CN102485244A - Application of Chinese medicinal composition in preparing gel for treating gynecological inflammation - Google Patents
Application of Chinese medicinal composition in preparing gel for treating gynecological inflammation Download PDFInfo
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Abstract
The invention relates to application of a Chinese medicinal composition in preparing a gel for treating gynecological inflammation, wherein, the Chinese medicinal composition is prepared by the following bulk medicines by weight: 2000 parts of cortex ailanthi, 1500 parts of sophora flavescens, 1500 parts of frankincense, 50 parts of borneol, and 1500 parts of cortex moutan. The gel prepared by the Chinese medicinal composition in the invention can overcome many defects of chemical medicines, exert the incomparable extensive curative effects (such as heat clearing and dehumidifying, leucorrhea stopping and itching relieving, necrotic tissue removing and granulation promoting) of chemical medicines, and can be widely applied in treating gynecological inflammation (such as damp-heat pouring downward leukorrhagia including bacterial vaginosis, vulvovaginal candidiasis, etc.) caused by bacteria, fungi, protozoa, chlamydiae, mycoplasmas and other pathogens.
Description
Technical field
The present invention relates to a kind of new purposes of Chinese medicine composition, particularly relate to a kind of application of Chinese medicine composition gel in the gel of preparation treatment gynecological inflammation that contains Cortex Ailanthi.
Background technology
Because the special physiological make-up characteristics of women, vaginitis is women of child-bearing age's commonly encountered diseases, frequently-occurring disease, and sickness rate accounts for the women of child-bearing age's 50%; Rural area women of child-bearing age's sickness rate is higher, because vaginitis can cause pruritus vulvae, leucorrhoea grow in quantity, vaginal orifice and urethral orifice burning sensation and pain etc.; Have a strong impact on women's operate as normal and life; Therefore, active prevention is to ensure that female body is healthy, the important channel of improving the female life quality with the treatment gynecological inflammation.
It is a lot of at present to be used for treating colpitic gynecological external use medicine kind on the domestic market, as being the gynecological external use lotion of representative with the JIEERYIN of Chengdu grace prestige pharmaceutical manufacturing, the FUYINJIE that Guangxi Yuan Antang produces; The miconazole of producing with Xi'an Yang Sen is the external suppository of representative; And metronidazole etc. is other conventional dosage forms of representative.But the Western medicine defective is apparent in view; As act on singlely, and be prone to produce anaphylaxis, zest, Drug resistance etc., be inappropriate for anemia of pregnant woman and women breast-feeding their children use; Intravaginal profitable strain had killing action equally; Be prone to cause dysbacteriosis in the vagina, destroy the self-cleaning system of vagina etc., that some medicine self also has is carcinogenic, the potential danger (like metronidazole, metronidazole etc.) of teratogenesis.Existing Chinese medicine is each some deficiency also, and the prescription that has is bigger, and the technology that has is loaded down with trivial details.JIEERYIN XIYE like Chengdu grace prestige pharmaceutical manufacturing has tens flavor medical materials, and medical material involved in the present invention has only the five tastes, and technology is also very simple.
Summary of the invention
The purpose of this invention is to provide a kind of application of Chinese medicine composition in the preparation of preparation treatment gynecological inflammation that contains Cortex Ailanthi.
For achieving the above object, the present invention provides the application of a kind of Chinese medicine composition in the gel of preparation treatment gynecological inflammation.
Wherein, said Chinese medicine composition is by following bulk drugs: 1750～2250 parts of Cortex Ailanthis, 1250～1750 parts of Radix Sophorae Flavescentiss, 1250～1750 parts of Olibanums, 40～60 parts of Borneolum Syntheticums, 1250～1750 parts of Cortex Moutans.
Preferably, said Chinese medicine composition is processed by following bulk drugs: 2000 parts of Cortex Ailanthis, 1500 parts of Radix Sophorae Flavescentiss, 1500 parts of Olibanums, 50 parts of Borneolum Syntheticums, 1500 parts of Cortex Moutans.
Said gel comprises the gel-type vehicle of above-mentioned Chinese medicine composition and following weight portion: 2 parts of 40 parts of bioadhesive polymers, 50 parts of wetting agents, 2 parts of emulsifying agents and antiseptic.
Preferably, said bioadhesive polymer is selected from one or more in hypromellose, methylcellulose, sodium carboxymethyl cellulose, carbomer, poloxamer, polyvinyl alcohol and the polyacrylamide.
The viscosity of said hydroxypropyl methylcellulose is 1000～1500, and the viscosity of methylcellulose is 1500, and the viscosity of sodium carboxymethyl cellulose is 600-1400, and the model of carbomer is 980PNF or 971PNF.
Said wetting agent is selected from one or both in glycerol and the propylene glycol.
Said antiseptic is selected from one or more in nipalgin, sodium sorbate, ethyl hydroxybenzoate and the sodium benzoate.
Said emulsifying agent is selected from one or both in Polysorbate, the sucrose ester.
Said gel is processed by following method:
1) Cortex Ailanthi adds 2-9 times of water gaging, and decocte with water 1-3 time decocted 1-2.5 hour at every turn, and collecting decoction filters, and filtrating is concentrated into the Cortex Ailanthi extractum that relative density is 1.05-1.10;
2) Radix Sophorae Flavescentis adds 6-12 times of water gaging, and decocte with water 1-3 time was soaked 0.5-1.5 hour before decocting for the first time, decocted 0.5-3 hour at every turn; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10-1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05-1.10;
3) Olibanum adds 6-10 times of water gaging, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, and collecting quality is the distillate of 4-8 times of medical material amount, places crystallize, filters, and gets the paeonol crystallization; The aqueous solution redistillation, collecting quality is the distillate of 2-4 times of medical material amount, places crystallize, filters, and merges the paeonol crystallization that obtains;
5) get it filled and join in the mixing clear paste of Cortex Ailanthi and Radix Sophorae Flavescentis, stir, place, make abundant swelling with bioadhesive polymer, wetting agent;
6) get paeonol crystallization that Borneolum Syntheticum, step 4) obtain with dissolve with ethanol after, add antiseptic and emulsifying agent, stir and make dissolving; The volatile oil that adds the step 3) Olibanum again; Join in the swollen solution that step 5) obtains, add the water mixing, place and made abundant swelling in 12-36 hour; Stir, packing promptly gets gel.
Preferably, the present invention provides the application of Chinese medicine composition in the gel of preparation treatment damp heat downward flowing type leukorrheal diseases.
More preferably, said damp heat downward flowing type leukorrheal diseases are bacterial vaginosis or VVC.
General every heavy 4 grams of above-mentioned Chinese medicine composition gel, administrated method is to get 1 every day just before going to bed to deliver medicine to the vagina depths.7 days is a course of treatment.
Except the gel dosage form, above-mentioned Chinese medicine composition can also be prepared into effervescent tablet, washing liquid, suppository or the like by common process, and convenient clinical various patients select to use.
Above-mentioned Chinese medicine composition gel is the compound Chinese medicinal preparation with the theory of Chinese medical science prescription; Both can overcome many deficiencies of chemical medicine, can bring into play the incomparable many-sided therapeutical effect of chemical medicine (, putrefaction-removing granulation-promoting antipruritic, astringing to arrest bleeding or the like) again, can be widely used in the former caused gynecological inflammation damp heat downward flowing type leukorrheal diseases etc. of bacterial vaginosis, VVC etc. (as comprise) that causes a disease such as antibacterial, fungus, protozoon, chlamydia, mycoplasma like removing damp-heat, leukorrhagia stopping; Simultaneously; Chinese traditional compound medicine also has the effect of pH buffer agent, through regulating vagina pH, makes the vagina self-cleaning function be able to recover; Suppress pathogenic microorganism or protozoacide growth and breeding through self-cleaning system; Chinese medicine will be better than Western medicine far away to the comprehensive inhibitory action of virus, therefore, has vast market prospect aspect the treatment gynecological inflammation.
The specific embodiment
Below in conjunction with embodiment, specific embodiments of the invention describes in further detail.
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
The preparation of the preferred clinical dosage form of embodiment 1 Chinese medicine composition of the present invention " Chinese toon curdling glue "
1) Cortex Ailanthi 2000g adds 6 times of water gagings, and decocte with water 2 times decocted 2 hours at every turn, and collecting decoction filters, and filtrating is concentrated into the Cortex Ailanthi extractum that relative density is 1.05-1.10 (60 ℃);
2) Radix Sophorae Flavescentis 1500g adds 9 times of water gagings, and decocte with water 2 times was soaked 1 hour before decocting for the first time, decocted 2 hours at every turn; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10-1.15 (60 ℃), puts cold; Add ethanol and make and contain alcohol amount and reach 60-70% (gravimeter records), left standstill 20 hours, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05-1.10 (60 ℃);
3) Olibanum 1500g adds 8 times of water gagings, distills 7 hours, collects volatile oil;
4) Cortex Moutan 1500g distills with steam distillation, and collecting quality is the distillate of 6 times of medical material amounts, places crystallize, filters, and gets the paeonol crystallization; The aqueous solution redistillation, collecting quality is the distillate of 3 times of medical material amounts, places crystallize, filters, and merges the paeonol crystallization that obtains;
5) get it filled and join in the mixing clear paste of Cortex Ailanthi and Radix Sophorae Flavescentis, stir, place, make abundant swelling with sodium carboxymethyl cellulose 40g, medicinal glycerin 50g;
6) get Borneolum Syntheticum 50g, paeonol crystallization with dissolve with ethanol after, add ethyl hydroxybenzoate 2g and Tween-80 2g, stirring makes dissolving; The volatile oil that adds Olibanum again; Join in the swollen solution that step 5) obtains, add water to the 1000g mixing, place and made abundant swelling in 12-36 hour; Stir, packing promptly gets gel.
Below further set forth the effect (the Chinese toon curdling glue with embodiment 1 is example) of Chinese medicine composition of the present invention through test.
The research of experimental example 1 toxicological test
1, acute toxicity test
Chinese medicine composition of the present invention with 4.0 with 2.0g crude drug/ml, 0.05ml/100g body weight, 4 rat vagina/cervix uteri administrations in 4 hours.Observed 24,48 hours and 7 days.Do not find phenomenons such as vagina/cervix uteri stimulation, allergy, mucosa, breathing, circulation, central nervous system, extremity activity etc. all do not have obvious poisoning manifestations, and body weight all increases to some extent.
2, long term toxicity test
Chinese medicine composition of the present invention 4.0,2.0,1.0g crude drug/ml concentration liquid, the 0.05ml/100g body weight, 2 rat vagina/cervix uteri administrations in 2 hours (4.0,2.0,1.0g crude drug/kg).In continuous 9 weeks, observed for 2 weeks after the drug withdrawal.Each is organized rat ordinary circumstance, body weight, food-intake, peripheral hemogram, ten biochemical indicators and compares with matched group with organ index, equal no significant differences, main organs, the no tangible pathological change of tissue.Showing the interior no obvious toxicity of Chinese medicine composition institute's amount of reagent scope of the present invention, is comparison safety.
3, sensitivity test
With Chinese medicine composition sensitization of the present invention with excite Cavia porcellus, do not cause skin allergy.
Above result provides reference for data for clinical drug use.
Experimental example 2 traditional Chinese medicine composition for treating women's candida albicans vaginitises of the present invention, trichomonal vaginitis (damp invasion of lower energizer disease) clinical observation are summed up
Be the clinical efficacy of research Chinese medicine composition of the present invention, we observe 20 routine women's candida albicans vaginitises, trichomonal vaginitis (damp invasion of lower energizer disease) patient, and observed result is following.
1, clinical data
1.1 case source: outpatient service.The case mean age is 33 years old, wherein minimum 21 years old, and maximum 50 years old.
1.2 ordinary circumstance: see the following form 1.
Table 1
1.3 tcm syndrome diagnosis and severity extent data: see table 2, table 3.
Table 2 tcm syndrome diagnosed SARS case catalog
Table 3 severity extent catalog
2, clinical diagnosis standard
2.1 Western medicine diagnose standard: with reference to " obstetrics and gynecology " (the 5th edition), " practical combination of Chinese and Western medicine gynecology " (the 1st edition) formulated.
2.1.1 candida albicans vaginitis
(1) symptom: pruritus vulvae, causalgia, the leucorrhea amount is many, and color is white, and stiff is bean dregs appearance;
(2) gynecologial examination: adhere to white membranoid substance on nympha inboard and the vaginal mucosa, expose red and swollen mucosal surface after wiping;
(3) vaginal secretions microscopy, cleannes II °-III °, Candida albicans (+).
2.1.2 trichomonal vaginitis
(1) symptom: pruritus vulvae, causalgia, the leucorrhea amount is many, thin show bubble;
(2) gynecologial examination: vaginal mucosa has diffusing punctation;
(3) vaginal secretions microscopy, cleannes II °-III °, infusorian (+).
2.2 diagnostic criteria after the Syndrome in TCM: draft with reference to " new Chinese medicine clinical research guideline " (1993 editions) related content:
Syndrome of dampness-heat diffusing downward: constitute by primary symptom, inferior disease and picture of the tongue, pulse condition.
Primary symptom: 1. profuse leukorrhea, yellow skin or be purulence, the matter thickness has foul smell; Or leukorrhagia color white matter thickness is bean dregs appearance; 2. pruritus vulvae, causalgia.
Inferior disease: 1. lower abdomen pain; 2. bitter taste greasy taste in the mouth; 3. uncomfortable in chest indigestion and loss of appetite; 4. it is not well to defecate; 5. frequent micturition, urgent micturition, dysurea.
Picture of the tongue: red tongue, yellow and greasy fur.Pulse condition: sliding number.
The tcm syndrome diagnostic criteria: possess primary symptom 1-2 discipline, and the 1-5 item possessing 2 in time disease, is diagnosable selected in conjunction with the tongue arteries and veins.
2.3 tcm syndrome scalar quantization standard:
Edit with reference to the Zheng Xiao cornel: " new Chinese medicine clinical research guideline " (trying), Beijing: Chinese Medicine science and technology publishing house, 2002
Primary symptom:
(1) profuse leukorrhea, yellow thick, frowziness;
The leukorrhagia amount is normal: 0 minute
The leukorrhagia amount is many slightly, and yellow skin is tasteless: 2 minutes
Profuse leukorrhea, the thick frowziness of yellow skin matter: 4 minutes
Profuse leukorrhea, the thick stink of yellow skin matter is heavy: 6 minutes
(2) pruritus vulvae, causalgia;
Do not have: 0 minute
The slight pruritus of pudendum does not influence life: 2 minutes
The itching of vulva pain obviously influences life: 4 minutes
The itching of vulva pain is felt restless: 6 minutes unbearably
Inferior disease:
(1) lower abdomen is had a pain
Do not have: 0 minute
Slight stomachache does not influence life: 1 minute
Stomachache obviously influences life: 2 minutes
Stomachache has a strong impact on live and work: 3 minutes unbearably
(2) bitter taste greasy taste in the mouth
Do not have: 0 minute
Idol has the bitter taste greasy taste in the mouth: 1 minute
Frequent bitter taste greasy taste in the mouth: 2 minutes
The bitter taste greasy taste in the mouth influences orthobiosis unbearably: 3 minutes
(3) uncomfortable in chest indigestion and loss of appetite
Do not have: 0 minute
The time have uncomfortable in chest, poor appetite: 1 minute
Often uncomfortable in chest, anorexia: 2 minutes
Unbearably uncomfortable in chest, anorexia: 3 minutes
(4) stool is not well
Do not have: 0 minute
Have: 1 minute
(5) frequent micturition, urgent micturition, dysurea
Do not have: 0 minute
Have: 1 minute
(6) picture of the tongue
Light red tongue, Tai Bubai: 0 minute
Red tongue, yellow and greasy fur: 1 minute
(7) pulse condition
Normal pulse is slow: 0 minute
Slippery and rapid pulse: 1 minute
2.4 the state of an illness is light, in, the major punishment calibration is accurate: edit with reference to the Zheng Xiao cornel: " new Chinese medicine clinical research guideline " (trying), Beijing: the scientific and technological publishing house of Chinese Medicine, 2002
Slightly: symptom integral≤8 minute;
Moderate: symptom integral 9～15 minutes;
Severe: symptom integral >=16 minute.
2.5 curative effect determinate standard
2.5.1 comprehensive therapeutic effect evaluation:
Clinical recovery: symptom, sign and laboratory examination all recover normally, and the curative effect integration is >=90;
Produce effects: transference cure, sign and laboratory examination have clear improvement, and the treatment back reduces 60-89% than the preceding integration of treatment;
Effectively: symptom, sign and laboratory examination all have and alleviate, the treatment back than treatment before integration reduction 30-59%;
Invalid: treatment back symptom, sign and laboratory examination do not have improvement, and the treatment back reduces≤30% than integration before treating.
2.5.2 tcm syndrome efficacy evaluation:
Clinical recovery: tcm symptom recovers normal, and the curative effect integration is >=90;
Produce effects: tcm symptom has clear improvement, and the treatment back reduces 60-89% than the preceding integration of treatment;
Effectively: sx, the treatment back reduces 30-59% than the preceding integration of treatment;
Invalid: treatment back nothing is improved, and the treatment back reduces≤30% than the preceding integration of treatment.
3, Therapeutic Method
Medicine: Chinese toon curdling glue is provided by Zhuzhou Qianjin Pharmacy Co., Ltd.
Administrated method: every day 1 time, each 1, behind the cleaning pudendum, fill in posterior fornix.
The course of treatment: 7 days is a course of treatment.The experimenter observes after using 1 course of treatment.
4, therapeutic outcome
Table 4 tcm syndrome therapeutic evaluation result
Table 5 vaginal secretions inspection Candida albicans, infusorian result
Annotate: * representes to have 1 routine patient still can detect leukocyte cell.* representes to have 2 routine patients still can detect leukocyte cell.
Table 6 severity extent improve the result
Table 7 comprehensive therapeutic effect evaluation result
Table analysis shows on the foundation, and these article have curative effect preferably to candida albicans vaginitis, trichomonal vaginitis, and its total effective rate is 100%, and cure rate is respectively 92.86%, 90.00%.
5, safety evaluatio
5.1 after these article in the observation process, found that the medication in 2 days of 4 routine patient's pro-is arranged, vagina had tangible burning sensation (wherein trichomonal vaginitis patient have 3 examples).
5.2 after these article used, there have a little medicine to fail to be dissolved fully, can remain in intravaginal.
5.3 patient's three big routines all belong to normally, do not find other serious adverse reaction.
6, discuss
6.1 totally 20 examples are observed in this clinical trial, the result shows that these article are better to the curative effect of candida albicans vaginitis, trichomonal vaginitis, and total effective rate is 100%.
6.2 these article are better to the effect of killing Candida albicans, infusorian.
6.3 behind these article of use, vagina has significantly burning sensation and a little drug residue in intravaginal, influences the use of medicine next time, therefore suggestion: patient's flushing vagina earlier before medication.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from know-why of the present invention; Can also make some improvement and retouching, these improvement and retouching also should be regarded as protection scope of the present invention.
Claims (10)
1. the application of Chinese medicine composition in the gel of preparation treatment gynecological inflammation; It is characterized in that said Chinese medicine composition is processed by following bulk drugs: 1750～2250 parts of Cortex Ailanthis, 1250～1750 parts of Radix Sophorae Flavescentiss, 1250～1750 parts of Olibanums, 40～60 parts of Borneolum Syntheticums, 1250～1750 parts of Cortex Moutans.
2. application according to claim 1 is characterized in that, said Chinese medicine composition is processed by following bulk drugs: 2000 parts of Cortex Ailanthis, 1500 parts of Radix Sophorae Flavescentiss, 1500 parts of Olibanums, 50 parts of Borneolum Syntheticums, 1500 parts of Cortex Moutans.
3. application according to claim 1 is characterized in that, said gel comprises the gel-type vehicle of claim 1 or 2 described Chinese medicine compositions and following weight portion: 2 parts of 40 parts of bioadhesive polymers, 50 parts of wetting agents, 2 parts of emulsifying agents and antiseptic.
4. application according to claim 3 is characterized in that said bioadhesive polymer is selected from one or more in hypromellose, methylcellulose, sodium carboxymethyl cellulose, carbomer, poloxamer, polyvinyl alcohol and the polyacrylamide.
5. application according to claim 3 is characterized in that said wetting agent is selected from one or both in glycerol and the propylene glycol.
6. application according to claim 3 is characterized in that said antiseptic is selected from one or more in nipalgin, sodium sorbate, ethyl hydroxybenzoate and the sodium benzoate.
7. application according to claim 3 is characterized in that said emulsifying agent is selected from one or both in Polysorbate and the sucrose ester.
8. according to each described application of claim 1-7, it is characterized in that said gel is processed by following method:
1) Cortex Ailanthi adds 2-9 times of water gaging, and decocte with water 1-3 time decocted 1-2.5 hour at every turn, and collecting decoction filters, and filtrating is concentrated into the Cortex Ailanthi extractum that relative density is 1.05-1.10;
2) Radix Sophorae Flavescentis adds 6-12 times of water gaging, and decocte with water 1-3 time was soaked 0.5-1.5 hour before decocting for the first time, decocted 0.5-3 hour at every turn; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10-1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05-1.10;
3) Olibanum adds 6-10 times of water gaging, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, and collecting quality is the distillate of 4-8 times of medical material amount, places crystallize, filters, and gets the paeonol crystallization; The aqueous solution redistillation, collecting quality is the distillate of 2-4 times of medical material amount, places crystallize, filters, and merges the paeonol crystallization that obtains;
5) get it filled and join in the mixing clear paste of Cortex Ailanthi and Radix Sophorae Flavescentis, stir, place, make abundant swelling with bioadhesive polymer, wetting agent;
6) get paeonol crystallization that Borneolum Syntheticum, step 4) obtain with dissolve with ethanol after, add antiseptic and emulsifying agent, stir and make dissolving; The volatile oil that adds the step 3) Olibanum again; Join in the swollen solution that step 5) obtains, add the water mixing, place and made abundant swelling in 12-36 hour; Stir, packing promptly gets gel.
9. application as claimed in claim 1 is characterized in that, said gynecological inflammation is the damp heat downward flowing type leukorrheal diseases.
10. application as claimed in claim 9 is characterized in that, said damp heat downward flowing type leukorrheal diseases are bacterial vaginosis or VVC.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474148A (en) * | 2015-01-16 | 2015-04-01 | 杜卫兵 | Traditional Chinese medicine composition used for treating dermatomycosis and preparation method thereof |
| CN110604795A (en) * | 2019-09-27 | 2019-12-24 | 山东佳硒雅生物有限公司 | Gynecological inflammation gel and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113797A (en) * | 1994-06-14 | 1995-12-27 | 蔡健 | Fuyanjing lubricant and its preparing method |
| CN1422652A (en) * | 2002-12-05 | 2003-06-11 | 株洲千金药业股份有限公司 | Chinese medicinal preparation for treating gynaecology disease of cervicitis |
| CN102085248A (en) * | 2009-12-07 | 2011-06-08 | 株洲千金药业股份有限公司 | Traditional Chinese medicinal composition for treating cervix diseases, method for preparing same and method for detecting same |
-
2010
- 2010-12-06 CN CN2010105800804A patent/CN102485244A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113797A (en) * | 1994-06-14 | 1995-12-27 | 蔡健 | Fuyanjing lubricant and its preparing method |
| CN1422652A (en) * | 2002-12-05 | 2003-06-11 | 株洲千金药业股份有限公司 | Chinese medicinal preparation for treating gynaecology disease of cervicitis |
| CN102085248A (en) * | 2009-12-07 | 2011-06-08 | 株洲千金药业股份有限公司 | Traditional Chinese medicinal composition for treating cervix diseases, method for preparing same and method for detecting same |
Non-Patent Citations (2)
| Title |
|---|
| 向大雄等: "椿乳凝胶成型工艺研究", 《中成药》 * |
| 胡耀菊等: "椿乳凝胶治疗湿热瘀阻型慢性宫颈糜烂的疗效观察", 《实用中西医结合临床》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474148A (en) * | 2015-01-16 | 2015-04-01 | 杜卫兵 | Traditional Chinese medicine composition used for treating dermatomycosis and preparation method thereof |
| CN110604795A (en) * | 2019-09-27 | 2019-12-24 | 山东佳硒雅生物有限公司 | Gynecological inflammation gel and preparation method thereof |
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Application publication date: 20120606 |