CN1879654A - An antibacterial antiinflammation pain-relieving tissue-regenerating medicine, its preparation method and use - Google Patents
An antibacterial antiinflammation pain-relieving tissue-regenerating medicine, its preparation method and use Download PDFInfo
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- CN1879654A CN1879654A CNA2006100187988A CN200610018798A CN1879654A CN 1879654 A CN1879654 A CN 1879654A CN A2006100187988 A CNA2006100187988 A CN A2006100187988A CN 200610018798 A CN200610018798 A CN 200610018798A CN 1879654 A CN1879654 A CN 1879654A
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Abstract
Disclosed is an antibiotic medicament for diminishing inflammation and reducing pain, its process and use, wherein the medicament is prepared from boneol, pearl powder, borax and compound of glauber-salt and liquorice through the steps of drying, disintegrating, grinding, sieving and mixing. The medicament can be prepared into suppository, effervescent tablet, soft electuary and coating film.
Description
Technical field
The present invention relates to a kind ofly to be used for the treatment of gynecological's leukorrheal diseases, the anorectal inflammation swells and ache and anal fissure, sores ulceration of skin swells and ache and the medicine that festers and preparation method thereof.
Background technology
Owing to reasons such as social competition's pressure is big, work rhythm quickenings, cause China gynaecopathia patient to increase, the sickness rate of gynaecopathias such as cervical erosion, cervical cancer obviously rises, and presents tangible rejuvenation trend.The raising of modern life level, the change of dietary structure, environmental pollution cause anorectal inflammation, rectal cancer, sores ulceration of skin sickness rate to improve year by year.
Cervical erosion is women's commonly encountered diseases, frequently-occurring disease, accounts for 50% of women of child-bearing age's sickness rate, and canceration rate is 2.5%, treatment cervical erosion, and especially treating moderate and severe cervical is the primary prevention of having done cervical cancer, is the important means that the blocking-up cervical cancer takes place.Cervical erosion belongs to the traditional Chinese medical science " leukorrheal diseases " category.Leukorrhagia amount showed increased, the color abnormal smells from the patient takes place unusual, or accompanies whole body local symptom person to be called " leukorrhagia ", is equivalent to cervical erosion, the vaginitis of western medicine, cervicitis, the leukorrhagia amount that pelvic inflammatory disease and gynecological tumor cause increases.
External treatment of tcm treatment gynecological, anorectal, local skin infection inflammation make the efficacy of a drug sick institute that go directly, " make medicine go into its space between skin and muscles from pore, logically pass through meridians, or carry it, or attack and loose it, than taking medicine especially effectively as saying in " Li Yue Pianwen, Rhymed Discourse for Topical Remedies "." the external treatment of tcm good effect, simple and easy to do, be easy to promote.
The existing western medical treatment method of cervical erosion has:
1, physiotherapy: select that laser, electricity are pressed, physiotherapy such as freezing for use,, certain contraindication is arranged though the naturopathy method has certain curative effect, and a large amount of discharge opeings of postoperative vagina, often make patient's fear; This therapy is difficult to popularize at basic hospital because of the restriction of the technical conditions that are subjected to equipment.
2, topical remedy's therapy: with 20%AgNO
3, 1-10% potassium dichromate, Albo+lhg1 (Albothyl) be applied to rotten to the corn face.
The Chinese medicine aspect, the Chinese medicine for outer use for the treatment of gynecological inflammation in the market has suppository, effervescent tablet, lotion etc., the production kind is few, and mainly based on heat-clearing and toxic substances removing, putrefaction-removing granulation-promoting medicines such as Radix Sophorae Flavescentis, dried Alumen, Borneolum Syntheticum, Radix Arnebiae (Radix Lithospermi)s, shortcoming is that the mucosa injury position has burn feeling.Also has " a kind of Chinese medicine preparation for the treatment of gynecological inflammation " (number of patent application 200410058110) pharmaceutical preparation made from Chinese medicines such as Radix Picriae felterrae, Herba Senecionis Scandentis, Radix Sophorae Flavescentis, Cortex Phellodendri, watermelon crystal, careless clear eggplant, Borneolum Syntheticums." a kind of suppository and effervescent tablet for the treatment of gynecological inflammation " (number of patent application 20041001407), it mainly consists of: Radix Et Rhizoma Rhei, Fructus Chebulae, Fructus Mume, Borax, Indigo Naturalis, Borneolum Syntheticum etc.
The Chinese medicine for outer use for the treatment of the anorectal inflammation in the market mainly contains suppository, ointment, lotion, and the production kind is few, mainly based on heat-clearing and toxic substances removing medicines such as Borneolum Syntheticum, Radix Sophorae Flavescentis, Cortex Phellodendris.The Chinese medicine for outer use that the treatment sores ulceration of skin swells and ache mainly contains powder, ointment, and the production kind is few, as JINHUANG SAN, golden yellow cream, mainly based on heat-clearing and toxic substances removing, reducing swelling and alleviating pain medicines such as Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Rhizoma Atractylodis.
Summary of the invention
The objective of the invention is at above-mentioned present situation, aim to provide a kind of effect, can treat effectively that gynecological's leukorrheal diseases, anorectal inflammation swell and ache, anal fissure, sores ulceration of skin swells and ache or the medicine that festers and preparation method thereof with heat-clearing and toxic substances removing, reducing swelling and alleviating pain, putrefaction-removing granulation-promoting.
The implementation of the object of the invention is, a kind of antibacterial antiinflammation pain-relieving tissue-regenerating medicine is made by following components in part by weight:
Borneolum Syntheticum 5-35 Margarita 4-17
Borax 60-400 Matrii Sulfas Exsiccatus 30-200.
A kind of preparation method of antibacterial antiinflammation pain-relieving tissue-regenerating medicine, the Matrii Sulfas Exsiccatus of Borax, 30-200 that with weight ratio is 60-400 is respectively at 100 ℃ of oven dry, be ground into fine powder, cross 120 mesh sieves, weight ratio is the Margarita micronizing of 4-17, with weight ratio is the Borneolum Syntheticum porphyrize of 5-35, with Borax powder, Matrii Sulfas Exsiccatus, Margarita powder facing-up, sieve, mixing gets patent medicine.
A kind of purposes of antibacterial antiinflammation pain-relieving tissue-regenerating medicine is characterized in that being used for the treatment of that gynecological's leukorrheal diseases, anorectal inflammation swell and ache, anal fissure, sores ulceration of skin swells and ache or fester.
The present invention is made into by Borneolum Syntheticum, Borax, Margarita and Matrii Sulfas Exsiccatus, and prescription is reasonable, and Borneolum Syntheticum leads to all keys, clearing heat for detumescence, granulation promoting pain relieving, can suppress or kill 5 kinds of common bacterias such as staphylococcus aureus, beta hemolytic streptococcus, and obvious anti-inflammatory and analgesic effect is arranged; The Borax heat-clearing and toxic substances removing, expectorant is anticorrosion, but external clearing heat for detumescence cool in nature is anticorrosion, it is monarch drug that escherichia coli, bacillus pyocyaneus, anthrax bacillus, bacterium flexneri, Bacillus typhi, Salmonella paratyphi, Bacillus proteus and staphylococcus, Candida albicans, Hemolytic streptococcus etc. are all had inhibitory action, Borneolum Syntheticum, Borax; Margarita detoxifcation removing the necrotic tissue and promoting granulation, have antibiotic, antiinflammation, staphylococcus aureus is had strong inhibitory action, the Margarita powder external application can promote the growth and the wound healing of granulation tissue, promote the hyperplasia differentiation, quicken blood circulation, the enhancing body anti-infection ability of wound surface; The Matrii Sulfas Exsiccatus detumescence of relieving inflammation or internal heat, the two is ministerial drug altogether.Full side four medicines close and use it, play the effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, putrefaction-removing granulation-promoting altogether.
The present invention has following advantage:
1, control proof really, reasonable recipe, compatibility be precise and appropriate, full side four medicines close and use it, play the effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, putrefaction-removing granulation-promoting altogether, be used for the treatment of gynecological's leukorrheal diseases, the anorectal inflammation swells and ache and anal fissure, sores ulceration of skin swells and ache and fester, evident in efficacy, treating both the principal and secondary aspects of a disease, effect are rapid;
2, Margarita is adopted micronizing technology, and the medicated powder fineness reaches micron order, has improved drug bioavailability, has strengthened curative effect of medication;
3, preparation method is simple, energy consumption is low, cost is low, stable and controllable for quality, be suitable for suitability for industrialized production;
4, each raw material resources of filling a prescription are rich and easy to get;
5, toxicity of the present invention is extremely low, and is safe, to mucocutaneous no any pessimal stimulation and anaphylaxis;
6, clinical application range of the present invention is wide, can be used for the local infection of vagina, cervix uteri, pelvic cavity, anorectal, skin, struvite and damaging non-infection lesion.
The specific embodiment
This medicine is that Borneolum Syntheticum 5-35, Margarita 4-17, Borax 60-400, Matrii Sulfas Exsiccatus 30-200 form by weight ratio.
Patent medicine adds suppository, effervescent tablet, ointment, liniment adjuvant and prepares suppository, effervescent tablet, ointment, liniment medicine by suppository, effervescent tablet, ointment, liniment preparation process.
Suppository is that 5-35 Borneolum Syntheticum, 4-17 Margarita, 100-400 Borax, 60-200 Matrii Sulfas Exsiccatus and suppository base are formed by weight ratio, and wherein suppository base is mixed fatty glycerides or Myrj 45.
Effervescent tablet is that 5-35 Borneolum Syntheticum, 4-17 Margarita, 100-400 Borax, 60-200 Matrii Sulfas Exsiccatus and effervescent tablet adjuvant are formed by weight ratio, and the effervescent tablet adjuvant comprises acid effervescent, alkaline effervescent, filler, disintegrating agent, lubricant, binding agent.
Wherein acid effervescent is an organic acid, as in citric acid, the tartaric acid one or both; The alkalescence effervescent is a carbonate, as in sodium bicarbonate, the sodium carbonate one or both, filler, disintegrating agent are one or more in starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, mannitol, the carboxymethylstach sodium, lubricant is magnesium stearate or micropowder silica gel, and binding agent is polyvinylpyrrolidone or starch slurry.
Ointment is that 10-35 Borneolum Syntheticum, 4-12 Margarita, 60-180 Borax, 30-90 Matrii Sulfas Exsiccatus and ointment base are formed by weight ratio, and ointment base is vaseline, white oil, lanoline, or other ointment base.
Enumerate the embodiment of the invention below:
Formulation Example of the present invention:
1, suppository embodiment: table 1 is listed formulation Example, and umber is a weight portion in the table:
Table 1
Preparation technology: Borax, Matrii Sulfas Exsiccatus respectively at 100 ℃ of oven dry, are ground into fine powder, cross 120 mesh sieves, the Margarita micronizing, with the Borneolum Syntheticum porphyrize, and with Borax powder, Matrii Sulfas Exsiccatus, Margarita powder facing-up, sieve, mixing.Above-mentioned fine powder is joined heat fused and be incubated to 42-50 ℃ mixed fatty glycerides, mix homogeneously, injection molding, cooling, promptly.
2, effervescent tablet embodiment: table 2 is listed formulation Example, and umber is a weight portion in the table:
Table 2
Preparation technology:
(1) with Borax, Matrii Sulfas Exsiccatus respectively at 100 ℃ of oven dry, be ground into fine powder, cross 120 mesh sieves, the Margarita micronizing, with Borax powder, Matrii Sulfas Exsiccatus facing-up, sieve, mixing.Borneolum Syntheticum is standby with the small amount of ethanol dissolving;
(2) the effervescent tablet adjuvant is dry respectively, it is standby to cross 100 mesh sieves; It is standby to prepare 5% polyvinylpyrrolidone ethanol solution;
(3) with above-mentioned fine powder, tartaric acid, sodium bicarbonate, starch, low-substituted hydroxypropyl cellulose mix homogeneously, add 5% polyvinylpyrrolidone ethanol solution and make soft material in right amount, granulate with 14 mesh sieves, dry the back granulate down, spray into the Borneolum Syntheticum ethanol solution at 60-70 ℃; Add magnesium stearate, mix homogeneously is pressed into special-shaped tablets.
3, ointment embodiment: table 3 is listed formulation Example, and umber is a weight portion in the table:
Table 3
Preparation technology: Borax, Matrii Sulfas Exsiccatus respectively at 100 ℃ of oven dry, are ground into fine powder, cross 120 mesh sieves, the Margarita micronizing becomes impalpable powder, with the Borneolum Syntheticum porphyrize, with Borax, Matrii Sulfas Exsiccatus, Margarita powder facing-up, sieve, mixing.Above-mentioned fine powder is added through 150 ℃ of sterilizations, puts in the cold white oil after filtering, stir evenly, again mixture joined through 150 ℃ of sterilizations, filter and be chilled in about 50-60 ℃ the vaseline and lanoline, and the continuation stirring is cooled to the ointment shape, promptly.
This medicine has been made pharmacodynamics test, and result of the test is as follows:
1, vitro antibacterial activity
Extracorporeal bacteria inhibitor test is the result show: this medicine is to common pathogen: staphylococcus aureus, staphylococcus epidermidis, beta hemolytic streptococcus, escherichia coli, Candida albicans, Bacillus proteus, Cryptococcus histolyticus all have inhibition and killing action in various degree.
2, vivo bacteria corrosion action
This medicine has therapeutical effect preferably to rat vagina inflammation, cervical erosion, cervicitis due to the infection of staphylococcus aureus, and can obviously alleviate the reaction of rat vagina mucosal inflammation.Illustrate that this medicine vagina administration has vivo bacteria corrosion action.
3, this medicine has therapeutical effect preferably to rat vagina inflammation, cervical erosion, cervicitis due to the candida albicans infection.
4, promote ulcer repair (promoting muscle growth functions).
Rat vagina inflammation, cervical erosion, cervicitis have therapeutical effect preferably due to this medicine Pyrogentisinic Acid, show that this medicine has to promote ulcer repair (promoting muscle growth functions) preferably.
5, rat experiment temper cervicitis disease had tangible antiinflammatory action.
6, significant antiinflammatory action is arranged
This medicine can obviously suppress dimethylbenzene induced mice auricle edema; Can obviously suppress swelling of rat toes and the bullate formation of rat granuloma due to the chondrus ocellatus Holmes.
7, significant analgesic activity is arranged
This medicine can obviously suppress acetic acid induced mice writhing response; Also can obviously prolong the hot plate method induced mice pain reaction time, improve threshold of pain index.
This medicine has been made toxicology test, and result of the test is as follows:
1, The acute toxicity tests shows that this drug toxicity is extremely low, and clinical practice is safe and reliable.
2, vagina local excitation result of the test shows that this medicine is to normal and the equal nonirritant of damaged vaginal mucosa.
3, the skin anaphylactic test result shows that this medicine does not have irritated reaction to guinea pig skin.
Claims (4)
1, a kind of antibacterial antiinflammation pain-relieving tissue-regenerating medicine is characterized in that being made up of following components in part by weight:
Borneolum Syntheticum 5-35 Margarita 4-17
Borax 60-400 Matrii Sulfas Exsiccatus 30-200.
2, the preparation method of the described a kind of antibacterial antiinflammation pain-relieving tissue-regenerating medicine of claim 1, it is characterized in that with weight ratio being that the Matrii Sulfas Exsiccatus of Borax, 30-200 of 60-400 is respectively at 100 ℃ of oven dry, be ground into fine powder, cross 120 mesh sieves, weight ratio is the Margarita micronizing of 4-17, with weight ratio is the Borneolum Syntheticum porphyrize of 5-35, with Borax powder, Matrii Sulfas Exsiccatus, Margarita powder facing-up, sieve, mixing gets patent medicine.
3, the preparation method of a kind of antibacterial antiinflammation pain-relieving tissue-regenerating medicine according to claim 2 is characterized in that patent medicine adds suppository, effervescent tablet, ointment, liniment adjuvant and prepares suppository, effervescent tablet, ointment, liniment medicine by suppository, effervescent tablet, ointment, liniment preparation process.
4, the purposes of the described a kind of antibacterial antiinflammation pain-relieving tissue-regenerating medicine of claim 1 is characterized in that being used for the treatment of that gynecological's leukorrheal diseases, anorectal inflammation swell and ache, anal fissure, sores ulceration of skin swells and ache or fester.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111617180A (en) * | 2019-02-28 | 2020-09-04 | 重庆新铜雀台整形美容医院有限公司 | Lip repair cream for tattooing and beautifying and preparation method thereof |
| CN111973636A (en) * | 2019-05-21 | 2020-11-24 | 王飞 | Anorectal gel and preparation method thereof |
| CN113398195A (en) * | 2021-07-05 | 2021-09-17 | 车国娟 | Antibacterial liquid for nursing private parts of women and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1181936A (en) * | 1997-11-02 | 1998-05-20 | 赵文昌 | Bingpeng buccal tablet and its production process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111617180A (en) * | 2019-02-28 | 2020-09-04 | 重庆新铜雀台整形美容医院有限公司 | Lip repair cream for tattooing and beautifying and preparation method thereof |
| CN111973636A (en) * | 2019-05-21 | 2020-11-24 | 王飞 | Anorectal gel and preparation method thereof |
| CN113398195A (en) * | 2021-07-05 | 2021-09-17 | 车国娟 | Antibacterial liquid for nursing private parts of women and preparation process thereof |
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| CN100450491C (en) | 2009-01-14 |
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