CN102058559B - Doxycycline hydrochloride effervescent tables for milk cows and preparation method thereof - Google Patents
Doxycycline hydrochloride effervescent tables for milk cows and preparation method thereof Download PDFInfo
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- CN102058559B CN102058559B CN2010106047643A CN201010604764A CN102058559B CN 102058559 B CN102058559 B CN 102058559B CN 2010106047643 A CN2010106047643 A CN 2010106047643A CN 201010604764 A CN201010604764 A CN 201010604764A CN 102058559 B CN102058559 B CN 102058559B
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- doxycycline hydrochloride
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- polyvinylpyrrolidone
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Abstract
The invention belongs to the technical field of medicine preparation, and relates to doxycycline hydrochloride effervescent tables for milk cows and a preparation method thereof. The effervescent tables comprise the following components in percentage by weight: 5-20% of doxycycline hydrochloride, 10-30% of tartaric acid, 15-45% of sodium bicarbonate, 1-15% of polyvinyl pyrrolidone, 1-10% of polyethylene glycol 6000, 20-50% of anhydrous glucose, and 0.01-3% of magnesium stearate. The preparation method comprises the following steps: pretreating raw materials, mixing, preparing damp mass, granulating, drying, grading, and tabletting. The doxycycline hydrochloride effervescent tables have the advantages of good effect, strong stability, and the like, and are convenient to carry and use.
Description
Technical field
The invention belongs to field of medicine preparing technology, relate in particular to a kind of milch cow with doxycycline hydrochloride effervescent tablet and preparation method thereof.
Background technology
In recent years; Development along with the milk cattle cultivating industry; Vagina such as the cow endometritis that pathogenic microorganisms such as antibacterial, fungus, mycoplasma, virus cause, vaginitis, uterus suppuration, puerperal infection, placenta retention and hysteropathy also increase gradually, already cause enormous economic loss for milk cattle cultivating, therefore are badly in need of strengthening the control of milch cow vagina and hysteropathy; Guarantee the healthy and sustainable development of milk cattle cultivating industry, thereby improve the economic benefit of milk cattle cultivating industry.
The chemical name of doxycycline hydrochloride is 6-methyl-4-(dimethylamino)-3,5,10,12; 12 α ,-penta hydroxy group-1,11-dioxo-1,4; 4 α, 5,5 α, 6; 11,12 α-octahydro-2-aphthacene carboxamide hydrochloride half ethanol semihydrate are the Tetracyclines broad ectrum antibiotic; Antimicrobial spectrum and other Tetracyclines seemingly, external and antibacterial activity in vivo are all strong than oxytetracycline, tetracycline, and pathogenic microorganisms such as escherichia coli, Salmonella, pasteurellosis bacillus, mycoplasma are all had very strong inhibition and killing action.Animal mainly contains conventional tablet, capsule, injection etc. with the doxycycline hydrochloride common formulations at present.When treatment milch cow vagina and hysteropathy, administrations are poured at present vaginas and uterus of adopting more, but poorly soluble owing to above drug form, little with the contact area of Uterine mucosa and vagina, cause overall therapeutic effect undesirable.
Summary of the invention
The purpose of this invention is to provide a kind of milch cow with doxycycline hydrochloride effervescent tablet and preparation method thereof.
The technical scheme that the present invention adopts is; A kind of milch cow is used the doxycycline hydrochloride effervescent tablet, comprises following components in weight percentage: doxycycline hydrochloride 5%～20%, tartaric acid 10%～30%, sodium bicarbonate 15%～45%, polyvinylpyrrolidone 1%～15%, polyethylene glycol 6000 1%～10%, anhydrous glucose 20%～50%, magnesium stearate 0.01%～3%.
A kind of milch cow is with the method for preparing of doxycycline hydrochloride effervescent tablet, and step is described below:
(1) with doxycycline hydrochloride, tartaric acid, sodium bicarbonate, polyethylene glycol 6000, anhydrous glucose drying, cross 80 mesh sieves, subsequent use;
(2) take by weighing each component in the step (1), with the equivalent incremental method, mixing forms mixture of powders;
(3) polyvinylpyrrolidone is dissolved in the alcoholic solution, mix homogeneously, subsequent use;
(4) in mixture of powders, evenly spray the polyvinylpyrrolidone alcoholic solution, process soft material;
(5) soft material being added comminutor granulates;
(6) with the granule that makes 40～50 ℃ of oven dry;
(7) cross 20 mesh sieves, granulate adds magnesium stearate, mixing;
(8) put into tablet machine, compacting promptly gets the doxycycline hydrochloride effervescent tablet in flakes.
The concentration of the alcoholic solution of polyethylene dissolving ketopyrrolidine is 95%.
Milch cow of the present invention uses the method for using of doxycycline hydrochloride effervescent tablet to be: directly place vagina of milch cow or uterus to get final product these article.
The advantage and the beneficial effect of doxycycline hydrochloride effervescent tablet of the present invention are:
(1) effervescent tablet is because its unique effervescent disintegrate drug release feature; Be particularly suitable for vagina, uterus topical; Effectively enlarge the contact area of medicine and inflammation part, and improve the concentration of topical remedy, the more common doxycycline hydrochloride topical formulations of antibacterial effect has obviously improved.
(2) the doxycycline hydrochloride effervescent tablet is a kind of milch cow vagina and uterus medication novel formulation, has advantage such as to carry, easy to use, effective, instant effect, stability are strong.
The specific embodiment
Through specific embodiment the present invention is done further detailed description below, implement row below being not limited to.
Embodiment 1
The present embodiment milch cow is used the doxycycline hydrochloride effervescent tablet, comprises following components in weight percentage: (by 1000 doxycycline hydrochloride effervescent tablet supplementary material proportionings, monolithic weighs 20 g):
Doxycycline hydrochloride 1100g
Tartaric acid 4200g
Sodium bicarbonate 5800g
Polyvinylpyrrolidone 1500g
Polyethylene glycol 6000 800g
Anhydrous glucose 6500g
Magnesium stearate 100g
Concrete preparation process is:
(1) with doxycycline hydrochloride, tartaric acid, sodium bicarbonate, polyethylene glycol 6000, anhydrous glucose drying, cross 80 mesh sieves, subsequent use;
(2) take by weighing each component in the step (1), with the equivalent incremental method, mixing forms mixture of powders;
(3) polyvinylpyrrolidone being dissolved in concentration is in 95% the alcoholic solution, and mix homogeneously is subsequent use;
(4) in mixture of powders, evenly spray the polyvinylpyrrolidone alcoholic solution, process soft material;
(5) soft material is added comminutor and carry out non-water granulation;
(6) granule that makes is dried under 40 ℃ of temperature conditions;
(7) cross 20 mesh sieves, granulate adds magnesium stearate, mixing;
(8) put into tablet machine, compacting promptly gets the doxycycline hydrochloride effervescent tablet in flakes.
Embodiment 2
The present embodiment milch cow is used the doxycycline hydrochloride effervescent tablet, comprises following components in weight percentage: (by 1000 doxycycline hydrochloride effervescent tablet supplementary material proportionings, monolithic weighs 20 g):
Doxycycline hydrochloride 2300g
Tartaric acid 4200g
Sodium bicarbonate 5800g
Polyvinylpyrrolidone 1500g
Polyethylene glycol 6000 800g
Anhydrous glucose 5300g
Magnesium stearate 100g
Concrete preparation process is:
(1) with doxycycline hydrochloride, tartaric acid, sodium bicarbonate, polyethylene glycol 6000, anhydrous glucose drying, cross 80 mesh sieves, subsequent use;
(2) take by weighing each component in the step (1), with the equivalent incremental method, mixing forms mixture of powders;
(3) polyvinylpyrrolidone being dissolved in concentration is in 95% the alcoholic solution, and mix homogeneously is subsequent use;
(4) in mixture of powders, evenly spray the polyvinylpyrrolidone alcoholic solution, process soft material;
(5) soft material is added comminutor and carry out non-water granulation;
(6) granule that makes is dried under 45 ℃ of temperature conditions;
(7) cross 20 mesh sieves, granulate adds magnesium stearate, mixing;
(8) put into tablet machine, compacting promptly gets the doxycycline hydrochloride effervescent tablet in flakes.
Embodiment 3
The present embodiment milch cow is used the doxycycline hydrochloride effervescent tablet, comprises following components in weight percentage: (by 1000 doxycycline hydrochloride effervescent tablet supplementary material proportionings, monolithic weighs 20 g):
Doxycycline hydrochloride 3100g
Tartaric acid 4200g
Sodium bicarbonate 5800g
Polyvinylpyrrolidone 1500g
Polyethylene glycol 6000 800g
Anhydrous glucose 4500g
Magnesium stearate 100g
Concrete preparation process is:
(1) with doxycycline hydrochloride, tartaric acid, sodium bicarbonate, polyethylene glycol 6000, anhydrous glucose drying, cross 80 mesh sieves, subsequent use;
(2) take by weighing each component in the step (1), with the equivalent incremental method, mixing forms mixture of powders;
(3) polyvinylpyrrolidone being dissolved in concentration is in 95% the alcoholic solution, and mix homogeneously is subsequent use;
(4) in mixture of powders, evenly spray the polyvinylpyrrolidone alcoholic solution, process soft material;
(5) soft material is added comminutor and carry out non-water granulation;
(6) granule that makes is dried under 50 ℃ of temperature conditions;
(7) cross 20 mesh sieves, granulate adds magnesium stearate, mixing;
(8) put into tablet machine, compacting promptly gets the doxycycline hydrochloride effervescent tablet in flakes.
Embodiment 4
Treat the observation of curative effect of milk cow colpitis with the effervescent tablet of the embodiment of the invention 2.
The clinical diagnosis standard: 1, the irregular purulent secretion that from vaginal orifice, flows out of sick cattle is bonded on vaginal orifice, root of the tail and the buttocks quilt hair on every side; 2, the inspection vagina can be found vaginal mucosa mild swelling, hyperemia or hemorrhage, does not have obvious clinical symptoms; 3, the vaginal mucosa deep layer has the constantly angry duty of inflammation seasonal disease cattle; Discharge purulent secretion red, stench property from vaginal orifice; And with the back of a bow, stick up tail, frequent micturition, fervescence, symptoms such as spirit is depressed, appetite descends, the minimizing of breast amount; The swelling of examination per vagina mucosa, erosion, necrosis, hemorrhage, intravaginal has purulent secretion.
Laboratory animal: 43 experiment milch cows are selected from people from Henan Province and the industry Science and Technology Ltd. that suckles spring, and the inspection of transvaginal prolapsus appliance is made a definite diagnosis suffers from vaginitis.
Experimental technique: will be diagnosed as colpitic trouble Niu Suiji and be divided into experimental group and matched group, 22 of experimental grouies, 21 of matched groups.The Therapeutic Method that the experimental group milch cow is adopted is 1 of a doxycycline hydrochloride effervescent tablet getting the embodiment of the invention 2, directly in putting vagina, every day 1 time; Matched group milch cow Therapeutic Method is: get 5g doxycycline hydrochloride powder, be dissolved in normal saline, carry out the vagina perfusion, every day 1 time.
Curative effect diagnostic criteria: (1) recovery from illness: clinical symptoms complete obiteration; (2) produce effects: clinical symptom relief, but not complete obiteration; (3) invalid: clinical symptoms does not have significant change, and the state of an illness is not seen and alleviated, even occurs worsening.
Experimental result: experimental group treatment cure rate is 90.91%, and is higher by 38.53% than matched group; Experimental group treatment total effective rate is 100%, and is higher by 23.81% than matched group; The mean treatment natural law of experimental group is 6.36, lacks 8.78 days (seeing table 1) than matched group.
The zooperal clinical treatment result of table 1 present embodiment
This shows that use the present invention to treat the milk cow colpitis convenient drug administration, result of use is good, cure rate and total effective rate are high.
Embodiment 5
Treat the observation of curative effect of cow endometritis with the effervescent tablet of the embodiment of the invention 3.
The clinical diagnosis standard: (1) acute catarrhal or mucositis purulence endometritis are often fallen ill in puerperal or Aborta 10 sky, sick cattle sometimes hogback, exert duty, from vaginal orifice, discharge mucus or sticking purulent secretion, putrefactive odor is arranged, General Symptoms is not obvious; (2) acute fibrin membranous endometritis Niu Changnu duty is discharged light red or brown xanchromatic secretions from vaginal orifice, include canescence mucous membrane tissue fritter, fervescence, and spirit is depressed, and loss of appetite or useless exhausted is ruminated and is stopped, and milk yield significantly descends; (3) the necrotic endometritis cattle is exerted duty, and labia is blue, from vaginal orifice, discharges brown, dun stench liquid, includes the corrupt Uterine mucosa fragment that decomposes, fervescence, and down in spirits, appetite is useless exhausted, and lactogenic stops; (4) chronic endometritis mainly shows as and joins infertilely repeatly, and vaginal secretions increases when oestrusing, and muddy (recessive endometritis) or the purulence thing is arranged slightly, other unclear symptoms show, so clinical diagnosis difficulty (especially recessive endometritis) comparatively.The most frequently used is uterine irrigation backflow inspection technique, after the uterine irrigation backflow of recessive endometritis leaves standstill certain hour, can find precipitate or cotton-shaped floating material; The uterine irrigation backflow of chronic Catarrhal endometritis resembles washing water of rice, and the uterine irrigation backflow of chronic mucositis purulence endometritis is like noodle soup or rice water, and the uterine irrigation backflow of chronic purulence endometritis is like batter or be yellow pus.
Laboratory animal: 72 experiment milch cows are selected from milk cattle cultivating field such as lotus milk industry development in science and technology company limited, two lakes, Qinyang City breed factory in people from Henan Province and spring milk industry Science and Technology Ltd., the Henan, are the cows in postpartum endometritis through clinical diagnosis.
Experimental technique: the trouble Niu Suiji that will be diagnosed as puerperal endometritis is divided into experimental group and matched group, 36 of experimental grouies, 36 of matched groups.The Therapeutic Method that the experimental group milch cow is adopted is 1 of a doxycycline hydrochloride effervescent tablet getting the embodiment of the invention 3, directly delivers to the deep, uterus, every day 1 time.Matched group is got the 5g doxycycline hydrochloride and is dissolved in normal saline and carries out rectum and hold the perfusion of formula palace, every day 1 time; For the milch cow that suffers from the purulence endometritis; At first through the scrubber, uterus the milk cattle uterus is washed with 40 ℃ normal saline; Until cleaning up, and then give the normal saline solution that the 5g doxycycline hydrochloride dissolves the intrauterine pus, carry out rectum and hold the perfusion of formula palace.
Curative effect diagnostic criteria: observe at any time after the medication and suffer from cattle performance, milk yield variation, uterus secretions discharge situation, and carry out examination per rectum.Oestrusing, the back is in good time breeds, and joins and carries out pregnancy diagnosis in back 3 months, and press following standard determination curative effect:
(1) clinical cure: uterus size, shape and quality recover normal, and contractile response is normal basically, and the mucus of discharging when oestrusing is limpid transparent.With conceived criterion after the breeding in preceding 3 estrus cycles after the last medication as clinical cure.
(2) clinical improvement: uterus size, shape are recovered normally basically, and contractile response is still poor, and the mucus of discharging when oestrusing is mixed with a small amount of flocculus, and breeding can not be conceived.
(3) clinical invalid: uterus size, the basic no change of shape, contractile response is still faint or do not have contractile response, still discharges Catarrhal or mucositis mycopus when oestrusing.
Experimental result: the experimental group cure rate is 80.56%, and is higher by 33.34% than matched group; Experimental group treatment total effective rate is 97.22%, and is higher by 22.22% than matched group; The medication of experimental group milch cow can be found to be clearly better in 2-3 days, and cow feeding amount, milk yield significantly rise, and average medication natural law reaches 4.86 days, the milch cow more than 80% is cured, and cure back 3 non-return rates up to 91.67% (seeing table 2).
The zooperal clinical treatment result of table 2 present embodiment
This shows, use the present invention to treat cows in postpartum endometritis dosage form convenient drug administration, effective, instant effect, cure rate is high, can significantly improve the economic benefit of cattle farm.
Claims (3)
1. a milch cow is used the doxycycline hydrochloride effervescent tablet; It is characterized in that component and corresponding percentage by weight are: doxycycline hydrochloride 5%～20%, tartaric acid 10%～30%, sodium bicarbonate 15%～45%, polyvinylpyrrolidone 1%～15%, polyethylene glycol 6000 1%～10%, anhydrous glucose 20%～50%, magnesium stearate 0.01%～3%.
2. one kind according to the method for preparing of the said milch cow of claim 1 with the doxycycline hydrochloride effervescent tablet, it is characterized in that concrete steps are described below:
(1) with doxycycline hydrochloride, tartaric acid, sodium bicarbonate, polyethylene glycol 6000, anhydrous glucose drying, cross 80 mesh sieves, subsequent use;
(2) take by weighing each component in the step (1),, form mixture of powders with equivalent incremental method mixing;
(3) polyvinylpyrrolidone is dissolved in the alcoholic solution, mix homogeneously, subsequent use;
(4) in mixture of powders, evenly spray the polyvinylpyrrolidone alcoholic solution, process soft material;
(5) soft material being added comminutor granulates;
(6) with the granule that makes 40～50 ℃ of oven dry;
(7) cross 20 mesh sieves, granulate adds magnesium stearate, mixing;
(8) put into tablet machine, compacting promptly gets the doxycycline hydrochloride effervescent tablet in flakes.
3. milch cow according to claim 2 is characterized in that with the method for preparing of doxycycline hydrochloride effervescent tablet the concentration of the described alcoholic solution of step (3) is 95%.
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| CN2010106047643A CN102058559B (en) | 2010-12-24 | 2010-12-24 | Doxycycline hydrochloride effervescent tables for milk cows and preparation method thereof |
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| CN2010106047643A CN102058559B (en) | 2010-12-24 | 2010-12-24 | Doxycycline hydrochloride effervescent tables for milk cows and preparation method thereof |
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| CN102058559B true CN102058559B (en) | 2012-06-20 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1326738A (en) * | 2000-06-02 | 2001-12-19 | 上海市徐汇区中心医院 | Minocycline vaginal effervescent tablets |
| CN1726910A (en) * | 2005-07-22 | 2006-02-01 | 福寿堂制药有限公司 | Effervescence tablet of miconazole nitrate for vagina and preparation technique |
| CN101869571A (en) * | 2010-07-14 | 2010-10-27 | 施瑞客（天津）生物技术有限公司 | Doxycycline hydrochloride and rifampicin effervescent granules for livestock and poultry and preparation method thereof |
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2010
- 2010-12-24 CN CN2010106047643A patent/CN102058559B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1326738A (en) * | 2000-06-02 | 2001-12-19 | 上海市徐汇区中心医院 | Minocycline vaginal effervescent tablets |
| CN1726910A (en) * | 2005-07-22 | 2006-02-01 | 福寿堂制药有限公司 | Effervescence tablet of miconazole nitrate for vagina and preparation technique |
| CN101869571A (en) * | 2010-07-14 | 2010-10-27 | 施瑞客（天津）生物技术有限公司 | Doxycycline hydrochloride and rifampicin effervescent granules for livestock and poultry and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张慧珍 等.米可定泡腾阴道片治疗霉菌性阴道炎120例临床观察.《长治医学院学报》.2001,第15卷(第2期),123-124. * |
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Address after: Minggang office, Zhengzhou Airport Economic Comprehensive Experimental Zone, Zhengzhou City, Henan Province Patentee after: Zhengzhou Bary Animal Pharmaceutical Co., Ltd. Address before: Huang Temple Road jinshuiqu 450000 Henan city of Zhengzhou province No. 16 gold India Business villas Kim E seat Patentee before: Zhengzhou Bary Animal Pharmaceutical Co., Ltd. |