CN109985037A - A kind of gynecological gel - Google Patents

A kind of gynecological gel Download PDF

Info

Publication number
CN109985037A
CN109985037A CN201910221319.XA CN201910221319A CN109985037A CN 109985037 A CN109985037 A CN 109985037A CN 201910221319 A CN201910221319 A CN 201910221319A CN 109985037 A CN109985037 A CN 109985037A
Authority
CN
China
Prior art keywords
parts
aqueous solution
fucoidin
clotrimazole
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910221319.XA
Other languages
Chinese (zh)
Inventor
徐珊
宋丽华
张小菜
裴巧丽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SECOND AFFILIATED HOSPITAL OF SHAANXI UNIVERSITY OF CHINESE MEDICINE
Original Assignee
SECOND AFFILIATED HOSPITAL OF SHAANXI UNIVERSITY OF CHINESE MEDICINE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SECOND AFFILIATED HOSPITAL OF SHAANXI UNIVERSITY OF CHINESE MEDICINE filed Critical SECOND AFFILIATED HOSPITAL OF SHAANXI UNIVERSITY OF CHINESE MEDICINE
Priority to CN201910221319.XA priority Critical patent/CN109985037A/en
Publication of CN109985037A publication Critical patent/CN109985037A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Abstract

The invention discloses a kind of gynecological gels, are prepared by the raw material of following parts by weight: 0.5~1.5 part of clotrimazole, 0.1~0.5 part of fucoidin, 5~8 parts of hyaluronic acid, 5~10 parts of lactic acid, 8~15 parts of polyethylene glycol glycosides, 15~25 parts of beta-cyclodextrin derivative, 0.5~3 part of chitosan, 10~20 parts of hydroxypropyl methylcellulose, 10% 0.5~1 part of ethyl hydroxy benzoate ethanol solution, 10% 0.5~1 part of sodium sulfite aqueous solution, 15~25 parts of Tween-80, water supply 400 parts.The resulting gelling agent of the present invention and affected part contact area are big, persistent, substantially nonirritant, dissolution is fast, and bioavilability is high, can be realized simultaneously the treatment of trichomoniasis Yu a variety of vaginal bacterial infections, and the adjusting of vagina environment may be implemented, vaginal flora environment is balanced, the recovery of vagina itself resistance is stimulated, improves vaginal dryness situation.

Description

A kind of gynecological gel
Technical field
The present invention relates to pharmaceutical preparation field, in particular to a kind of gynecological gel.
Background technique
The disease of female reproductive system is gynecological disease, because of the particularity of vagina physilogical characteristics and anatomical structure, Weakly acidic local environment, various policy parasitism floras and conditioned pathogen interdependence mutually restrict, but these normal floras Also the risk of pathogenic bacteria can be changed into, and the appearance of pathogenic bacteria will lead to reproductive tract infection, cause the easy recurrent exerbation of vaginitis, seriously Influence female reproductive health.
It for the primary treatment measure of the disease is treated by antibiotic or fungicide at present, it is logical to kill all vaginal bacterias Thoroughly to clean vagina.Generally require long time by the vagina after treatment and carry out self maintenance, more serious person can because Malpractice and cause vagina to lose capacity of self-regulation, vagina becomes dry and astringent, and not only inflammation repeatedly, but also influences sexual life, It shows as vulvovaginal dryness, dyspareunia, repeated the symptoms such as vaginitis.
Summary of the invention
In view of the above technical problems, the present invention provides a kind of gynecological gels, can improve while curing vaginitis Vagina environment.
The invention is realized by the following technical scheme:
A kind of gynecological gel is prepared by the raw material of following parts by weight:
0.5~1.5 part of clotrimazole, 0.1~0.5 part of fucoidin, 5~8 parts of hyaluronic acid, 5~10 parts of lactic acid, polyethylene glycol (PEG) 8~15 parts of glucoside, 15~25 parts of beta-cyclodextrin derivative, 0.5~3 part of chitosan, hypromellose Plain 10~20 parts, 10% 0.5~1 part of ethyl hydroxy benzoate ethanol solution, 10% 0.5~1 part of sodium sulfite aqueous solution, Tween-80 15~25 parts, water supply 400 parts.
Preferably, it is prepared by the raw material of following parts by weight:
0.5 part of clotrimazole, 0.1 part of fucoidin, 5 parts of hyaluronic acid, 5 parts of lactic acid, 8 parts of polyethylene glycol (PEG) glucoside, 15 parts of beta-cyclodextrin derivative, 0.5 part of chitosan, 10 parts of hydroxypropyl methylcellulose, 10% ethyl hydroxy benzoate ethanol solution 0.5 part, 10% 0.5 part of sodium sulfite aqueous solution, 15 parts of Tween-80, water supply 400 parts.
Preferably, it is prepared by the raw material of following parts by weight:
1.5 parts of clotrimazole, 0.5 part of fucoidin, 8 parts of hyaluronic acid, 10 parts of lactic acid, 15 parts of polyethylene glycol (PEG) glucoside, 25 parts of beta-cyclodextrin derivative, 3 parts of chitosan, 20 parts of hydroxypropyl methylcellulose, 10% ethyl hydroxy benzoate ethanol solution 1 Part, 10% 1 part of sodium sulfite aqueous solution, 25 parts of Tween-80, water supply 400 parts.
Preferably, it is prepared by the raw material of following parts by weight:
1 part of clotrimazole, 0.75 part of fucoidin, 6.5 parts of hyaluronic acid, 7.5 parts of lactic acid, polyethylene glycol (PEG) glucoside 11.5 parts, 20 parts of beta-cyclodextrin derivative, 1.75 parts of chitosan, 15 parts of hydroxypropyl methylcellulose, 10% ethyl hydroxy benzoate 0.75 part of ethanol solution, 10% 0.75 part of sodium sulfite aqueous solution, 20 parts of Tween-80, water supply 400 parts.
The resulting gelling agent of the present invention and affected part contact area are big, and persistent is substantially nonirritant, and dissolution is fast, biology Availability is high, can be realized simultaneously the treatment of trichomoniasis Yu a variety of vaginal bacterial infections, and vagina environment may be implemented Adjusting, balance vaginal flora environment, stimulate vagina itself resistance recovery, improve vaginal dryness situation.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, below in conjunction with embodiment to the present invention make into One step it is described in detail.
Embodiment 1
A kind of gynecological gel is prepared by the raw material of following parts by weight:
0.5 part of clotrimazole, 0.1 part of fucoidin, 5 parts of hyaluronic acid, 5 parts of lactic acid, 8 parts of polyethylene glycol (PEG) glucoside, 15 parts of beta-cyclodextrin derivative, 0.5 part of chitosan, 10 parts of hydroxypropyl methylcellulose, 10% ethyl hydroxy benzoate ethanol solution 0.5 part, 10% 0.5 part of sodium sulfite aqueous solution, 15 parts of Tween-80, water supply 400 parts.
Embodiment 2
A kind of gynecological gel is prepared by the raw material of following parts by weight:
1.5 parts of clotrimazole, 0.5 part of fucoidin, 8 parts of hyaluronic acid, 10 parts of lactic acid, 15 parts of polyethylene glycol (PEG) glucoside, 25 parts of beta-cyclodextrin derivative, 3 parts of chitosan, 20 parts of hydroxypropyl methylcellulose, 10% ethyl hydroxy benzoate ethanol solution 1 Part, 10% 1 part of sodium sulfite aqueous solution, 25 parts of Tween-80, water supply 400 parts.
Embodiment 3
A kind of gynecological gel is prepared by the raw material of following parts by weight:
1 part of clotrimazole, 0.75 part of fucoidin, 6.5 parts of hyaluronic acid, 7.5 parts of lactic acid, polyethylene glycol (PEG) glucoside 11.5 parts, 20 parts of beta-cyclodextrin derivative, 1.75 parts of chitosan, 15 parts of hydroxypropyl methylcellulose, 10% ethyl hydroxy benzoate 0.75 part of ethanol solution, 10% 0.75 part of sodium sulfite aqueous solution, 20 parts of Tween-80, water supply 400 parts.
Embodiment 4
A kind of gynecological gel, as obtained by following steps preparation:
S1, it weighs by weight: 0.5 part of clotrimazole, 0.1 part of fucoidin, 5 parts of hyaluronic acid, 5 parts of lactic acid, polyethylene glycol (PEG) 8 parts of glucoside, 15 parts of beta-cyclodextrin derivative, 0.5 part of chitosan, 10 parts of hydroxypropyl methylcellulose, 10% 0.5 part of ethyl hydroxy benzoate ethanol solution, 10% 0.5 part of sodium sulfite aqueous solution, 15 parts of Tween-80, water supply 400 parts；
S2, by clotrimazole it is finely ground after, put into saturated aqueous solution made of the inclusion material of 10 parts of beta-cyclodextrin derivatives；
After the saturated aqueous solution is stirred 1.5-2.5 hours at a temperature of 45 DEG C -55 DEG C, cooling and standings 5.5-6.6 hours；
Drying process is filtered to saturated aqueous solution after the standing, obtains clotrimazole inclusion compound；
S3, by fucoidin it is finely ground after, and put into 5 parts of beta-cyclodextrin derivatives inclusion material made of saturated aqueous solution；
After the saturated aqueous solution is stirred 1.5-2.5 hours at a temperature of 45 DEG C -55 DEG C, cooling and standings 5.5-6.6 hours；
Drying process is filtered to saturated aqueous solution after the standing, obtains fucoidin inclusion compound；
S4, the clotrimazole inclusion compound and the fucoidin inclusion compound are subjected to mixed processing, and add hydroxypropyl methylcellulose, Water, chitosan, 10% ethyl hydroxy benzoate ethanol solution, 10% sodium sulfite aqueous solution and Tween-80 are mixed, and are obtained To gelling agent.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (4)

1. a kind of gynecological gel, it is characterised in that: be prepared by the raw material of following parts by weight:
0.5~1.5 part of clotrimazole, 0.1~0.5 part of fucoidin, 5~8 parts of hyaluronic acid, 5~10 parts of lactic acid, polyethylene glycol (PEG) 8~15 parts of glucoside, 15~25 parts of beta-cyclodextrin derivative, 0.5~3 part of chitosan, hypromellose Plain 10~20 parts, 10% 0.5~1 part of ethyl hydroxy benzoate ethanol solution, 10% 0.5~1 part of sodium sulfite aqueous solution, Tween-80 15~25 parts, water supply 400 parts.
2. a kind of gynecological gel as described in claim 1, it is characterised in that: be prepared by the raw material of following parts by weight:
0.5 part of clotrimazole, 0.1 part of fucoidin, 5 parts of hyaluronic acid, 5 parts of lactic acid, 8 parts of polyethylene glycol (PEG) glucoside, 15 parts of beta-cyclodextrin derivative, 0.5 part of chitosan, 10 parts of hydroxypropyl methylcellulose, 10% ethyl hydroxy benzoate ethanol solution 0.5 part, 10% 0.5 part of sodium sulfite aqueous solution, 15 parts of Tween-80, water supply 400 parts.
3. a kind of gynecological gel as described in claim 1, it is characterised in that: be prepared by the raw material of following parts by weight:
1.5 parts of clotrimazole, 0.5 part of fucoidin, 8 parts of hyaluronic acid, 10 parts of lactic acid, 15 parts of polyethylene glycol (PEG) glucoside, 25 parts of beta-cyclodextrin derivative, 3 parts of chitosan, 20 parts of hydroxypropyl methylcellulose, 10% ethyl hydroxy benzoate ethanol solution 1 Part, 10% 1 part of sodium sulfite aqueous solution, 25 parts of Tween-80, water supply 400 parts.
4. a kind of gynecological gel as described in claim 1, it is characterised in that: be prepared by the raw material of following parts by weight:
1 part of clotrimazole, 0.75 part of fucoidin, 6.5 parts of hyaluronic acid, 7.5 parts of lactic acid, polyethylene glycol (PEG) glucoside 11.5 parts, 20 parts of beta-cyclodextrin derivative, 1.75 parts of chitosan, 15 parts of hydroxypropyl methylcellulose, 10% ethyl hydroxy benzoate 0.75 part of ethanol solution, 10% 0.75 part of sodium sulfite aqueous solution, 20 parts of Tween-80, water supply 400 parts.
CN201910221319.XA 2019-03-22 2019-03-22 A kind of gynecological gel Pending CN109985037A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910221319.XA CN109985037A (en) 2019-03-22 2019-03-22 A kind of gynecological gel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910221319.XA CN109985037A (en) 2019-03-22 2019-03-22 A kind of gynecological gel

Publications (1)

Publication Number Publication Date
CN109985037A true CN109985037A (en) 2019-07-09

Family

ID=67129714

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910221319.XA Pending CN109985037A (en) 2019-03-22 2019-03-22 A kind of gynecological gel

Country Status (1)

Country Link
CN (1) CN109985037A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111888430A (en) * 2020-08-14 2020-11-06 深圳市英汉斯科技有限公司 Composite antibacterial gel and preparation method and application thereof
CN116077417A (en) * 2022-12-29 2023-05-09 汤臣倍健股份有限公司 Gastric retention tablet and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103520232A (en) * 2013-09-30 2014-01-22 绥化学院 Preparation method for gel
CN104288173A (en) * 2014-07-14 2015-01-21 湖北博康医药科技有限公司 Chitosan antibacterial gel biological dressing
CN107243017A (en) * 2017-06-09 2017-10-13 成都珂萝瑞诗化妆品有限公司 A kind of antibacterial balance gynecological gel and preparation method thereof
CN108452293A (en) * 2018-04-12 2018-08-28 广西达庆生物科技有限公司 A kind of gynaecology's gel and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103520232A (en) * 2013-09-30 2014-01-22 绥化学院 Preparation method for gel
CN104288173A (en) * 2014-07-14 2015-01-21 湖北博康医药科技有限公司 Chitosan antibacterial gel biological dressing
CN107243017A (en) * 2017-06-09 2017-10-13 成都珂萝瑞诗化妆品有限公司 A kind of antibacterial balance gynecological gel and preparation method thereof
CN108452293A (en) * 2018-04-12 2018-08-28 广西达庆生物科技有限公司 A kind of gynaecology's gel and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111888430A (en) * 2020-08-14 2020-11-06 深圳市英汉斯科技有限公司 Composite antibacterial gel and preparation method and application thereof
CN116077417A (en) * 2022-12-29 2023-05-09 汤臣倍健股份有限公司 Gastric retention tablet and preparation method thereof
CN116077417B (en) * 2022-12-29 2024-03-22 汤臣倍健股份有限公司 Gastric retention tablet and preparation method thereof

Similar Documents

Publication Publication Date Title
CN109985037A (en) A kind of gynecological gel
CN104043098A (en) Antimicrobial peptide freeze-dried preparation for treating colpitis and preparation method thereof
CN102793742B (en) Film coating agent for disinfecting dairy cow breasts and preparation method of film coating agent
CN1823813A (en) Nursing and treating composition for female vagina and its preparation method
CN101380447A (en) Chitose foaming agent for treating gynecologic disease and preparation method thereof
CN101829082B (en) Method for preparing veterinary injection of spectinomycin hydrochloride and lincomycin hydrochloride
CN103908469B (en) A kind of compositions and application thereof regulating microecology in vaginas to balance and/or treat atrophic vaginitis
CN100586441C (en) Compound sulfamonomethoxine sodium injection and preparation method thereof
CN104069124B (en) Compositions and preparation for gynecological infection
CN103191408A (en) Medicine composition and gel for treating colpitis and applications thereof
CN101797269A (en) Physiological balance liquid for adjusting microecology in vaginas of women
CN101966178A (en) Composition for treating chicken proventriculitis and preparation method thereof
CN1301106C (en) Sterilizing gel
CN107049960A (en) Lysozyme cross-link dextran sustained-release micro-spheres and preparation method thereof
CN114588253B (en) Pharmaceutical composition for repairing and preventing vaginal mucosa aging and preparation thereof
CN110327287A (en) It is a kind of for prevent and treat vaginitis containing lactose prod and its production technology
CN1943593A (en) External use anti-bacteria foaming agent for gynecology
CN106266037B (en) Liquid gel and preparation method thereof
CN115501328A (en) Sodium azulene sulfonate chitosan gel and preparation process thereof
CN103768089A (en) Chitosan antibacterial lotion for gynecology and preparation method thereof
CN108904780B (en) Gynecological gel and preparation method thereof
CN101966201A (en) Compound norfloxacin nicotinic soluble powder and preparation method thereof
CN108066278B (en) Gynecological gel containing chitosan oligosaccharide and preparation method thereof
CN107982275B (en) Application of mannose in gynecological antibacterial product
CN113209202A (en) Bacteriostatic gynecological lotion and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20190709

RJ01 Rejection of invention patent application after publication