CN100592915C - Ecological vagina cleaning bacteriostasis liquid - Google Patents
Ecological vagina cleaning bacteriostasis liquid Download PDFInfo
- Publication number
- CN100592915C CN100592915C CN200710005695A CN200710005695A CN100592915C CN 100592915 C CN100592915 C CN 100592915C CN 200710005695 A CN200710005695 A CN 200710005695A CN 200710005695 A CN200710005695 A CN 200710005695A CN 100592915 C CN100592915 C CN 100592915C
- Authority
- CN
- China
- Prior art keywords
- liquid
- ecological
- vagina
- lactic acid
- azone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The present invention discloses one kind of ecological vagina cleaning bacteriostasis liquid, each 1000 ml of which contains lactobacillus polysaccharide 4-10 g, grape fruit extract 5-10g, lactic acid10-15 ml, peppermint oil 0.5 ml, cocoanut amide propyl betaine 0.5ml; azone 2-5ml, ethanol solution (95 %) 200-250ml, and essence 1-2ml, except pure water. The present invention can reach the effectsof cleaning surface and permeating to deep part to inhibit germ growth, regulate micro ecologic environment, and treat vulvitis, pudendal pruritus, etc.
Description
Technical field
The present invention relates to a kind of ecological vagina cleaning bacteriostasis liquid.
Background technology
Vaginitis is the inflammation of connective tissue under vaginal mucosa and the mucosa, is the common disease of gynecological's outpatient service.Normal health women, because anatomy and biochemistry characteristics, vagina has the nature defense function to the intrusion of pathogen, when the natural defense function of vagina is destroyed, then pathogen is easy to invade, cause colpitis, the postmenopausal women is owing to estrogen deficiency, and vagina epithelium is poor, the former content of endocellular sugar reduces, vagina PH is up to about 7, and is so vagina is lower for the resistance, easily more infected than the adolescence and the women of child-bearing age.
Vaginitis changes with the character of leucorrhea and the pruritus vulvae causalgia is a cardinal symptom clinically, and common dyspareunia during urinary tract infection, can have symptoms such as dysurea, urgent micturition.Common vaginitis has bacterial vaginitis, trichomonal vaginitis, colpitis mycotica, senile vaginitis.
In recent years, because types of applications is put on market in a large number and is used in the partial antibiotic of vagina, the vagina lavation is improper etc. in addition, and the lactobacillus more than 95% that accounts for all permanent bacterium of intravaginal under the normal condition is destroyed, and causes the intravaginal dysbacteriosis and causes vaginitis.The vaginal microbial flora analysis is found, during the intravaginal dysbacteriosis, the superiority of ability of Lactobacillus in human vagina is often replaced by a large amount of Gardner Salmonellas or Combination anaerobic bacteria flora, particularly anaerobe can increase thousands of times, the quantity of its pathogen can be up to 109 in every gram secretions, thereby cause detesting, the aerobe serious disproportion.
Summary of the invention
The technical issues that need to address of the present invention just are to provide a kind of ecological vagina cleaning bacteriostasis liquid and preparation method thereof.
For addressing the above problem, the present invention adopts following technical scheme:
A kind of ecological vagina cleaning bacteriostasis liquid of the present invention contains in every 1000ml antibacterial liquid: lactobacillus polysaccharide 4-10g; Grapefruit extract 5-10g; Lactic acid 10-15ml; Oleum menthae 0.5ml, cocamido propyl betaine 0.5ml; Azone 2-5ml; Ethanol (95%) 200-250ml; Essence 1-2ml, adding pure water to antibacterial liquid is 1000ml.
Preferably, ecological vagina cleaning bacteriostasis liquid of the present invention contains in every 1000ml antibacterial liquid: lactobacillus polysaccharide 4-6g; Grapefruit extract 5-8g; Lactic acid 10-12ml; Oleum menthae 0.5ml, cocamido propyl betaine 0.5ml; Azone 2-4ml; Ethanol (95%) 200-220ml; Essence 1ml, adding pure water to antibacterial liquid is 1000ml.
Further preferred, ecological vagina cleaning bacteriostasis liquid of the present invention contains in every 1000ml antibacterial liquid: lactobacillus polysaccharide 5g; Grapefruit extract 6g; Lactic acid 11ml; Oleum menthae 0.5ml, cocamido propyl betaine 0.5ml; Azone 3ml; Ethanol (95%) 220ml; Essence 1ml, adding pure water to antibacterial liquid is 1000ml.
Perhaps, another preferred version, ecological vagina cleaning bacteriostasis liquid of the present invention contains in every 1000ml antibacterial liquid: lactobacillus polysaccharide 6-10g; Grapefruit extract 8-10g; Lactic acid 12-15ml; Oleum menthae 0.5ml, cocamido propyl betaine 0.5ml; Azone 4-5ml; Ethanol (95%) 220-250ml; Essence 2ml, adding pure water to antibacterial liquid is 1000ml.
Further preferred, ecological vagina cleaning bacteriostasis liquid of the present invention contains in every 1000ml antibacterial liquid: lactobacillus polysaccharide 8g; Grapefruit extract 9g; Lactic acid 14ml; Oleum menthae 0.5ml, cocamido propyl betaine 0.5ml; Azone 4ml; Ethanol (95%) 240ml; Essence 2ml, adding pure water to antibacterial liquid is 1000ml.
The present invention discloses a kind of method for preparing described ecological vagina cleaning bacteriostasis liquid, the steps include:
1), extracting lactic acid granulose 4-10g, be dissolved in water, regulating pH value with lactic acid 10-15ml is 3-5, filter, filtrate;
2), get grapefruit extract 5-10g, Oleum menthae 0.5ml and essence 1-2ml with 200-250ml ethanol (95%) dissolving emulsifying, add in the filtrate,
3) add cocamido propyl betaine 0.5ml, azone 2-5ml successively, again in filtrate, stir, filter, filtrate adds pure water to 1000ml.
The present invention is mucocutaneous antibacterial disinfecting sprays, and using method is the position that is sprayed on the uncomfortable place of mucocutaneous infections.Every day 1-2 time, in logotype 1-3 week, the bigot uses 1-2 month.Be applicable to antibiotic, antiinflammatory, the detoxifcation, antipruritic of skins such as male and female pudendum, gynecological inflammation, urinary system.Mycete in the woman vagina, Candida albicans, staphylococcus aureus etc. there is good inhibition effect.
Among the present invention, the lactobacillus polysaccharide plays protection in microecological environment, promotes the growth and breeding of probiotics, is the prebiotics (probiotics factor) of probiotics.
Lactic acid is used to regulate the acid-base value of vaginal environment, helps suppressing harmful bacterium, the growth of protection probiotics.
Grapefruit extract is the extract of grapefruit seed, Main Ingredients and Appearance is naringin, limonin and multivitamin A, B, C, E, P, it is a kind of natural sterilization factors, antibacterial action with powerful high-efficiency broad spectrum can effectively kill the Candida albicans that causes various pudendum discomforts and inflammation, staphylococcus aureus, escherichia coli, noxious bacteria brood bodies such as gonococcus, active force is strong, and sterilizing rate reached 99.9% in 3 minutes.Probiotics is not hindered in directed sterilization, keeps the pudendum colony balance, safeguards and reinforcement pudendum self-purification capacity, contains multivitamin simultaneously and can repair impaired mucosa, has features such as natural fruit fragrance.
Vagina is the body cavity of a closure, and its deep does not almost have air, so bacterial parasite is the bacterial strain based on anaerobe or facultative anaerobe, normal intravaginal anaerobe is 2: 1 to 5: 1 with the ratio of aerobe.The superiority of lactobacillus is then replaced by a large amount of Gardnerellas or Combination anaerobic bacteria flora when the intravaginal dysbacteriosis, especially anaerobe can increase thousands of times, pathogen quantity can be up to 109 in every gram vaginal secretions, and anaerobe can reach 100: 1 to 1000: 1 with the ratio of aerobe.Thisly serious detest, the aerobe imbalance is to cause Gardnerella vaginitis and other colpitic main cause.For this reason, it is sterilization factors that the present invention adopts with natural plant grapefruit extract, is equipped with the lactobacillus polysaccharide that helps the probiotics growth, the acid-base value that adopts lactic acid to regulate, cocamido propyl betaine is a foaming agent, and azone is a penetrating agent, and Oleum menthae is a freshener, making this solution reach shallow table cleans, the effect of deep infiltration promptly suppresses the growth of the harmful bacterium of vagina, adjusts micro-ecological bacterial group deficiency disorder, remove abnormal flavour, effectively improve symptoms such as female vulva inflammation, pudendum Pruritus.
The specific embodiment
Embodiment 1
1), extracting lactic acid granulose 8g, be dissolved in water, regulating pH value with lactic acid 10ml is 3-4, filter, filtrate;
2), get grapefruit extract 8g, Oleum menthae 0.5ml and essence 1.5ml with 220ml ethanol (95%) dissolving emulsifying, add in the filtrate,
3) add cocamido propyl betaine 0.5ml, azone 3ml successively, again in filtrate, stir, filter, filtrate adds water to 1000ml.
Prepare the following example by embodiment 1 method:
Embodiment 10
By to the colpitic clinical treatment of 46 routine Gardnerellas, the vagina normal flora of having corrected destroyed preferably makes the Gardnerella vaginitis obtain very fast recovery, now is reported as follows:
Experimental group: 23 people are organized in the vagina cleaning bacteriostasis liquid treatment with embodiment 1 preparation, and the age, the mean age was 27 years old ± 2.52 years old at 24 years old～35 years old.4 diagnostic criterias of writing on " practical obstetrics and gynecology " by Su Yingkuan etc. are diagnosed as Gardnerella vaginitis person, treat from this very day after coming institute to check to determine.Expose vagina with aseptic specula earlier, wash down intravaginal secretions, the aseptic cotton balls examination of reuse solid carbon dioxide branch with eliminating cold for resuscitation water.Get two of the prior cotton balls that in the antibacterial liquid of the embodiment of the invention 1 preparation, soaks into the aseptic son of taking the photograph, preparation is coated on the vaginal wall, the appropriateness massage, every day 2-3 time, and will be with the preparation cotton balls to remain in intravaginal, 10 days is a course of treatment.
Matched group: 23 people are organized in the metronidazole treatment, 25 years old～35 years old age, 28 years old ± 1.6 years old mean age, go up diagnostic criteria by " practical obstetrics and gynecology " and be diagnosed as Gardnerella vaginitis person, after the same method cleaning treatment, metronidazole 200mg is put in intravaginal, every day three times, logotype 10 days (Gardnerella is all responsive to sulfanilamide, tetracycline, metronidazole).
The patient that goes to a doctor then is divided into two groups sequentially once making a definite diagnosis, and respectively with two kinds of methods treatments, and does following project and observes; Observe the characteristics of leucorrhea; Measure the vagina pH value; The test of vaginal secretions ammonium; With wet sheet and Gram two method line inspection funicular cells; Finish the back respectively at the 10th day, 40 days, 90 days, 180 days check patients in the course of treatment, observe above-mentioned every situation.
Curative effect is judged:
The criterion of cure vaginal secretions is normal, and abnormal smells from the patient disappears, pH＜4.5, and vaginal secretions is poly-not in heaps, and sign disappears, Gram's staining microscopy no trace cell, the darker G+ lactobacillus that dyes increases.
Improvement standard vaginal secretions reduces, and abnormal smells from the patient alleviates, and clues cell be can not find out under the blended wet sheet mirror of vaginal secretions and normal saline in pH4.5～5.0, can see a small amount of G+ lactobacillus on the Gram's staining sheet.
Invalid standard secretions is not seen minimizing even increases that rancid or fishlike smell does not disappear, and inspection can be seen typical milk sample secretions under the sight glass, pH＞5.0, and wet sheet still can be seen a large amount of clues cells, and positive sign does not disappear.
Table 1 46 routine patients judge with the curative effect of two kinds of method treatment back different times respectively
Last table result shows, matched group and the microbial vaginitis of experimental group treatment Gardner, after medication preceding 10 days, two method cure rates are 100%, after 30 days, the former 91%, the latter still is 100%, 3 months to six months cure rate and matched group significant difference is arranged, the embodiment of the invention 1 treatment group obviously is better than metronidazole treatment group.
In recent years, because types of applications is put on market in a large number and is used in the partial antibiotic of vagina, the vagina lavation is improper etc. in addition, and the lactobacillus more than 95% that accounts for all permanent bacterium of intravaginal under the normal condition is destroyed, and causes the intravaginal dysbacteriosis and causes vaginitis.The vaginal microbial flora analysis is found, during the intravaginal dysbacteriosis, the superiority of ability of Lactobacillus in human vagina is often replaced by a large amount of Gardner Salmonellas or Combination anaerobic bacteria flora, particularly anaerobe can increase thousands of times, the quantity of its pathogen can be up to 109 in every gram secretions, thereby cause detesting, the aerobe serious disproportion.According to this analysis result, we adopt the ecological vagina cleaning bacteriostasis liquid preparation of the embodiment of the invention 1 preparation to adjust and recover intravaginal normal flora.By colpitic treatment proves to 46 routine Gardnerellas with the ecological vagina cleaning bacteriostasis liquid preparation of the embodiment of the invention 1 preparation and two kinds of methods of metronidazole, two kinds of methods all have therapeutical effect to the Gardnerella vaginitis, though the oral and local use of metronidazole has certain effect in the colpitic treatment of Gardnerella, but the growth that this has also just suppressed pathogenic bacterium does not make normal dominant bacteria-lactobacillus rebuild in vagina.Thereby also have recurrence about 20% (because of the recurrence of bacterial vaginitis is not to infect again, but recurrence) after the treatment.Moreover oral metronidazole often causes gastrointestinal reaction, and trimester of pregnancy can not use etc., so be not ideal medicine.The ecological agent of the embodiment of the invention 1 preparation is the normal bacterium in the healthy women vagina, and it as the active bacteria formulation of ecosystem cure, can make the flora of lacking of proper care in the vagina rebuild in treatment Gardnerella vaginitis.Moreover the colpitic genesis mechanism of Gardnerella be since in the microorganism of imbalance the ratio of anaerobe substantially exceed aerobe, the intervention of antibacterial in the embodiment of the invention 1 ecological agent, can change this ratio widely, make it can see obvious effects in a short period of time.So, be fundamentally to treat with the embodiment of the invention 1 preparation for treating Gardnerella vaginitis, so long-term efficacy is remarkable than metronidazole, and there are not side effects of pharmaceutical drugs, can diseases prevention control infection, have certain function of health care again, very big application value is arranged.
The present invention is not limited to above-mentioned preferred forms, and other any identical with the present invention or akin products that anyone draws under enlightenment of the present invention all drop within protection scope of the present invention.
Claims (6)
1, a kind of ecological vagina cleaning bacteriostasis liquid is characterized in that containing in every 1000ml antibacterial liquid: lactobacillus polysaccharide 4-10g; Grapefruit extract 5-10g; Lactic acid 10-15ml; Oleum menthae 0.5ml, cocamido propyl betaine 0.5ml; Azone 2-5ml; Ethanol (95%) 200-250ml; Essence 1-2ml, adding pure water to antibacterial liquid is 1000ml.
2, ecological vagina cleaning bacteriostasis liquid as claimed in claim 1 is characterized in that containing in every 1000ml antibacterial liquid: lactobacillus polysaccharide 4-6g; Grapefruit extract 5-8g; Lactic acid 10-12ml; Oleum menthae 0.5ml, cocamido propyl betaine 0.5ml; Azone 2-4ml; Ethanol (95%) 200-220ml; Essence 1ml, adding pure water to antibacterial liquid is 1000ml.
3, ecological vagina cleaning bacteriostasis liquid as claimed in claim 2 is characterized in that containing in every 1000ml antibacterial liquid: lactobacillus polysaccharide 5g; Grapefruit extract 6g; Lactic acid 11ml; Oleum menthae 0.5ml, cocamido propyl betaine 0.5ml; Azone 3ml; Ethanol (95%) 220ml; Essence 1ml, adding pure water to antibacterial liquid is 1000ml.
4, ecological vagina cleaning bacteriostasis liquid as claimed in claim 1 is characterized in that containing in every 1000ml antibacterial liquid: lactobacillus polysaccharide 6-10g; Grapefruit extract 8-10g; Lactic acid 12-15ml; Oleum menthae 0.5ml, cocamido propyl betaine 0.5ml; Azone 4-5ml; Ethanol (95%) 220-250ml; Essence 2ml, adding pure water to antibacterial liquid is 1000ml.
5, ecological vagina cleaning bacteriostasis liquid as claimed in claim 1 is characterized in that containing in every 1000ml antibacterial liquid: lactobacillus polysaccharide 8g; Grapefruit extract 9g; Lactic acid 14ml; Oleum menthae 0.5ml, cocamido propyl betaine 0.5ml; Azone 4ml; Ethanol (95%) 240ml; Essence 2ml, adding pure water to antibacterial liquid is 1000ml.
6, a kind of method for preparing ecological vagina cleaning bacteriostasis liquid as claimed in claim 1 is characterized in that:
1), extracting lactic acid granulose 4-10g, be dissolved in water, regulating pH value with lactic acid 10-15ml is 3-5, filter, filtrate;
2), get grapefruit extract 5-10g and Oleum menthae 0.5ml, essence 1-2ml with 200-250ml ethanol (95%) dissolving emulsifying, add in the filtrate,
3) add cocamido propyl betaine 0.5ml, azone 2-5ml successively, again in filtrate, stir, filter, filtrate adds pure water to 1000ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710005695A CN100592915C (en) | 2007-03-13 | 2007-03-13 | Ecological vagina cleaning bacteriostasis liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710005695A CN100592915C (en) | 2007-03-13 | 2007-03-13 | Ecological vagina cleaning bacteriostasis liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101019954A CN101019954A (en) | 2007-08-22 |
| CN100592915C true CN100592915C (en) | 2010-03-03 |
Family
ID=38707880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200710005695A Expired - Fee Related CN100592915C (en) | 2007-03-13 | 2007-03-13 | Ecological vagina cleaning bacteriostasis liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100592915C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416926B (en) * | 2008-11-21 | 2011-03-16 | 福建福泽医药器械科技有限公司 | Grapefruit mouth spraying agent and preparation method thereof |
| CN102451152B (en) * | 2010-10-25 | 2012-12-19 | 浙江诗洁生物制药有限公司 | Novel female care solution and its preparation method |
| CN110090195A (en) * | 2019-05-08 | 2019-08-06 | 广州睿森生物科技有限公司 | A kind of women secret nursing gel and preparation method thereof |
| KR102224920B1 (en) * | 2019-07-17 | 2021-03-10 | (주)인벤티지랩 | Cleansing composition for women's vagina comprising natural |
-
2007
- 2007-03-13 CN CN200710005695A patent/CN100592915C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101019954A (en) | 2007-08-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2409368C2 (en) | Composition and method to control and maintain bacterial microflora and acidity of vagina | |
| ES2623382T3 (en) | Vaginal ovule comprising lactic acid | |
| CN1271291A (en) | Pharmaceutical formulation for stimulating the growth of gram-positive bacilli and increasing the acidity in vagina and use thereof | |
| EP3520785A1 (en) | Uses of bacteriostatic agent formula in preparing composition for vaginal use and composition for vaginal use | |
| CN107073019B (en) | Vaginal composition and application thereof | |
| CN110090195A (en) | A kind of women secret nursing gel and preparation method thereof | |
| TW201212935A (en) | Antimicrobial agent | |
| WO2011041938A1 (en) | Composition comprising benzoic acid in combination with organic acid preservatives as active components and use thereof | |
| CN106727849A (en) | A kind of gynecological gel | |
| CN102028705A (en) | Gynecologic article containing biological antifungal components | |
| CN107961399A (en) | A kind of water-based body lotion containing complex antimicrobials | |
| CN100592915C (en) | Ecological vagina cleaning bacteriostasis liquid | |
| CN101797269B (en) | Physiological balance liquid for adjusting microecology in vaginas of women | |
| CN105232526A (en) | Application of medicine containing catechin to preparation of antibacterial medicines | |
| US6964949B2 (en) | Pharmaceutical compositions for promoting the growth of gram-positive bacilli and increasing the acidity in the vagina and the use thereof | |
| AU2018248728A1 (en) | Natural composition for use in gynaecology | |
| Schwartz | Ozone therapy in the treatment of recurrent vulvo-vaginitis by Candida albicans | |
| MX2007011885A (en) | A method for preventing and/or treating vaginal and vulval infections. | |
| CN108125797A (en) | A kind of hand mouth wet tissue and preparation method thereof | |
| CN109464341A (en) | A kind of health care composition | |
| CN107308104A (en) | A kind of preparation method of gynecological gel | |
| CN111632073A (en) | Antibacterial and anti-inflammatory female privates probiotic composition and preparation thereof | |
| CN104941010B (en) | A kind of Medical vagina lubricating fluid and preparation method thereof | |
| CN101530403A (en) | Xylitol compound for curing or preventing female colpitis and cervical erosion | |
| TW201121580A (en) | Vaginal cleaner and manufacture method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Zhengzhou Kin Kin Technology & Trade Co., Ltd. Assignor: Gu Zhenjiang Contract record no.: 2010410000039 Denomination of invention: Ecological vagina cleaning bacteriostasis liquid Granted publication date: 20100303 License type: Exclusive License Open date: 20070822 Record date: 20100427 |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100303 Termination date: 20130313 |