CN111467404A

CN111467404A - Binghuang hemorrhoid fistula fumigation lotion and preparation process thereof

Info

Publication number: CN111467404A
Application number: CN202010525637.8A
Authority: CN
Inventors: 林康泉
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-06-10
Filing date: 2020-06-10
Publication date: 2020-07-31

Abstract

The invention discloses a yellow fumigation lotion for hemorrhoids and fistula and a preparation process thereof, wherein the fumigation lotion for hemorrhoids and fistula comprises the following raw materials in parts by weight: 30-120 parts of purslane, 30-120 parts of phellodendron, 30-120 parts of rhubarb, 30-120 parts of glauber salt, 10-50 parts of lithospermum, 30-120 parts of dried alum, 30-120 parts of sophora flavescens, 20-60 parts of fructus cnidii, 20-60 parts of honeysuckle and 20-60 parts of natural borneol. Respectively carrying out ultramicro vibration grinding on the raw materials, and sieving the raw materials with a 200-mesh sieve to obtain traditional Chinese medicine fine powder for later use; taking the traditional Chinese medicine fine powder and absolute ethyl alcohol according to a certain proportion, uniformly stirring to form infiltration paste powder, dividing into 2 parts, adding auxiliary materials, adding the anhydrous citric acid fine powder into one part, uniformly mixing, drying and granulating, adding the sodium bicarbonate fine powder into one part, uniformly mixing, drying and granulating, adding the 2 parts of granules into the yellow dextrin and the magnesium stearate, uniformly mixing, and pressing into tablets to obtain the borneol yellow hemorrhoid fistula fumigation lotion. The invention contains antibacterial drugs, anti-inflammatory, detumescence and analgesia, hemostasis and astringency, and antipruritic drugs, has obvious curative effect, and is suitable for treating anorectal diseases such as internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, anal fistula, anal fissure and the like.

Description

Binghuang hemorrhoid fistula fumigation lotion and preparation process thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a yellow-ice hemorrhoid fistula fumigation lotion and a preparation process thereof.

Background

Hemorrhoids are the most common anorectal diseases and can occur at any age, but the incidence rate gradually increases with age. The hemorrhoids are classified into internal hemorrhoids, external hemorrhoids and mixed hemorrhoids according to the different parts. A visible zigzag line called anal canal dentate line is arranged at the junction of the anal canal skin and the rectal mucosa. The internal hemorrhoid is above the dentate line; external hemorrhoid below dentate line, and coating anal canal mucosa; the mixed hemorrhoid is also the internal hemorrhoid and the external hemorrhoid. The hemorrhoids are mainly characterized by hemafecia, the nature of the hemafecia can be painless, intermittent, fresh blood after the hemafecia, the hemafecia is dripped or the blood is carried on the toilet paper, the constipation, the wine drinking or the food intake is aggravated, the simple internal hemorrhoids have no pain, only have the feeling of falling and swelling, can bleed, develop to prolapse, are combined with the thrombosis, and the pain appears when the infection occurs.

The main modes of treating hemorrhoids include drug treatment and surgical treatment, and the common treatment method is surgery or infusion treatment. The treatment methods can cause the patients to be accompanied with complications in the treatment process, the patients are slow to recover, easy to relapse, unable to relieve the pain of the patients in time, and not easy to cure the diseases radically, and the work and life of the patients are seriously affected.

Disclosure of Invention

The invention aims to provide a yellow-ice hemorrhoid fistula fumigation lotion and a preparation process thereof, which aim to solve the problems in the background technology.

The invention is achieved by the following specific technical means:

the icy yellow hemorrhoid fistula fumigation lotion comprises the following raw materials in parts by weight: 30-120 parts of purslane, 30-120 parts of phellodendron, 30-120 parts of rhubarb, 30-120 parts of compound of glauber salt, 10-50 parts of lithospermum, 30-120 parts of dried alum, 30-120 parts of sophora flavescens, 20-60 parts of fructus cnidii, 20-60 parts of honeysuckle, 20-60 parts of natural borneol, 500 parts of anhydrous citric acid, 150 parts of sodium bicarbonate, 650 parts of yellow dextrin and 500 parts of magnesium stearate.

As a further scheme of the invention: the Binghuang hemorrhoid fistula fumigation lotion comprises the following raw materials in parts by weight: 40-110 parts of purslane, 40-110 parts of phellodendron, 40-110 parts of rhubarb, 40-110 parts of compound of glauber salt, 20-40 parts of lithospermum, 40-110 parts of dried alum, 40-110 parts of sophora flavescens, 20-40 parts of fructus cnidii, 20-40 parts of honeysuckle, 30-50 parts of natural borneol, 400 parts of anhydrous citric acid, 600 parts of sodium bicarbonate, 600 parts of yellow dextrin and 400 parts of magnesium stearate.

As a further scheme of the invention: 400 parts of anhydrous citric acid.

As a further scheme of the invention: 600 parts of sodium bicarbonate.

A preparation process of a yellow ice fumigation lotion for hemorrhoids and fistula comprises the following steps:

1) respectively pulverizing herba Portulacae, cortex Phellodendri, radix et rhizoma Rhei, Natrii sulfas, radix Arnebiae, dried Alumen, radix Sophorae Flavescentis, fructus Cnidii, flos Lonicerae, and natural Borneolum Syntheticum into superfine Chinese medicinal powder by ultramicro vibromill wall breaking machine, and sieving with 200 mesh sieve to obtain superfine Chinese medicinal powder;

2) weighing the traditional Chinese medicine fine powder and absolute ethyl alcohol in proportion, uniformly mixing and stirring to form impregnating compound powder, standing the impregnating compound powder for 10-60min, dividing the impregnating compound powder into two parts after standing, and adding auxiliary materials: adding anhydrous citric acid fine powder into one part, weighing the anhydrous citric acid fine powder according to a proportion, uniformly mixing, stirring, drying simultaneously, taking out after 1h, and finally granulating: adding sodium bicarbonate fine powder into the other part, weighing the sodium bicarbonate fine powder according to the proportion, uniformly mixing and stirring, simultaneously drying, taking out after 1h, and finally granulating;

mixing the above two granules with yellow dextrin and magnesium stearate, and making into tablet.

As a further scheme of the invention: the proportion of the traditional Chinese medicine fine powder and the absolute ethyl alcohol in the step 2) is 100: 0.5-3.

As a further scheme of the invention: the stirring speed in the step 2) is 50-150 r/min.

As a further scheme of the invention: the drying temperature in step 2) is 40-60 ℃.

Compared with the prior art, the invention has the beneficial effects that:

the rhubarb and the compound Chinese angelica powder have the effects of clearing heat and relieving swelling, softening hardness and dissipating blood stasis, the purslane and the lithospermum have the effects of clearing heat and removing toxicity, cooling blood and relieving swelling, the borneol has the effects of relieving pain and eliminating swelling, the purslane and the lithospermum have the effects of clearing heat and removing toxicity, cooling blood and relieving swelling, and the dried alum has the effects of astringing dampness and healing sore and stopping bleeding.

The invention is placed in a bidet of anorectal department, a little boiling water is poured into the bidet to fumigate for 5 minutes, and then warm water (30-40 ℃) is filled in the bidet to perform hip bath for 5-10 minutes; if a fumigation and washing instrument is matched with a clinical department, the absorption and the action of the medicine can be more effectively promoted (the traditional Chinese medicine preparation can be placed for fumigation and washing and operated according to a program), the medicine directly acts on an affected part and a wound surface by virtue of the action of heat, so that the qi and blood channels and collaterals of the local perianal part are warmed and dredged, the blood circulation is promoted, the local function is improved and recovered, and meanwhile, the anal sphincter can be relaxed by virtue of fumigation, washing and sitting bath, so that the effects of dispersing pathogenic factors, relieving muscles, reducing swelling, relieving pain, warming channels, dredging collaterals. The malignant circulation of edema and pain is improved and eliminated to the maximum extent, and the pain is relieved and the sphincter spasm is relieved while the edema is eliminated.

Combining with modern pharmacological research, the fumigating lotion for hemorrhoids and fistula contains antibacterial drugs, anti-inflammatory, detumescence and analgesia, hemostatic and astringent, antipruritic drugs, exudative drugs, sphincter spasm reduction, antithrombotic drugs and drugs for promoting wound healing. The invention is suitable for treating internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, anal fissure, perianal abscess, anal fistula, anal sinusitis, anal eczema, anal nerve function, rectal inflammation and the like. Through years of clinical research and application, the hemorrhoid and fistula fumigation lotion which is pure herbal and easy to absorb is developed by selecting genuine medicinal materials and combining the original pure manual ointment making process with the modern biological wall breaking technology, and the hemorrhoid and fistula fumigation lotion is deeply appreciated by patients due to the characteristics of unique method and obvious curative effect.

The clinical effects of the invention are as follows:

1. patients with conservative treatment: has antibacterial, antiinflammatory, hemostatic, analgesic, intestinal mucosa protecting, and anal fissure relieving effects on hemorrhoid complicated with anal fistula.

2. Patients for preoperative external use: has effects of relieving swelling and pain for hemorrhoid diseases, promoting pus discharge and removing toxic substance for perianal abscess, and reducing wound surface of operation.

3. Patients for postoperative topical use: reducing postoperative complications, diminishing inflammation, relieving pain, stopping bleeding, and promoting healing (healing time is advanced 1/3).

Drawings

Fig. 1 is a functional diagram of the fumigating lotion for hemorrhoids and fistula.

FIG. 2 is a graph showing the comparison of the therapeutic effects of the same products in the clinical study in example 4 of the present invention.

Fig. 3 is a diagram of the improvement of symptoms of anal fistula fumigation lotion of the invention in example 4.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention:

example 1

In the embodiment of the invention, the Binghuang hemorrhoid fistula fumigation lotion comprises the following raw materials: 30 parts of purslane, 30 parts of phellodendron, 30 parts of rhubarb, 30 parts of compound of glauber salt, 10 parts of lithospermum, 30 parts of dried alum, 30 parts of sophora flavescens, 20 parts of fructus cnidii, 20 parts of honeysuckle, 20 parts of natural borneol, 100 parts of anhydrous citric acid, 150 parts of sodium bicarbonate, 150 parts of yellow dextrin and 100 parts of magnesium stearate.

2) mixing the traditional Chinese medicine fine powder and absolute ethyl alcohol according to a proportion (100: 3) weighing, uniformly mixing and stirring (the stirring speed is 50-150r/min) to form impregnating compound powder, standing the impregnating compound powder for 60min, dividing the impregnating compound powder into two parts after standing, and adding auxiliary materials: adding anhydrous citric acid fine powder into one part, weighing the anhydrous citric acid fine powder according to the proportion, uniformly mixing and stirring (stirring speed is 100r/min), simultaneously drying (drying temperature is 50 ℃) for 1h, taking out and finally granulating: adding sodium bicarbonate fine powder into the other part, weighing the sodium bicarbonate fine powder according to the proportion, uniformly mixing and stirring (stirring speed is 100r/min), simultaneously drying (drying temperature is 50 ℃), taking out after 1h, and finally granulating;

Example 2

In the embodiment of the invention, the Binghuang hemorrhoid fistula fumigation lotion comprises the following raw materials: 40 parts of purslane, 40 parts of phellodendron, 40 parts of rhubarb, 40 parts of mirabilite, 20 parts of lithospermum, 40 parts of dried alum, 40 parts of radix sophorae flavescentis, 40 parts of fructus cnidii, 40 parts of honeysuckle, 30 parts of natural borneol, 120 parts of anhydrous citric acid, 120 parts of sodium bicarbonate, 120 parts of yellow dextrin and 120 parts of magnesium stearate.

2) mixing the traditional Chinese medicine fine powder and absolute ethyl alcohol according to a proportion (100: 1.5) weighing, uniformly mixing and stirring (the stirring speed is 90/min) to form impregnating compound powder, standing the impregnating compound powder for 60min, dividing the impregnating compound powder into two parts after standing is finished, and adding auxiliary materials: adding anhydrous citric acid fine powder into one part, weighing the anhydrous citric acid fine powder according to the proportion, uniformly mixing and stirring (stirring speed is 90r/min), simultaneously drying (drying temperature is 55 ℃) for 1h, taking out and finally granulating: adding sodium bicarbonate fine powder into the other part, weighing the sodium bicarbonate fine powder according to the proportion, uniformly mixing and stirring (stirring speed is 90r/min), simultaneously drying (drying temperature is 55 ℃), taking out after 1h, and finally granulating;

Example 3

In the embodiment of the invention, the Binghuang hemorrhoid fistula fumigation lotion comprises the following raw materials: 120 parts of purslane, 120 parts of phellodendron, 120 parts of rhubarb, 120 parts of compound of glauber salt, 50 parts of lithospermum, 120 parts of dried alum, 120 parts of sophora flavescens, 60 parts of fructus cnidii, 60 parts of honeysuckle, 60 parts of natural borneol, 500 parts of anhydrous citric acid, 650 parts of sodium bicarbonate, 650 parts of yellow dextrin and 500 parts of magnesium stearate.

2) mixing the traditional Chinese medicine fine powder and absolute ethyl alcohol according to a proportion (100: 1) weighing, uniformly mixing and stirring (the stirring speed is 150r/min) to form impregnating compound powder, standing the impregnating compound powder for 60min, dividing the impregnating compound powder into two parts after standing, and adding auxiliary materials: adding anhydrous citric acid fine powder into one part, weighing the anhydrous citric acid fine powder according to the proportion, uniformly mixing and stirring (the stirring speed is 150r/min), simultaneously drying (the drying temperature is 60 ℃) for 1h, taking out and finally granulating: adding sodium bicarbonate fine powder into the other part, weighing the sodium bicarbonate fine powder according to the proportion, uniformly mixing and stirring (the stirring speed is 150r/min), simultaneously drying (the drying temperature is 40-60 ℃) for 1h, taking out and finally granulating;

Example 4

And (3) clinical trials:

130 patients observed in the study are outpatient patients with hemorrhoids, anal fissure and anal fistula from 2014 to 2016, wherein 65 patients are male patients and 65 patients are female patients. The two groups are divided into 60 treatment groups and 60 control groups randomly, the two groups have equality in the aspects of age, sex, disease course, operation range, wound area size, symptoms and physical signs of patients before administration, and the two groups of cases have comparability. The treatment group uses the fumigation lotion for hemorrhoids and fistula of the invention 5 to perform the treatment by warm water hip bath for 2 times per day and adding bath for 1 time after defecation for 5-10 minutes. Potassium permanganate 1 for control group: hip bath with 5000 warm water for 2 times a day, and 1 time after defecation for treatment.

Standard of care

The effect is shown: no bleeding and bleeding, obviously reduced pain and obviously shortened wound healing time; the method has the following advantages: no bleeding and bleeding occur, the pain is relieved, and the healing time of the wound surface is shortened; and (4) invalidation: little bleeding or little bleeding, no pain relief and no obvious shortening of the healing time of the wound surface.

The results are shown in Table 1.

TABLE 1

As can be seen from the table 1, the lotion for treating anal fistula of the invention has obvious curative effect on anal fistula, obviously shortens the healing time in clinical use, has an average treatment course of 6.5 days in a treatment group and an average treatment course of 10 days in a control group, has obvious difference between the two groups, and is superior to the control group in the treatment group.

The therapeutic effect comparison graph of the similar products in the clinical research of the invention is shown in figure 2. From the comparison chart of clinical research, the corresponding anal diseases are classified more carefully, and the advantages of the hemorrhoid fistula fumigation lotion in clinical use of the anal diseases can be more accurately understood. Particularly, the pus discharging and toxin expelling effects are more obvious on perianal abscess; in the aspect of promoting healing, the potassium permanganate hip bath only has the sterilization and disinfection effects, and has no effect of promoting healing on wounds and wound surfaces.

The invention improves the symptoms: the curative effect on the five symptoms and signs of bleeding, pain, edema, anal sphincter spasm and pruritus is shown in the following figure 3. The results show that the fumigation lotion for hemorrhoids and fistula has remarkable curative effects on improving five symptoms and physical signs of bleeding, pain, edema, anal sphincter spasm, pruritus and the like.

Conclusion of clinical study: the hemorrhoid and fistula fumigation lotion has obvious curative effect on hemorrhoid, anal fissure, anal fistula, perianal abscess, anal eczema, anal sinusitis and proctitis, and can relieve or obviously improve related symptoms caused by diseases.

Typical cases are:

case 1: aged 58 years old, with hemorrhoids for many years, diagnosed in second stage, with large hemorrhoids, which can escape from the anus during defecation, and can be received by oneself after defecation with blood drip during defecation. The hip bath is carried out for 2 times every day, the improvement is seen in 5 days, no blood dripping occurs after 12 days, the dropping does not occur, and the disease does not relapse after the medicine is stopped for half a year.

Case 2; Wu-Chi, female, age 33, after the child has grown, the phenomena of bloody embolus hemorrhoid and Canton appear, the pain is hard to endure, the defecation can not be normally done by means of enema, the glacial yellow hemorrhoid fistula fumigation lotion is used for warm water hip bath for 7 days, the bloody embolus hemorrhoid is eliminated, the Canton phenomenon is obviously softened, the defecation can be performed automatically, and the disease can be returned after 1 year without relapse.

Case 3, namely, plum, male, 37 years old, perianal abscess, 3 days of disease, swelling and pain which can not be taken down, hip bath of the medicine of the invention for 3 times a day, pus discharge after 1 day and detumescence; after 10 days, pus is basically beaten out, pus discharge openings are gradually healed, after 15 days, the pus is healed, and after 3 years, the pus is returned without relapse.

Case 4; zhangzhi, male, 45 years old, diagnosed as anal fissure, recurrent morbidity for half a year, pain in the stool, with laceration sensation accompanied by blood dripping, fumigating and hip-bathing the medicine 2 times a day, relieving the stool after 1 day, relieving pain, not bleeding after 3 days, clinical symptoms disappearing after 7 days, revisiting after 1 year, having 1 recurrence, and improving after smearing.

The clinical effects of the invention are as follows:

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims

1. The icy yellow hemorrhoid fistula fumigation lotion is characterized by comprising the following raw materials in parts by weight: 30-120 parts of purslane, 30-120 parts of phellodendron, 30-120 parts of rhubarb, 30-120 parts of compound of glauber salt, 10-50 parts of lithospermum, 30-120 parts of dried alum, 30-120 parts of sophora flavescens, 20-60 parts of fructus cnidii, 20-60 parts of honeysuckle, 20-60 parts of natural borneol, 500 parts of anhydrous citric acid, 150 parts of sodium bicarbonate, 650 parts of yellow dextrin and 500 parts of magnesium stearate.

2. The glacial yellow hemorrhoid fistula fumigation lotion according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 40-110 parts of purslane, 40-110 parts of phellodendron, 40-110 parts of rhubarb, 40-110 parts of compound of glauber salt, 20-40 parts of lithospermum, 40-110 parts of dried alum, 40-110 parts of sophora flavescens, 20-40 parts of fructus cnidii, 20-40 parts of honeysuckle, 30-50 parts of natural borneol, 400 parts of anhydrous citric acid, 600 parts of sodium bicarbonate, 600 parts of yellow dextrin and 400 parts of magnesium stearate.

3. The curling stone and anal fistula fumigant lotion according to claim 1 or 2, wherein the anhydrous citric acid is 400 parts.

4. The curling stone and anal fistula lotion according to claim 1 or 2, wherein the sodium bicarbonate is 600 parts.

5. The process for preparing a lotion for curing hemorrhoids and fistula as claimed in any one of claims 1 to 4, comprising the steps of:

2) weighing the traditional Chinese medicine fine powder and absolute ethyl alcohol in proportion, uniformly mixing and stirring to form impregnating compound powder, standing the impregnating compound powder for 10-60min, dividing the impregnating compound powder into two parts after standing, and adding auxiliary materials: adding anhydrous citric acid fine powder into one part, weighing the anhydrous citric acid fine powder according to a proportion, uniformly mixing, stirring, drying simultaneously, taking out after 1h, and finally granulating: adding sodium bicarbonate fine powder into the other part, weighing the sodium bicarbonate fine powder in proportion, uniformly mixing and stirring, drying at the same time,

after 1h, taking out and finally granulating;

mixing the above two granules with yellow dextrin and magnesium stearate at a certain proportion, tabletting,

the product can be used for treating hemorrhoid complicated by anal fistula.

6. The preparation process of the Binghuang hemorrhoid fistula fumigation lotion as claimed in claim 5, wherein the ratio of the traditional Chinese medicine fine powder and the absolute ethyl alcohol in the step 2) is 100: 0.5-3.

7. The process for preparing a fumigation lotion for treating hemorrhoids and fistula as defined in claim 5, wherein the stirring rate in step 2) is 50-150 r/min.

8. The process for preparing a fumigation lotion for treating hemorrhoids and fistula as set forth in claim 5, wherein the drying temperature in the step 2) is 40-60 ℃.