CN107243017A - A kind of antibacterial balance gynecological gel and preparation method thereof - Google Patents
A kind of antibacterial balance gynecological gel and preparation method thereof Download PDFInfo
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- CN107243017A CN107243017A CN201710432233.2A CN201710432233A CN107243017A CN 107243017 A CN107243017 A CN 107243017A CN 201710432233 A CN201710432233 A CN 201710432233A CN 107243017 A CN107243017 A CN 107243017A
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Abstract
The invention discloses antibacterial balance gynecological gel of one kind and preparation method thereof, wherein, antibacterial balance gynecological gel includes following components in percentage by weight：Cationic polysaccharide 0.1 2.0%, NMF 5.0 20%, thickener 0.1 2.0%, balance flora composite extract 5 25%, acidity regulator 0.1 2.0%, surplus is purified water.The present invention passes through scientific and reasonable collocation; the composition of several bacteriostasis is combined; suppressing the growth of harmful bacteria, synergy is played in terms of the growth for promoting probiotics, thickener and cationic polysaccharide are combined; synergy can be played in terms of product viscosity is increased; make product easy to use, active ingredient concentration suitably increases, while along with the effect of NMF; the protective barrier of skin is formed, increases its lubricity.
Description
Technical field
The invention belongs to the amenities technical field of vagina routine servicing, and in particular to a kind of antibacterial balance gynaecology
Gel and preparation method thereof.
Background technology
Vaginal flora plays irreplaceable effect to the stabilization and regulation of safeguarding vagina environment.Vaginal flora is very
Complexity, in addition to protozoon, fungi, still including many aerobic bacterias and anaerobic bacteria, such as streptococcus lactis, enterobacteria, proteus, Jia Fuji
Coccus, Wei Yong coccuses etc. are common in vagina lower end, these microorganisms can be divided into it is commensalism and pathologic, be all grown in this be total to
In same environment, there may be the anti-effect of tangerine between each microorganism.What another influenceed its growth is hydrogen ion concentration, in pH3.8
When~4.2, be conducive to the breeding of commensalism probiotics, especially Bacillus acidi lactici, this is the main prebiotic strain in healthy vagina, it is cloudy
Density in road liquid is up to 105~108Ml, after vagina is by cause pathogeny imcrobe infection, if Bacillus acidi lactici is dominant, remains to dimension
The weakly acidic condition of intravaginal pH3.8~4.2 is held, disease will not then occur for vagina, it is important that Bacillus acidi lactici can also produce H202,
It is toxic to other microorganisms effect and suppress its breeding.Once pathogenic microorganism reproductive capacity exceedes probiotics, benefit will be destroyed
The growing environment of raw bacterium, and then vagina environment is destroyed, ultimately result in gynecological disease.After gynecological disease occurs, often not
The effectively adjustment for the treatment of of energy, and obstinate inflammation recurrent exerbation, have a strong impact on female reproductive health.
Primary treatment measure currently for the disease is treated by antibiotic or bactericide, logical to kill all vaginal bacterias
Thoroughly to clean vagina.Generally require to carry out self maintenance for a long time by the vagina after treatment, more severe patient can be because control
Treatment is improper to cause vagina to lose capacity of self-regulation.By consulting existing product and patent, it has been found that there is regular code
Privates nursing gel product on sale is to add quaternary ammonium cationoid as bactericide by way of sterilization, such as mostly：Acetic acid chlorine
Fixed, benzalkonium chloride etc., by changing bacterial cytoplasm membrane permeability, makes thalline endochylema extravasation, hinders it to be metabolized and rise and kill
The effect of going out.This series bactericidal agent acts on stronger to gram-positive bacteria, to Pseudomonas aeruginosa, acid-fast bacilli and bacterial spore then without substantially
Effect.Have been reported that this series bactericidal agent can cause allergic conjunctivitis, hypopsia, contact dermatitis etc., severe patient is even
Cause death.This series bactericidal agent also kills probiotics, probiotics dies, intravaginal rings while harmful bacteria is killed
Border is also just disintegrated.In addition, there is some washing lotion pin vagina and vulvas capable of washing, but containing surfactant and it is in alkali more than these washing lotions more
Property or neutrality, with the shower cream or running water of alkalescence, to clean be unscientific, frequently using washing lotion, disinfection pad etc., also easily
Destroy vagina weak acid environment.
The maintenance of vagina is treated, it is necessary to careful care, rigorous and scientific, it is impossible to antibacterial, the sterilization of blindness, to protect benefit
On the premise of raw bacterium, the growth of pathogen is controlled, the root of itself is treated and conserved by the regulating power of vagina itself
Portion.Therefore, invent a kind of by adjusting the breeding of vagina growth of probiotics, so as to realize vagina self-control and then stable interior environment
Product, will be optimal vagina care products.
The content of the invention
For above-mentioned deficiency of the prior art, the invention provides the antibacterial balance gynecological gel of one kind and its preparation side
Method, can effectively solve the problem of existing product also destroys growth of probiotics while harmful bacteria is removed.
To achieve the above object, the technical solution adopted for the present invention to solve the technical problems is：
A kind of antibacterial balance gynecological gel, including following components in percentage by weight：Cationic polysaccharide 0.1-2.0%, moisturizing
Agent 5.0-20%, thickener 0.1-2.0%, balance flora composite extract 5-25%, acidity regulator 0.1-2.0%, surplus is pure
Change water；
Wherein, cationic polysaccharide is chitosan；
It is the ecological nutrient liquid that Ou Xilisi companies of France AXIALYS Innovations are produced to balance flora composite extract
（Composition：Inulin, water, alpha-glucans oligosaccharides）, Shanghai writing brush her corporate agent EVE-SOLUTION（Punica granatum L. extract, smoked plum are carried
Take thing, orange extract, lotus flower leaf extract, undaria pinnitafida extract, lactic acid, gluconolactone）, lotus leaf extract, tealeaves carries
Take the one or more in thing, guava leaf extract, A. gigas extract and Gotu Kola P.E.
Further, a kind of antibacterial balance gynecological gel, including following components in percentage by weight：Cationic polysaccharide
1.5%th, NMF 10%, thickener 0.2%, balance flora composite extract 7%, acidity regulator 0.2%, surplus is purified water.
Further, NMF is propane diols, glycerine, butanediol, glycine betaine, sodium lactate, polyethylene glycol -200 and gathered
One or more in ethylene glycol -400.
Further, thickener is cellulose thickener.
Further, acidity regulator is the one or more of lactic acid, citric acid and malic acid.
The preparation method of above-mentioned antibacterial balance gynecological gel, comprises the following steps：
（1）Room temperature is cooled to after purified water is heated into 100 DEG C, constant temperature 5min；
（2）Acidity regulator is added into the purified water after cooling, regulation solution ph is 2.5-4.5；
（3）To step（2）Add cationic polysaccharide and thickener in gains, stirring is to being completely dissolved；
（4）To step（3）NMF and balance flora composite extract, mixing are sequentially added in gains；
（5）Removal step（4）Foam in gains, is made antibacterial balance gynecological gel.
Further, step（4）20min is stirred after a kind of middle material of addition, a kind of lower raw material is added, wherein, rotating speed
For 400r/min.
A kind of antibacterial balance gynecological gel that the present invention is provided and preparation method thereof, has the advantages that：
（1）Chitosan is unique cationic polysaccharide in nature, with good biocompatibility, is sticked
Property, degradability, biocidal property and plasticity, wound healing and regeneration can be promoted, the material can be combined with thickener, cooperateed with
Play a part of thickening, combined with balance flora composite extract, collaboration plays suppression harmful bacteria and promotes growth of probiotics
Effect, so as to adjust vaginal flora environment, is allowed to be in poised state.
Inventive formulation is cationic system, and the harmful bacteria at vagina is generally negatively charged, when running into cation,
Under Coulomb's law, cation can puncture the cell membrane of bacterium, into intracellular, pass through the collaboration of restraining and sterilizing bacteria composition in formula
Effect, can play a part of antibacterial or kill bacterium.
NMF is polyalcohol collocation natural moisture preserving agent, and safe, excitant is low, can improve moisture content of skin, is formed
Skin sparing barrier and the lubricity for increasing product.
It is a variety of natural plant extracts to balance flora composite extract, and its collocation is scientific and reasonable, can maintain intravaginal acid
Soda balance, there is inhibition to Hemophilus vaginalis(Hemophilus vaginalis), promotes the propagation of Lactobacillus acidophilus, and enhancing vagina is immune and metabolic,
Vagina is produced self-purification capacity and defence capability, not only inside cleanable vagina, can also improve vaginal health and vagina checking, peace
Full performance is high, non-stimulated to skin.
Acidity regulator used in this programme, security performance is high, and excitant is low, can adjust product to being conducive to the vagina to have
In the range of the pH of beneficial bacteria growth.
（2）This programme is combined by scientific and reasonable collocation, the composition of several bacteriostasis, is suppressing the life of harmful bacteria
It is long, synergy is played in terms of the growth for promoting probiotics, thickener and cationic polysaccharide are combined, can be glued in increase product
Synergy is played in terms of degree, makes product easy to use, active ingredient concentration suitably increases, while along with the work of NMF
With the protective barrier of formation skin increases its lubricity.
（3）Antibacterial balance gynecological gel prepared by the present invention is in addition to it can suppress the growth of vagina harmful levels of pathogens, additionally it is possible to
Promote the growth and breeding of vagina beneficial flora, adjusting vagina environment by vagina beneficial flora balances, and reaches to vagina day
The purpose often conserved.
（4）Antibacterial balance gynecological gel prepared by the present invention is free of any antibiotic, will not produce any drug resistance, and not
Containing bactericide, the probability for adverse reaction occur is reduced, is a kind of daily foster available for gynaecology's auxiliary treatment and vagina
The Multipurpose gel with antibacterial balance of shield.
Embodiment
Embodiment 1
A kind of antibacterial balance gynecological gel, including following components in percentage by weight：Chitosan 0.6%, hydroxy ethyl fiber
Element 0.5%, propane diols 5.0%, glycerine 3.0%, sodium lactate 5.0%, ecological nutrient liquid 0.5%, EVE-SOLUTION 20.0%, breast
Acid 0.5%, surplus is purified water.
The preparation method of above-mentioned antibacterial balance gynecological gel, comprises the following steps：
（1）Room temperature is cooled to after purified water is heated into 100 DEG C, constant temperature 5min；
（2）It is 2.5-4.5 that lactic acid regulation solution ph is added into the purified water after cooling；
（3）To step（2）Add chitosan and hydroxyethyl cellulose in gains, stirring is to being completely dissolved；
（4）To step（3）Propane diols, glycerine, sodium lactate, ecological nutrient liquid and EVE- are sequentially added in gains
SOLUTION, mixing；Add and 20min is stirred after every kind of material, rotating speed is 400r/min, and lower one kind is added after stirring
Raw material；
（5）Removal step（4）Foam in gains, is made antibacterial balance gynecological gel.
Obtained antibacterial balance gynecological gel is filled into the salable propeller of sterilizing（5~15ml）In, after packing
Put and preserved at shady and cool ventilation.
Application method：It is disposable, propeller is inserted into about 3 centimeters of vagina, forefinger compresses push rod, and gel is disposable
Intravaginal is injected, 15min is stopped.
Embodiment 2
A kind of antibacterial balance gynecological gel, including following components in percentage by weight：Chitosan 1.2%, hydroxy ethyl fiber
Element 0.2%, glycerine 3.0%, glycine betaine 2.0%, ecological nutrient liquid 2.0%, lactic acid 0.12%, surplus is purified water.
The preparation method of above-mentioned antibacterial balance gynecological gel, comprises the following steps：
（1）Room temperature is cooled to after purified water is heated into 100 DEG C, constant temperature 5min；
（2）It is 2.5-4.5 that lactic acid regulation solution ph is added into the purified water after cooling；
（3）To step（2）Add chitosan and hydroxyethyl cellulose in gains, stirring is to being completely dissolved；
（4）To step（3）Glycerine, glycine betaine and ecological nutrient liquid are sequentially added in gains, is mixed；Add after every kind of material
20min is stirred, rotating speed is 400r/min, a kind of lower raw material is added after stirring；
（5）Removal step（4）Foam in gains, is made antibacterial balance gynecological gel.
Obtained antibacterial balance gynecological gel is filled into the salable propeller of sterilizing（5~15ml）In, after packing
Put and preserved at shady and cool ventilation.
Application method：It is disposable, propeller is inserted into about 3 centimeters of vagina, forefinger compresses push rod, and gel is disposable
Intravaginal is injected, 15min is stopped.
Embodiment 3
A kind of antibacterial balance gynecological gel, including following components in percentage by weight：Chitosan 1.2%, hydroxy ethyl fiber
Element 0.1%, propane diols 5.0%, glycerine 3.0%, glycine betaine 2.0%, ecological nutrient liquid 2.0%, centella extract solution 5.0%, lactic acid
1.0%, surplus is purified water.
The preparation method of above-mentioned antibacterial balance gynecological gel, comprises the following steps：
（1）Room temperature is cooled to after purified water is heated into 100 DEG C, constant temperature 5min；
（2）It is 2.5-4.5 that lactic acid regulation solution ph is added into the purified water after cooling；
（3）To step（2）Add chitosan and hydroxyethyl cellulose in gains, stirring is to being completely dissolved；
（4）To step（3）Propane diols, glycerine, glycine betaine, ecological nutrient liquid and centella is sequentially added in gains to extract
Liquid, mixing；Add and 20min is stirred after every kind of material, rotating speed is 400r/min, a kind of lower raw material is added after stirring；
（5）Removal step（4）Foam in gains, is made antibacterial balance gynecological gel.
Obtained antibacterial balance gynecological gel is filled into the salable propeller of sterilizing（5~15ml）In, after packing
Put and preserved at shady and cool ventilation.
Application method：It is disposable, propeller is inserted into about 3 centimeters of vagina, forefinger compresses push rod, and gel is disposable
Intravaginal is injected, 15min is stopped.
Experimental example 1
Object：The antibacterial balanced gel prepared from Candida albicans testing example 1-3 is to the inhibitions of pathogenic bacteria.
Vaccination ways：Test tube and plating Candida albicans is respectively adopted.
Experiment packet：This experimental example sets blank group, positive controls, physiological saline group and treatment group, treatment group difference
Using the product prepared by embodiment 1, embodiment 2 and embodiment 3.
Blank control group：Only 15ml sabouraud culture mediums.
Positive controls：It is 1 × 10 to take bacterial strain quantity3White chain pearl bacterium 0.5ml be inoculated in 15ml sabouraud culture mediums,
In 37 DEG C, 48h is cultivated under the conditions of 220r/min.
Physiological saline group：It is 1 × 10 to take bacterial strain quantity3White chain pearl bacterium 0.5ml be inoculated in 15ml sabouraud culture mediums,
Then 0.5ml physiological saline is added, in 37 DEG C, 48h is cultivated under the conditions of 220r/min.
Treatment group：It is 1 × 10 to take bacterial strain quantity3White chain pearl bacterium 0.5ml be inoculated in 15ml sabouraud culture mediums, then
0.5ml products of the present invention are added, in 37 DEG C, 48h is cultivated under the conditions of 220r/min.
Experimental result：Compared with not adding the positive controls of gel, the nutrient solution transparency for the treatment of group is as clear as crystal, and
Positive controls are white opacity liquid.Treatment group transparency and blank control group, physiological saline group are consistent, display addition gel
Afterwards, the growth of white chain pearl bacterium is totally constrained, the product best results that especially prepared by embodiment 3.
Experimental example 2
Object：Influence of the antibacterial balanced gel to probiotics prepared from Lactobacillus acidophilus testing example 1-3.
Vaccination ways：Test tube and plating Lactobacillus acidophilus is respectively adopted.
Experiment packet：This experimental example sets blank group, positive controls, physiological saline group and treatment group, treatment group difference
Using the product prepared by embodiment 1, embodiment 2 and embodiment 3.
Blank control group：Only 15ml MRS culture mediums.
Positive controls：It is 1 × 10 to take bacterial strain quantity5Lactobacillus acidophilus 0.5ml be inoculated in 15ml MRS culture mediums,
In 37 DEG C, 24h is cultivated under the conditions of 220r/min.
Physiological saline group：It is 1 × 10 to take bacterial strain quantity5Lactobacillus acidophilus 0.5ml be inoculated in 15ml MRS culture mediums,
Then 0.5ml physiological saline is added, in 37 DEG C, 24h is cultivated under the conditions of 220r/min.
Treatment group：It is 1 × 10 to take bacterial strain quantity5Lactobacillus acidophilus 0.5ml be inoculated in 15ml sabouraud culture mediums, then
0.5ml products of the present invention are added, in 37 DEG C, 48h is cultivated under the conditions of 220r/min.
Experimental result：With the nutrient solution turbidity and sun of the treatment group for not plus compared with the positive controls of gel, adding gel
Property control group it is consistent, be faint yellow turbid solution.Blank control group, physiological saline group are as clear as crystal liquid.As a result show, benefit
The growth of raw bacterium is not suppressed because of addition gel, and in other words, growth of the antibacterial balanced gel to probiotics has guarantor
Shield is acted on, the product best results that especially prepared by embodiment 3.
Claims (7)
1. a kind of antibacterial balance gynecological gel, it is characterised in that including following components in percentage by weight：Cationic polysaccharide
0.1-2.0%, NMF 5.0-20%, thickener 0.1-2.0%, balance flora composite extract 5-25%, acidity regulator 0.1-
2.0%, surplus is purified water；
Wherein, cationic polysaccharide is chitosan；
It is ecological nutrient liquid, EVE-SOLUTION, lotus leaf extract, tea extract, guava to balance flora composite extract
One or more in leaf extract, A. gigas extract and Gotu Kola P.E.
2. antibacterial balance gynecological gel according to claim 1, it is characterised in that include the group of following percentage by weight
Point：Cationic polysaccharide 1.2%, NMF 10%, thickener 0.1%, balance flora composite extract 7%, acidity regulator
0.2%, surplus is purified water.
3. antibacterial balance gynecological gel according to claim 1 or 2, it is characterised in that NMF is propane diols, the third three
One or more in alcohol, butanediol, glycine betaine, sodium lactate, polyethylene glycol -200 and PEG-4000.
4. antibacterial balance gynecological gel according to claim 1 or 2, it is characterised in that thickener thickens for cellulose family
Agent.
5. antibacterial balance gynecological gel according to claim 1 or 2, it is characterised in that acidity regulator is lactic acid, lemon
The one or more of acid and malic acid.
6. the preparation method of the antibacterial balance gynecological gel described in claim any one of 1-5, it is characterised in that including following step
Suddenly：
（1）Room temperature is cooled to after purified water is heated into 100 DEG C, constant temperature 5min；
（2）Acidity regulator is added into the purified water after cooling, regulation solution ph is 2.5-4.5；
（3）To step（2）Add cationic polysaccharide and thickener in gains, stirring is to being completely dissolved；
（4）To step（3）NMF and balance flora composite extract, mixing are sequentially added in gains；
（5）Removal step（4）Foam in gains, is made antibacterial balance gynecological gel.
7. the preparation method of antibacterial balance gynecological gel according to claim 6, it is characterised in that step（4）It is middle to add
20min is stirred after a kind of material, a kind of lower raw material is added, wherein, rotating speed is 400r/min.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108969208A (en) * | 2018-04-25 | 2018-12-11 | 四川生命源健康管理有限公司 | The feminine sanitary napkin of anticancer function |
| CN109010124A (en) * | 2018-09-27 | 2018-12-18 | 青岛琛蓝海洋生物工程有限公司 | A kind of ocean essence gynaecology bacteriostatic gel and preparation method thereof |
| CN109260124A (en) * | 2018-11-30 | 2019-01-25 | 成都珂萝瑞诗化妆品有限公司 | A kind of women secret nursing lubricating fluid and preparation method thereof |
| CN109985037A (en) * | 2019-03-22 | 2019-07-09 | 陕西中医药大学第二附属医院 | A kind of gynecological gel |
| CN110090195A (en) * | 2019-05-08 | 2019-08-06 | 广州睿森生物科技有限公司 | A kind of women secret nursing gel and preparation method thereof |
| CN110101655A (en) * | 2019-05-31 | 2019-08-09 | 杨平芝 | A kind of composition repaired uterine neck and prevent bacterial vaginitis |
| CN110124017A (en) * | 2019-05-21 | 2019-08-16 | 张静 | A kind of bacteriostatic gel |
| CN111449973A (en) * | 2020-04-30 | 2020-07-28 | 西安贝迪斯可生物科技有限公司 | Foaming agent for restoring microecological balance of female vagina and preparation method thereof |
| CN111481498A (en) * | 2020-05-20 | 2020-08-04 | 西安贝迪斯可生物科技有限公司 | Antibacterial gel for regulating microecological balance of female vagina and preparation method thereof |
| CN112675257A (en) * | 2020-12-24 | 2021-04-20 | 许仲田 | Gel for regulating female vaginal flora and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922235A (en) * | 2015-05-15 | 2015-09-23 | 浙江中医药大学 | Gel agent used for vagina and containing total coptis alkaloids |
| CN106177188A (en) * | 2016-08-02 | 2016-12-07 | 马南行 | A kind of probiotic composition for the antibacterial balance of women and preparation method thereof |
-
2017
- 2017-06-09 CN CN201710432233.2A patent/CN107243017A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922235A (en) * | 2015-05-15 | 2015-09-23 | 浙江中医药大学 | Gel agent used for vagina and containing total coptis alkaloids |
| CN106177188A (en) * | 2016-08-02 | 2016-12-07 | 马南行 | A kind of probiotic composition for the antibacterial balance of women and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 徐鸿华: "《中草药识别与应用图谱》", 31 January 2017, 广东科技出版社 * |
| 梅全喜: "《广东地产药材研究》", 31 May 2011, 广东科技出版社 * |
| 赵中振: "《当代药用植物典.第一册》", 30 September 2007, 世界图书出版公司 * |
| 马维娜: "药用凝胶剂的研究进展", 《实用药物与临床》 * |
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| CN108969208A (en) * | 2018-04-25 | 2018-12-11 | 四川生命源健康管理有限公司 | The feminine sanitary napkin of anticancer function |
| CN109010124A (en) * | 2018-09-27 | 2018-12-18 | 青岛琛蓝海洋生物工程有限公司 | A kind of ocean essence gynaecology bacteriostatic gel and preparation method thereof |
| CN109260124A (en) * | 2018-11-30 | 2019-01-25 | 成都珂萝瑞诗化妆品有限公司 | A kind of women secret nursing lubricating fluid and preparation method thereof |
| CN109985037A (en) * | 2019-03-22 | 2019-07-09 | 陕西中医药大学第二附属医院 | A kind of gynecological gel |
| CN110090195A (en) * | 2019-05-08 | 2019-08-06 | 广州睿森生物科技有限公司 | A kind of women secret nursing gel and preparation method thereof |
| CN110124017A (en) * | 2019-05-21 | 2019-08-16 | 张静 | A kind of bacteriostatic gel |
| CN110101655A (en) * | 2019-05-31 | 2019-08-09 | 杨平芝 | A kind of composition repaired uterine neck and prevent bacterial vaginitis |
| CN111449973A (en) * | 2020-04-30 | 2020-07-28 | 西安贝迪斯可生物科技有限公司 | Foaming agent for restoring microecological balance of female vagina and preparation method thereof |
| CN111481498A (en) * | 2020-05-20 | 2020-08-04 | 西安贝迪斯可生物科技有限公司 | Antibacterial gel for regulating microecological balance of female vagina and preparation method thereof |
| CN112675257A (en) * | 2020-12-24 | 2021-04-20 | 许仲田 | Gel for regulating female vaginal flora and preparation method and application thereof |
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