CN107281338B

CN107281338B - Application of red onion in treating metritis of sow

Info

Publication number: CN107281338B
Application number: CN201710615658.7A
Authority: CN
Inventors: 王红星
Original assignee: Guangzhou Baiyun Huanan Bio Tech Co ltd
Current assignee: Guangzhou Baiyun Huanan Bio Tech Co ltd
Priority date: 2017-07-26
Filing date: 2017-07-26
Publication date: 2021-04-02
Anticipated expiration: 2037-07-26
Also published as: CN107281338A

Abstract

The invention relates to application of red onion in treating hysteritis of sows. The inventor selects the required medicinal materials from a large amount of Chinese medicinal materials and finds that the red onion has unique effect on treating the metritis of the sow through repeated experiments, and the red onion can realize the effects of resisting bacteria and diminishing inflammation, promoting blood circulation to remove blood stasis, expelling toxin and pus, and tonifying middle-jiao and Qi as a single medicament, thereby realizing the effect of effectively treating the metritis of the sow. In addition, the red onion can be planted in a large area, the cost is low, most importantly, the sow suffering from the metritis can not generate drug resistance after taking the red onion, and piglets born by the sow taking the red onion can not generate the drug resistance.

Description

Application of red onion in treating metritis of sow

Technical Field

The invention belongs to the field of animal husbandry and particularly relates to application of red onion to treatment of metritis of sows.

Background

The metritis of the sow refers to inflammation caused by infection of the uterus during delivery and postpartum of the sow, is one of main diseases in the reproductive disorder of the sow, has extremely complex etiology and mainly comprises the following components: dystocia, retained placenta, prolapsed uterus, unclean operation during midwifery, rough operation, uterus injury, postpartum infection, incomplete disinfection during artificial insemination, pathogenic bacteria in reproductive organs or semen of boars during natural mating and the like. In addition, sow malnutrition, emaciation, resistance reduction and non-pathogenic bacteria in reproductive tract can also cause sow metritis.

The metritis of the sows can be divided into acute endometritis and chronic endometritis, wherein the acute endometritis is frequently generated after the sows are delivered and are abortive, the symptoms are obvious, the body temperature is raised, the spirit is not vibrating, the appetite is reduced or exhausted, the people are usually helpfully, especially when the sows are just laid down, white mucus or foul-smelling dirty reddish brown mucus or purulent secretion flowing out of the vagina is adhered to the tail part, the smelling of the mucus is bad, and sometimes the sows also have abdominal pain symptoms; chronic endometritis is mostly converted from untimely treatment of acute endometritis, sow symptoms are not obvious, a small amount of turbid mucus is discharged from the vagina periodically, the estrus is delayed or abnormal, and even if the estrus is regularly released, infertility is caused.

The metritis of the sows is an important problem which troubles the pig raising in a large-scale pig farm, and the sows tend to spread gradually in recent years, and the incidence rate is usually about 20 percent, and can reach more than 40 percent in some cases. The existing treatment modes are generally as follows:

(1) in the acute postpartum period, inflammatory secretion accumulated in the uterus of the sow is firstly removed, the uterus is washed by 1 percent saline or 0.02 percent benzalkonium bromide solution, 0.1 percent potassium permanganate solution and 0.2 percent furazolidone solution, then the residual solution is completely discharged until the discharged washing solution is completely transparent, and finally 100ml of metritis-eliminating agent is injected into the uterus;

(2) systemic therapy: intramuscular injection is carried out for 2 times a day by using 40-80 million IU of antibiotic and 100 million IU of streptomycin, when aureomycin or oxytetracycline hydrochloride is used, sow weight is 40mg per kilogram, intramuscular injection is carried out for 2 times a day, sulfadiazine sodium is 0.05-0.1g per kilogram, and intramuscular injection or intravenous injection is carried out for 2 times a day;

(3) for chronic endometritis, penicillin 20-40 ten thousand IU and streptomycin 100 ten thousand IU are deeply injected into uterus in 20ml of high-pressure sterilized vegetable oil, and pituitrin 20-40 ten thousand IU is injected subcutaneously to promote uterine contraction and discharge intraluminal inflammatory secretion.

The treatment method uses a large amount of antibiotics, has high treatment cost and a large number of side effects, and the sows can generate drug resistance after being used, and piglets produced by the sows after being used with the antibiotics also can generate drug resistance, so that the health of the piglets is not facilitated. Therefore, pig farm feeders and the related technicians are always searching for a method for treating the metritis of the sow, which can be simple and effective and can not generate drug resistance.

Disclosure of Invention

In view of the problems, the inventor finds that the sow metritis can be effectively treated by adding the red onion into the feed in the feeding process of the sow suffering from the sow metritis through repeated experiments, and the feed is low in dosage, good in taste, quick in effect taking and free of obvious side effects.

In order to achieve the above object, the present invention provides use of red onion for treating metritis of sows.

In the invention, the red onion is the whole herb of the Iridaceae plant red onion Eleutherone plicata Herb, is native to the west India Islands, is widely distributed in the places of Guangxi, Yunnan and the like in China, and is a folk medicinal plant. It is used for treating hematemesis, hemoptysis, dysentery, amenorrhea and abdominal pain, rheumatalgia, and traumatic injury, and has effects of clearing heat, cooling blood, promoting blood circulation, dredging channels, relieving swelling and removing toxic substance. The folk herbal medicine can be used for treating menorrhagia, metrorrhagia, epistaxis, gastrointestinal hemorrhage, traumatic hemorrhage, dysentery, rheumatic arthralgia, traumatic injury, arthralgia, dizziness, palpitation, chest distress, and general fatigue. According to modern pharmacological research, the red onion has various pharmacological activities of reducing blood fat, reducing blood sugar, resisting oxidation, resisting mutagenesis, resisting bacteria, increasing coronary blood flow, inhibiting HIV (human immunodeficiency virus), inhibiting human topoisomerase II and the like. However, according to the current data research, no research report on the treatment of metritis by red onion is found.

The inventor selects the required medicinal materials from a large amount of Chinese medicinal materials and finds that the red onion has unique effect on treating the metritis of the sow through repeated experiments, and the red onion can realize the effects of resisting bacteria and diminishing inflammation, promoting blood circulation to remove blood stasis, expelling toxin and pus, and tonifying middle-jiao and Qi as a single medicament, thereby realizing the effect of effectively treating the metritis of the sow. In addition, the red onion can be planted in a large area, the cost is low, most importantly, the sow suffering from the metritis can not generate drug resistance after taking the red onion, and piglets born by the sow taking the red onion can not generate the drug resistance.

Preferably, in the above use, the amount of red onion is 0.1-0.5 g per kg body weight of the sow, 2-4 times per day, preferably 0.15-0.4 g per kg body weight of the sow, 2-4 times per day, more preferably 0.17-0.32 g per kg body weight of the sow, 2-4 times per day.

Preferably, in the use, the red onion is whole red onion and red onion extract.

More preferably, the red onion extract is a product obtained by extracting with ethanol as a solvent, namely an ethanol extract.

Preferably, the red onion ethanol extract can be prepared into various dosage forms such as granules, capsules, oral liquids, tablets, sustained-release preparations, controlled-release preparations, pills, suspensions, powders, injection and the like with conventional acceptable auxiliary materials.

More preferably, the preparation method of the red onion ethanol extract comprises the following steps: extracting herba Alii Fistulosi with 30-95% ethanol at a solid-to-liquid ratio of 1:9-1:12 under reflux for 1-3 times, each for 1-2 hr, filtering, mixing filtrates, concentrating at 5-60 deg.C to relative density of 1.2-1.39, drying, and pulverizing.

Preferably, in the invention, the whole red onion can also be prepared into granules together with the conventional acceptable auxiliary materials.

More preferably, the preparation method of the granule prepared from the whole red onion comprises the following steps: crushing the whole red onion, uniformly mixing the red onion with brown sugar according to the weight ratio of (4-8) to (1), and then preparing into granules.

The red onion granules are obtained by mixing and granulating crushed red onion and brown sugar, so that the taste of the red onion is obviously improved.

Compared with the prior art, the invention has the following advantages and beneficial effects:

(1) the invention can effectively treat the metritis of the sow, more than 95 percent of sick sows with the metritis of the sow can be cured 7 days after continuously feeding the sows, and successful hybridization can be realized;

(2) the red onion is not an antibiotic medicine and is a traditional Chinese medicinal material, so that the drug resistance of sick sows cannot be generated after the sick sows take the medicine, and the drug resistance of piglets born by the sick sows after the sick sows are cured cannot be generated;

(3) the red onions are low in price and easy to plant on a large scale, can be well popularized, are convenient to process and good in taste, and cannot cause sick sows to have a boring mind.

Detailed Description

In order to make the objects and advantages of the invention more concise, the invention will be described in more detail with reference to the following examples, to which it is in no way limited. The following examples are merely preferred examples of the present invention and are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. It should be understood that any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

In the invention, the red onion can be either fresh red onion or dried red onion, but the weight of the red onion after drying is referred to in the aspect of the weight of the red onion.

Formulation examples

Formulation example 1 Red onion granules

Crushing 3000g of red onion, then uniformly mixing the crushed red onion with 500g of brown sugar, and then preparing into granules to obtain the red onion granules.

Formulation example 2 granules prepared from ethanol extract of red onion

Extracting 1000g herba Alii Fistulosi with 70% ethanol 8000g for 1 hr for 2 times, filtering, mixing extractive solutions, concentrating at 60 deg.C to obtain fluid extract with relative density of 1.35, drying to obtain herba Alii Fistulosi ethanol extract, mixing with 150g brown sugar, granulating, and drying to obtain granule

Formulation example 3 oral liquid prepared from ethanol extract of red onion

Extracting 1000g of red onion in 8000g of ethanol with the mass fraction of 70% for 2 times, wherein the extraction time is 1h each time, filtering and combining the extracting solutions, then concentrating the extracting solutions to obtain clear paste with the relative density of 1.35 at the temperature of 60 ℃, drying the clear paste to obtain the red onion ethanol extract, then uniformly mixing the red onion ethanol extract with 500g of deionized water, adding 50g of simple syrup under the stirring condition until the mixture is uniform, and then standing, filtering and sterilizing the mixture to obtain the oral liquid.

Effects of the embodiment

In order to verify the effect of the invention, the sick sow is tested, and the test site is selected from a certain pig farm in Meizhou.

500 sows with similar age and weight of about 225 kg and suffering from metritis were selected and randomly divided into 5 groups, namely experiment group 1, experiment group 2, experiment group 3, experiment group 4 and control group, and the specific test method is as follows:

experimental group 1: the red onion powder prepared in the preparation example 1 of the invention is mixed with feed for continuous feeding twice a day, and 40 g/head of the feed is fed each time until the recovery;

experimental group 2: the red onion powder prepared in the preparation example 1 of the invention is mixed with feed for continuous feeding twice a day, 50 g/head each time, until the recovery;

experimental group 3: the red onion powder prepared in the preparation example 1 of the invention is mixed with feed for continuous feeding twice a day, 60 g/head each time, until the recovery;

experimental group 4: the granules prepared from the ethanol extract of the red onion in the preparation example 2 of the invention are mixed with feed for continuous feeding twice a day, 60 g/head each time, until the recovery;

control group: selecting 0.8 mg/head of chloroprostenol and 8 mg/head of estradiol benzoate, performing neck injection until healing,

wherein the recovery standard is that the body temperature of the sick sow is reduced to normal, the appetite is normal, the spirit is good, vaginal discharge disappears, and the sow naturally estruses and is pregnant after 5-7 days of administration.

The results of the experiment are shown in table 1.

TABLE 1 therapeutic Effect of the experimental groups

As can be seen from the table above, the red scallion adopted by the invention can obviously cure the metritis of the sow, the effect is obviously superior to that of a western medicine treatment method, the cure rate is high, the sow can quickly enter the oestrus stage after the medicine is taken, and the quick breeding of the sow can be realized.

Variations and modifications to the above-described embodiments may occur to those skilled in the art, which fall within the scope and spirit of the above description. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and some modifications and variations of the present invention should fall within the scope of the claims of the present invention. Furthermore, although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.

Claims

1. The application of the red onion in preparing the medicine for treating the metritis of the sow is characterized in that the dosage of the red onion is 0.1-0.5 g per kilogram of body weight of the sow and 2-4 times per day, wherein the red onion is an ethanol extract of the red onion, and the preparation method of the ethanol extract of the red onion comprises the following steps: extracting herba Alii Fistulosi with 30-95% ethanol at a solid-to-liquid ratio of 1:9-1:12 under reflux for 1-3 times, each for 1-2 hr, filtering, mixing filtrates, concentrating at 5-60 deg.C to relative density of 1.2-1.39, drying, and pulverizing.

2. The use as claimed in claim 1, wherein the amount of red onion is 0.15-0.4 g per kg body weight of the sow, 2-4 times daily.

3. The use as claimed in claim 1, wherein the amount of red onion is 0.17-0.32 g per kg body weight of the sow, 2-4 times daily.

4. The use as claimed in claim 1, wherein the ethanol extract of red onion is formulated with conventional acceptable adjuvants into granule, capsule, oral liquid, tablet, sustained release preparation, controlled release preparation, pill, suspension, powder.