CN1679733A

CN1679733A - External-applied preparation for treating frostbite

Info

Publication number: CN1679733A
Application number: CN 200510010643
Authority: CN
Inventors: 朱建华
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-02-04
Filing date: 2005-02-04
Publication date: 2005-10-12
Anticipated expiration: 2025-02-04
Also published as: CN100337664C

Abstract

An exterior-applied Chinese medicine for treating frostbite is prepared from honeysuckle flower, houttuynia, shellfish pricklyash, garlic cloves and iodine contained alcohol. Its advantages are high curative effect and no pollution.

Description

A kind of external preparation for the treatment of chilblain

Technical field

The present invention relates to that a kind of preparation for the treatment of chilblain---the chilblain spirit belongs to external preparation.

Background technology

Chilblain generally is the zonal cold damage of body local.At severe cold season especially out of doors, often fall ill because of warming the taking effective measures of keeping out the cold.Freeze it is divided into cold damage of the property freezed and the cold damage of the non-property freezed by whether tissue taking place.Chilblain often occurs in positions such as finger, toes, auricle, nose, and more serious also can occur in positions such as wrist, forearm, foot, face, elbow.Skin whitening during beginning, and then the red class of cruentate edema occurs at the place of enduring cold, the edge is cerise, and boundary is unclear, very itches hard to bear and with sensation of pricking, and the minority severe patient is also with affected part ulcer flowing water etc.The disease though chilblain is nothing is very itched and brought incomparable misery to people, and regular meeting's recurrence in one to winter, and is red and swollen, is difficult to be completely cured.Also do not see at present the report of relevant treatment chilblain specific drug.Usual way is to keep the warm drying of illing skin, avoid enduring cold as far as possible, during ulceration with 3% boric acid solution soak, take a favorable turn the slightly YUSHIZHI RUANGAO external application of reuse 10%, its curative effect is very general, moreover, can make the affected part uncomfortable after the medication, easily pollute things such as glove, footgear, bedding.Therefore, be necessary to develop a kind of external preparation for the treatment of chilblain.

Summary of the invention

The object of the present invention is to provide a kind of curative effect obvious, easy to use, do not pollute the chilblain external preparation of wear---chilblain spirit.

The present invention realizes by following technical proposal: a kind of external preparation for the treatment of chilblain is characterized in that it is made by following raw materials by weight percent:

Flos Lonicerae 7～12% Herba Houttuyniae 4～8%

Pericarpium Zanthoxyli 70～85% Bulbus Alliis 4～10%

Add the ethanol that contains iodine 2～3%, and the amount of ethanol is 4～6 times of the Pericarpium Zanthoxyli amount.

Wherein, the main component of described Flos Lonicerae is chlorogenic acid, isochlorogenic acid, can strengthen immune function of human body, has effects such as antiinflammatory, analgesic, blood fat reducing; Described Herba Houttuyniae energy heat-clearing and toxic substances removing, alleviating pain and detumescence; Pericarpium Zanthoxyli contains peppery plain Saponin, the energy promoting blood circulation to remove blood stasis; Bulbus Allii contains garlicin, can sterilization, antiinflammatory, pain relieving, invigorate blood circulation.

The external preparation of treatment chilblain provided by the invention is made by following method: Flos Lonicerae, Herba Houttuyniae were boiled cold filtration, filtrate for later use 2～4 hours with 4～6 times water; Smash Bulbus Allii to pieces add 1～3 times water and boiled 2～4 hours, behind the cold filtration, filtrate for later use; With medical alcohol immersion 2～3 weeks that contain iodine 2～3% of dried Pericarpium Zanthoxyli with 4～6 times, after the filtration, filtrate for later use; With above-mentioned filtrate mix homogeneously, get the agent of chilblain Lingshui Spring.After perhaps above-mentioned filtrate being mixed, concentrated, get chilblain spirit external preparation.

The present invention has following advantage and effect: adopt such scheme, can activate the affected part blood capillary rapidly and promote the blood circulation at this place, make the active component of effects such as having promoting blood circulation to remove blood stasis, anti-inflammatory analgetic, refreshing and detoxicating, repellent antipruritic, meridians dredging in the preparation enter the deep, affected part with epidermis cell, alleviate very fast itch, pain and red and swollen symptom, can take a turn for the better even fully recover after several days, said preparation also has easy to use, have no side effect, non-greasy, do not pollute characteristics such as effect is remarkable.

For effect of the present invention is described, the present invention is through 100 routine clinical observations, and its result is as follows:

One, data and method

1, physical data

Typical chilblain disease patient 100 examples are arranged, the oldest person 65 years old, reckling 7 years old, wherein red and swollen symptom's 90 examples, red and swollen and with affected part ulcer flowing water person 10 examples, inspection confirms to have above-mentioned disease through the skin training in the week.Now all kinds of cases are divided at random matched group and treatment and organize two groups, two groups of case ordinary circumstances see Table 1.

Two groups of patients' ordinary circumstance (n=100) is organized in table 1 matched group and treatment

Project	Red and swollen disease (n=90) treatment group matched group (n=60) (n=30)	Red and swollen ulcer flowing water (n=10) treatment group matched group (n=6) (n=4)
Project			Sex masculinity femininity age 07-15 year 16-50 year 50-65 year	? ????25????16 ????35????14 ? ????25????9 ????25????8 ????10????13	? ????2???????1 ????4???????3 ? ? ????4???????2 ????2???????2

Through X ²Check, two groups of ages, sex, state of an illness all have comparability (p＞0.05)

2, Therapeutic Method

Matched group uses commercially available unguentum perniosis, three times on the one, drought, in, evening each once.

The treatment group is used the present invention's liniment " Dongchuangling " for curing chilblain, three times on the one, drought, in, evening each once.

Two groups are all used by identical one week of the course of treatment, and stop using other medicine during treating.

3, observational technique

Observe once every day during the medication, comprises the doing well,improving situation, untoward reaction.Treatment finished in two weeks, by special messenger's check, observed skin and improved situation.

Two, curative effect judgment criteria

1, curative effect determinate standard

Cure: ulcer wound surface healing, smooth, red and swollen dissipation, sufferings complete obiteration;

Produce effects: the ulcer wound surface healing, red and swollen, purple red color spot dissipates to some extent, and sufferings disappear;

Effectively: ulcer wound surface heals substantially, and erubescence swell and itch disease alleviates to some extent;

Invalid: ulcer wound surface does not change, and erubescence swell and itch disease is not improved.

2, statistical method

Enumeration data adopts X ²The t check is adopted in check, measurement data.

Total effective rate=cure rate+obvious effective rate+effective percentage

Three, result

1, red and swollen improvement situation sees Table 2, and red and swollen ulcer flowing water disease improvement situation sees Table 3.

Table 2, red and swollen improvement situation (90 example)

	Cure	Produce effects	Effectively	Invalid	Effective percentage
	Cure	Produce effects	Effectively	Invalid	Effective percentage	60 matched groups 30 are organized in treatment	????22	????23 ????10	????15 ????10	? ??10	????100％ ????66.67％

Treatment group curative effect obviously is better than matched group ((p＞0.01))

Table 3, red and swollen companion's ulcer flowing water doing well,improving situation (10 example)

	Cure	Produce effects	Effectively	Invalid	Effective percentage
	Cure	Produce effects	Effectively	Invalid	Effective percentage	6 matched groups 4 are organized in treatment	????2	????2 ????1	????1 ????1	????1 ????2	??83.33％ ??50.00％

2, untoward reaction

Treatment group patient and matched group patient all have no adverse reaction.

Four, discuss

Annual one enters winter, and the incidence rate and the relapse rate of chilblain are higher, sufferings sense of discomfort that it brings the patient is not only and is difficult to restrain oneself, and can't say table especially, and usually allow the people be in very awkward condition.The present invention is a raw material with the pure natural herbaceous plant, and according to the theory of Chinese medicine " blockage of meridian then QI and blood coagulate ", effects such as the promoting blood circulation to remove blood stasis that has in the combined formulation, anti-inflammatory analgetic, refreshing and detoxicating, repellent antipruritic, meridians dredging, chilblain is taken a turn for the better rapidly, ulcer healing, improve skin cell metabolism and skin vitality and elasticity, strengthen antibiotic, the anti-virus ability of skin, make skin smooth, moisten.Therefore, cure rate reaches more than 80%, and effective percentage reaches 97%, thereby for the chilblain patient eliminates the torment of sufferings, and no longer recur after curing.The present invention's chilblain spirit preparation is subjected to patient's favor deeply after developing.It is a treatment of perniosis preparation with DEVELOPMENT PROSPECT and exploitation value.

The specific embodiment

Below in conjunction with embodiment the present invention is described further.

Embodiment 1

Get the 1000g raw material by following proportioning, wherein:

Flos Lonicerae 70g

Herba Houttuyniae 40g

Pericarpium Zanthoxyli 850g

Bulbus Allii 40g

And by the preparation of following method: 70g Flos Lonicerae and 40g Herba Houttuyniae are added water 440ml, boil and endure 2 hours, cold filtration, filtrate, the 40g Bulbus Allii smashed to pieces add the 60ml decocting in water and endured 2 hours, cold filtration, get filtrate, the dried Pericarpium Zanthoxyli of 850g was soaked for 2 weeks with the medical alcohol 3400ml that contains iodine 2%, filter to get filtrate, merge above-mentioned four kinds of filtrates, promptly get liniment " Dongchuangling " for curing chilblain.

Embodiment 2

Get the 1000g raw material by following proportioning, wherein:

Flos Lonicerae 120g

Herba Houttuyniae 80g

Pericarpium Zanthoxyli 700g

Bulbus Allii 100g

And by the preparation of following method: 120g Flos Lonicerae and 80g Herba Houttuyniae are added water 1200ml, boil and endure 4 hours, cold filtration, filtrate, the 100g Bulbus Allii smashed to pieces add the 400ml decocting in water and endured 3 hours, cold filtration, get filtrate, the dried Pericarpium Zanthoxyli of 700g was soaked for 3 weeks with the medical alcohol 4200ml that contains iodine 3%, filter to get filtrate, merge above-mentioned four kinds of filtrates, promptly get chilblain spirit spray.

Embodiment 3

Get the 1000g raw material by following proportioning, wherein:

Flos Lonicerae 100g

Herba Houttuyniae 60g

Pericarpium Zanthoxyli 780g

Bulbus Allii 60g

And by the preparation of following method: 100g Flos Lonicerae and 60g Herba Houttuyniae are added water 800ml, boil and endure 3 hours, cold filtration, filtrate, the 60g Bulbus Allii smashed to pieces add the 180ml decocting in water and endured 3 hours, cold filtration, get filtrate, the dried Pericarpium Zanthoxyli of 780g was soaked for 2 weeks with the medical alcohol 3900ml that contains iodine 2%, filter to get filtrate, merge above-mentioned four kinds of filtrates, make chilblain spirit cream after concentrating.

Claims

1, a kind of external preparation for the treatment of chilblain is characterized in that it is made by following raw materials by weight percent:

Flos Lonicerae 7～12% Herba Houttuyniae 4～8%

Pericarpium Zanthoxyli 70～85% Bulbus Alliis 4～10%

2, the external preparation of treatment chilblain according to claim 1 is characterized in that described external preparation is liniment or spray or unguentum.

3, the external preparation of treatment chilblain according to claim 1 is characterized in that described external preparation makes by following method: Flos Lonicerae, Herba Houttuyniae were boiled cold filtration, filtrate for later use 2～4 hours with 4～6 times water; Smash Bulbus Allii to pieces add 1～3 times water and boiled 2～4 hours, behind the cold filtration, filtrate for later use; With medical alcohol immersion 2～3 weeks that contain iodine 2～3% of dried Pericarpium Zanthoxyli with 4～6 times, after the filtration, filtrate for later use; With above-mentioned filtrate mix homogeneously, get the agent of chilblain Lingshui Spring.After perhaps above-mentioned filtrate being mixed, concentrated, get chilblain spirit external preparation.