CN102335120A - Povidone iodine effervescent suppository for treating hysteritis and vaginitis of sows - Google Patents
Povidone iodine effervescent suppository for treating hysteritis and vaginitis of sows Download PDFInfo
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- CN102335120A CN102335120A CN2011103573726A CN201110357372A CN102335120A CN 102335120 A CN102335120 A CN 102335120A CN 2011103573726 A CN2011103573726 A CN 2011103573726A CN 201110357372 A CN201110357372 A CN 201110357372A CN 102335120 A CN102335120 A CN 102335120A
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- povidone iodine
- suppository
- effervescent suppository
- effervescent
- vaginitis
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Abstract
The invention relates to the technical field of animal remedy, in particular to a povidone iodine effervescent suppository for treating hysteritis and vaginitis of sows. The effervescent suppository is prepared from the following raw materials in percentage by weight: 7.5-15% of povidone iodine, 10-20% of foaming agent, 64-81.5% of suppository base and 1% of mold release agent. The effervescent suppository provided by the invention has a slow release function and can enable the medicament to distribute widely and deeply in vaginal folds, and the effervescent suppository is liable to be in contact with secretion, thereby effectively treating hysteritis and vaginitis of sows.
Description
Technical field
The present invention relates to the veterinary drug technical field, be specifically related to a kind of treatment sow metritis, colpitic povidone iodine effervescent suppository.
Background technology
Metritis, vaginitis are the common genital diseases of sow, in the disease that the large scale of pig farm field takes place, occupy certain ratio.After fetus was discharged when its reason was Farrowing, the tire table was detained or afterbirth comes off incomplete; Also have because of fetus is individual big, intrapartum hemorrhage too much causes uterus meromorphosis with the damage endometrium; Particularly at high temperature season, sow body consumption is more, force of labor is not enough, puerperal health bad, cause the bacterial infection sickness rate obviously to rise, than improving more than 20% other seasons.Trouble metritis, colpitic sow can cause lactogenic minimizing or agalactia puerperal, make piglet can not get enough milk, and then influence the growth in piglets growth.Sow after the wean also can factor cervicitis disease and non-estrus or oestrus after unmatch repeatly, influence the normal performance of sow reproductive performance.Therefore, prevention and treatment sow metria, vaginitis fall originally most important to the joint money of large scale of pig farm.
Povidone iodine (CAS:25655-41-8) is the complex of polyvidone k30 and iodine.At present existing povidone iodine effervescent suppository and the povidone iodine suppository research report aspect people doctor and milch cow; Type of effervescent suppository can make medicine be distributed in the lyra of vagina deep widely; Contact with secretions, disintegrate is fast, lather quickness is fast, zest is little, clinical effectiveness good (people doctor); The application of povidone iodine bolt on milch cow mainly is that it has effects such as has a broad antifungal spectrum, antifungal, antiinflammatory and pain relieving, can improve genitals's hypertrophy process, shortens the convalescence of disease cattle.
Based on above-mentioned research, the present invention is intended to develop that a kind of suitable sow uses, and treatment sow metritis, colpitic povidone iodine effervescent suppository escort for breeding production better.
Summary of the invention
To the deficiency that exists in the prior art, the object of the present invention is to provide a kind of suitable sow to use, safe in utilization and povidone iodine novel form easily.
To achieve these goals, the present invention has taked following technical measures:
A kind ofly be used to treat sow metritis, colpitic povidone iodine effervescent suppository; This effervescent suppository is formed by following feedstock production by weight percentage: povidone iodine 7.5%-15%, foaming agent 10%-20%; Suppository base 64%-81.5%, releasing agent 1%.
Preferably, this effervescent suppository is formed by following feedstock production by weight percentage: povidone iodine 8.0%-10.0%, foaming agent 15%-20%, suppository base 69%-80.0%, releasing agent 1%.
Best, this effervescent suppository is formed by following feedstock production by weight percentage: povidone iodine 8%, foaming agent 20%, suppository base 71%, releasing agent 1%.
Described foaming agent is one or more the mixture in sodium bicarbonate, citric acid and the tartaric acid;
Described suppository base is one or more the mixture in glycerin gelatine (glycerol-gelatin-water), polyoxyethylene stearate 40 esters (S-40), polyethylene glycol 6000, poloxamer p-188 and the mixed fatty glycerides (model 36);
Described releasing agent is a liquid paraffin.
The method for preparing of this effervescent suppository is following: at first suppository base is placed 60 ℃ of water-baths; After treating fusion, add foaming agent, stir with the speed of 200r/min; Back adding povidone iodine stirs; Inject the mould that scribbles releasing agent after continue stirring 2min, fast after the cooling and demolding, pack promptly with foil sealing and to get.
This effervescent suppository can be processed different shape through different dies, like bullet type, spindle-type etc.
Mainly be to adopt suitable potassium permanganate solution to clean for sow metritis and colpitic treatment clinically at present, but this method has tangible deficiency: promptly too high meeting burn endometrium, it is low then invalid to cross.The potassium permanganate solution temperature is lower than the normal body temperature of pig, has shrinkage during flushing, influences lochia and discharges, and the uterus is scalded in the too high meeting of temperature and the intravaginal mucosa causes inflammation to increase the weight of.But effervescent suppository can avoid these problems, and effervescent suppository makes medicine be distributed in the gauffer deep of inflammation part widely, is prone to contact with secretions, and disintegrate is fast, and lather quickness is fast, and zest is little, can be advantageously applied to clinical.
The specific embodiment
Through concrete embodiment the present invention is specified below, but following examples limit protection scope of the present invention never in any form.
Embodiment 1
A kind ofly be used to treat sow metritis, colpitic povidone iodine effervescent suppository, it is prepared from following raw materials by weight percent:
Povidone iodine 9.00%,
Sodium bicarbonate 5.20%,
Tartaric acid 4.80%,
S-40 48.00％，
Polyethylene glycol 6000 32.00%,
Liquid paraffin 1.00%,
Method for preparing is following: after the mixture of S-40 and polyethylene glycol 6000 is placed 60 ℃ of water-bath fusions; Add sodium bicarbonate and tartaric acid; Speed with 200r/min stirs, and the back that stirs adds the povidone iodine continued and stirs 2min, injects the mould that scribbles liquid paraffin; Fast after the cooling and demolding, pack promptly with foil sealing and to get.
Embodiment 2
A kind ofly be used to treat sow metritis, colpitic povidone iodine effervescent suppository, it is prepared from following raw materials by weight percent:
Povidone iodine 8.00%,
Sodium bicarbonate 7.80%,
Tartaric acid 7.20%,
Mixed fatty glycerides (model 36) 76.00%,
Liquid paraffin 1.00%,
Method for preparing is following: after mixed fatty glycerides is placed 60 ℃ of water-bath fusions; Add sodium bicarbonate and tartaric acid; Speed with 200r/min stirs; The back that stirs adds the povidone iodine continued and stirs 2min, injects the mould that scribbles liquid paraffin, packs promptly with foil sealing after the cooling and demolding fast to get.
Embodiment 3
A kind ofly be used to treat sow metritis, colpitic povidone iodine effervescent suppository, it is prepared from following raw materials by weight percent:
Povidone iodine 10.00%,
Sodium bicarbonate 10.50%,
Tartaric acid 9.50%,
Poloxamer p-188 69.00%,
Liquid paraffin 1.00%,
Method for preparing is following: after poloxamer p-188 is placed 60 ℃ of water-bath fusions; Add sodium bicarbonate and tartaric acid; Speed with 200r/min stirs; The back that stirs adds the povidone iodine continued and stirs 2min, injects the mould that scribbles liquid paraffin, packs promptly with foil sealing after the cooling and demolding fast to get.
Embodiment 4
A kind ofly be used to treat sow metritis, colpitic povidone iodine effervescent suppository, it is prepared from following raw materials by weight percent:
Povidone iodine 8.00%,
Sodium bicarbonate 10.40%,
Tartaric acid 9.60%,
S-40 71.00％，
Liquid paraffin 1.00%,
Method for preparing is following: after S-40 is placed 60 ℃ of water-bath fusions; Add sodium bicarbonate and tartaric acid; Speed with 200r/min stirs; The back that stirs adds the povidone iodine continued and stirs 2min, injects the mould that scribbles liquid paraffin, packs promptly with foil sealing after the cooling and demolding fast to get.
Embodiment 5
A kind ofly be used to treat sow metritis, colpitic povidone iodine effervescent suppository, it is prepared from following raw materials by weight percent:
Povidone iodine 9.00%,
Glycerol 35.00%,
Gelatin 17.50%,
Water 17.50%,
Sodium bicarbonate 10.40%,
Tartaric acid 9.60%,
Liquid paraffin 1.00%,
Method for preparing is following: gelatin and water are fully soaked; Stir, after adding glycerol is placed on 60 ℃ of water-bath fusions, add sodium bicarbonate and tartaric acid; Speed with 200r/min stirs; The back that stirs adds the povidone iodine continued and stirs 2min, injects the mould that scribbles liquid paraffin, packs promptly with foil sealing after the cooling and demolding fast to get.
Embodiment 6
A kind ofly be used to treat sow metritis, colpitic povidone iodine effervescent suppository, it is prepared from following raw materials by weight percent:
Povidone iodine 8.00%,
Sodium bicarbonate 8.20%,
Tartaric acid 6.80%,
Polyethylene glycol 6000 76.00%,
Liquid paraffin 1.00%,
Method for preparing is following: after polyethylene glycol 6000 is placed 60 ℃ of water-bath fusions; Add sodium bicarbonate and tartaric acid; Speed with 200r/min stirs; The back that stirs adds the povidone iodine continued and stirs 2min, injects the mould that scribbles liquid paraffin, packs promptly with foil sealing after the cooling and demolding fast to get.
Embodiment 7
A kind ofly be used to treat sow metritis, colpitic povidone iodine effervescent suppository, it is prepared from following raw materials by weight percent:
Povidone iodine 10.00%,
Sodium bicarbonate 10.40%,
Citric acid 9.60%,
S-40 69.00％，
Liquid paraffin 1.00%,
Method for preparing is following: after S-40 is placed 60 ℃ of water-bath fusions; Add sodium bicarbonate and citric acid; Speed with 200r/min stirs; The back that stirs adds the povidone iodine continued and stirs 2min, injects the mould that scribbles liquid paraffin, packs promptly with foil sealing after the cooling and demolding fast to get.
Povidone iodine effervescent suppository clinical efficacy
Suffer from metritis, colpitic 240 of the sows of catching an illness 1.1 choose the pig farm, all have significantly fervescence, difficulty return feelings, vagina symptom such as suppurate.
1.2 the ill sow of Therapeutic Method is divided into 8 groups at random, 30 every group.One group is matched group (not administration); All the other each groups are test group (carry out administration with embodiment 1,2,3,4,5,6,7 prepared povidone iodine effervescent suppositorys respectively, specification: the content of every suppository available iodine is 0.02g); 8 groups of first potassium permanganate solutions (temperature is 31.7 ℃～40 ℃) with 0.1% of ill sow fully wash the uterus, and uterus and intravaginal lochia are discharged.Then the povidone iodine effervescent suppository is filled in uterus or the intravaginal of the ill sow of test group, 1 of every day, continuous use 7 days, not administration of matched group.
1.3 the curative effect judging standard recovery from illness: body temperature normally, normally returns feelings, vagina no pus; Effectively: part body temperature is normal, part is normally returned feelings, part vagina no pus; Invalid: fervescence, difficulty are returned feelings, vagina is suppurated.
1.4 the symptom of matched group (not administration) is obvious as a result, the symptom of test group (administration) all has clear improvement, and the result sees table 1～7.
Table 1 embodiment 1 clinical observation on the therapeutic effect result
Table 2 embodiment 2 clinical observation on the therapeutic effect results
Table 3 embodiment 3 clinical observation on the therapeutic effect results
Table 4 embodiment 4 clinical observation on the therapeutic effect results
Table 5 embodiment 5 clinical observation on the therapeutic effect results
Table 6 embodiment 6 clinical observation on the therapeutic effect results
Table 7 embodiment 7 clinical observation on the therapeutic effect results
Claims (6)
1. one kind is used to treat sow metritis, colpitic povidone iodine effervescent suppository, it is characterized in that this effervescent suppository by weight percentage; Form by following feedstock production: povidone iodine 7.5%-15%; Foaming agent 10%-20%, suppository base 64%-81.5%, releasing agent 1%.
2. povidone iodine effervescent suppository according to claim 1 is characterized in that, this effervescent suppository is formed by following feedstock production by weight percentage: povidone iodine 8.0%-10.0%, foaming agent 15%-20%, suppository base 69%-80.0%, releasing agent 1%.
3. povidone iodine effervescent suppository according to claim 1 is characterized in that, this effervescent suppository is formed by following feedstock production by weight percentage: povidone iodine 8%, foaming agent 20%, suppository base 71%, releasing agent 1%.
4. according to arbitrary described povidone iodine effervescent suppository among the claim 1-3, it is characterized in that: described foaming agent is one or more the mixture in sodium bicarbonate, citric acid and the tartaric acid.
5. according to arbitrary described povidone iodine effervescent suppository among the claim 1-3, it is characterized in that: described suppository base is one or more the mixture in glycerin gelatine, polyoxyethylene stearate 40 esters, polyethylene glycol 6000, poloxamer p-188 and the mixed fatty glycerides.
6. according to arbitrary described povidone iodine effervescent suppository among the claim 1-3, it is characterized in that: described releasing agent is a liquid paraffin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103573726A CN102335120A (en) | 2011-11-11 | 2011-11-11 | Povidone iodine effervescent suppository for treating hysteritis and vaginitis of sows |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103573726A CN102335120A (en) | 2011-11-11 | 2011-11-11 | Povidone iodine effervescent suppository for treating hysteritis and vaginitis of sows |
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| CN102335120A true CN102335120A (en) | 2012-02-01 |
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| CN2011103573726A Pending CN102335120A (en) | 2011-11-11 | 2011-11-11 | Povidone iodine effervescent suppository for treating hysteritis and vaginitis of sows |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405382A (en) * | 2013-08-15 | 2013-11-27 | 成都益贝乐医疗器械有限公司 | Formula and preparation technology of chitosan-iodine suppository |
| CN103784948A (en) * | 2012-11-05 | 2014-05-14 | 上海高科联合生物技术研发有限公司 | Effervescent suppository for treating mammal vaginitis |
| CN105726563A (en) * | 2016-02-02 | 2016-07-06 | 广州自远生物科技有限公司 | Effervescent suppository capable of preventing and treating reproductive system diseases of animals and preparation method thereof |
| CN109364241A (en) * | 2018-10-18 | 2019-02-22 | 武汉华扬动物药业有限责任公司 | A kind of oxytocins suppository and its application |
Citations (1)
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|---|---|---|---|---|
| CN1650888A (en) * | 2004-02-05 | 2005-08-10 | 刘家鹤 | Povidone-iodine suppository for treating dairy cattle endometritis |
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2011
- 2011-11-11 CN CN2011103573726A patent/CN102335120A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1650888A (en) * | 2004-02-05 | 2005-08-10 | 刘家鹤 | Povidone-iodine suppository for treating dairy cattle endometritis |
Non-Patent Citations (3)
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| 张秀珍 等: "聚维酮碘泡腾栓的研制", 《中国药学杂志》 * |
| 李忠忠 等: "聚维酮碘泡腾栓的研制与应用", 《中国新药杂志》 * |
| 李忠忠 等: "聚维酮碘泡腾栓的稳定性", 《中国医院药学杂志》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784948A (en) * | 2012-11-05 | 2014-05-14 | 上海高科联合生物技术研发有限公司 | Effervescent suppository for treating mammal vaginitis |
| CN103405382A (en) * | 2013-08-15 | 2013-11-27 | 成都益贝乐医疗器械有限公司 | Formula and preparation technology of chitosan-iodine suppository |
| CN105726563A (en) * | 2016-02-02 | 2016-07-06 | 广州自远生物科技有限公司 | Effervescent suppository capable of preventing and treating reproductive system diseases of animals and preparation method thereof |
| CN105726563B (en) * | 2016-02-02 | 2019-03-26 | 广州自远生物科技有限公司 | It is a kind of can prophylactic treatment animals' reproduction systemic disease type of effervescent suppository and preparation method thereof |
| CN109364241A (en) * | 2018-10-18 | 2019-02-22 | 武汉华扬动物药业有限责任公司 | A kind of oxytocins suppository and its application |
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Application publication date: 20120201 |