CN107213402B - Binghuang hemorrhoids ointment - Google Patents
Binghuang hemorrhoids ointment Download PDFInfo
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- CN107213402B CN107213402B CN201710531025.8A CN201710531025A CN107213402B CN 107213402 B CN107213402 B CN 107213402B CN 201710531025 A CN201710531025 A CN 201710531025A CN 107213402 B CN107213402 B CN 107213402B
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Abstract
The invention discloses an ice yellow hemorrhoids ointment and a preparation process thereof, and the hemorrhoids ointment comprises the following raw materials in parts by weight: 30-120 parts of coptis chinensis, 30-120 parts of golden cypress, 30-120 parts of rheum officinale, 10-50 parts of dragon's blood, 10-50 parts of lithospermum, 30-120 parts of radix stemonae, 30-120 parts of radix sophorae flavescentis, 30-120 parts of bletilla striata, 10-50 parts of pearl, 100 parts of calcined gypsum, 30-90 parts of natural borneol, 20-80 parts of mint, 1900-2100 parts of vaseline and 25-35 parts of tea oil. Respectively crushing the raw materials, and sieving the crushed raw materials with a 200-mesh sieve for later use; weighing vaseline and oleum Camelliae, mixing, heating, cooling to 60-70 deg.C, adding Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, and Gypsum Fibrosum Preparatum, stirring, adding Margarita, herba Menthae, and natural Borneolum Syntheticum, stirring, and cooling to room temperature. The invention contains antibacterial drugs and anti-inflammatory, detumescence, analgesia and antipruritic drugs, has obvious curative effect and is suitable for treating internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, anal fissure and the like.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to hemorrhoid ointment containing borneol and rhubarb and a preparation process thereof.
Background
Hemorrhoids are the most common anorectal diseases and can occur at any age, but the incidence rate gradually increases with age. The hemorrhoids are classified into internal hemorrhoids, external hemorrhoids and mixed hemorrhoids according to the different parts. A visible zigzag line called anal canal dentate line is arranged at the junction of the anal canal skin and the rectal mucosa. The internal hemorrhoid is above the dentate line; external hemorrhoid below dentate line, and coating anal canal mucosa; the mixed hemorrhoid is also the internal hemorrhoid and the external hemorrhoid. The hemorrhoids are mainly characterized by hemafecia, the nature of the hemafecia can be painless, intermittent, fresh blood after the hemafecia, the hemafecia is dripped or the blood is carried on the toilet paper, the constipation, the wine drinking or the food intake is aggravated, the simple internal hemorrhoids have no pain, only have the feeling of falling and swelling, can bleed, develop to prolapse, are combined with the thrombosis, and the pain appears when the infection occurs.
The main modes of treating hemorrhoids include drug treatment and surgical treatment, and the common treatment method is surgery or infusion treatment. The treatment methods can cause the patients to be accompanied with complications in the treatment process, the patients are slow to recover, easy to relapse, unable to relieve the pain of the patients in time, and not easy to cure the diseases radically, and the work and life of the patients are seriously affected.
Disclosure of Invention
The invention aims to provide an ice cream hemorrhoid ointment and a preparation process thereof, which aim to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
the ice yellow hemorrhoids ointment comprises the following raw materials in parts by weight: 30-120 parts of coptis chinensis, 30-120 parts of golden cypress, 30-120 parts of rheum officinale, 10-50 parts of dragon's blood, 10-50 parts of lithospermum, 30-120 parts of radix stemonae, 30-120 parts of radix sophorae flavescentis, 30-120 parts of bletilla striata, 10-50 parts of pearl, 100 parts of calcined gypsum, 30-90 parts of natural borneol, 20-80 parts of mint, 1900-2100 parts of vaseline and 25-35 parts of tea oil.
As a further scheme of the invention: the ice yellow hemorrhoids ointment comprises the following raw materials in parts by weight: 40-110 parts of coptis chinensis, 40-110 parts of golden cypress, 40-110 parts of rheum officinale, 20-40 parts of dragon's blood, 20-40 parts of lithospermum, 40-110 parts of radix stemonae, 40-110 parts of radix sophorae flavescentis, 40-110 parts of bletilla striata, 20-40 parts of pearl, 120-280 parts of calcined gypsum, 40-80 parts of natural borneol, 30-70 parts of mint, 1950-2050 parts of vaseline and 28-32 parts of tea oil.
As a further scheme of the invention: 2000 parts of vaseline.
As a further scheme of the invention: 30 parts of tea oil.
The invention also aims to provide a preparation process of the ice yellow hemorrhoids cream, which comprises the following steps:
1) pulverizing Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, Margarita, Gypsum Fibrosum Preparatum, natural Borneolum Syntheticum, and herba Menthae respectively, and sieving with 200 mesh sieve;
2) weighing vaseline and oleum Camelliae, mixing, heating to 75-85 deg.C, cooling to 60-70 deg.C, adding Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, and Gypsum Fibrosum Preparatum, stirring at the above temperature for 10-40min, adding Margarita, herba Menthae, and natural Borneolum Syntheticum, and stirring until cooling to normal temperature.
As a further scheme of the invention: in the step 2), vaseline and tea oil are weighed and mixed, heated to 80 ℃, and cooled to 65 ℃.
As a further scheme of the invention: in step 2), adding Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, and Gypsum Fibrosum Preparatum, and stirring at the above temperature for 15-30 min.
As a further scheme of the invention: in the step 2), the stirring speed is 100-300 r/min.
As a further scheme of the invention: in step 2), adding Margarita, herba Menthae, and natural Borneolum Syntheticum for 20-90 min.
Compared with the prior art, the invention has the beneficial effects that:
the coptis chinensis and the phellodendron bark in the invention clear heat and dry dampness, detoxify and purge fire, and the two medicines are used together to remove carrion and make new meat raw; rhubarb relieves heat toxin, breaks food retention and moves blood stasis; dragon's blood has the functions of promoting blood circulation to disperse blood clots, stopping pain and bleeding, healing wound and promoting granulation; the lithospermum, the stemona root and the lightyellow sophora root cool blood and activate blood, detoxify and promote eruption; bletilla striata, pearl and calcined gypsum are used for astringency and hemostasis, removing necrotic tissue and promoting granulation and promoting wound healing; the natural borneol is used as adjuvant drug and has the functions of clearing heat, dissipating fire, promoting blood circulation, relieving swelling and alleviating pain; mint can relieve spasm and promote eruption. The medicines are used together to play the effects of removing necrotic tissue and promoting granulation, clearing heat and reducing swelling, detoxifying and astringing dampness, and activating blood and promoting qi circulation to relieve pain.
Combined with modern pharmacological research, the hemorrhoids ointment contains antibacterial drugs, anti-inflammatory, detumescence, analgesia, itching relieving drugs, exudation reducing drugs, sphincter spasm reducing drugs, antithrombotic drugs and drugs for promoting wound healing. The invention is suitable for treating internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, anal fissure, perianal abscess, anal fistula, anal sinusitis, anal eczema, anal nerve function, rectal inflammation and the like. Through years of clinical research and application, the hemorrhoid ointment which is purely herbaceous and easy to absorb is developed by selecting genuine medicinal materials and combining the original purely manual ointment making process with the modern biological wall breaking technology, and the hemorrhoid ointment is deeply praised by vast patients due to the characteristics of unique method and obvious curative effect.
Clinical effects of the invention
1. Patients with conservative treatment: has antibacterial, antiinflammatory, hemostatic, analgesic, intestinal mucosa protecting, and anal fissure relieving effects on hemorrhoid complicated with anal fistula.
2. Patients for preoperative external use: has effects of relieving swelling and pain for hemorrhoid diseases, and promoting pus discharge and removing toxic substance for perianal abscess. Make the operation wound surface small
3. Patients for postoperative topical use: reducing postoperative complications. Diminish inflammation, stop pain, stop bleeding and promote healing (the healing time is advanced 1/3).
Drawings
FIG. 1 is a diagram of the mechanism of action of the hemorrhoid ointment of the present invention;
FIG. 2 is a graph comparing the efficacy of similar products in a clinical study in example 6 of the present invention;
FIG. 3 is a graph showing the improvement of the symptoms of the hemorrhoidal ointment of the present invention in example 6 of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
In the embodiment of the invention, the Binghuang hemorrhoids ointment comprises the following raw materials: 30g of coptis chinensis, 30g of golden cypress, 30g of rhubarb, 10g of dragon's blood, 10g of lithospermum, 30g of radix stemonae, 30g of radix sophorae flavescentis, 30g of bletilla striata, 10g of pearl, 100g of calcined gypsum, 30g of natural borneol, 20g of mint, 1900g of vaseline and 25g of tea oil.
A preparation process of the borneol yellow hemorrhoids ointment comprises the following steps:
1) pulverizing Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, Margarita, Gypsum Fibrosum Preparatum, natural Borneolum Syntheticum, and herba Menthae respectively, and sieving with 200 mesh sieve.
2) Weighing vaseline and oleum Camelliae, mixing, heating to 75 deg.C, cooling to 60 deg.C, adding Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, and Gypsum Fibrosum Preparatum, stirring at the above temperature for 10min, adding Margarita, herba Menthae, and natural Borneolum, stirring, and cooling to room temperature.
Example 2
In the embodiment of the invention, the Binghuang hemorrhoids ointment comprises the following raw materials: 120g of coptis chinensis, 120g of golden cypress, 120g of rhubarb, 50g of dragon's blood, 50g of lithospermum, 120g of radix stemonae, 120g of radix sophorae flavescentis, 120g of bletilla striata, 50g of pearl, 300g of calcined gypsum, 90g of natural borneol, 80g of mint, 2100g of vaseline and 35g of tea oil.
A preparation process of the borneol yellow hemorrhoids ointment comprises the following steps:
1) pulverizing Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, Margarita, Gypsum Fibrosum Preparatum, natural Borneolum Syntheticum, and herba Menthae respectively, and sieving with 200 mesh sieve.
2) Weighing vaseline and oleum Camelliae, mixing, heating to 85 deg.C, cooling to 70 deg.C, adding Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, and Gypsum Fibrosum Preparatum, stirring at the above temperature for 40min, adding Margarita, herba Menthae, and natural Borneolum Syntheticum, stirring, and cooling to room temperature.
Example 3
In the embodiment of the invention, the Binghuang hemorrhoids ointment comprises the following raw materials: 40g of coptis chinensis, 40g of golden cypress, 40g of rhubarb, 20g of dragon's blood, 20g of lithospermum, 40g of radix stemonae, 40g of radix sophorae flavescentis, 40g of bletilla striata, 20g of pearl, 120g of calcined gypsum, 40g of natural borneol, 30g of mint, 1950g of vaseline and 25g of tea oil.
A preparation process of the borneol yellow hemorrhoids ointment comprises the following steps:
1) pulverizing Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, Margarita, Gypsum Fibrosum Preparatum, natural Borneolum Syntheticum, and herba Menthae respectively, and sieving with 200 mesh sieve.
2) Weighing vaseline and tea oil, mixing, heating to 78 deg.C, cooling to 62 deg.C, adding Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, and Gypsum Fibrosum Preparatum, stirring at the temperature for 15min, adding Margarita, herba Menthae, and natural Borneolum, stirring at 100r/min, and adding Margarita, herba Menthae, and natural Borneolum for 20min until cooling to normal temperature.
Example 4
In the embodiment of the invention, the Binghuang hemorrhoids ointment comprises the following raw materials: 110g of coptis chinensis, 110g of golden cypress, 110g of rhubarb, 40g of dragon's blood, 40g of lithospermum, 110g of radix stemonae, 110g of radix sophorae flavescentis, 110g of bletilla striata, 40g of pearl, 280g of calcined gypsum, 80g of natural borneol, 70g of mint, 2050g of vaseline and 35g of tea oil.
A preparation process of the borneol yellow hemorrhoids ointment comprises the following steps:
1) pulverizing Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, Margarita, Gypsum Fibrosum Preparatum, natural Borneolum Syntheticum, and herba Menthae respectively, and sieving with 200 mesh sieve.
2) Weighing vaseline and tea oil, mixing, heating to 82 deg.C, cooling to 68 deg.C, adding Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, and Gypsum Fibrosum Preparatum, stirring at the temperature for 30min, adding Margarita, herba Menthae, and natural Borneolum Syntheticum, stirring at 300r/min, and adding Margarita, herba Menthae, and natural Borneolum Syntheticum for 90min until cooling to normal temperature.
Example 5
In the embodiment of the invention, the Binghuang hemorrhoids ointment comprises the following raw materials: 80g of coptis chinensis, 70g of phellodendron, 90g of rhubarb, 30g of dragon's blood, 30g of lithospermum, 60g of radix stemonae, 70g of radix sophorae flavescentis, 50g of bletilla striata, 30g of pearl, 200g of calcined gypsum, 60g of natural borneol, 50g of mint, 2000g of vaseline and 30g of tea oil.
A preparation process of the borneol yellow hemorrhoids ointment comprises the following steps:
1) pulverizing Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, Margarita, Gypsum Fibrosum Preparatum, natural Borneolum Syntheticum, and herba Menthae respectively, and sieving with 200 mesh sieve.
2) Weighing vaseline and tea oil, mixing, heating to 80 ℃, cooling to 65 ℃, adding coptis chinensis, phellodendron, rheum officinale, dragon's blood, lithospermum, radix stemonae, radix sophorae flavescentis, bletilla striata and calcined gypsum, stirring at the temperature for 20min, then adding pearl, mint and natural borneol, stirring while adding, wherein the stirring speed is 100-300r/min, and the total time for adding pearl, mint and natural borneol is 50min until the temperature is reduced to normal temperature.
EXAMPLE 6 clinical trial
120 patients observed in the study are outpatient patients with hemorrhoids, anal fissure and anal fistula from 2014 to 2016, wherein 60 patients are male patients and 60 patients are female patients. The two groups are divided into 60 treatment groups and 60 control groups randomly, the two groups have equality in the aspects of age, sex, disease course, operation range, wound area size, symptoms and physical signs of patients before administration, and the two groups of cases have comparability. Treatment groups were treated with hemorrhoid treatment cream of example 5 of the present invention. The control group was treated with a certain ointment of horse.
Standard of care
The effect is shown: no bleeding and bleeding, obviously reduced pain and obviously shortened wound healing time; the method has the following advantages: no bleeding and bleeding occur, the pain is relieved, and the healing time of the wound surface is shortened; and (4) invalidation: little bleeding or little bleeding, no pain relief and no obvious shortening of the healing time of the wound surface.
The results are shown in Table 1.
TABLE 1
| Group of | Cases (example) | Obvious effect (example) | Effective (example) | Invalid (example) | Total effective rate (%) |
| |
60 | 16 | 34 | 10 | 83.33 |
| |
60 | 38 | 20 | 2 | 96.67 |
As can be seen from Table 1, the hemorrhoid ointment of the present invention has significant efficacy on anal fistula, and significantly shortens the healing time in clinical use.
The therapeutic effect comparison graph of the similar products in the clinical research of the invention is shown in figure 2. From the comparison chart of clinical research, the corresponding anal diseases are classified more carefully, and the advantages of the hemorrhoid ointment in the clinical use of the anal diseases can be more accurately understood. Particularly, the pus discharging and toxin expelling effects are more obvious on perianal abscess; in the aspect of anal eczema, a certain horse brand is oily ointment and has poor air permeability, while a certain water-based cream is easy to form water ripples, so that eczema is generated after the affected part is applied for a long time.
The invention improves the symptoms: the curative effect on the five symptoms and signs of bleeding, pain, edema, laceration and pruritus is shown in the following figure 3. The results show that the hemorrhoid ointment has obvious curative effects on improving five symptoms and physical signs of bleeding, pain, edema, cleft, pruritus and the like.
Conclusion of clinical study: the hemorrhoid ointment has obvious curative effects on hemorrhoid, anal fissure, anal fistula, perianal abscess, anal eczema, anal sinusitis and proctitis, and can relieve or obviously improve related symptoms caused by diseases.
Typical cases are:
case 1: aged 58 years old, with hemorrhoids for many years, diagnosed in second stage, with large hemorrhoids, which can escape from the anus during defecation, and can be received by oneself after defecation with blood drip during defecation. The medicine is applied for 2 times every day, the disease is improved after 5 days, blood dripping and dropping do not occur after 12 days, and the disease does not recur after the medicine is stopped for half a year.
Case 2; Wu-Chi, female, age 33, child who has grown up, has thrombotic hemorrhoid and Canton phenomenon, pain is hard to endure, and unable to defecate normally, it is necessary to rely on enema, daub the medicine for 7 days, the thrombotic hemorrhoid is eliminated, Canton phenomenon is softened obviously, can defecate by oneself, visit after 1 year, no recurrence.
Case 3, namely, plum, male, 37 years old, perianal abscess, 3 days of disease, swelling and pain which can not be seated, the medicine of the invention is smeared for 3 times a day, and pus is discharged after 1 day, thus reducing swelling; after 10 days, pus is basically beaten out, pus discharge openings are gradually healed, after 15 days, the pus is healed, and after 3 years, the pus is returned without relapse.
Case 4; zhangyi, male, 45 years old, diagnosed as anal fissure, recurrent morbidity for half a year, pain in the stool, with laceration sensation, accompanied by blood dripping during defecation, applying the medicine 2 times a day, relieving the stool after 1 day, relieving pain, no bleeding after 3 days, clinical symptoms disappearing after 7 days, revisiting after 1 year, having recurrence for 1 time, and improving after applying.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (8)
1. The ice yellow hemorrhoids ointment is characterized by comprising the following raw materials in parts by weight: 30-120 parts of coptis chinensis, 30-120 parts of golden cypress, 30-120 parts of rheum officinale, 10-50 parts of dragon's blood, 10-50 parts of lithospermum, 30-120 parts of radix stemonae, 30-120 parts of radix sophorae flavescentis, 30-120 parts of bletilla striata, 10-50 parts of pearl, 100 parts of calcined gypsum, 30-90 parts of natural borneol, 20-80 parts of mint, 1900-2100 parts of vaseline and 25-35 parts of tea oil, and the preparation process of the borneol-yellow hemorrhoid ointment comprises the following steps:
1) pulverizing Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, Margarita, Gypsum Fibrosum Preparatum, natural Borneolum Syntheticum, and herba Menthae respectively, and sieving with 200 mesh sieve;
2) weighing vaseline and oleum Camelliae, mixing, heating to 75-85 deg.C, cooling to 60-70 deg.C, adding Coptidis rhizoma, cortex Phellodendri, radix et rhizoma Rhei, sanguis Draxonis, radix Arnebiae, radix Stemonae, radix Sophorae Flavescentis, rhizoma Bletillae, and Gypsum Fibrosum Preparatum, stirring at the above temperature for 10-40min, adding Margarita, herba Menthae, and natural Borneolum Syntheticum, and stirring until cooling to normal temperature.
2. The ice yellow hemorrhoid ointment according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 40-110 parts of coptis chinensis, 40-110 parts of golden cypress, 40-110 parts of rheum officinale, 20-40 parts of dragon's blood, 20-40 parts of lithospermum, 40-110 parts of radix stemonae, 40-110 parts of radix sophorae flavescentis, 40-110 parts of bletilla striata, 20-40 parts of pearl, 120-280 parts of calcined gypsum, 40-80 parts of natural borneol, 30-70 parts of mint, 1950-2050 parts of vaseline and 28-32 parts of tea oil.
3. The cream according to claim 1 or 2, wherein said vaseline comprises 2000 parts.
4. The Binghuang hemorrhoid ointment according to claim 1 or 2, wherein the tea oil is 30 parts.
5. The Binghuang hemorrhoid ointment of claim 1, wherein in the step 2) of the preparation process, vaseline and tea oil are weighed and mixed, heated to 80 ℃, and then cooled to 65 ℃.
6. The Binghuang hemorrhoid ointment of claim 1, wherein in the step 2) of the preparation process, coptis chinensis, phellodendron, rhubarb, dragon's blood, lithospermum, stemona root, sophora flavescens, bletilla striata and calcined gypsum are added, and stirred at the temperature for 15-30 min.
7. The Binghuang hemorrhoid ointment of claim 1, wherein in the step 2) of the preparation process, the stirring speed is 100-300 r/min.
8. The Binghuang hemorrhoid ointment of claim 1, wherein the total time for adding the pearl, the mint and the natural borneol in the step 2) of the preparation process is 20-90 min.
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