CN105125632A - Traditional Chinese medicine composition for treating oestrus delay of female animals as well as preparation method and application of composition - Google Patents
Traditional Chinese medicine composition for treating oestrus delay of female animals as well as preparation method and application of composition Download PDFInfo
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- CN105125632A CN105125632A CN201510628543.2A CN201510628543A CN105125632A CN 105125632 A CN105125632 A CN 105125632A CN 201510628543 A CN201510628543 A CN 201510628543A CN 105125632 A CN105125632 A CN 105125632A
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Abstract
The invention provides a traditional Chinese medicine composition for treating oestrus delay of female animals. The traditional Chinese medicine composition is prepared from the following raw medicinal materials in parts by weight: 10 to 30 parts of herba epimedii, 10 to 30 parts of motherwort, 5 to 15 parts of Angelica sinensis, 5 to 15 parts of myrrh, 5 to 15 parts of wormwood and 5 to 15 parts of semen cuscutae. The invention also provides a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition prepared by the preparation method provides a highly-efficient, low-cost, simple, convenient and safe medicament for a veterinarian to treat oestrus delay of the female animals and has a broad market prospect.
Description
Technical field
The present invention relates to and a kind ofly treat female animal and to oestrus slow Chinese medicine composition and its production and use, belong to drug world.
Background technology
Female animal oestruses slow, and immediate cause is that hypo ovaria or Monitoring Ovarian Function disorder cause, and generally all use reproductive hormone to female animal slow treatment of oestrusing at present, the good results are evident, but cost is very high.Excessive use reproductive hormone class medicine makes the sexual cycle of female animal be upset, and female animal sexual function can be caused to lose, and the normal growth having a strong impact on female animal is grown.
In recent years, the theoretical and herbal treatment of Chinese veterinarian be widely used in treating female animal oestrus slow.Chinese herbal medicine source is wide, easy to use, be not with any hormone, has no side effect, and has no adverse effects to the mankind.Therefore, it is slow that Chinese medicine replacement hormone medicine treatment female animal oestruses, and is a method safely and effectively.
Be used for the treatment of at present female animal slow Chinese medicine of oestrusing clinically more, but it is wide in range, on the high side to there is prescription, and some Chinese medicine also need with hormone medicine with the use of etc. problem.Therefore active research exploitation can be treated oestrus slow efficient, inexpensive, convenient, safety, noresidue, non-stimulated medicine of female animal and had very important significance.
Summary of the invention
Technical scheme of the present invention there is provided a kind ofly treats female animal and to oestrus slow Chinese medicine composition and its production and use.
The invention provides and a kind ofly treat female animal and to oestrus slow Chinese medicine composition, it is characterized in that: it is prepared from by the crude drug of following weight proportioning:
Herba Epimedii 10-30 part, Herba Leonuri 10-30 part, Radix Angelicae Sinensis 5-15 part, Myrrha 5-15 part, Folium Artemisiae Argyi 5-15 part, Semen Cuscutae 5-15 part.
Preferably, described Chinese medicine composition is prepared from by the crude drug of following weight proportioning:
Herba Epimedii 20 parts, Herba Leonuri 15 parts, Radix Angelicae Sinensis 10 parts, Myrrha 10 parts, Folium Artemisiae Argyi 10 parts, Semen Cuscutae 10 parts.
Wherein, described Chinese medicine composition is by the protogenic medicinal powder of Herba Epimedii, Herba Leonuri, Radix Angelicae Sinensis, Myrrha, Folium Artemisiae Argyi, Semen Cuscutae, water or extractive with organic solvent, adds the pharmaceutically conventional preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
Wherein, described preparation is decoct, powder, granule, unguentum, microcapsule, filling agent, liniment, transdermal agent or injection.
The invention provides the method preparing described Chinese medicine composition, comprise the steps:
Take the crude drug of prescription amount, directly beat powder or water or organic solvent extraction, extracting liquid filtering, concentrated, add pharmaceutically acceptable adjuvant or complementary composition is prepared into pharmaceutically conventional preparation.
Preferably, the preparation method of described Chinese medicine composition comprises the steps:
A. take the crude drug of prescription amount, add 30 times of water gagings, decoct three times, each 1 hour, collecting decoction, filter, filtrate is concentrated into 300ml;
B. add ethanol in the concentrated solution of step a, make alcohol content reach 70%, cold preservation, filter, filtrate recycling ethanol;
C. add 200m water in the filtrate of step b, then add ethanol and make alcohol content reach 60%, cold preservation, filter, filtrate recycling ethanol;
Add water to 750ml in the filtrate of d. step c, then after charcoal treatment, embedding, sterilizing, to obtain final product.
The invention provides the purposes that described Chinese medicine composition is oestrused in slow medicine preparation treatment female animal.
Preferably, described medicine is treatment sow and/or the slow medicine of estrus of cow.
Chinese medicine composition of the present invention is made up of according to specific proportioning Herba Epimedii, Herba Leonuri, Radix Angelicae Sinensis, Myrrha, Folium Artemisiae Argyi, Semen Cuscutae.In side, Herba Epimedii has nourishing YIN and invigorating YANG, effect that tonifying YANG is kept fit, and suitable insomniac uses; Herba Leonuri have invigorate blood circulation, silt of dispelling, regulating menstruation, the water that disappears effect, be usually used in treating menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, the treatment of carbuncle skin infection at hematuria; Radix Angelicae Sinensis has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation, anticancer, anti-ageing anti-old, immune effect; Myrrha is the dry resin of olive subject plant Herba Violae tree or Ha Didingshu, and have dissipating blood stasis analgesic therapy, effect of detumescence and promoting granulation, is usually used in obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation ， mass in the abdomen is suffered from abdominal pain, rheumatic arthralgia, traumatic injury, the treatment of the diseases such as carbuncle skin infection; Folium Artemisiae Argyi has warming the meridian, dries, cold expelling, hemostasis, antiinflammatory, relieving asthma, cough-relieving, the effect such as antiabortive, antiallergic; Semen Cuscutae has effect of the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, solid tire stopping leak.All medicines share, and gather kidney invigorating and YANG supporting altogether, restore menstrual flow and invigorate blood circulation, silt tissue regeneration promoting of dispelling, and promote follicular development and ovulation, improve the effect of estrogen level, can effectively treat female animal oestrus slow.
Chinese medicine composition prepared by the present invention can effectively treat female animal oestrus slow, than hormone medicine, there is noresidue, the advantage such as non-stimulated, slowly provide a kind of efficient, inexpensive, easy, safe drugs for veterinary clinic treatment female animal oestruses, there is wide market prospect.
Detailed description of the invention is by the following examples described in further detail foregoing of the present invention again.But this should be interpreted as that the above-mentioned subject area of the present invention is only limitted to following instance.Under the prerequisite not departing from the above-mentioned technological thought of the present invention, the various replacement made according to ordinary skill knowledge and customary means or change, all should comprise within the scope of the invention.
Detailed description of the invention
The preparation of embodiment 1 Chinese medicine composition filling agent of the present invention
Raw material is taken by following proportioning:
Herba Epimedii 200g, Herba Leonuri 150g, Radix Angelicae Sinensis 100g, Myrrha 100g, Folium Artemisiae Argyi 100g, Semen Cuscutae 100g
Preparation method is as follows:
A. take the crude drug of prescription amount, add 30 times of water (weight ratio), decoct three times, each 1 hour, collecting decoction, filter, filtrate is concentrated into 1000ml;
B. add ethanol in the concentrated solution of step a, make alcohol content reach 70%, cold preservation, filter, filtrate recycling ethanol;
C. add 500ml water in the filtrate of step b, then add ethanol and make alcohol content reach 60%, cold preservation, filter, filtrate recycling ethanol;
Add water to 800ml in the filtrate of d. step c, then after charcoal treatment, embedding, sterilizing, to obtain final product.
The preparation of embodiment 2 Chinese medicine composition filling agent of the present invention
Raw material is taken by following proportioning:
Herba Epimedii 200g, Herba Leonuri 200g, Radix Angelicae Sinensis 100g, Myrrha 100g, Folium Artemisiae Argyi 100g, Semen Cuscutae 100g
Preparation method is as follows:
A. take the crude drug of prescription amount, add 30 times of water (weight ratio), decoct three times, each 1 hour, collecting decoction, filter, filtrate is concentrated into 1000ml;
B. add ethanol in the concentrated solution of step a, make alcohol content reach 70%, cold preservation, filter, filtrate recycling ethanol;
C. add 500ml water in the filtrate of step b, then add ethanol and make alcohol content reach 60%, cold preservation, filter, filtrate recycling ethanol;
Add water to 800ml in the filtrate of d. step c, then after charcoal treatment, embedding, sterilizing, to obtain final product.
The preparation of embodiment 3 Chinese medicine composition filling agent of the present invention
Raw material is taken by following proportioning:
Herba Epimedii 300g, Herba Leonuri 100g, Radix Angelicae Sinensis 150g, Myrrha 50g, Folium Artemisiae Argyi 100g, Semen Cuscutae 100g preparation method is as follows:
A. take the crude drug of prescription amount, add 30 times of water (weight ratio), decoct three times, each 1 hour, collecting decoction, filter, filtrate is concentrated into 300ml;
B. add ethanol in the concentrated solution of step a, make alcohol content reach 70%, cold preservation, filter, filtrate recycling ethanol;
C. add 300ml water in the filtrate of step b, then add ethanol and make alcohol content reach 60%, cold preservation, filter, filtrate recycling ethanol;
Add water to 800ml in the Ethylene recov of d. step c, then after charcoal treatment, embedding, sterilizing, to obtain final product.
The preparation of embodiment 4 Chinese medicine composition filling agent of the present invention
Raw material is taken by following proportioning:
Herba Epimedii 200g, Herba Leonuri 150g, Radix Angelicae Sinensis 150g, Myrrha 100g, Folium Artemisiae Argyi 100g, Semen Cuscutae 100g
Preparation method is as follows:
A. take the crude drug of prescription amount, add 30 times of water (weight ratio), decoct three times, each 1 hour, collecting decoction, filter, filtrate is concentrated into 300ml;
B. add ethanol in the concentrated solution of step a, make alcohol content reach 70%, cold preservation, filter, filtrate recycling ethanol;
C. add 300ml water in the filtrate of step b, then add ethanol and make alcohol content reach 60%, cold preservation, filter, filtrate recycling ethanol;
Add water to 800ml in the filtrate of d. step c, then after charcoal treatment, embedding, sterilizing, to obtain final product.
Beneficial effect of the present invention is proved below by way of specific experiment.
Experimental example 1 traditional Chinese medicine composition for treating of the present invention female animal oestruses slow experiment
1. experimental technique
1.1 laboratory sample
According to Chinese medicine composition filling agent prepared by embodiment 1
1.2 animal grouping and administrations
Select the sow 40 of a month non-estrus of weaning puerperal, be divided into matched group 1 and Chinese drug-treated group 1 at random; Select the cow 40 of a month non-estrus of weaning puerperal, be divided into matched group 2 and Chinese drug-treated group 2 at random; Chinese drug-treated group selects Chinese medicine composition filling agent of the present invention, wherein, and Chinese drug-treated group 1 intramuscular injection 20ml, Chinese drug-treated group 2 intramuscular injection 35ml.Matched group selects estradiol benzoate injection, wherein, matched group 1 shot 3ml, matched group 2 intramuscular injection 5ml, 7 days courses for the treatment of.Take breeding boar to try feelings breeding to the sow that oestruses, artificial insemination is taked to cow in estrus.
1.3 oestrus of sow standards of perfection: vaginal orifice flushing swelling, loss of appetite, performance is uneasy, and frequent micturition, with hand Ren sus domestica portion, stands transfixed to the ground, and vagina flows out transparent slightly albescent mucus.
1.4 estrus of cow standards of perfection: vaginal orifice swelling, vaginal orifice is flowed out transparent mucus and is stain tail, climbs other cow of hip.
2 experimental results, in table 1.
Table 1 Chinese medicine composition of the present invention is promoted the sexual maturity statistical effect table
3. experiment conclusion
Result shows: Chinese medicine composition of the present invention has the effect significantly improving sow, estrus of cow rate, and female animal conception rate is also significantly improved, and substantially increases the fertility performance of female animal.Show that Chinese medicine composition of the present invention effectively can treat sow, estrus of cow is slow, slowly provide a kind of noresidue, non-stimulated, efficient, inexpensive, easy, safe drugs for veterinary clinic treatment female animal oestruses, there is wide market prospect.
Claims (8)
1. treat female animal to oestrus a slow Chinese medicine composition, it is characterized in that: it is prepared from by the crude drug of following weight proportioning:
Herba Epimedii 10-30 part, Herba Leonuri 10-30 part, Radix Angelicae Sinensis 5-15 part, Myrrha 5-15 part, Folium Artemisiae Argyi 5-15 part, Semen Cuscutae 5-15 part.
2. Chinese medicine composition according to claim 1, is characterized in that: it is prepared from by the crude drug of following weight proportioning:
Herba Epimedii 20 parts, Herba Leonuri 15 parts, Radix Angelicae Sinensis 10 parts, Myrrha 10 parts, Folium Artemisiae Argyi 10 parts, Semen Cuscutae 10 parts.
3. Chinese medicine composition according to claim 1 and 2, it is characterized in that: it is by the protogenic medicinal powder of Herba Epimedii, Herba Leonuri, Radix Angelicae Sinensis, Myrrha, Folium Artemisiae Argyi, Semen Cuscutae, water or extractive with organic solvent, add the pharmaceutically conventional preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
4. Chinese medicine composition according to claim 3, is characterized in that: described preparation is decoct, powder, granule, unguentum, microcapsule, filling agent, liniment, transdermal agent or injection.
5. prepare the method for the Chinese medicine composition described in claim 1-4 any one, it is characterized in that: step is as follows: the crude drug taking prescription amount, directly beat powder or water or organic solvent extraction, extracting liquid filtering, concentrated, add pharmaceutically acceptable adjuvant or complementary composition is prepared into pharmaceutically conventional preparation.
6. method according to claim 5, is characterized in that: comprise the steps:
A. take the crude drug of prescription amount, add 30 times of water gagings, decoct three times, each 1 hour, collecting decoction, filter, filtrate is concentrated into 300ml;
B. add ethanol in the concentrated solution of step a, make alcohol content reach 70%, cold preservation, filter, filtrate recycling ethanol;
C. add 300ml water in the filtrate of step b, then add ethanol and make alcohol content reach 60%, cold preservation, filter, filtrate recycling ethanol;
Add water to 800ml in the filtrate of d. step c, then after charcoal treatment, embedding, sterilizing, to obtain final product.
7. the purposes that the Chinese medicine composition described in claim 1-4 any one is oestrused in slow medicine preparation treatment female animal.
8. purposes according to claim 7, is characterized in that: described treatment female animal slow medicine of oestrusing is treatment sow and/or the slow medicine of estrus of cow.
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Cited By (4)
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| CN105832804A (en) * | 2016-06-02 | 2016-08-10 | 牙韩温 | Medicine for treating sow anestrus |
| CN106177839A (en) * | 2016-07-26 | 2016-12-07 | 谢晓玲 | A kind of cow is promoted the sexual maturity Chinese medicine |
| CN106306371A (en) * | 2016-02-05 | 2017-01-11 | 王相生 | Nanoscale traditional Chinese medicine feed additive facilitating promotion of oestrus of dams and preparation method of nanoscale traditional Chinese medicine feed additive |
| CN108902036A (en) * | 2018-07-25 | 2018-11-30 | 西藏自治区农牧科学院畜牧兽医研究所 | A kind of cultural method improving hiding pig farrowing rate |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106306371A (en) * | 2016-02-05 | 2017-01-11 | 王相生 | Nanoscale traditional Chinese medicine feed additive facilitating promotion of oestrus of dams and preparation method of nanoscale traditional Chinese medicine feed additive |
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| CN106177839A (en) * | 2016-07-26 | 2016-12-07 | 谢晓玲 | A kind of cow is promoted the sexual maturity Chinese medicine |
| CN108902036A (en) * | 2018-07-25 | 2018-11-30 | 西藏自治区农牧科学院畜牧兽医研究所 | A kind of cultural method improving hiding pig farrowing rate |
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Application publication date: 20151209 |