CN111329790B - Bacteriostatic low-foam lotion for women and preparation method thereof - Google Patents

Abstract

The invention discloses a natural female bacteriostatic low-foam lotion and a preparation method thereof. Firstly, the bacteriostatic essential oil composition is pure natural in components and has a good bacteriostatic effect on pathogenic bacteria such as candida albicans and the like, and a surfactant and a formula system are explored and optimized based on the bacteriostatic essential oil composition, so that the bacteriostatic low-foam lotion for women is developed. The lotion takes the combination of tea tree essential oil, grapefruit essential oil, bergamot essential oil, inulin and alpha-glucan oligosaccharide as main bacteriostatic components, and is supplemented with a perfectly-compounded surfactant and a formula system, so that the bacteriostatic low-foam lotion product has a strong bacteriostatic effect on escherichia coli, staphylococcus aureus and candida albicans, and particularly has a remarkably improved bacteriostatic effect on candida albicans; and the lotion has highly natural components, weak acidity, mildness and no stimulation.

Description

Bacteriostatic low-foam lotion for women and preparation method thereof

Technical Field

The invention belongs to the technical field of daily chemicals. More particularly, relates to a bacteriostatic low-foaming lotion for women and a preparation method thereof.

Background

The female private parts are affected by physiological, fertility, sanitary, clean, economic and cultural factors, and are very easy to cause various infections. It is shown by the relevant data that in adult women around the world, about 85% suffer from varying degrees of gynecological inflammation, of which 46% of patients have problems with recurrent attacks of the disease, and the target consumers present a tendency to be younger, with 53.9% of students having symptoms associated with vaginitis, of which bacterial vaginitis is predominant (35.9%), followed by candidal vaginitis (23.6%).

The washing liquid with the functions of bacteriostasis and sterilization in the current market has two types of medical and daily nursing, the medical washing liquid is used for treating various gynecological diseases, and the daily nursing washing liquid is mainly used for cleaning and bacteriostasis; the ingredients are mostly chemical bacteriostatic ingredients with over-strong efficacy, and can play a role in bacteriostasis, but also seriously destroy the proliferation of beneficial bacteria, further destroy the normal pH of private parts, cause flora disorder, seriously reduce the self-cleaning effect of organisms, and easily have the problems of poor water solubility and the like in chemical ingredients, and the chemical ingredients are not safe enough to human bodies, can also generate certain stimulation to the skin, and can also cause environmental pollution.

The female bacteriostatic lotion is different from chemical lotion and cleaning solution in daily life, and is distinguished from the conventional bath lotion in formula design and use because of the involvement of mucous membrane cleaning. Compared with the prior art, the lotion for women needs to be milder, refreshing and low in residue, conforms to the physiological metabolism characteristics of normal women, achieves the balance of daily maintenance and self-antibacterial maintenance, and has wide applicability and higher safety. Also in view of concerns about chemical safety, more and more consumers are inclined to use "green health" products. Therefore, the development of a highly natural special lotion product for women, which is suitable for daily care, has a good bacteriostatic effect on pathogenic bacteria and high safety, and has important significance and prospect.

Disclosure of Invention

The invention aims to provide a highly natural special lotion product for women, which is suitable for daily care, has good bacteriostatic effect on pathogenic bacteria and high safety. The invention firstly provides the bacteriostatic essential oil composition which is pure natural in components and good in bacteriostatic effect on pathogenic bacteria, and a surfactant and a formula system are explored and optimized on the basis to develop the bacteriostatic low-foaming lotion for women, so that the product is highly natural in components, good in bacteriostatic effect on the pathogenic bacteria and high in safety.

The invention aims to provide a bacteriostatic essential oil composition.

The invention also aims to provide the bacteriostatic low-foam lotion for women and a preparation method thereof.

The above purpose of the invention is realized by the following technical scheme:

a bacteriostatic composition comprises tea tree essential oil, grapefruit essential oil, and bergamot essential oil.

Preferably, in the antibacterial composition, the mass ratio of the tea tree essential oil to the grapefruit essential oil to the bergamot essential oil is 0.01-0.05:0.01-0.05:0.001-0.1.

More preferably, the mass ratio of the tea tree essential oil to the grapefruit essential oil to the bergamot essential oil is 0.025:0.025:0.01.

the research shows that the bacteriostatic performance of different essential oil types and different combinations is greatly different, especially on candida albicans; most of the essential oils have strong inhibitory effect on escherichia coli and staphylococcus aureus, but have little effect on candida albicans. Researches show that the combination of the tea tree essential oil, the grapefruit essential oil and the bergamot essential oil has a good bacteriostatic effect on candida albicans.

In addition, in order to improve the bacteriostatic action of the essential oil composition on candida albicans, intensive research is carried out, and a scheme capable of improving the bacteriostatic effect of the essential oil composition on candida albicans is obtained by exploring, namely inulin and alpha-glucan oligosaccharide are compounded. Experimental data show that the inulin and the alpha-glucan oligosaccharide can obviously improve the bacteriostatic effect of the combination of the tea tree essential oil, the grapefruit essential oil and the bergamot essential oil on candida albicans, and are very suitable for personal care products for women.

Therefore, a bacteriostatic composition consisting of tea tree essential oil, grapefruit essential oil, bergamot essential oil, inulin and alpha-glucan oligosaccharide is also within the scope of the present invention.

Preferably, the mass ratio of the tea tree essential oil, the grapefruit essential oil, the bergamot essential oil, the inulin and the alpha-glucan oligosaccharide is 0.01-0.05:0.01-0.05:0.001-0.1:0.05-0.1:0.005-0.1.

More preferably, the mass ratio of the tea tree essential oil, the grapefruit essential oil, the bergamot essential oil, the inulin and the alpha-glucan oligosaccharide is 0.025:0.025:0.01:0.07:0.015.

in addition, the application of the antibacterial composition in preparing antibacterial products is also within the protection scope of the invention. The bacteriostasis refers to inhibiting escherichia coli, candida albicans and/or staphylococcus aureus.

Specifically, the bacteriostatic products comprise special lady lotion, clothing care products, body bath products and the like with bacteriostatic action.

The invention develops a natural lady bacteriostatic low-foaming lotion based on the bacteriostatic composition.

Specifically, as a preferred alternative, the formula of the natural female bacteriostatic low-foaming lotion comprises the following components (by mass):

phase A: water and sodium benzoate 0.2-0.6% for making up the 100% of the full formula;

phase B: 0.5-1.5% of xanthan gum;

and C phase: 0.05-0.1% of zwitterionic surfactant, 0.02-0.06% of anionic surfactant, 0.02-0.05% of nonionic surfactant and 0.05-0.1% of weak anionic surfactant;

phase D: tea tree essential oil 0.01-0.05%, grapefruit essential oil 0.01-0.05%, bergamot essential oil 0.005-0.02%, solubilizing emulsifier 0.4-0.6%, phenoxyethanol 0.1-0.2%, and ethylhexyl glycerin 0.1-0.2%;

phase E: inulin 0.05-0.1%, alpha-glucan oligosaccharide 0.01-0.02%;

and (3) phase F: 0.05 to 0.2 percent of pH regulator;

in addition, 3 to 8 percent of propylene glycol is also contained, and the propylene glycol is divided into two parts according to the mass ratio of 3 to 5:1 to be respectively used as one raw material in the phase B and the phase D.

More preferably, the formula of the natural female bacteriostatic low-foaming lotion is as follows (mass ratio):

phase A: water and sodium benzoate 0.4% for making up 100% of the full formula;

phase B: 1% of xanthan gum;

and C phase: 0.075% of zwitterionic surfactant, 0.04% of anionic surfactant, 0.035% of nonionic surfactant and 0.075% of weak anionic surfactant;

phase D: tea tree essential oil 0.025%, grapefruit essential oil 0.025%, bergamot essential oil 0.01%, solubilizing emulsifier 0.5%, phenoxyethanol 0.15%, and ethylhexyl glycerin 0.15%;

phase E: inulin 0.07%, alpha-glucan oligosaccharide 0.015%;

and (3) phase F: 0.1% of pH regulator;

and also contains 5 percent of propylene glycol, and is divided into two parts according to the mass ratio of 4:1 as a B phase and a D phase respectively.

In the formula of the lotion, the bacteriostatic combination consisting of the three essential oils, the inulin and the alpha-glucan oligosaccharide synergistically exerts the bacteriostatic effect, and meanwhile, the bacteriostatic effect of the product is remarkably improved by perfectly matching a proper surfactant system and an optimized formula. Adjusting the pH value to weak acidity by citric acid; the components of the whole formula system are highly natural, mild and non-irritating, and the bacteriostatic effect is strong.

Wherein, preferably, the zwitterionic surfactant is cocamidopropyl betaine.

Preferably, the anionic surfactant is sodium lauryl glucarate.

Preferably, the nonionic surfactant is lauryl glucoside.

Preferably, the weak anionic surfactant is disodium cocoyl glutamate.

Preferably, the solubilizing emulsifier is present in a mass ratio of 0.1 to 2:0.1-2 (preferably 1:1) of PPG-26-Butanepolyether-26 and PEG-40 hydrogenated castor oil.

Preferably, the pH adjusting agent is citric acid.

Preferably, the water is deionized water.

Further preferably, the washing solution is prepared by the following process:

s1, accurately weighing phase A water, adding sodium benzoate, stirring and heating, and heating to 85-90 ℃; adding premix to form B phase, keeping the temperature for 10-20min, and cooling to 55-65 deg.C;

s2, adding the phase C raw materials, keeping the temperature, stirring uniformly, and continuously cooling to 45-48 ℃;

s3, adding the premixed phase D to the transparent phase D, and uniformly stirring the mixture under the condition of heat preservation; adding the raw material of the E phase, and stirring uniformly;

s4, adjusting the pH value to 4.5-6.5 by using the phase F to obtain a uniform, transparent and semitransparent gelatinous product.

More preferably, the washing solution is prepared by the following process:

s1, accurately weighing phase A water, adding sodium benzoate, stirring and heating, and heating to 85 ℃; adding premixed phase B, keeping the temperature for 15min, and cooling to 60 ℃;

s2, adding the phase C raw materials, keeping the temperature, stirring uniformly, and continuously cooling to 45 ℃;

s3, adding the premixed phase D to the transparent phase D, and uniformly stirring the mixture under the condition of heat preservation; adding the phase E raw material, and uniformly stirring;

and S4, adjusting the pH value to 5.5 by using the phase F to obtain a uniform, transparent and semitransparent gel product.

In step S1, if the emulsification container is opened or too large, evaporation loss of water is easy, and 2% more water than the formula amount can be added to compensate for the evaporation loss of water.

The invention has the following beneficial effects:

according to the invention, a group of natural essential oil combinations with strong antibacterial activity is obtained through research, namely tea tree essential oil, grapefruit essential oil and bergamot essential oil, and inulin and alpha-glucan oligosaccharide are added as auxiliary materials, so that the bacteriostatic effect on escherichia coli, staphylococcus aureus and candida albicans is good, and the composition is suitable for preparing products related to lotion for women.

Based on the above, the bacteriostatic lotion special for women is developed, a proper surfactant system is perfectly compounded, the formula is optimized, the stability of the bacteriostatic effect of the essential oil is ensured, the components are highly natural, the composition is weakly acidic, mild and non-irritant, and the product is in a gel shape, less in foam, soft, fine and greasy, and easy to clean.

Detailed Description

The present invention will be further described with reference to the following specific examples, which are not intended to limit the invention in any manner.

The reagents, methods and apparatus employed in the present invention are conventional in the art, except as otherwise indicated.

Unless otherwise indicated, reagents and materials used in the present invention are commercially available.

Example 1 essential oil bacteriostasis test

1. Through a large amount of researches and optimization researches on the basis of wide essential oil source and low cost, the combination of tea tree essential oil, grapefruit essential oil and bergamot essential oil is preliminarily determined, and the bacteriostatic effects on the three bacteria are all the highest (as shown in table 1).

TABLE 1

The test result shows that most essential oils have stronger inhibition effect on escherichia coli and staphylococcus aureus, but have little or weaker effect on candida albicans.

2. Optimization of essential oil combination proportion

After the antibacterial combination of the essential oil is obtained, single-factor and orthogonal experiments are carried out on the proportion of the antibacterial combination of the essential oil, and the combination proportion is optimized. The result shows that the mass ratio of the tea tree essential oil to the grapefruit essential oil to the bergamot essential oil needs to be controlled to be 0.01-0.05:0.01-0.05:0.001-0.1, preferably 0.025:0.025:0.01. (partial data are shown in Table 2).

TABLE 2

3. Through reasonable compounding and proportion blending of the essential oil, the bacteriostatic effect of the essential oil composition on candida albicans can be obviously improved. But the total bacteriostasis rate still can hardly reach more than 50%. In order to realize better antibacterial effect, further exploration is carried out to obtain a scheme of combining inulin and alpha-glucan oligosaccharide with essential oil, and the antibacterial effect is remarkably improved. The mass ratio of the tea tree essential oil, the grapefruit essential oil, the bergamot essential oil, the inulin and the alpha-glucan oligosaccharide is preferably 0.01-0.05:0.01-0.05:0.001-0.1:0.05-0.1:0.005-0.1; most preferably 0.025:0.025:0.01:0.07:0.015. (partial data are shown in Table 3).

TABLE 3

Example 2 development of bacteriostatic Low-foaming lotion

1. Lotion base formula Table 4

TABLE 4

The texture of the lotion formulations of each group was tested and the results were as follows:

the clarity of the group I experiment system is greatly different along with the change of temperature, and the material body becomes turbid when the temperature is above 20 ℃;

the experiment in the group II is not greatly different from the experiment in the group I, and is more astringent after being cleaned;

the experimental material bodies in group III are not easy to thicken, and precipitate is separated out after standing for a period of time after uniform stirring;

the IV group of experimental materials are not easy to thicken and rich in foam, and precipitate is separated out at the temperature of 0 ℃;

the consistency of the experimental materials in group V is a little larger;

the experimental body in the VI group has proper consistency, and the body is in a gel state.

2. Based on the basic system, the formula of the bacteriostatic low-foam lotion for women is further researched and optimized, and is shown in table 5:

EXAMPLE 3 bacteriostatic Low-foaming lotion

The bacteriostatic low-foaming lotion formulation is shown in table 6.

TABLE 6

The preparation process of the lotion comprises the following steps:

s1, accurately weighing phase A water, adding sodium benzoate, stirring and heating, and heating to 85 ℃; adding premixed phase B, keeping the temperature for 15min, and cooling to 60 ℃;

s2, adding the phase C raw materials, keeping the temperature, stirring uniformly, and continuously cooling to 45 ℃;

s3, adding the premixed phase D to the transparent phase D, and uniformly stirring the mixture under the condition of heat preservation; adding the phase E raw material, and uniformly stirring;

and S4, adjusting the pH value to 5.5 by using the phase F to obtain a uniform, transparent and semitransparent gel product.

In step S1, if the emulsification container is opened or too large, evaporation loss of water is easy, and 2% more water than the formula amount can be added to compensate for the evaporation loss of water.

EXAMPLE 4 bacteriostatic Low-foaming lotion

The bacteriostatic low-foaming lotion formulation is shown in Table 7 and prepared in the same manner as in example 3.

TABLE 7

EXAMPLE 5 bacteriostatic Low-foaming lotion

The bacteriostatic low-foaming lotion formulation is shown in Table 8 and prepared in the same manner as in example 3.

TABLE 8

Comparative example 1

The bacteriostatic low-foaming lotion formulation is shown in Table 9 and prepared in the same manner as in example 3.

TABLE 9

Comparative example 2

The bacteriostatic low-foaming lotion formulation is shown in Table 10 and prepared in the same manner as in example 3.

Watch 10

Example 5 the lotions of examples 3 to 5 and comparative examples 1 to 2 were tested for their bacteriostatic effects

1. The test method is as follows:

the testing of the bacteriostatic effect of the lotion is entrusted to Hunan mountain and water testing Limited.

The tests for Escherichia coli, candida albicans, staphylococcus aureus were provided by Kyork, guangdong, microscience and technology, inc. Culturing on slant for 24 hr, washing thallus Porphyrae with PBS, diluting with PBS to desired concentration, dripping 20ul of the diluted solution onto sterilized cloth (1.0 cm × 1.0 cm), oven drying to recover bacterial colony of 1 × 10 ⁴ cfu/mL-9×10 ⁴ cfu/mL to obtain a bacterial carrier.

The detection basis is as follows: GB 15979-2002 appendix C.

Detecting the environment: the temperature is 23.2-24.5 ℃, and the relative humidity is 53-56%.

The detection method comprises the following steps: respectively taking a washing liquid sample and a control matrix (PBS) and placing in a sterilization flat dish, respectively soaking a bacteria carrier in the washing liquid sample and the control matrix, respectively acting for 2min, 5min, 10min and 20min, respectively taking out the carrier by using a sterile forceps, respectively moving into a test tube containing 5.0ml of PBS, shaking and knocking for 80 times, uniformly mixing, absorbing 0.5ml of bacteria-medicine mixed liquid, adding into a test tube containing 4.5ml of PBS diluent, uniformly mixing, respectively absorbing 1.0ml of the bacteria-medicine mixed liquid, and pouring into the dish to count viable bacteria colonies. The test was repeated three times, and the control group served as a positive control.

2. The test result data are shown in tables 11 and 12 below: the lotion has the bacteriostasis rate of 94.38 percent, 96.66 percent and 99.29 percent on candida albicans, staphylococcus aureus and escherichia coli after 2min of action. The antibacterial effect meets the requirement of GB 15979-2002 appendix C C4.2.2 of hygienic Standard for Disposable sanitary articles.

TABLE 11 EXAMPLE 3 inhibition of three bacteria by the action of the lotion for different periods of time

TABLE 12 inhibition rate of each lotion on three bacteria at different time

Example 6

The bacteriostatic low-foaming lotion of example 3 is taken as an example, and the quality, safety and stability of the bacteriostatic low-foaming lotion are tested.

Entrusted testing organization: hunan mountain and water detection Co Ltd

1. The safety test results are shown in Table 13

Watch 13

2. Stability test of bacteriostatic Effect of washing solution

Candida albicans ATCC10231 was supplied by Kyork, guangdong, microbial technology, inc. Inoculating the bacterial suspension to slant culture 24h, washing lawn with PBS, and diluting to concentration of 1 × 10 ⁴ CFU/g-9×10 ⁴ CFU/g. And testing the bacteriostasis rate of the lotion.

After the washing liquid sample is placed in a constant temperature box with the relative humidity of 80 percent at the temperature of 37 +/-1 ℃ for 90 days, the sample has no color change, no sediment and no layering, and the average bacteriostasis rate of the sample on the candida albicans is shown in the table 14.

TABLE 14

Note: before stabilization, the lotion is in the original shape after stabilization; negative controls were established.

The expiration date of the product can be 2 years according to the provisions of GB 15979-2002 hygienic Standard for Disposable sanitary articles appendix C C6.2.2.

3. Skin irritation test

(1) Experimental animals: rabbits, offered by changsha, tianjiu biotechnology limited. The temperature of the animal room is 24-28 ℃ and the relative humidity is 54-60%.

(2) The detection basis is as follows: disinfection Specification 2002 edition 2.3.3.

(3) The detection method comprises the following steps:

3 white rabbits, 2 males and 1 female rabbit, the weight of the rabbits is 2.0-2.5kg, the hair on the two sides of the backs of the rabbits is cut 24 hours before the experiment, the hair-removed areas on the left side and the right side are about 3cm multiplied by 3cm, the left side is a medicine-applying area, and the right side is a control area. Respectively weighing 0.5ml of the test substance, smearing the test substance on the skin of the medicine application area, covering the test substance with a layer of non-irritating plastic film, fixing the test substance with a non-irritating adhesive tape, and applying the test substance for 24 hours. The control group was coated with an equal amount of distilled water.

After 24h of application, the application area was rinsed with warm water to remove residues. The local skin reactions were observed at 1h, 24h, and 48h after removal of the test substance, respectively. The experiment was repeated three times and the mean value was taken. The highest skin irritation index is taken, and the level of the animal skin irritation intensity of the test substance is evaluated according to the disinfection technical Specification 2002 edition tables 2-12.

(4) The results are shown in Table 15: after the administration is carried out for 2h, the local skin of the medicine-applying area of the animal is cleaned by warm water, no skin erythema or edema is observed in 1h, 24h or 48h, and no other abnormal phenomena occur in the animal in the observation period. The highest skin irritation index is 0, and the skin in the control area has no abnormal phenomenon.

Watch 15

According to the skin irritation intensity grading standard in the 2002 edition of the disinfection technical Specification, the test result of the acute once complete skin irritation of the washing lotion on the rabbit is as follows: has no irritation and meets the requirement of 2.3.13.1, 2002 edition.

4. Vaginal mucosa irritation test

(1) Experimental animals: rabbits, offered by changsha, tianjiu biotechnology limited. The temperature of the animal room is 24-28 ℃ and the relative humidity is 54-60%.

(2) The detection basis is as follows: disinfection Specification 2002 edition 2.3.5.

(3) The detection method comprises the following steps:

experimental animals were randomly divided into a toxicant group (1 group) and a control group (2 groups), 3 animals per group, blunt-ended flexible tubes 8cm in length were connected to 2ml syringes, and were filled with test solution for use, one set for each animal.

Fixing the animal on the back, exposing perineum and vaginal orifice, soaking the catheter with the test solution, inserting into vagina gently for 4-5cm, slowly injecting 2ml of test solution with an injector, and withdrawing the catheter to complete contamination. Control animals were treated with saline as well.

24h after infection, the animals are killed by an air embolism method, the whole vagina is taken out after laparotomy, the longitudinal incision is carried out, and whether congestion, edema and other manifestations exist is observed. Then, the vagina is put into 10% formalin solution for fixation for more than 24h, tissues at two ends and 3 parts in the center of the vagina are selected for flaking, histopathology examination is carried out after HE staining, and the stimulation reaction is scored according to the vaginal mucosa stimulation reaction scoring standard in the 2002 edition 2.3.5 of the disinfection technical Specification.

(4) And (3) detection results:

the animals in the control group and the infected group have no abnormal conditions such as food intake, drinking, defecation and urination, behavioral activities and the like in the later treatment period. After 24 toxicant exposure, the vaginal mucosa is basically intact, and no obvious congestion, edema and other manifestations are seen. The pathological examination result shows that the vagina mucosa irritation index of the infected group is 0.78. According to the skin irritation intensity grading standard in the 2002 edition of the technical Specification for disinfection, the test result of the irritation test of the lotion on the vaginal mucosa of the rabbit is as follows: has no irritation, and meets the requirements of 2.3.13.1, 2002 edition of disinfection technical Specification.

In addition, the washing lotion has high proportion of natural components, more than 95 percent of the components are natural sources, and the natural sources pass natural certification of the international organic certification authority.

Example 7 evaluation of population use

A human use test analysis was performed using the bacteriostatic low-foaming lotion of example 3 as a sample. The population sample (81 total) was 13.58% less than 25 years old, 62.96% between 25 and 35 years old, 14.81% between 35 and 45 years old, and 8.64% more than 45 years old.

The evaluation results show that: compared with a plurality of products sold on the market, the lotion product has the highest satisfaction degree of fragrance.

The lotion evaluates the irritation feeling of the private parts, namely the mild irritation feeling accounts for 96.3, the slight irritation feeling accounts for 3.7 percent, and the strong irritation feeling accounts for 0 percent.

The evaluation of the washing performance of the washing liquid, especially, the ratio of easy washing was 23.46%, the ratio of easy washing was 74.07%, and the ratio of difficult washing was 2.47%.

After washing with lotion, the efficacy and feeling evaluation shows that the private part dryness relieving ratio is 12.35%, the private part sensitivity is reduced by 7.41%, the private part lubrication feeling ratio is increased by 11.11%, the private part inside and outside cleaning and nursing ratio 86.42%, the private part pruritus relieving ratio, the peculiar smell relieving ratio is 25.93%, and the cleaning and bacteriostasis ratio is 49.38%.

The satisfaction degree of the trial evaluation of the lotion of the invention is higher overall.

The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (14)

1. An antibacterial composition is characterized by comprising, by mass, 0.01-0.05:0.01-0.05:0.001-0.1:0.05-0.1:0.005-0.1 of tea tree essential oil, grapefruit essential oil, bergamot essential oil, inulin and alpha-glucan oligosaccharide, wherein the bacteriostasis refers to inhibition of candida albicans, escherichia coli and/or staphylococcus aureus.

2. The bacteriostatic composition according to claim 1, wherein the mass ratio of the tea tree essential oil, the grapefruit essential oil, the bergamot essential oil, the inulin and the alpha-glucan oligosaccharide is 0.025:0.025:0.01:0.07:0.015.

3. use of a bacteriostatic composition according to claim 1 or 2 in the preparation of a bacteriostatic product for inhibiting candida albicans, escherichia coli and/or staphylococcus aureus.

4. A bacteriostatic low-foaming lotion for natural women, which is characterized in that the bacteriostatic composition of claim 1 or 2 is used as a bacteriostatic component, and the bacteriostatic component is used for inhibiting Candida albicans, escherichia coli and/or Staphylococcus aureus.

5. The washing lotion according to claim 4, wherein the formulation is as follows, in terms of mass ratio:

phase A: water and sodium benzoate 0.2-0.6% for making up the 100% of the full formula;

phase B: 0.5 to 1.5 percent of xanthan gum;

and C phase: 0.05-0.1% of zwitterionic surfactant, 0.02-0.06% of anionic surfactant, 0.02-0.05% of nonionic surfactant and 0.05-0.1% of weak anionic surfactant;

phase D: tea tree essential oil 0.01-0.05%, grapefruit essential oil 0.01-0.05%, bergamot essential oil 0.005-0.02%, solubilizing emulsifier 0.4-0.6%, phenoxyethanol 0.1-0.2%, and ethylhexyl glycerin 0.1-0.2%;

phase E: inulin 0.05-0.1%, alpha-glucan oligosaccharide 0.01-0.02%;

and (3) phase F: 0.05 to 0.2 percent of pH regulator;

in addition, 3-8% of propylene glycol is contained, and the propylene glycol is divided into two parts according to the mass ratio of 3-5:1 to be respectively used as one raw material in the B phase and the D phase.

6. The washing lotion according to claim 5, wherein the formulation is as follows, in terms of mass ratio:

phase A: water and sodium benzoate 0.4% for making up 100% of the full formula;

phase B: 1% of xanthan gum;

and C phase: 0.075% of zwitterionic surfactant, 0.04% of anionic surfactant, 0.035% of nonionic surfactant and 0.075% of weak anionic surfactant;

phase D: tea tree essential oil 0.025%, grapefruit essential oil 0.025%, bergamot essential oil 0.01%, solubilizing emulsifier 0.5%, phenoxyethanol 0.15%, and ethylhexyl glycerin 0.15%;

e phase: inulin 0.07%, alpha-glucan oligosaccharide 0.015%;

and (3) phase F: 0.1 percent of pH regulator;

and also contains 5 percent of propylene glycol, and is divided into two parts according to the mass ratio of 4:1 as a B phase and a D phase respectively.

7. A lotion according to claim 5 or 6, characterized in that the zwitterionic surfactant is cocamidopropyl betaine.

8. A lotion according to claim 5 or 6, characterized in that the anionic surfactant is sodium lauryl glucarate.

9. The lotion according to claim 5 or 6, wherein the nonionic surfactant is lauryl glucoside.

10. A lotion according to claim 5 or 6, characterized in that the weak anionic surfactant is disodium cocoyl glutamate.

11. A washing solution according to claim 5 or 6, wherein the solubilizing emulsifier is present in a mass ratio of 0.1 to 2:0.1-2 parts of PPG-26-Butanethol-26 and PEG-40 hydrogenated castor oil.

12. The washing solution according to claim 5 or 6, wherein the pH adjusting agent is citric acid and the water is deionized water.

13. The washing lotion according to claim 5 or 6, characterized by being prepared by the following process:

s1, accurately weighing phase A water, adding sodium benzoate, stirring and heating, and heating to 85-90 ℃; adding premixed phase B, keeping the temperature for 10-20min, and cooling to 55-65 ℃;

s2, adding the phase C raw materials, keeping the temperature, stirring uniformly, and continuously cooling to 45-48 ℃;

s3, adding the premixed phase D to the transparent phase D, and uniformly stirring the mixture under the condition of heat preservation; adding the phase E raw material, and uniformly stirring;

s4, adjusting the pH value to 4.5-6.5 by using the phase F to obtain a uniform, transparent and semitransparent gelatinous product.

14. The washing lotion according to claim 13, wherein the washing lotion is prepared by the following process:

s1, accurately weighing phase A water, adding sodium benzoate, stirring and heating, and heating to 85 ℃; adding premixed phase B, keeping the temperature for 15min, and cooling to 60 ℃;

s2, adding the phase C raw materials, keeping the temperature, stirring uniformly, and continuously cooling to 45 ℃;

s3, adding the premixed phase D to the transparent phase D, and uniformly stirring the mixture under the condition of heat preservation; adding the phase E raw material, and uniformly stirring;

and S4, adjusting the pH value to 5.5 by using the phase F to obtain a uniform, transparent and semitransparent gel product.