CN116077423B - Female private care gel and preparation method and application thereof - Google Patents
Female private care gel and preparation method and application thereof Download PDFInfo
- Publication number
- CN116077423B CN116077423B CN202310106375.5A CN202310106375A CN116077423B CN 116077423 B CN116077423 B CN 116077423B CN 202310106375 A CN202310106375 A CN 202310106375A CN 116077423 B CN116077423 B CN 116077423B
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- Prior art keywords
- ceramide
- parts
- care gel
- feminine
- gel
- Prior art date
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- 239000000047 product Substances 0.000 claims description 56
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 39
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 39
- 229940106189 ceramide Drugs 0.000 claims description 39
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 39
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 39
- 239000000284 extract Substances 0.000 claims description 26
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Classifications
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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Abstract
The invention provides a female private care gel and a preparation method and application thereof. The female private care gel has a good anti-infection effect and a good inhibition effect on various dermatophytes through the synergistic effect of polydeoxyribonucleotide, a probiotic fermentation product and a plant extract; the chitosan and chitosan are adopted as the preparation materials of the gel, so that the biocompatibility and swelling property of the gel can be effectively improved, and meanwhile, the comfort level of use is improved, so that the gel has good synergistic antibacterial effect, good sterilizing and itching relieving effects are achieved, and the use effect is further improved. In addition, the preparation method of the female private care gel is simple and easy to operate, and has excellent practicability.
Description
Technical Field
The invention belongs to the field of female private care products, and particularly relates to female private care gel and a preparation method and application thereof.
Background
At present, the working and living pressures of people are larger and larger, the living work and the rest are extremely irregular, the biological clock is disturbed, the body resistance is reduced, the immunity of private parts is continuously reduced, harmful bacteria enter in the deficiency, various gynecological inflammations are caused, and even if people pay attention to personal hygiene at ordinary times, the poor resistance still can induce the inflammations. The vagina of a female is an open cavity, is communicated with the outside, is an important microecological area of the female, and is the weakest part of the body, so that the female needs careful care.
At present, most of the problems of female private parts are pruritus vulvae, excessive leucorrhea, dry vagina and vaginal relaxation. Common gynecological inflammations include vulvitis, colpitis, cervicitis and pelvic inflammation, which are mostly caused by bacterial or fungal infection, which can cause vaginal secretion to increase, and symptoms such as itching, pain, odor and the like, and a series of complications are serious. Therefore, health care of women, especially the care and cleaning of female pudendum, is increasingly being appreciated by modern women.
In order to solve the health problem of female vagina parts, a plurality of private care products can be purchased in the market, however, most of the private care products are synthesized by using chemical components, the components can generate stronger stimulation to vagina mucosa parts, and further can destroy vaginal flora balance, especially the weak acidic environment maintained by lactobacillus, so that gynecological verification problems are easy to repeatedly occur, and the effects of the products on vaginal dryness, vaginal relaxation and other problems are not obvious. Therefore, developing a female private care gel which has excellent antibacterial, moisturizing and tightening effects, does not destroy the growth of beneficial bacteria lactobacillus in the vagina and is mild and non-irritating is one of the problems to be solved in the field.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a female private care gel and a preparation method and application thereof.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
In a first aspect, the invention provides a female privacy care gel, wherein the raw materials for preparing the female privacy care gel comprise polydeoxyribonucleotide, a probiotic fermentation product, chitosan, plant extracts, silver ions, totarol and a thickener.
The Polydeoxyribonucleotide (PDRN) in the female private care gel provided by the invention is taken as an important genetic material of organisms, is a nucleic acid which is known to be the most similar to human DNA at present, and can activate the cell DNA activity, regulate the cell immunity, inhibit inflammation and promote inflammation repair; the probiotic fermentation product is matched with silver ions and the totarol, so that excessive reproduction of staphylococcus aureus, pseudomonas aeruginosa, candida albicans and escherichia coli can be effectively reduced, the balance of beneficial bacteria groups is improved, and the private immune function is improved; the plant extract contains a large amount of bioactive components, has a good anti-infection effect and has a good inhibition effect on various dermatophytes; the chitosan and chitosan are used as the preparation materials of the hydrogel, so that the biocompatibility and swelling property of the gel can be effectively improved, and meanwhile, the comfort level of use is improved, so that the hydrogel has good synergistic sterilization effect, good sterilization and itching relieving effects are achieved, and the use effect is further improved.
Preferably, the preparation raw materials of the female private care gel comprise, by weight, 2-8 parts of polydeoxyribonucleotide, 1-10 parts of a probiotic fermentation product, 0.1-2 parts of chitosan, 1-5 parts of a plant extract, 0.001-0.01 part of silver ion, 0.1-1 part of stratoside and 0.1-1 part of a thickener.
Wherein, the weight portion of the polydeoxyribonucleotide can be 2 portions, 3 portions, 4 portions, 5 portions, 6 portions, 7 portions or 8 portions, etc.;
the weight parts of the probiotic fermentation product can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts, etc.;
The weight portion of the chitosan can be 0.2 part, 0.4 part, 0.6 part, 0.8 part, 1 part, 1.2 part, 1.5 part, 1.7 part or 1.9 part, etc.;
the chitosan may be 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.7 parts, 1.9 parts, etc.;
the plant extract may be 1.5 parts, 2.0 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, etc.;
The silver ion may be 0.002 parts, 0.004 parts, 0.005 parts, 0.006 parts, 0.008 parts, 0.009 parts, etc.;
The weight parts of the tourbillon can be 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part or 0.9 part and the like;
The weight portion of the thickener may be 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8 or 0.9, etc.
Preferably, the probiotic fermented product comprises lactobacillus/soy milk fermented product filtrate and/or lactobacillus/mung bean seed extract/sodium glutamate fermented product filtrate.
Preferably, the probiotic fermented product is a combination of lactobacillus/soy milk fermented product filtrate and lactobacillus/mung bean seed extract/sodium glutamate fermented product filtrate.
Preferably, the mass ratio of the lactobacillus/soybean milk fermentation product filtrate to the lactobacillus/mung bean seed extract/sodium glutamate fermentation product filtrate is (1-3): 0.5-2.
Wherein, the first "1-3" can be 1.2, 1.5, 1.8, 2, 2.2, 2.5 or 2.8, etc.;
The second "0.5-2" may be 0.6, 0.8, 1, 1.2, 1.4, 1.6, 1.8, 2, etc.
In the invention, when the probiotics fermentation products are lactobacillus/soybean milk fermentation product filtrate and lactobacillus/mung bean (PHASEOLUS RADIATUS) seed extract/sodium glutamate fermentation product filtrate, on one hand, the probiotics fermentation products contain polypeptide compounds with bacteriostasis such as lactobacillus, and the like, and can effectively inhibit propagation and growth of staphylococcus aureus, candida albicans, escherichia coli, and the like; on the other hand, the anti-inflammatory agent can be adhered to epidermal cells to form a protective barrier for skin, protect the skin from being attacked by external environment, and further facilitate the regulation of immune system and relieve skin inflammation.
Preferably, the plant extract comprises any one or a combination of at least two of gentian root extract, baical skullcap root extract, wild chrysanthemum flower extract, honeysuckle flower extract, purslane extract, asiatic centella root extract, hydrolyzed procyanidine and supercritical magnolia flower essential oil.
Preferably, the plant extract is a combination of gentian extract, purslane extract, hydrolyzed procyanidins and supercritical magnolia essential oil.
Preferably, the mass ratio of the gentian root extract to the purslane extract to the hydrolyzed procyanidine to the supercritical magnolia flower essential oil is (1-3): 2-4): 0.1-1): 1-2.
Wherein, "1-3" may be 1.2, 1.5, 1.8, 2, 2.2, 2.5, 2.8, or the like;
"2-4" may be 2.2, 2.5, 2.8, 3, 3.2, 3.5, 3.8, etc.;
"0.1-1" may be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, etc.;
"1-2" may be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, etc.
As a preferable technical scheme of the invention, the active ingredients of the gentian extract, the purslane extract, the hydrolyzed procyanidine and the supercritical magnolia essential oil have good antibacterial and anti-inflammatory effects, and the long-acting antibacterial and anti-inflammatory properties of the plant extract can be greatly improved under a specific mass ratio, so that the immunity defense capacity of vagina is enhanced.
Preferably, the thickener comprises an ammonium acryloyldimethyl taurate/VP copolymer.
Preferably, the raw materials for preparing the female private care gel further comprise any one or a combination of at least two of a humectant, an active polypeptide or a compound ceramide.
Preferably, the preparation raw materials of the female private care gel further comprise 1-5 parts of humectant, for example, 1.5 parts, 2.0 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts or 4.5 parts, etc. by weight.
Preferably, the preparation raw materials of the female private care gel further comprise 1-3 parts of active polypeptide, for example, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts or 2.8 parts, etc. by weight.
Preferably, the preparation raw materials of the female private care gel further comprise 1-3 parts of compound ceramide, for example, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts or 2.8 parts, etc. by weight.
The humectant comprises any one or a combination of at least two of sodium hyaluronate, hydrolyzed sodium hyaluronate and acetylated sodium hyaluronate.
Preferably, the active polypeptide comprises any one or a combination of at least two of acetyl hexapeptide-8, palmitoyl tripeptide-1, palmitoyl pentapeptide-4, hexapeptide-9.
Preferably, the compound ceramide comprises any one or a combination of at least two of ceramide NS/ceramide NG, ceramide NP, ceramide EOP, ceramide AS and ceramide AP.
Preferably, the complex ceramide is a combination of ceramide NS/ceramide NG, ceramide NP, and ceramide EOP.
Preferably, the mass ratio of the ceramide NS/ceramide NG, the ceramide NP and the ceramide EOP is (1-2): 0.1-1): 0.5-2.
Wherein "1-2" may be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, etc.;
"0.1-1" may be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, etc.;
"0.5-2" may be 0.7, 0.9, 1, 1.2, 1.4, 1.6, 1.8, etc.
According to the nursing gel disclosed by the invention, the skin affinity of the gel can be well improved and the protective film can be well formed by adding the compound ceramide, and the compound ceramide is matched with the ceramide NS/ceramide NG, the ceramide NP and the ceramide EOP in a specific proportion, so that the barrier function of the vagina of a female can be more effectively enhanced, the deep moisturizing effect is achieved, and the using feel of the gel can be well improved.
Other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
In a second aspect, the invention provides a method for preparing the female care gel according to the first aspect, which comprises dissolving and homogenizing polydeoxyribonucleotide, a probiotic fermented product, chitosan, plant extract and a thickener in deionized water to obtain the female care gel.
Preferably, the preparation method comprises the following steps:
(1) Heating deionized water to 80-85 ℃, then adding a thickening agent, stirring, and uniformly stirring the humectant;
(2) And (3) cooling to below 40 ℃, sequentially adding polydeoxyribonucleotide, a probiotic fermentation product, a plant extract, chitosan, active polypeptide and compound ceramide, and uniformly stirring to obtain the female private care gel.
In a third aspect, the present invention provides the use of a feminine care gel as described in the first aspect for the preparation of a feminine care product.
Compared with the prior art, the invention has the following beneficial effects:
the Polydeoxyribonucleotide (PDRN) in the female private care gel provided by the invention is taken as an important genetic material of organisms, is a nucleic acid which is known to be the most similar to human DNA at present, and can activate the cell DNA activity, regulate the cell immunity, inhibit inflammation and promote inflammation repair; the probiotic fermentation product is matched with silver ions and the totarol, so that the excessive reproduction of staphylococcus aureus, candida albicans and escherichia coli can be effectively reduced, and the private immune function is improved; the plant extract contains a large amount of bioactive components, has a good anti-infection effect and has a good inhibition effect on various dermatophytes; the chitosan and chitosan are adopted as the preparation materials of the gel, so that the biocompatibility and swelling property of the gel can be effectively improved, and meanwhile, the comfort level of use is improved, so that the gel has good synergistic antibacterial effect, good sterilizing and itching relieving effects are achieved, and the use effect is further improved.
Detailed Description
In order to further describe the technical means adopted by the present invention and the effects thereof, the following describes the technical scheme of the present invention in combination with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.
The following examples and comparative examples relate to the following partial materials and brand information:
The remaining materials can be used as long as they are purchased from a regular dealer.
Example 1
The embodiment provides a female private care gel, which is prepared from 5 parts of polydeoxyribonucleotide, 4 parts of lactobacillus/soybean milk fermentation product filtrate, 1.5 parts of lactobacillus/mung bean seed extract/sodium glutamate fermentation product filtrate, 1 part of chitosan, 3 parts of plant extract, 0.005 part of silver ion, 0.8 part of peach tourbillon, 3 parts of sodium hyaluronate, 0.6 part of acrylamide-dimethyl taurate/VP copolymer, 1.5 parts of acetyl hexapeptide-8, 2 parts of compound ceramide and 100 parts of supplementary deionized water;
Wherein the plant extracts are the combination of gentian root extract, purslane extract, hydrolyzed procyanidine and supercritical magnolia flower essential oil in a mass ratio of 2:3:1:1;
The compound ceramide is a combination of ceramide NS/ceramide NG, ceramide NP and ceramide EOP with the mass ratio of 3:1:2.
The preparation method of the female private care gel comprises the following steps:
(1) Heating deionized water to 83 ℃, adding a thickening agent, stirring, and uniformly stirring the humectant;
(2) Cooling to 38 ℃, sequentially adding polydeoxyribonucleotide, a probiotic fermentation product, a plant extract, chitosan, active polypeptide and compound ceramide, and uniformly stirring to obtain the female private care gel.
Example 2
The embodiment provides a female private care gel, which is prepared from 7 parts of polydeoxyribonucleotide, 1 part of lactobacillus/soybean milk fermentation product filtrate, 2 parts of lactobacillus/mung bean seed extract/sodium glutamate fermentation product filtrate, 0.5 part of chitosan, 1.5 parts of chitosan, 5 parts of plant extract, 0.003 part of silver ion, 0.5 part of peach tourbillon, 1 part of acetylated sodium hyaluronate, 0.6 part of acrylamide/VP copolymer, 3 parts of palmitoyl tripeptide-1 1 parts of compound ceramide and 100 parts of supplementary deionized water;
Wherein the plant extracts are the combination of gentian root extract, purslane extract, hydrolyzed procyanidine and supercritical magnolia flower essential oil in a mass ratio of 3:2:0.5:2;
the compound ceramide is a combination of ceramide NS/ceramide NG, ceramide NP and ceramide EOP with the mass ratio of 2:1:2.
The preparation method of the female privacy care gel is described with reference to example 1.
Example 3
The embodiment provides a female private care gel, which is prepared from 3 parts of polydeoxyribonucleotide, 6 parts of lactobacillus/soybean milk fermentation product filtrate, 1 part of lactobacillus/mung bean seed extract/sodium glutamate fermentation product filtrate, 1.5 parts of chitosan, 0.5 part of chitosan, 2 parts of plant extract, 0.008 part of silver ion, 1 part of peach tourbillon, 5 parts of hydrolyzed sodium hyaluronate, 0.8 part of beta-cyclodextrin, 1.5 parts of hexapeptide-9 2 parts of compound ceramide and 100 parts of supplementary deionized water;
Wherein the plant extracts are the combination of gentian root extract, purslane extract, hydrolyzed procyanidine and supercritical magnolia essential oil in a mass ratio of 1:4:0.8:1.5;
The compound ceramide is a combination of ceramide NS/ceramide NG, ceramide NP and ceramide EOP with the mass ratio of 1:0.3:1.8.
The preparation method of the female privacy care gel is described with reference to example 1.
Example 4
This example provides a feminine care gel which differs from example 1 only in that the probiotic fermented product is only lactobacillus/mung bean seed extract/sodium glutamate fermented product filtrate, and the amounts of the probiotic fermented product added remain unchanged, the remaining components and amounts of addition are the same as in example 1, the preparation method being as described in example 1.
Example 5
This example provides a feminine care gel that differs from example 1 only in that the probiotic fermented product is only lactobacillus/soy milk fermented product filtrate, and the amounts of probiotic fermented product added remain unchanged, the remaining components and amounts of added are identical to example 1, the preparation method being as described in example 1.
Example 6
The present example provides a female private care gel, which is different from example 1 only in that the plant extracts are a combination of gentian extract, purslane extract and hydrolyzed procyanidine in a mass ratio of 2:3:1, and the addition amount of the plant extracts is kept unchanged, and the rest components and addition amounts are the same as those of example 1, and the preparation method refers to example 1.
Example 7
The present example provides a female private care gel, which is different from example 1 only in that the mass ratio of the plant extracts is a combination of gentian root extract, purslane extract and supercritical magnolia flower essential oil in a mass ratio of 2:3:1, and the addition amount of the plant extracts is kept unchanged, and the other components and addition amounts are the same as those of example 1, and the preparation method refers to example 1.
Example 8
The present example provides a female private care gel, which is different from example 1 only in that the plant extract is a combination of gentian root extract, hydrolyzed procyanidine and supercritical magnolia essential oil in a mass ratio of 2:1:1, and the addition amount of the plant extract is kept unchanged, and the other components and addition amounts are the same as those of example 1, and the preparation method refers to example 1.
Example 9
The present example provides a female private care gel, which is different from example 1 only in that the plant extract is a combination of purslane extract, hydrolyzed procyanidine and supercritical magnolia essential oil in a mass ratio of 3:1:1, and the addition amount of the plant extract is kept unchanged, and the other components and addition amounts are the same as those of example 1, and the preparation method refers to example 1.
Example 10
This example provides a feminine care gel that differs from example 1 only in that no complex ceramide is included, and the remaining components and amounts added are consistent with example 1, with the preparation method being referred to example 1.
Example 11
This example provides a feminine care gel differing from example 1 only in that the composite ceramide is a combination of ceramide NS/ceramide NG and ceramide NP in a mass ratio of 3:1, and the addition amount of the composite ceramide is kept unchanged, and the remaining components and addition amounts are the same as those of example 1, and the preparation method is referred to example 1.
Example 12
This example provides a feminine care gel differing from example 1 only in that the composite ceramide is a combination of ceramide NS/ceramide NG and ceramide EOP in a mass ratio of 3:2, and the addition amount of the composite ceramide is kept unchanged, and the remaining components and addition amounts are the same as those of example 1, and the preparation method is referred to example 1.
Example 13
This example provides a feminine care gel differing from example 1 only in that the composite ceramide is a combination of ceramide NP and ceramide EOP in a mass ratio of 1:2, and the addition amount of the composite ceramide is kept unchanged, and the remaining components and addition amounts are the same as those of example 1, and the preparation method is referred to example 1.
Comparative example 1
This comparative example provides a feminine care gel that differs from example 1 only in that the probiotic fermented product is excluded, the remaining components and the amounts added are in accordance with example 1, the preparation method being referred to example 1.
Comparative example 2
This comparative example provides a feminine care gel that differs from example 1 only in that polydeoxyribonucleotides are not included, and the remaining components and amounts added are consistent with example 1, the preparation method being referred to example 1.
Comparative example 3
This comparative example provides a feminine care gel differing from example 1 only in that no plant extract is included, the remaining components and amounts added are in accordance with example 1, and the method of preparation is referenced in example 1.
Test example 1
The female private care gels prepared in examples 1-10 and comparative examples 1-3 were subjected to a 24-hour bacteriostasis test to characterize the inhibition of pathogenic bacteria at the private parts by each product. The test method is specifically referred to in the specification of disinfection technology (2002 edition). The results are shown in Table 1.
TABLE 1
Sample of | Coli bacterium | Pseudomonas aeruginosa | Staphylococcus aureus | Candida albicans |
Example 1 | >99% | >99% | >99% | >99% |
Example 2 | >99% | >99% | >99% | >99% |
Example 3 | >99% | >99% | >99% | >99% |
Example 4 | 95% | 93% | 92% | 94% |
Example 5 | 95% | 94% | 94% | 92% |
Example 6 | 93% | 95% | 91% | 93% |
Example 7 | 94% | 91% | 95% | 91% |
Example 8 | 92% | 92% | 91% | 90% |
Example 9 | 93% | 95% | 94% | 89% |
Example 10 | 95% | 96% | 93% | 94% |
Comparative example 1 | 78% | 80% | 72% | 65% |
Comparative example 2 | 85% | 89% | 78% | 76% |
Comparative example 3 | 80% | 83% | 76% | 68% |
As can be seen from Table 1, the female privacy care gels obtained in examples 1-3 have higher inhibition rates against E.coli, pseudomonas aeruginosa, staphylococcus aureus, candida albicans, and in examples 4-9, the inhibition rate of the gel is reduced when the probiotic fermented product or the plant extract is not the combination selected in the present invention; from comparative examples 1 to 3, it is known that polydeoxyribonucleotide, a probiotic fermented product and a plant extract have a synergistic effect in bacteriostasis, and that the effect of inhibiting harmful bacteria of the gel is reduced when any one of the above three components is not added to the gel for female privacy care.
Test example 2
Coli, lactobacillus plantarum and lactobacillus acidophilus were inoculated into an agar nutrient medium containing 5% of the female privacy care gel prepared in examples 1 to 5, 10 to 13 and comparative examples 1 to 3 (the formulation of which is referred to the "sterilization technical Specification" (2002 edition)) at a viable count ratio of 1:1:1, and after culturing for 24 hours according to a standard method, the colony count of each bacterial population was counted. The physical condition of the private colony under the condition of patient administration is simulated by co-culturing resident bacteria at the private and pathogenic bacteria causing the destruction of microecological balance in the same environment, and the pharmacological actions of the female private care gel on up-regulating resident bacteria and down-regulating pathogenic bacteria are illustrated by the change of abundance of different bacteria. The results are shown in Table 2.
As can be seen from table 2, the female private care gel of the invention is more conducive to the growth of resident bacteria, and has good inhibitory effect on pathogenic bacteria; wherein the selection of the type of the probiotic fermentation product and the compound ceramide has an influence on the growth of resident bacteria.
Test example 3:
The female private care gels of the above examples 1 to 3, 10 and comparative examples 1 to 3 were subjected to trial evaluation, and any gynecological cleansing product (cosmetic or external medicine or oral health care product) could not be used during the trial period, and the use effects were as follows: each trial group number is 15, and after 15 days of continuous use, the cleaning effect, the moistening degree and the itching relieving effect are evaluated, and the evaluation results are shown in table 3.
TABLE 3 Table 3
As can be seen from the data in table 3: as can be seen from comparative examples 1 and 10, the female private care gel according to the present invention has excellent cleansing, moisturizing and antipruritic effects, and the moisturizing effect of the gel is poor when the composite ceramide is absent; in comparative example 1 and comparative examples 1-4, the moisturizing and antipruritic properties of the products of the present invention are negatively affected by the lack of any of the three components of the probiotic fermented product, polydeoxyribonucleotide, and plant extract in the feminine care gel.
The applicant states that the present invention is illustrated by the above examples as well as methods of making and using the same, but the invention is not limited to, i.e., does not necessarily rely on, the above examples to practice the invention. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.
The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the scope of the technical concept of the present invention, and all the simple modifications belong to the protection scope of the present invention.
In addition, the specific features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described further.
Claims (13)
1. The female private care gel is characterized by comprising, by weight, 2-8 parts of polydeoxyribonucleotide, 1-10 parts of a probiotic fermentation product, 0.1-5 parts of chitosan, 0.1-2 parts of chitosan, 1-5 parts of a plant extract, 0.001-0.01 part of silver ion, 0.1-1 part of peach tourbillon, 0.1-1 part of a thickener and 1-3 parts of composite ceramide;
the probiotic fermentation product is a combination of lactobacillus/soybean milk fermentation product filtrate and lactobacillus/mung bean seed extract/sodium glutamate fermentation product filtrate;
the plant extract is a combination of gentian root extract, purslane extract, hydrolyzed procyanidine and supercritical magnolia flower essential oil;
the compound ceramide is a combination of ceramide NS/ceramide NG, ceramide NP and ceramide EOP.
2. The feminine care gel as set forth in claim 1, wherein the mass ratio of lactobacillus/soybean milk fermentation product filtrate to lactobacillus/mung bean seed extract/sodium glutamate fermentation product filtrate is (1-3): 0.5-2.
3. The female privacy care gel of claim 1, wherein the mass ratio of gentian extract, purslane extract, hydrolyzed procyanidins, and supercritical magnolia essential oil is (1-3): 2-4): 0.1-1): 1-2.
4. The feminine care gel as set forth in claim 1, wherein said thickening agent comprises an ammonium acryloyldimethyl taurate/VP copolymer or β -cyclodextrin.
5. The feminine private care gel as set forth in claim 1, wherein said feminine private care gel is prepared from a material further comprising a humectant and/or an active polypeptide.
6. The feminine private care gel as set forth in claim 5, wherein said feminine private care gel is prepared from said humectant in an amount of 1 to 5 parts by weight.
7. The feminine private care gel as set forth in claim 5, wherein said feminine private care gel is prepared from said raw materials further including, in parts by weight, 1-3 parts of active polypeptide.
8. The feminine private care gel as set forth in claim 5, wherein said humectant comprises any one or a combination of at least two of sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate.
9. The feminine private care gel as set forth in claim 5, wherein said active polypeptide comprises any one or a combination of at least two of acetyl hexapeptide-8, palmitoyl tripeptide-1, palmitoyl pentapeptide-4, hexapeptide-9.
10. The feminine care gel as set forth in claim 1 wherein said ceramide NS/ceramide NG, ceramide NP, and ceramide EOP have a mass ratio of (1-2): 0.1-1): 0.5-2.
11. The method for preparing a feminine care gel as set forth in claim 1, wherein the method comprises dissolving polydeoxyribonucleotide, a probiotic fermented product, chitosan, plant extract, silver ion, totarol, thickener, compound ceramide in deionized water and homogenizing to obtain the feminine care gel.
12. The method of preparing a feminine care gel as set forth in claim 5, wherein said method of preparing comprises:
(1) Heating deionized water to 80-85 ℃, then adding a thickening agent, stirring, and uniformly stirring the humectant;
(2) And (3) cooling to below 40 ℃, sequentially adding polydeoxyribonucleotide, a probiotic fermentation product, a plant extract, chitosan, active polypeptide, compound ceramide, silver ions and totarone, and uniformly stirring to obtain the female private care gel.
13. Use of a feminine care gel according to any one of claims 1-10 in the preparation of a feminine care product.
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Citations (2)
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EP2745849A1 (en) * | 2012-12-19 | 2014-06-25 | Idea Medical Devices S.r.l. | Polydeoxyribonucleotides composition and uses thereof |
CN110090195A (en) * | 2019-05-08 | 2019-08-06 | 广州睿森生物科技有限公司 | A kind of women secret nursing gel and preparation method thereof |
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EP2745849A1 (en) * | 2012-12-19 | 2014-06-25 | Idea Medical Devices S.r.l. | Polydeoxyribonucleotides composition and uses thereof |
CN110090195A (en) * | 2019-05-08 | 2019-08-06 | 广州睿森生物科技有限公司 | A kind of women secret nursing gel and preparation method thereof |
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