CN110090195A - A kind of women secret nursing gel and preparation method thereof - Google Patents
A kind of women secret nursing gel and preparation method thereof Download PDFInfo
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- CN110090195A CN110090195A CN201910381322.8A CN201910381322A CN110090195A CN 110090195 A CN110090195 A CN 110090195A CN 201910381322 A CN201910381322 A CN 201910381322A CN 110090195 A CN110090195 A CN 110090195A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The present invention provides a kind of women secret nursing gel compositions, it comprises the following components in parts by weight: 0.3-0.8 parts of fermentation of bacillus product, 0.2-0.8 parts of grape fruit extract, 0.5-0.8 parts of blue gum leaf extract, 0.8-2 parts of inulin, 0.2-0.5 parts of alpha-glucans oligosaccharides, 0.6-2 parts of hydroxyethyl cellulose, 0.1-0.5 parts of lactic acid, 0.1-0.5 parts of sodium lactate.Microbicide compositions source of the present invention natural no stimulation, the identification beneficial bacterium and harmful bacteria of the property of can choose, and can guarantee the normal growth of beneficial bacterium；The present invention adds the active material that can promote lactobacillus growth, further suppress the growth of harmful bacteria, the effect of this formula, not only stays in antibacterial bacteriostatic, and it can help to rebuild microecology in vaginas system, reduce the probability of inflammation recurrence, normal population use will not bring undesirable influence, can prevent the generation of gynaecological imflammation.
Description
Technical field
The invention belongs to filed of daily-use chemical industry, and in particular to a kind of women secret nursing gel and preparation method thereof.
Background technique
As rhythm of life is accelerated, the operating pressure and life stress of people is increasing, the disease at women secret
It is more and more common.The vagina of women is an open cavity, communicates with the external world, is the important Tiny ecosystem area of women.Yin
Environment is acid environment in road, and pH value is 3.8~4.5, and there are many Bacillus acidi lacticis for intravaginal in the health for maintaining vaginal environment,
Number is seldom at nominal conditions for other bacteriums, fungi, if there is external interference or cause of disease are invaded, is likely to result in germ
Hyperplasia infection causes vulvovaginal is uncomfortable even to generate gynaecological imflammation.Common gynaecological imflammation has vulvitis, vaginitis, uterine neck
Scorching and pelvic inflammatory disease, these inflammation are that will lead to vaginal fluid increase since bacterium or fungal infection cause, scabies occur mostly
Itch, pain, there are the symptoms such as stink, situation is serious, and there are also a series of complication.Therefore, the health maintenance of women, especially
The maintenance of female private part is with cleaning increasingly by the attention of modern female.There is a variety of normal micro- lifes for healthy women intravaginal
Object bacterium colony, based on Bacillus acidi lactici, it is constituted between host, environment, and mutually restriction, mutually coordinated, dynamic Tiny ecosystem is flat
Weighing apparatus, maintains the pH value of vagina, brings to WomanHealth comfortable and happy.Vagina is a complicated Tiny ecosystem system, one
The microecological balance of denier vagina is destroyed, and will lead to intravaginal flora imbalance, is caused a variety of diseases, is relied solely on bactericidal
It is far from being enough to control the speed of growth of harmful bacteria, it is also necessary to help to re-establish the bacterium colony balance of vagina.
The research and development of women privates gel solve the problems, such as to cause related female gynecological disease because of hygienic issues reason.Because thin
Bacterium fungal infection causes some gynaecological diseases to need to be cleaned or injected at secret with some dedicated fungicide.Currently, sterilization
Agent mainly has following a few classes: disinfectant class, such as organic disinfectant, chlorine-containing disinfectant, and such fungicide bactericidal effect is good, but pierces
Swash greatly, there is certain damage to skin and mucosa；Bactericidal nano-silver agent, bactericidal effect is limited, and additive amount is higher, product cost compared with
It is high；Traditional Chinese medicine extraction species, often effect is slow for pure Chinese medicine fungicide, with for it is clearing heat and detoxicating, female reproductive system can be caused
Negative destruction；And the product of antibiotic or fungicide is added, though effect is fast, side effect is larger, commonly using can destroy
Environment in female genital tract, or even generate drug resistance.
Prior art emphasis point only antibacterial and it is antibacterial on, and the fungicide selected stimulates heavier or color mostly
Smell is heavier, does not focus on the reconstruction of vagina bacterium colony and the maintenance of pH value.
Such as: patent CN108186546A discloses antibacterial using fermentation of bacillus product and folium artemisiae argyi compounding preparation women
Gel, the experimental data that such gel only provides fungistatic effect, and do not quantify；Patent CN108186546A discloses one kind
Bacteriostatic lotion is prepared using traditional Chinese medicine ingredients such as fermentation of bacillus product, folium artemisiae argyi, cortex dictamni, Cortex Phellodendri, Rhizoma Atractylodis Macrocephalaes, equally also referring to has
Bacteriostasis efficacy does not have antibiotic effect；Patent CN104225015A discloses a kind of feminine care Chinese medicine composition, wherein adopting
The Chinese medicine composition of antibacterial bacteriostatic is prepared with Chinese traditional medicine composition and prebiotics collocation, but essential oil of traditional Chinese medicine is needed using solubilising or cream
Agent is emulsified, and is affected to the appearance and taste of product, and solubilizer and emulsifier to skin irritatin compared with
Greatly, especially for mucosal tissue；Patent CN1061099587A discloses a kind of drug of reparation microecology in vaginas of women balance
Composition, purpose essentially consists in the growth for helping Bacillus acidi lactici, but antibacterial bacteriostatic effect is general.
Summary of the invention
In view of the above-mentioned problems of the prior art, the present invention provides a kind of women secret nursing gel compositions.For
It achieves the object of the present invention, is realized using following technical scheme:
A kind of women secret nursing gel composition comprises the following components in parts by weight: fermentation of bacillus product 0.2-3
Part, 0.1-3 parts of grape fruit extract, 0.2-1 parts of blue gum leaf extract, 0.2-5 parts of inulin, 0.2-3 parts of alpha-glucans oligosaccharides, hydroxyl
0.6-2 parts of ethyl cellulose, 0.1-0.5 parts of lactic acid, 0.1-0.5 parts of sodium lactate, the pH value of the gel combination is 4.0-
4.5。
Preferably, the women secret nursing gel composition, comprises the following components in parts by weight: fermentation of bacillus produces
0.2-1 parts of object, 0.2-1 parts of grape fruit extract, 0.4-0.8 parts of blue gum leaf extract, 0.2-3 parts of inulin, alpha-glucans oligosaccharides
0.2-2 parts, 0.8-1.6 parts of hydroxyethyl cellulose, 0.2-0.4 parts of lactic acid, 0.1-0.2 parts of sodium lactate, the gel combination
PH value is 4.0-4.5.
Preferably, the women secret nursing gel composition, comprises the following components in parts by weight: fermentation of bacillus produces
0.4-0.8 parts of object, 0.3-0.6 parts of grape fruit extract, 0.3-0.6 parts of blue gum leaf extract, 0.4-1 parts of inulin, alpha-glucans
0.2-1 parts of oligosaccharides, 0.8-1.0 parts of hydroxyethyl cellulose, 0.2-0.4 parts of lactic acid, 0.1-0.2 parts of sodium lactate, the Gel Compositions
The pH value of object is 4.0-4.5.
Preferably, the women secret nursing gel composition, comprises the following components in parts by weight: fermentation of bacillus produces
0.6 part of object, 0.4 part of grape fruit extract, 0.4 part of blue gum leaf extract, 1 part of inulin, 0.6 part of alpha-glucans oligosaccharides, ethoxy
1.0 parts of cellulose, 0.3 part of lactic acid, 0.2 part of sodium lactate, the pH value of the gel combination is 4.0-4.5.
The present invention also provides a kind of preparation methods of women secret nursing gel composition, comprising the following steps:
Cellulose is dissolved by heating first to the gel state of clear, colorless in advance, lactic acid is added after being cooled to 45 DEG C
PH value is adjusted to 4.0-4.5 with sodium lactate；Fermentation of bacillus product, grape fruit extract, Eucalyptus globulus Labill leaf is sequentially added to extract
Object, inulin, alpha-glucans oligosaccharides stir evenly, and can be obtained Gel Compositions of the invention.
Beneficial effects of the present invention: women secret nursing gel group object of the invention, which closes, uses natural bacillus
Tunning, grape fruit extract, blue gum leaf extract composite bactericide, safe and non-stimulating, system is transparent, no special odor,
And with the bactericidal effect of wide spectrum after compounding, additive amount is lower, lower production costs.The fungicide of such compounding is to lactic acid bar
The influence of bacterium is smaller, selective killing disinfect pathogen.To using Escherichia coli as the Gram-negative bacteria of representative, with golden yellow Portugal
Grape coccus is the gram-positive bacteria of representative, all has preferable antibacterial action by the fungi of representative of Candida albicans.
Meanwhile it being added only provide the inulin and alpha-glucans oligosaccharides increase Bacillus acidi lactici of food to Bacillus acidi lactici in formula
Competence for added value further suppresses the growth of disinfect pathogen, maintains the normal bacterium colony of vagina to balance, restores the normal ph of vagina,
Reduce the probability of later period recurrence.
The normal ph of vagina is maintained, lactic acid is the metabolite of Bacillus acidi lactici, and lactic acid and sodium lactate is selected to establish pH
It is worth buffer system, makes the growth pH value for maintaining Bacillus acidi lactici between the pH value 4.0-4.5 of formula system, not by external environment
It influences.
Specific embodiment
The formula of embodiment 1-7 and comparative example 1-7 gel combination is shown in Table 1:
Table 1: the formula of embodiment 1-9 and comparative example 1-7 gel combination
Embodiment 10
The present embodiment provides a kind of preparation methods of women secret nursing gel composition, comprising the following steps:
Each component is weighed according to the parts by weight of embodiment 1, surplus is water.Hydroxyethyl cellulose is added in cold water first,
90 DEG C are to slowly warm up to, keeps the temperature 30min, lasting stir (400-500r/min) is to clear, colorless gel state；It is being cooled to 45
After DEG C plus lactic acid and sodium lactate adjust pH value to 4.0-4.5, sequentially add fermentation of bacillus product, grape fruit extract,
Blue gum leaf extract, inulin, alpha-glucans oligosaccharides stir 10min, and holding stirs speed in 400-600r/min to colorless and transparent
Obtain women secret nursing gel combination of the invention.
The gel combination of resulting embodiment 1-9 and comparative example 1-7 is subjected to effect assessment
Test 1: antibacterial effect test: test method refers to People's Republic of China's light industry standard QB/T 2738-
2012 daily chemical products antibacterial bacteriostatic effect evaluation methods, the results are shown in Table 2.
Table 2: the antibacterial effect of case study on implementation and comparison case
Show that the Example formulations product of women secret nursing gel of the invention has significant antibacterial by the above results
Effect.
Test 2: beneficial bacterium (lactobacterium acidophilus GDMCC1.208) growth effect test: preparation lactobacterium acidophilus' bacteria suspension
(1.0×104~9.0 × 104), women secret nursing gel dilution (1:10) 5ml is taken, it is outstanding that 0.1ml lactobacterium acidophilus bacterium is added
Liquid is put into MSR culture medium after acting on 2min in 37 DEG C, culture 12h, for 24 hours, does the counting of viable bacteria bacterium colony, and calculate Bacillus acidi lactici
Survival rate.Survival rate calculates as follows:
It the results are shown in Table 3.
Table 3: case study on implementation and comparison case are to beneficial bacterium growth effect effect
Experiment shows that the embodiment of the present invention is unobvious to the influence of vagina beneficial bacterium, and vagina beneficial bacterium quantity is bright
It is aobvious, show that inventive formulation product is smaller to the growth effect of the beneficial bacterium of vagina while killing vaginal pathogenic, for a long time
Using safer, and there is good effect for the prevention of vaginitis.As shown in Table 2, embodiment 5 is of the invention best
Scheme, the content of each component had both been able to satisfy the killing effect to harmful bacteria in formula, while having an impact to probiotics, at
This is lower, and technique production is simply conducive to industrial production.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (5)
1. a kind of women secret nursing gel composition, which is characterized in that comprise the following components in parts by weight: fermentation of bacillus
0.2-3 parts of product, 0.1-3 parts of grape fruit extract, 0.2-1 parts of blue gum leaf extract, 0.2-5 parts of inulin, alpha-glucans oligosaccharides
0.2-3 parts, 0.6-2 parts of hydroxyethyl cellulose, 0.1-0.5 parts of lactic acid, 0.1-0.5 parts of sodium lactate, the pH of the gel combination
Value is 4.0-4.5.
2. women secret nursing gel composition as described in claim 1, which is characterized in that the group including following parts by weight
Point: 0.2-1 parts of fermentation of bacillus product, 0.2-1 parts of grape fruit extract, 0.4-0.8 parts of blue gum leaf extract, inulin 0.2-
3 parts, 0.2-2 parts of alpha-glucans oligosaccharides, 0.8-1.6 parts of hydroxyethyl cellulose, 0.2-0.4 parts of lactic acid, 0.1-0.2 parts of sodium lactate,
The pH value of the gel combination is 4.0-4.5.
3. women secret nursing gel composition as described in claim 1, which is characterized in that the group including following parts by weight
Point: 0.4-0.8 parts of fermentation of bacillus product, 0.3-0.6 parts of grape fruit extract, 0.3-0.6 parts of blue gum leaf extract, inulin
0.4-1 parts, 0.2-1 parts of alpha-glucans oligosaccharides, 0.8-1.0 parts of hydroxyethyl cellulose, 0.2-0.4 parts of lactic acid, sodium lactate 0.1-0.2
Part, the pH value of the gel combination is 4.0-4.5.
4. women secret nursing gel composition described in claim 1, which is characterized in that comprise the following components in parts by weight:
0.6 part of fermentation of bacillus product, 0.4 part of grape fruit extract, 0.4 part of blue gum leaf extract, 1 part of inulin, alpha-glucans are few
0.6 part of sugar, 1.0 parts of hydroxyethyl cellulose, 0.3 part of lactic acid, 0.2 part of sodium lactate, the pH value of the gel combination is 4.0-
4.5。
5. a kind of prepare the preparation method such as any one of claim 1-4 women secret nursing gel composition, which is characterized in that
The following steps are included:
Cellulose is dissolved by heating first to the gel state of clear, colorless in advance, lactic acid and cream are added after being cooled to 45 DEG C
Sour sodium adjusts pH value to 4.0-4.5；Sequentially add fermentation of bacillus product, grape fruit extract, blue gum leaf extract, chrysanthemum
Powder, alpha-glucans oligosaccharides stir evenly, and can be obtained gel combination of the invention.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329790A (en) * | 2020-02-19 | 2020-06-26 | 株洲千金药业股份有限公司 | Bacteriostatic low-foam lotion for women and preparation method thereof |
| CN111514181A (en) * | 2020-04-01 | 2020-08-11 | 广州睿森生物科技有限公司 | Antibacterial composition, antibacterial composite nano-particles, preparation method of antibacterial composite nano-particles and targeted slow-release nano-private gel |
| CN112089827A (en) * | 2020-10-30 | 2020-12-18 | 湖南婕妙生物科技有限公司 | Prebiotic-containing pharmaceutical composition for regulating female vaginal microecological balance, preparation and use thereof |
| CN112675257A (en) * | 2020-12-24 | 2021-04-20 | 许仲田 | Gel for regulating female vaginal flora and preparation method and application thereof |
| CN114344192A (en) * | 2022-01-24 | 2022-04-15 | 耀然实业股份有限公司 | Personal care composition, personal care product and personal care product |
| CN116077423A (en) * | 2023-02-13 | 2023-05-09 | 广州阿基米德生物科技有限公司 | Female private care gel and preparation method and application thereof |
| CN116077423B (en) * | 2023-02-13 | 2024-04-23 | 阿基米德(广州)化妆品研究有限公司 | Female private care gel and preparation method and application thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329790A (en) * | 2020-02-19 | 2020-06-26 | 株洲千金药业股份有限公司 | Bacteriostatic low-foam lotion for women and preparation method thereof |
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| CN111514181A (en) * | 2020-04-01 | 2020-08-11 | 广州睿森生物科技有限公司 | Antibacterial composition, antibacterial composite nano-particles, preparation method of antibacterial composite nano-particles and targeted slow-release nano-private gel |
| CN111514181B (en) * | 2020-04-01 | 2022-10-04 | 广州睿森生物科技有限公司 | Antibacterial composition, antibacterial composite nano-particles, preparation method of antibacterial composite nano-particles and targeted slow-release nano-private gel |
| CN112089827A (en) * | 2020-10-30 | 2020-12-18 | 湖南婕妙生物科技有限公司 | Prebiotic-containing pharmaceutical composition for regulating female vaginal microecological balance, preparation and use thereof |
| CN112675257A (en) * | 2020-12-24 | 2021-04-20 | 许仲田 | Gel for regulating female vaginal flora and preparation method and application thereof |
| CN114344192A (en) * | 2022-01-24 | 2022-04-15 | 耀然实业股份有限公司 | Personal care composition, personal care product and personal care product |
| CN116077423A (en) * | 2023-02-13 | 2023-05-09 | 广州阿基米德生物科技有限公司 | Female private care gel and preparation method and application thereof |
| CN116077423B (en) * | 2023-02-13 | 2024-04-23 | 阿基米德(广州)化妆品研究有限公司 | Female private care gel and preparation method and application thereof |
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Application publication date: 20190806 |