CN104288173A - Chitosan antibacterial gel biological dressing - Google Patents
Chitosan antibacterial gel biological dressing Download PDFInfo
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- CN104288173A CN104288173A CN201410333306.9A CN201410333306A CN104288173A CN 104288173 A CN104288173 A CN 104288173A CN 201410333306 A CN201410333306 A CN 201410333306A CN 104288173 A CN104288173 A CN 104288173A
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- chitosan
- dressing
- pharmagel
- purified water
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A provided chitosan antibacterial gel biological dressing is characterized by being prepared by mainly mixing 25%-35% by mass of chitosan, 15%-25% by mass of medicinal gelatin and 45%-55% by mass of purified water to obtain a gel. The chitosan antibacterial gel biological dressing is mainly applied to symptomatic treatment or auxiliary treatment on various hemorrhoids, is substantial in curative effect, simple and rapid to use, safe, reliable and free of pain, and is suitable for symptomatic treatment or auxiliary treatment on various hemorrhoids and female reproduction tract infection.
Description
Technical field
The present invention relates to external used medicine technical field, refer to a kind of chitosan anti-bacteria gel biological dressing for anti-inflammation and preparation thereof particularly.
Background technology
Hemorrhoid are a kind of common diseases being positioned at anus position, and any age all can fall ill, but with age, sickness rate increases gradually.In China, hemorrhoid are modal anal and intestinal diseases, have the saying of " ten male nine hemorrhoid ", " ten female ten hemorrhoid ".
Hemorrhoid belong to a kind of common anal and intestinal disease, the disease that it can cause hemorrhage, thromboembolism and deviate from.Current hemorrhoid treating method roughly can be summed up as pharmacotherapy, operative therapy and physiotherapy three major types.The large multipotency of pharmacotherapy improves symptom, but curative effect is comparatively slow, treatment is not thorough, is difficult to eliminate focus.Long-term prescription patient spends is high, and has side effect.The main method for the treatment of hemorrhoid is still performed the operation both at home and abroad at present.Though this method can by hemorrhoid once resecting, patient is painful large, and damage is heavy, and the postoperative appearance recurrence of few patients and complication.In physiotherapy, infrared ray radiation short term effect is comparatively obvious, and late result is not yet extremely affirmed.Cryotherapy after-operation response and complication more, therefore now seldom to adopt.As for laser therapy, due to otch surrounding tissue generation degeneration, necrosis during excision, postoperative easy accompanying infection, hemorrhage, cicatricial stricture etc., also seldom adopt at present.
Female genital tract infection, mainly comprises cervical erosion, cervicitis, all kinds of vaginitis and leucorrhea abnormal etc.Common sympton mainly pudendum and the pruritus of vagina of gynecological inflammation, the locally generation had is rotten to the corn, and companion's causalgia, dysurea, frequent micturition, vaginal secretions increase, red and swollen etc.Gynaecopathia is women's commonly encountered diseases, frequently-occurring disease.But because many people lack due understanding to gynaecopathia, lack the health care to health, in addition various bad life habits etc., physiological health is go from bad to worse, some women's diseases are caused to be burdened with, and obstinate, give normal life, work and bring great inconvenience.
Chitosan has broad spectrum antibiotic activity; obvious inhibition is all had to pathogenic microorganisms such as escherichia coli, staphylococcus aureus, Candida albicans; also there is hemostasis, protection wound surface; the effects such as Promotive union, thus the wound surface that can be used for the positions such as skin, oral cavity, throat, vagina, anus stops blooding, repairs and preventing and curing infection.This product is nontoxic to human-body safety, meets national standard.
Summary of the invention
The object of the present invention is to provide a kind of evident in efficacy, and the chitosan anti-bacteria gel biological dressing of quick, safe and reliable, no pain easy to use and preparation thereof.
To achieve these goals, technical scheme of the present invention is: the dressing of a kind of chitosan anti-bacteria gel biological, it is characterized in that it is mixed into gel primarily of chitosan, pharmagel and purified water raw material stirring, the mass percentage between each raw material is: chitosan: 25%-35%; Pharmagel: 15%-25%; Purified water: 45%-55%.
Preferably, the mass percentage of each raw material of described chitosan anti-bacteria gel biological dressing is: chitosan: pharmagel: purified water=30%:20%:50%.
Preferably, described chitosan molecule amount is 350,000-50 ten thousand, deacetylation is 86%-99%.
In addition, present invention also offers the preparation method of a kind of chitosan anti-bacteria gel biological dressing, it is characterized in that it comprises the following steps:
(1) by the mass percentage between each raw material be: chitosan: 25%-35%; Pharmagel: 15%-25%; Purified water: 45%-55% measures chitosan, pharmagel and purified water raw material, for subsequent use;
(2) purified water is heated to 100 DEG C, add the chitosan, the pharmagel that measure in order successively, continuous stirring simultaneously makes chitosan, pharmagel dissolves completely, continue stirring 15 minutes, make the abundant mix homogeneously of solution, keep solution temperature to be 100 DEG C, heat after 10 minutes, stop heating;
(3) open cooling device, solution temperature is down to 50 DEG C, namely forms gel state, whole process for preparation must complete in 2 hours.
Above-mentioned chitosan anti-bacteria gel biological dressing is used for the treatment of hemorrhoid.
Above-mentioned chitosan anti-bacteria gel biological dressing is used for the treatment of gynecological inflammation.
The therapeutical effect principle of chitosan:
Utilize chitosan Antibacterial activity, hemostasis and promote tissue repair and regeneration; layer protecting film can be formed at hemorrhoid position; bleeding hemorrhoids caused by hemorrhoid different times and mixed hemorrhoid, rectal tenesmus, blood stasis prolapsus, hemorrhoid mucous hyperemia edema are all improved significantly; significantly can reduce blood stasis; make the thrombosis of hemorrhoid patients, edema, inflammation, incarceration, falling inflation, pain, hemorrhagely to be alleviated, prevent the infection because hemorrhoid cause.The present invention is applicable to symptomatic treatment or the auxiliary treatment of all kinds hemorrhoid.
Utilize chitosan Antibacterial activity, stronger inhibitory action is had to pathogenic bacterium such as Candida albicans, staphylococcus aureus, pyococcuss, and promote the effect of tissue repair and regeneration, effectively can suppress above-mentioned microbial inflammation of causing a disease, recover the normal function of body tissue.This product is used for Candida albicans, staphylococcus aureus, vaginitis that pyococcus causes, the treatment of pruritus of vagina or auxiliary treatment.
The present invention adopts and is mixed into gel by chitosan, pharmagel and purified water raw material stirring, directly act on human body affected part, the invasion that one deck antibacterial protecting film suppresses adventitious viruses microorganism can be formed at positions such as infection and inflammation, can enter in cell by penetration cell wall in addition, upset metabolism and the synthesis of antibacterial, thus reach the therapeutic purposes of anti-inflammation; Compare with prior art, percdation of the present invention, thorough elimination is not recurred, and therapeutic effect is remarkable.
Using method:
Rectum uses.Open compact, removes the protecting film of chitosan anti-bacteria gel front end, firmly extrudes body gently, get a small amount of uniform application of chitosan anti-bacteria gel in disease sites, every day 4-6 time.During for internal hemorrhoid, infusion appliance is enclosed within the mouth of pipe, after tightening; Infusion appliance is inserted anal, after clamp-oning appropriate chitosan anti-bacteria gel, discards infusion appliance.
Vagina uses.Before sleeping every night, remove the protective cap of chitosan anti-bacteria gel front end, the propeller that gel is housed slowly is inserted vagina deep, utilizes boosting bar that gel is pushed vagina.Every day 1 time, each 1; Continuous use 5-7 days is a course for the treatment of.Severe patient is followed the doctor's advice.
Antibacterial classification: have very strong antibacterial action to the various crissum antibacterials in Candida albicans, staphylococcus aureus, pyococcus and blood stasis.
Cure mainly: be clinically applicable to Candida albicans, all kinds hemorrhoid that staphylococcus aureus, pyococcus cause and vaginitis, the treatment of pruritus of vagina or auxiliary treatment.
Points for attention:
1, this product is exterior-applied article, forbids oral.
2, this product only supplies single use, packages in damaged condition, prohibits the use.
If 3, use during this product and the phenomenon such as local excitation or allergy occurs, after stopping using, symptom can disappear.
4, please this product is placed in child and not easily takes place.
Accompanying drawing explanation
Fig. 1 is angle of rake external structure schematic diagram of the present invention;
Fig. 2 is the piston of propeller inside of the present invention and the structural representation of injecting bar
In figure: 1-advances body, 2-cap head, 3-piston, 4-injects bar.
Detailed description of the invention
In order to understand the present invention better, illustrate content of the present invention further below in conjunction with embodiment, but content of the present invention is not only confined to the following examples.
The primary raw material of chitosan anti-bacteria gel biological of the present invention dressing comprises chitosan, pharmagel and purified water.The mass percentage of above-mentioned each raw material is: chitosan: 25%-35%; Pharmagel: 15%-25%; Purified water: 45%-55%.
Embodiment 1:
The dressing of chitosan anti-bacteria gel biological, makes primarily of chitosan, pharmagel and purified water, and the proportion relation between each raw material is: chitosan: pharmagel: purified water=30%:20%:50%.
For the technique of the preparation of 1000 grams of chitosan anti-bacteria gel biologicals dressing, comprise the steps:
(1) by the mass percentage of each raw material be: chitosan: pharmagel: purified water=30%:20%:50% measures chitosan 300 grams, pharmagel 200 grams and purified water 500 grams, for subsequent use;
(2) purified water is heated to 100 DEG C, add the chitosan, the pharmagel that measure in order successively, continuous stirring simultaneously makes chitosan, pharmagel dissolves completely, continue stirring 15 minutes, make the abundant mix homogeneously of solution, keep solution temperature to be 100 DEG C, heat after 10 minutes, stop heating;
(3) open cooling device, solution temperature is down to 50 DEG C, namely forms gel state.
The present invention is after test of many times is analyzed, what draw thisly adds chitosan, the mode of pharmagel and heating-up temperature and mixing time, only under this mixed prescription formula, its medicament contg of antibacterial gel of gained is the most uniform after measured, also only have and just can avoid in this manner entering bubble in gel, whole process for preparation must complete in 2 hours.
Adopt propeller as depicted in figs. 1 and 2 to carry out administration, medicine is positioned at and advances body 1, medicine is advanced to cap head 2 place carries out administration by injecting bar 4 and piston 3.
As containing bubble in gel, can cause: in use, the inaccurate or local drug concentration of dosage is inconsistent for patient, thus cause sterilization not thoroughly or delay treatment.
The chitosan anti-bacteria gelling properties of the acid extraction in the technique that the present invention finds out from a large amount of production process and reinforced method gained is the most stable, and medicament contg is the most even, and gel outward appearance is the most nice, and uniform color is colourless or clear pale yellow color.
Clinical trial:
Chitosan anti-bacteria gel biological dressing obtained by above-described embodiment 1 is used for the treatment clinical observation of hemorrhoid:
1, object: outpatient clinic have blood in stool patient totally 120 example, 20-50 year.Be divided into 2 groups at random, often organize 60 people.Wherein test group uses the dressing of chitosan anti-bacteria gel biological, and external, uses to specifications; Matched group uses ZHICHUANG GAO, external, gets appropriate painting and puts affected part on the skin, 1 time on the one.
The clinical efficacy contrast that table 1 liang group patient medication was had blood in stool after the course for the treatment of
Patient medication was compared after the course for the treatment of, and the curative effect that two groups of hemorrhoid cause to have blood in stool all takes an evident turn for the better, but from result of the test, the effective percentage of chitosan anti-bacteria gel biological dressing test group is significantly better than matched group.
2, object: the hemorrhoid of outpatient clinic cause patient's totally 120 examples of pendant pain, 20-50 year.Be divided into 2 groups at random, often organize 60 people.Wherein test group uses the dressing of chitosan anti-bacteria gel biological, and external, uses to specifications; Matched group uses ZHICHUANG GAO, external, gets appropriate painting and puts affected part on the skin, 1 time on the one.
Table 2 liang group patient medication one falls the clinical efficacy contrast of pain symptom the course for the treatment of
Compare after the course for the treatment of, the pendant pain symptom and sign of two groups all takes an evident turn for the better, and from result of the test, the effective percentage of chitosan anti-bacteria gel biological dressing test group is significantly better than matched group.
3, object: the hemorrhoid of outpatient clinic cause patient's totally 120 examples of prolapsus, 20-50 year.Be divided into 2 groups at random, often organize 60 people.Wherein test group uses the dressing of chitosan anti-bacteria gel biological, and external, uses to specifications; Matched group uses ZHICHUANG GAO, external, gets appropriate painting and puts affected part on the skin, 1 time on the one.
Table 3 liang group patient medication course for the treatment of to prolapse the clinical efficacy contrast of symptom
Compare after the course for the treatment of, the prolapsus symptom and sign of two groups all takes an evident turn for the better, and from result of the test, the effective percentage of chitosan anti-bacteria gel biological dressing test group is significantly better than matched group.
Curative effect judging standard: recovery from illness: symptom and sign disappears; Effective: symptom and sign is clearly better; Effective: symptom and sign slightly improves; Invalid: symptom and sign is without improvement.Effective percentage=(recovery from illness+effective+effectively number of cases)/with total number of cases × 100% of group.
After observing a course for the treatment of of medication, chitosan antibacterial gel is respectively the effective percentage of symptom as have blood in stool, fall pain and prolapsus that hemorrhoid cause: 100%, 80%, 83.3%.
Chitosan anti-bacteria gel biological dressing obtained by above-described embodiment 1 is used for the treatment clinical observation of female genital tract infection:
4, object: the female gynecological patient of outpatient clinic is totally 120 examples, 20-55 year.Be divided into 2 groups at random, often organize 60 people.Wherein test group uses the dressing of chitosan anti-bacteria gel biological, and external, uses to specifications; Matched group uses gynecological's capsule.
Before and after table 4 liang group patient medication treatment, symptom and sign check result compares
Female patient medication was compared after the course for the treatment of, and the symptom and sign of two groups all takes an evident turn for the better, but from result of the test, used the test group successful of chitosan anti-bacteria gel biological dressing to be better than matched group.
A table 5 liang group patient medication treat one the course for the treatment of symptom and sign disappearance rate compare
Female patient medication was compared after the course for the treatment of, the vaginal secretions character symptom and sign disappearance rate of two groups has significant difference (P < 0.05), other symptom and sign disappearance rate no difference of science of statistics (P > 0.05), two groups of symptom and sign disappearance rate are all obvious, but from result of the test, use the test group successful of chitosan anti-bacteria gel biological dressing to be better than matched group.
Claims (7)
1. a chitosan anti-bacteria gel biological dressing, is characterized in that: it is mixed into gel primarily of chitosan, pharmagel and purified water raw material stirring, and the mass percentage between each raw material is: chitosan: 25%-35%; Pharmagel: 15%-25%; Purified water: 45%-55%.
2. chitosan anti-bacteria gel biological according to claim 1 dressing, is characterized in that: the quality proportion relation between each raw material is: chitosan: pharmagel: purified water=30%:20%:50%.
3. chitosan anti-bacteria gel biological according to claim 2 dressing, is characterized in that: the dressing of every 1000 grams of described chitosan anti-bacteria gel biologicals is made up of the raw material of following weight proportioning: chitosan: 300 grams; Pharmagel: 200 grams; Purified water: 500 grams.
4. chitosan anti-bacteria gel biological according to claim 1 dressing, is characterized in that: described chitosan molecule amount is 350,000-50 ten thousand, deacetylation is 86%-99%.
5. the preparation method of chitosan anti-bacteria gel according to claim 1, is characterized in that comprising the following steps:
(1) by the mass percentage of each raw material be: chitosan: 25%-35%; Pharmagel: 15%-25%; Purified water: 45%-55% measures chitosan, pharmagel and purified water, for subsequent use;
(2) purified water is heated to 100 DEG C, add the chitosan, the pharmagel that measure in order successively, continuous stirring simultaneously makes chitosan, pharmagel dissolves completely, continue stirring 15 minutes, make the abundant mix homogeneously of solution, keep solution temperature to be 100 DEG C, heat after 10 minutes, stop heating;
(3) open cooling device, solution temperature is down to 50 DEG C, namely forms gel state, whole process for preparation must complete in 2 hours.
6. chitosan anti-bacteria gel biological according to claim 1 dressing, is characterized in that: described chitosan anti-bacteria gel biological dressing is used for the treatment of hemorrhoid.
7. the preparation method of chitosan anti-bacteria gel biological according to claim 5 dressing, is characterized in that: described chitosan anti-bacteria gel biological dressing is used for the treatment of gynecological inflammation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410333306.9A CN104288173A (en) | 2014-07-14 | 2014-07-14 | Chitosan antibacterial gel biological dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410333306.9A CN104288173A (en) | 2014-07-14 | 2014-07-14 | Chitosan antibacterial gel biological dressing |
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| Publication Number | Publication Date |
|---|---|
| CN104288173A true CN104288173A (en) | 2015-01-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410333306.9A Pending CN104288173A (en) | 2014-07-14 | 2014-07-14 | Chitosan antibacterial gel biological dressing |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105496944A (en) * | 2015-12-18 | 2016-04-20 | 安徽省微赢生物科技有限公司 | Chitosan gel and preparation method thereof |
| CN109985037A (en) * | 2019-03-22 | 2019-07-09 | 陕西中医药大学第二附属医院 | A kind of gynecological gel |
| US11058712B2 (en) | 2017-07-19 | 2021-07-13 | Universidade Da Beira Interior | Film for topical application in the treatment of skin lesions and method of obtaining and applying same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757071A (en) * | 2010-02-01 | 2010-06-30 | 广东广济堂医药保健品有限公司 | Irreversible vagina antibiosis gel preparation and preparation method thereof |
| CN101879324A (en) * | 2010-07-02 | 2010-11-10 | 西南大学 | Method for preparing chitosan-based composite dressing for medical use |
-
2014
- 2014-07-14 CN CN201410333306.9A patent/CN104288173A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757071A (en) * | 2010-02-01 | 2010-06-30 | 广东广济堂医药保健品有限公司 | Irreversible vagina antibiosis gel preparation and preparation method thereof |
| CN101879324A (en) * | 2010-07-02 | 2010-11-10 | 西南大学 | Method for preparing chitosan-based composite dressing for medical use |
Non-Patent Citations (1)
| Title |
|---|
| 黄春兰 等: "壳聚糖凝胶体系研究进展及其展望", 《食品研究与开发》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105496944A (en) * | 2015-12-18 | 2016-04-20 | 安徽省微赢生物科技有限公司 | Chitosan gel and preparation method thereof |
| US11058712B2 (en) | 2017-07-19 | 2021-07-13 | Universidade Da Beira Interior | Film for topical application in the treatment of skin lesions and method of obtaining and applying same |
| CN109985037A (en) * | 2019-03-22 | 2019-07-09 | 陕西中医药大学第二附属医院 | A kind of gynecological gel |
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Application publication date: 20150121 |