CN101530403A - Xylitol compound for curing or preventing female colpitis and cervical erosion - Google Patents
Xylitol compound for curing or preventing female colpitis and cervical erosion Download PDFInfo
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- CN101530403A CN101530403A CN200810084624A CN200810084624A CN101530403A CN 101530403 A CN101530403 A CN 101530403A CN 200810084624 A CN200810084624 A CN 200810084624A CN 200810084624 A CN200810084624 A CN 200810084624A CN 101530403 A CN101530403 A CN 101530403A
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Abstract
The invention provides a method for preparing compound of xylitol and lactic acid; the solution of the compound can directly wash vagina and cervix. The compound can cure or prevent colpitis and cervical erosion, can rapidly improve the congestion of vagina and cervix, can remove white or yellow purulent secretion, and can remove the inflammation of the vagina and cervix, thus recovering the health of the patient.
Description
Technical field:
The present invention relates to the treatment and the prevention of gynecological infection, particularly the present invention relates to xylitol and lactic acid composition collocation method and the application aspect gynecological infection treatment and prevention thereof.
Background technology:
Vaginitis is women's commonly encountered diseases, a frequently-occurring disease, brings many miseries to the patient, has a strong impact on the healthy of numerous women.Clinically, according to the cause of disease difference of vagina inflammatory diseases, and vaginitis is divided into non-specific, fungoid, bacillary, viral and protozoon property vaginitis.Therapeutic Method at present commonly used has 1, contain compound preparation that Oleum Curcumae makes such as BAOFUKANG SHUAN, Confort Pessaries; 2, policresulen bolt; 3, the compound suppository that contains metronidazole, clotrimazole, ciprofloxacin; 4, with the solution flushing that contains potassium permanganate, hibitane or povidone iodine and some Chinese medicine preparation.Above-mentioned various Therapeutic Method all has certain effect.But the social problem that the frequent use of the antibiotic in the said method can cause dysbacteriosis and bacterial resistance, above-mentioned disinfectant flushing also can cause the stimulation to mucosa, brings discomfort.Find, invent gentle, hommization more more prevention and Therapeutic Method is that doctor and patient is paid close attention to always.
Cervical erosion also is the modal chronic disease of gynecological, nearly 30% the women of child-bearing age suffer from this disease, and the patient who has has obvious leucorrhoea grow in quantity, lumbosacral aching pain and bearing down, if local inflammation is obvious, also purulent leukorrhea, contact bleeding can occur, need treat.Methods such as the domestic Therapeutic Method that adopts at present usually has that electricity is pressed, freezing, laser, microwave and LEEP cutter, described Therapeutic Method exists generally such as damaging normal structure, vaginal secretions rolls up during the treatment, and be attended by stench flavor, symptom unsatisfactory part such as could progressively disappear after month.Simultaneously, curative effect is unsatisfactory again, also is subject to seasonal restrictions, and also should not adopt above-mentioned method treatment usually summer.The Albothyl concentrated solution is a treatment cervical erosion local topical medicine preferably, but needs repeatedly to change dressings to hospital, influences patient's operate as normal again.
The women of child-bearing age, because estrogen secretion is more, the cervix uteri transitional zone moves outward, and the phosphorus columnar epithelium of cervix uteri mouth portio vaginalis is that columnar epithelium substitutes, and takes on a red color, and having much is " pseudoerosion ", does not have symptom, need not treat.The positional structure that the cervix uteri mouth is special, acute and chronic cervicitis, cervical erosion appear in the easier bacteria attack that is subjected to.
Xylitol (birch sugar) is a kind of natural carbohydrate, and it is present in the special plant part of tree, vegetable and fruit, exists on a small quantity with free form in the metabolite in addition and in the middle of the people.The mankind have just known xylitol the nineties from 19th-century at least organic chemistry.Before more than 100 years, German and French researcher has at first chemically been produced xylitol.During nineteen thirties, finally determined the characteristic of xylitol and it has been purified.Although from chemical aspect, xylitol has quite long history, and it is considered to a kind of in several sweet carbohydrates for a long time.But a lot of countries of shortage owing to sugar increase xylitol interest during the Second World War.Studied its noninsulin dependent performance up to researcher, its biological characteristics just obtains understanding, up to nineteen seventies, a lot of countries are just with the sweeting agents of xylitol as diabetics, with parenteral alimentation promptly by blood vessel directly give with nutrition or treatment islets of langerhans disposition go into a coma relevant.Just begin in odontology, to use xylitol during nineteen seventies.The chewing gum of xylitol has at first appearred containing in Finland in 1975, and it is used to control dental caries.
Xylitol is a kind of sugar alcohol of pentitol type, and it has 5 carbon atoms and 5 hydroxyls.Xylitol belongs to polyhydric alcohol, and polyhydric alcohol is not a sugar on the stricti jurise.But they are relevant with sugar on biochemistry, because produced by sugar, and can be converted into sugar.In addition, some chemical handbook are defined as the carbohydrate of crystallization, sweet taste with sugar, and it is the category that covers xylitol.
When in bacteriology test, using xylitol, do not detect the mutation characteristic, i.e. the increasing of natural mutation frequency.In addition, internal and international authority estimates its toxicity, thinks that its toxicity is so low, to such an extent as to for acceptable daily intaking amount without any restriction.Referring to (English) sieve R.C. " 796 pages of xylitol of pharmaceutic adjuvant handbook (original work the 4th edition).
Primary research and certified bacterial action are the effects to tooth, and it mainly is the effect of the structure generation of this chemical compound.Polyhydric alcohol in most of diet is a hexitol.According to the viewpoint of evolving, bacterial decomposition other things except that hexitol are disadvantageous.Therefore, most of antibacterials are of no use with the equipment on the zymetology of using short its growth of pentitol.
Chinese invention patent " Xylitol compositions that is used for the treatment of upper respiratory conditions " (number of patent application 99806536.6) xylitol is because to the strep mutant, a kind of antibacterial that causes the dental caries dental plaque, effect is arranged and can reduce dental caries, thereby be widely studied.These studies confirm that the effect of xylitol by weakening antibacterial and being produced caries prevention adhering to of dental plaque.Paul Naaber discovery clostridium has similar tack to descend in the presence of xylitol and is difficult to rest in the internal organs.No matter Kontiokai in 1998 finds still to exist 2.5% xylitol solution will reduce the adhesive ability of antibacterial in antibacterial at the nasal mucosa cell.Solution when 5% is present in antibacterial and the mucomembranous cell, the pneumonia strep, and a kind of main pathogen, adhesive force can reduce 2/3rds, drops to 13 from 41 antibacterials of every cell.His article is concluded:
" these phenomenons and monosaccharide only can suppress tack when high concentration the fact is consistent, and that is easy to reach in the oral cavity.Pneumococcal anti-penicillin bacterial strain is spread wide in the world and has been confirmed to adopt the necessity of new method prevention bacterial infection.The xylitol utmost point promises to be the reagent that is used for this purpose.”
Chinese invention patent " comprising the wound care products that suppresses the material of bacterial growth in the wound " (number of patent application 200480037774.6) verifies that by experiment staphylococcus aureus adds the xylitol of different content respectively in being rich in nutrient medium, staphylococcic growth is suppressed, the xylitol content that adds is high more, suppress obvious more, same experiment all shows also that for anti-various antibiotic staphylococcus aureuses, Type B streptococcus, G type streptococcus, bacillus pyocyaneus the xylitol content of adding is high more, suppresses obvious more.
Lactic acid: normal intravaginal parasitism lactobacillus, streptococcus, staphylococcus epidermidis, vagina Gartner bacterium and escherichia coli and anaerobic Peptostreptococcus, dyspepsiacoccus, anaerobism lactobacillus, bacteroid etc., these bacterium keep certain ratio, are maintaining the intravaginal ecological balance.Every milliliter has 106 colony-forming units in the normal women vaginal secretions.
Normal women of child-bearing age, under the effect of endocrine hormone, the vaginal epithelial cell hypertrophy, its cells of superficial layer contains abundant glycogen, is very beneficial for the growth of oxygen lactobacillus of holding concurrently, and this antibacterial accounts for more than 90% of vagina.The lactic acid that the lactobacillus metabolism produces remains between 3.8～4.2 the pH value of vagina.This pH value helps the growth of intravaginal fungal component, suppresses the growth of other pathogenic bacterium.Formed a normal ecological balance at vagina.
Summary of the invention:
The object of the present invention is to provide a kind of evident in efficacy to indication, have no side effect, do not damage normal structure, and vagina, cervical orifice rheuminess thing are reduced and the treatment and the prevention method of doing well,improving.
Before the present invention, nobody illustrates or recognizes that xylitol and lactic acid share the great potential aspect treatment and prevention gynecological infection.And can become the powerful mean of resisting gynecological's bacterial infection existence and growth, and antibacterial is the principal element that causes vaginitis and cervical erosion.And nobody recognizes that can produce suitable gynecological with xylitol washes care product.
Cause that cervical erosion and colpitic main cause are antibacterials, if can remove partial antibacterial, suppress the bacterial growth of vagina and cervix uteri mouth or prevent the adhesion of alien bacteria at vagina or cervix uteri mouth, just can vaginitis and cervical erosion have been treated and prevent, xylitol just in time possesses this characteristic, so our compositions for use contains xylitol.The appropriateness of lactic acid exists, and helps the existence of vagina fungal component, and is unfavorable for the existence of pathogenic bacterium so add an amount of lactic acid xylitol being had synergism.
The maximum characteristics of the present invention are more to meet, comply with the human physilogical characteristic: used several compositions: xylitol, lactic acid, sodium chloride, pure water all participate in the body metabolism or the intermediate product of human body biochemical metabolism in normal physiological, the present invention is applied to human body, theory and practice proof can not cause that allergy, no local excitation phenomenon, more exhausted nothing three cause the anxiety of (teratogenesis, carcinogenic, disable).Than the used treatment gynecological infection medicine of listing now all more safely, have more biocompatibility.
Douche therapy is a kind of method commonly used in gynecological, as the ozone flushing, hydrogen peroxide flushing, the flushing of povidone iodine diluent, the flushing of potassium permanganate diluent, dissipation class chloroethene is fixed, the flushing of Benzalkonii Chloridum aqueous solution, and Chinese medicine all is in great demand with the flushing liquor of JIEERYIN representative very much, but after the flushing of above-mentioned flushing liquor, the one, mucosa there is stimulation, patient does not tolerate (JIEERYIN is relatively good), and the 2nd, pollution clothes, the 3rd, the flushing back is recovered normal vaginal environment and is reached tens of hours; Certainly also has not pollution clothes, flushing liquor that can fast quick-recovery vaginal environment such as pure water, 0.9% normal saline, low concentration lactic acid but clinical effectiveness is not obvious.
The present invention has described the example of configuration xylitol and lactic acid composition in detail, and by carrying out pH value, vaginal mucosa irritation and clinical effectiveness with xylitol and compare with lactic acid, list with sodium chloride, list with single, show that Xylitol compositions is an ideal prescription, treatment bacterial vaginitis and cervical erosion are effective.
In order to obtain best xylitol, the lactic acid prescription of containing, we design as follows:
Lactic acid, xylitol, the sodium chloride of measuring or taking by weighing injection stage respectively in the toilet is configured to 1% lactic acid (W/V aqueous solution), 10% xylitol (W/V aqueous solution), 0.9% normal saline (W/V aqueous solution), solution of the present invention (8% xylitol, 0.1% lactic acid, 0.5% sodium chloride) each 1000ml and buys commercially available JIEERYIN XIYE standby.
The accurate pH value of the warp of above-mentioned solution is measured and is as follows through rabbit vaginal mucosa irritation experimental result:
| The medicinal liquid of variable concentrations and prescription | PH value | Zest |
| (1) 1% lactic acid (W/V aqueous solution) | 2.5-3.0 | Do not have |
| (2) 10% xylitol (W/V aqueous solution) | 5.0-7.0 | Do not have |
| (3) 0.9% normal saline (W/V aqueous solution) | 4.5-7.0 | Do not have |
| (4) JIEERYIN XIYE (commercially available) | 3.5 | Idol has that local flushing increases the weight of, twinge |
| (5) the present invention (W/V aqueous solution) | 3.8-4.5 | Do not have |
The present invention is as follows in hospital's gynecological clinic paired observation:
1 materials and methods
1.1 the object of observation: it is the bacterial vaginitis patient through the leucorrhea laboratory diagnosis that 72 routine outpatient services are extracted in outpatient service year February at random in August, 2006-2008.Between 18 ~ 50 years old age.
1.2 medicament selection: use 1% lactic acid (W/V aqueous solution), 10% xylitol (W/V aqueous solution), 0.9% normal saline (W/V aqueous solution), composition solution (8% xylitol, 0.1% lactic acid, 0.5% sodium chloride) and 10 times of commercially available JIEERYIN XIYE dilutions standby respectively.
1.3 administration time:, remove and forbid other medicines in addition with menstruation per vaginam flushing in clean 3 to 8 days.
1.4 administrated method: concrete operations are to clean pudendum with warm water earlier before sleeping evening every day, the FL-A type women washer of then medicinal liquid 200ML being poured into after the cleaning (is worth 45 yuan, can reuse), the patient position of lying, the shower nozzle of washer is inserted vagina, and the pulling pull bar washes, once-a-day, continuous use flushing 7 days, drug withdrawal was checked in 3 days.Sexual life condom in the treatment phase.
1.5 the observation of curative effect mouth is advised and case history doctor's advice patient pays a return visit, and is divided into healing, and is effectively, invalid.And in conjunction with woman's inspection and laboratory and patient main suit's feedback, analysis-by-synthesis observe the curative effect.
1.6 statistical procedures adopts the x2 check.
2 results
It is suitable with JIEERYIN treatment bacterial vaginitis effect that xylitol, lactic acid, sodium chloride make up flushing liquor, no difference of science of statistics (P〉0.05), xylitol, lactic acid, sodium chloride combination flushing liquor treatment bacterial vaginitis effect all are higher than list and use the sodium chloride group with xylitol group, list with lactic acid group and list, and significant difference (P＜0.05) is arranged.
72 routine bacterial vaginitis therapeutic outcome contrasts:
| The flushing liquor kind | The example number | Cure (routine number) | Effectively (routine number) | Invalid (routine number) | Total effective rate (%) |
| 1% lactic acid group | 10 | 1 | 3 | 6 | 40 |
| 10% xylitol group | 10 | 3 | 4 | 3 | 70 |
| 0.9% sodium chloride group | 10 | 0 | 2 | 8 | 20 |
| The compositions group | 20 | 12 | 8 | 0 | 100 |
| The JIEERYIN group | 22 | 10 | 11 | 1 | 95.45 |
The specific embodiment:
Be with several model cases of the invention process below:
Example one, king so-and-so, women, in May, 1972 date of birth.Increase because of pruritus vulvae and burn feeling, vagina discharge opeing and go to a doctor with off-odor on October 15th, 2007 (last menstrual period October 3), the doctor finds intravaginal secretions increase when checking with vaginal speculum, be canescence, thickness very, but the inflammation of vaginal wall is not obvious; Clues cell reaches 25% under the high power lens; The test of ammonia stink is positive; PH value 5.7.Be diagnosed as bacterial vaginitis.
Doctor's advice: configuration contains the solution vaginadouche of 8% xylitol, 0.1% lactic acid, 0.5% sodium chloride, in addition, need not take orally or the external other medicines.Concrete operations are to use earlier the warm water washing pudendum before sleeping evening every day, the solution 200ML that will contain xylitol then pours the FL-A type women washer (be worth 45 yuan, can reuse) after the cleaning into, the patient position of lying, the shower nozzle of washer is inserted vagina, and the pulling pull bar washes.
After 7 days, October 22, the patient came further consultation, and the main suit does not have discomfort.Check and find that vagina does not have peculiar secretions; No trace cell under the high power lens; The test of ammonia stink is negative; PH value 4.5.Belong to clinical cure.
The xylitol solution layoutprocedure: in the clean room, take by weighing 800 gram injection stage xylitol, 10ml lactic acid, 50 gram injection stage sodium chloride and slowly add in the pure water of 10000ML, jolting makes dissolving.The xylitol solution configuration that is used for gynecological's flushing finishes.
Example two, Jiang, women, in January, 1976 date of birth.On January 8th, 2008 (last menstrual period December 28 days) because of hemorrhage with bed, vaginal secretions increases, lumbosacral aching pain is gone to a doctor, the doctor checks discovery pudendum (-) intravaginal secretions yellow-white, thickness very, severe cervical erosion.
B ultrasonic (-)
The liquid based cytology audit report is single:
Pathological diagnosis: normal cell is smeared sheet
Slight inflammation
Cell project: squamous cell is arranged
Interior cervix cells is arranged
Biochemical cell is arranged
Microorganism project: do not see candidiasis
Do not see infusorian
Virus project: do not see herpesvirus infection
Do not see parillomarvirus infections
Sample satisfaction: satisfied
Inflammatory cell/covering ratio: be lower than 50%
Diagnostician's suggestion: do not look into and see upward Intradermal sick cell and cancerous cell, check liquid basal cell in 1 year.
The diagnosis of seeing and treating patients: cervical erosion severe
Doctor's advice: configuration contains the solution vaginadouche of 7% xylitol, 0.1% lactic acid, 0.45% sodium chloride, in addition, need not take orally or the external other medicines.Concrete operations are to use earlier the warm water washing pudendum before sleeping evening every day, the solution 200ML that will contain xylitol then pours the FL-A type women washer (be worth 45 yuan, can reuse) after the cleaning into, the patient position of lying, the shower nozzle of washer is inserted vagina, and the pulling pull bar washes.
After 7 days, January 15, the patient came further consultation, and the main suit washes the beginning in the 3rd day of treatment back and just no longer includes courageous and upright secretions, has become totally on the underwear, and lumbar vertebra does not have sense of discomfort yet.Check and find that vagina does not have peculiar secretions; The cervix uteri mouth is little red, wouldn't need treatment because of asymptomatic.
The xylitol solution layoutprocedure: in the clean room, take by weighing 700 gram injection stage xylitol, 10ml lactic acid, 45 gram injection stage sodium chloride and slowly add in the pure water of 10000ML, jolting makes dissolving.The xylitol solution configuration that is used for gynecological's flushing finishes.
Example three, Zhao so-and-so, women, May nineteen sixty-eight date of birth.On January 20th, 2008 (last menstrual period January 8) is because of pudendum and intravaginal has burn feeling, seriously pruritus is gone to a doctor, when checking with vaginal speculum, the doctor finds that the intravaginal leucorrhea is curdy, the white stiff, the hyperemia of vaginal mucosa height, the redness of its below, consideration may be monilial vaginitis.
Doctor's advice: configuration contains the solution vaginadouche of 8% xylitol, 0.1% lactic acid, 0.5% sodium chloride, in addition, need not take orally or the external other medicines.Concrete operations are to use earlier the warm water washing pudendum before sleeping evening every day, the solution 200ML that will contain xylitol then pours the FL-A type women washer (be worth 45 yuan, can reuse) after the cleaning into, the patient position of lying, the shower nozzle of washer is inserted vagina, and the pulling pull bar washes.
After 7 days, January 27, the patient came further consultation, and the main suit does not have discomfort.Belong to clinical cure.
The xylitol solution layoutprocedure: in the clean room, take by weighing 800 gram injection stage xylitol, 10ml lactic acid, 50 gram injection stage sodium chloride and slowly add in the pure water of 10000ML, jolting makes dissolving.The xylitol solution configuration that is used for gynecological's flushing finishes.
The present invention does not limit in the above-described embodiment, and according to the knowledge on the pharmaceutics, lactic acid can be used replacements such as acetic acid, citric acid, citric acid, as long as suitable pH value is between 3.8-4.5.
The existing prescription of this product can be used as gynecological's daily nursing product.Because it is raw materials used all compatible with human body, the amount that lactic acid adds is equivalent to the content of normal vagina, xylitol suppresses the noxious bacteria breeding and prevents that noxious bacteria from adhering in vaginal mucosa, can also promote the growth of profitable strain, is the multiplicaiton factor of bacillus bifidus and lactobacillus.
To the further improved thinking of the present invention is to add gynecological such as Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Cnidii to use always again to the stable Chinese medicine extract of xylitol chemical property.Can further increase curative effect of the present invention.The enhanced while of curative effect may increase some local irritations.But than using antibiotic suppository and worth promotions such as potent stimulation dissipation class irrigation such as hibitane.
Claims (6)
1, a kind of compositions that is used for the treatment of or prevents patient's vagina or the hyperemia of cervix uteri mouth, bacterial vaginitis or cervicitis, said composition contain xylitol and lactic acid (or pharmaceutically the weak organic acid of character gentleness such as the sub of lactic acid such as acetic acid, citric acid, citric acid).
2, the compositions of claim 1, said composition are the localized liquid washing form that contains xylitol, lactic acid.
3, the compositions of claim 1 contains 1-64 gram xylitol in 100 ml waters in the wherein said solution.
4, the compositions of claim 1 contains 0-1 gram (about 1ml) lactic acid in 100 ml waters in the wherein said solution.
5, the compositions of claim 4 wherein contains 0-0.9% sodium chloride.
6, the optimum formula of above-mentioned composition is: all the other add to 100ml for pure water xylitol 8 gram lactic acid 0.1 gram (about 0.1ml) sodium chloride 0.5 gram.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810084624A CN101530403A (en) | 2008-03-14 | 2008-03-14 | Xylitol compound for curing or preventing female colpitis and cervical erosion |
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| CN200810084624A CN101530403A (en) | 2008-03-14 | 2008-03-14 | Xylitol compound for curing or preventing female colpitis and cervical erosion |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013508269A (en) * | 2009-10-19 | 2013-03-07 | チェ，ウォンソン | External composition for skin containing salt and sugar as active ingredients for the prevention and treatment of vaginosis and use thereof |
| CN109223706A (en) * | 2018-09-06 | 2019-01-18 | 杭州金花医药生物科技有限公司 | A kind of progress in Intelligent Hydrogel and preparation method thereof for preventing and treating cervical disease |
-
2008
- 2008-03-14 CN CN200810084624A patent/CN101530403A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013508269A (en) * | 2009-10-19 | 2013-03-07 | チェ，ウォンソン | External composition for skin containing salt and sugar as active ingredients for the prevention and treatment of vaginosis and use thereof |
| EP2490700A4 (en) * | 2009-10-19 | 2013-08-07 | Won Seog Choi | A skin external composition comprising a salt and sugar as active ingredients for preventing and treating vaginosis and the use thereof |
| EP3192516A1 (en) * | 2009-10-19 | 2017-07-19 | Choi, Won Seog | A skin external composition comprising a salt and sugar as active ingredients for preventing and treating vaginosis and the use thereof |
| CN109223706A (en) * | 2018-09-06 | 2019-01-18 | 杭州金花医药生物科技有限公司 | A kind of progress in Intelligent Hydrogel and preparation method thereof for preventing and treating cervical disease |
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Open date: 20090916 |