alcohol 2%～40% weight;
Aescine 0.5%～10% weight;
The liquid paraffin surplus.
Wherein: the better content range in the described prescription is:
Gelatin 10%～30% weight;
Sodium carboxymethyl cellulose 10%～30% weight;
Polyvinyl alcohol 5%～15% weight;
Aescine 1%～2% weight;
The liquid paraffin surplus.
Wherein: the optimum content scope in the described prescription is:
Gelatin 20%～30% weight;
Sodium carboxymethyl cellulose 20%～30% weight;
Polyvinyl alcohol 5%～25% weight;
Aescine 1%～5% weight;
The liquid paraffin surplus.
2, about preparation method of the present invention be: described gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol and aescine sodium raw materials are worn into fine powder, sieve, press formula ratio, add liquid paraffin, grind the neither too hard, nor too soft mastic of furnishing and get final product.
3, in the such scheme, described active constituents of medicine comprises one of following ancillary drug or both and both above combinations: Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Scutellariae, Borneolum Syntheticum, Sanguis Draxonis.These ancillary drug therapeutical effect mainly are: heat-clearing and toxic substances removing, cooling blood for hemostasis, putrefaction-removing granulation-promoting.
4, in the such scheme, the content of hydrophilic high molecular materials such as described starch, alginate jelly, carboxy-propyl cellulose, carboxyethyl propyl cellulose and gelatin, carboxymethyl cellulose, polyvinyl alcohol are similar.
5, ZHICHUANG GAO treatment mechanism of the present invention
Hydrophilic macromolecular compounds gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol etc. are met water in a humid environment and are expanded rapidly in this preparation, evenly are adsorbed on the anorectal region mucomembranous surface, to impaired or have the mucosa of inflammation to shield.Aescine wherein has the obvious suppression effect to the lysosome activity in the serum, stablize lysosome membrane, the metabolism of impede protein enzyme body, obviously reduce capillary permeability, to exudation, can prevent and remove hyperemia, the edema of tissue, thereby the many symptoms that suppressed the internal hemorrhoid acute attack reach the purpose for the treatment of hemorrhoid.
6, innovative point
Innovative point of the present invention is mastic substrate: the application of ointment in the treatment hemorrhoid that hydrophilic high molecular polymer is made with oil medium.Therefore a kind of protecting film that reaches more than 12 hours that forms at the anorectal region mucomembranous surface can be provided; and can slowly discharge the preparation of medicine for a long time in the part; in addition; feces wraps up through gluey film; lubricate during defecation; feces can be avoided and alleviate to mechanical stimuluss such as the friction of hemorrhoid and push-and-pulls, the symptom that hemorrhoid are deviate from can be improved effectively.
7, because such scheme uses, the present invention compared with prior art has following advantage and effect
1, advantage: 1) effect is rapid, and duration of efficacy is long, and effect is remarkable
2) easy to use, patient dependence is good
3) easy to make, low cost of manufacture
2, effect:
Select internal hemorrhoid, mixed hemorrhoid patient's 30 examples at 18～60 years old age, male's 12 examples, women's 18 examples, after anus was cleaned with clear water, it was an amount of to inject this ZHICHUANG GAO, sooner or later respectively once, logotype 6 days, 6 days is a course of treatment, and continuous use is judged curative effect after one course of treatment, the result: cure 25 examples (83.33%), produce effects 3 examples (10%), effective 2 examples (6.67%), invalid 0 example (0%) is not seen untoward reaction in the medication process.
The specific embodiment
Below in conjunction with embodiment the present invention is further described:
Embodiment one: a kind of aescine ZHICHUANG GAO, and the effective ingredient of thing preparation is made up of following prescription:
Gelatin 25g;
Sodium carboxymethyl cellulose 25g;
Polyvinyl alcohol 15g;
Aescine 2g;
Liquid paraffin 33g.
Preparation technology: described gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol and aescine sodium raw materials are worn into fine powder, sieve, press formula ratio, add liquid paraffin, grind the neither too hard, nor too soft mastic of furnishing and get final product.
Embodiment two: a kind of aescine ZHICHUANG GAO, and the effective ingredient of thing preparation is made up of following prescription:
Gelatin 30g;
Sodium carboxymethyl cellulose 30g;
Polyvinyl alcohol 5g;
Aescine 2g;
Liquid paraffin 33g.
Preparation technology: described gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol and aescine sodium raw materials are worn into fine powder, sieve, press formula ratio, add liquid paraffin, grind the neither too hard, nor too soft mastic of furnishing and get final product.
Embodiment three: sodium carboxymethyl cellulose 25g;
Polyvinyl alcohol 25g;
Starch 10g;
Aescine 2g;
Borneolum Syntheticum 1g;
Liquid paraffin 37g.
Preparation technology: described sodium carboxymethyl cellulose, polyvinyl alcohol, starch, aescine and Borneolum Syntheticum raw material are worn into fine powder, sieve, press formula ratio, add liquid paraffin, grind the neither too hard, nor too soft mastic of furnishing and get final product.
Embodiment four: gelatin 20g;
Polyvinyl alcohol 20g;
Sodium carboxymethyl cellulose 10g;
Starch 10g;
Aescine 3g;
Radix Scutellariae 4g;
Sanguis Draxonis 1g;
Liquid paraffin 32g.
Preparation technology: described gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol, starch, aescine, Radix Scutellariae and Sanguis Draxonis raw material are worn into fine powder, sieve, press formula ratio, add liquid paraffin, grind the neither too hard, nor too soft mastic of furnishing and get final product.
Embodiment five: gelatin 20g;
Polyvinyl alcohol 15g;
Starch 20g;
Aescine 1.5g;
Pseudobulbus Bletillae (Rhizoma Bletillae) 10g;
Borneolum Syntheticum 1.5g;
Liquid paraffin 32g.
Preparation technology: described gelatin, polyvinyl alcohol, starch, aescine, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Borneolum Syntheticum raw material are worn into fine powder, sieve, press formula ratio, add liquid paraffin, grind the neither too hard, nor too soft mastic of furnishing and get final product.
Model case:
Zhang, woman, 40 years old, shop assistant.Gu rectal tenesmus, just meaning is 1 year not to the utmost, rectal tenesmus during prescription on individual diagnosis, and companion's dull pain discomfort during stool, constipation with dry stool meaning frequency, physical examination: it is special that anus does not have outward, touches pain in 6 position anuses of touch, following 6 the dark red edema of position anal valves of anoscope, anal papilla also increases edema.Sooner or later it is an amount of that give the aescine ZHICHUANG GAO every day, and symptom obviously alleviates after 2 days, transference cure after 6 days, and physical examination, anal papilla is light red, and the light red no edema of anal valves is followed up a case by regular visits to and is not had recurrence half a year.
The foregoing description only is explanation technical conceive of the present invention and characteristics, and its purpose is to allow the personage who is familiar with this technology can understand content of the present invention and enforcement according to this, can not limit protection scope of the present invention with this.All equivalences that spirit is done according to the present invention change or modify, and all should be encompassed within protection scope of the present invention.
Claims (6)
1, a kind of ZHICHUANG GAO is characterized in that: the effective ingredient of pharmaceutical preparation mainly is made up of following prescription:
Mastic substrate: hydrophilic high molecular polymer 30%～80% weight;
Active constituents of medicine: aescine 0.5%～10% weight;
Oil medium solvent: liquid paraffin surplus;
Described hydrophilic high molecular polymer is selected one of following material or both and both above combinations:
Gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol, starch, alginate jelly, carboxy-propyl cellulose, carboxyethyl propyl cellulose.
2, ZHICHUANG GAO according to claim 1 is characterized in that: the effective ingredient of pharmaceutical preparation is made up of following prescription:
Gelatin 5%～50% weight;
Sodium carboxymethyl cellulose 5%～50% weight;
Polyvinyl alcohol 2%～40% weight;
Aescine 0.5%～10% weight;
The liquid paraffin surplus.
3, ZHICHUANG GAO according to claim 2 is characterized in that: the better content range in the described prescription is:
Gelatin 10%～30% weight;
Sodium carboxymethyl cellulose 10%～30% weight;
Polyvinyl alcohol 5%～15% weight;
Aescine 1%～2% weight;
The liquid paraffin surplus.
4, ZHICHUANG GAO according to claim 2 is characterized in that: the optimum content scope in the described prescription is:
Gelatin 20%～30% weight;
Sodium carboxymethyl cellulose 20%～30% weight;
Polyvinyl alcohol 5%～25% weight;
Aescine 1%～5% weight;
The liquid paraffin surplus.
5, according to claim 2 or 3 or 4 described ZHICHUANG GAO, it is characterized in that: preparation method is: described gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol and aescine sodium raw materials are worn into fine powder, sieve, press formula ratio, add liquid paraffin, grind the neither too hard, nor too soft mastic of furnishing and get final product.
6, ZHICHUANG GAO according to claim 1 is characterized in that: described active constituents of medicine comprises one of following ancillary drug or both and both above combinations: Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Scutellariae, Borneolum Syntheticum, Sanguis Draxonis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510094953 CN1771981A (en) | 2005-10-18 | 2005-10-18 | Pile ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510094953 CN1771981A (en) | 2005-10-18 | 2005-10-18 | Pile ointment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1771981A true CN1771981A (en) | 2006-05-17 |
Family
ID=36759232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510094953 Pending CN1771981A (en) | 2005-10-18 | 2005-10-18 | Pile ointment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1771981A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041378A (en) * | 2012-12-06 | 2013-04-17 | 青岛海芬海洋生物科技有限公司 | Bedsore nursing liquid |
| CN101416976B (en) | 2007-10-26 | 2013-05-01 | 江苏中康药物科技有限公司 | External medicine composition preparation with anti-inflammation detumescence pain-easing function |
| CN104288167A (en) * | 2014-10-29 | 2015-01-21 | 马应龙药业集团股份有限公司 | Sodium aescinate preparation curing haemorrhoids and preparation method for sodium aescinate preparation |
| US20220151918A1 (en) * | 2018-04-25 | 2022-05-19 | Ferring B.V. | Topical pharmaceutical composition for treatment of anal fissures and hemorrhoids |
-
2005
- 2005-10-18 CN CN 200510094953 patent/CN1771981A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416976B (en) | 2007-10-26 | 2013-05-01 | 江苏中康药物科技有限公司 | External medicine composition preparation with anti-inflammation detumescence pain-easing function |
| CN103041378A (en) * | 2012-12-06 | 2013-04-17 | 青岛海芬海洋生物科技有限公司 | Bedsore nursing liquid |
| CN104288167A (en) * | 2014-10-29 | 2015-01-21 | 马应龙药业集团股份有限公司 | Sodium aescinate preparation curing haemorrhoids and preparation method for sodium aescinate preparation |
| US20220151918A1 (en) * | 2018-04-25 | 2022-05-19 | Ferring B.V. | Topical pharmaceutical composition for treatment of anal fissures and hemorrhoids |
| US11865207B2 (en) * | 2018-04-25 | 2024-01-09 | Ferring B.V. | Topical pharmaceutical composition for treatment of anal fissures and hemorrhoids |
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