CN110604795A - Gynecological inflammation gel and preparation method thereof - Google Patents
Gynecological inflammation gel and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of external paste, in particular to gynecological inflammation gel and a preparation method thereof. The gynecological inflammation gel mainly comprises the following raw materials in parts by weight: 2-5 parts of selenium malt, 20-35 parts of dandelion, 10-18 parts of motherwort, 10-15 parts of kudzu root, 16-18 parts of ailanthus bark, 8-12 parts of frankincense, 3-8 parts of hairyvein agrimonia herb and bud extract, 1-3 parts of sodium alginate, 4-5 parts of carboxymethyl cellulose, 1-3 parts of azone, 1-4 parts of a tween-80 and hydroxypropyl methyl cellulose compound, 3-5 parts of a natural moisturizing factor and 1-2 parts of sorbic acid. The gynecological inflammation gel and the preparation method thereof have the advantages of reasonable compatibility, synergistic effect among the components, obvious antibacterial, lubricating and moisturizing effects, good effect on treating vaginitis and difficulty in relapse.
Description
Technical Field
The invention relates to the technical field of external paste, in particular to gynecological inflammation gel and a preparation method thereof.
Background
Gynecological inflammation has been a disease afflicting many women. It is a frequently encountered disease and common disease of women. In gynecological inflammation, chronic pelvic inflammation, vaginitis, chronic cervicitis and the like generally occur at a high incidence rate. After women get gynecological inflammation, the female can have inconvenience for life. For example: increased leucorrhea, increased odor, etc. Therefore, women need to pay special attention to personal hygiene and avoid gynecological inflammation. Gynecological inflammation is caused by a plurality of reasons, and the pudendum is in moist and sultry for a long time; the female vagina is the same as the outside, so that germs enter; the decline of immunity causes the breeding of vaginal bacteria, etc. These are the causes of gynecological diseases.
The existing administration modes for treating gynecological inflammation are divided into injection, oral administration and external application, and patients are more prone to take external medicines due to large toxic and side effects and slow effect of the injection and the oral administration. The external medicine is lotion containing antibiotics, although the antibacterial and anti-inflammatory effects of the medicines are obvious and quick, the medicine resistance caused by excessively depending on the antibiotics can increase the treatment difficulty, has no effect on the complications of the gynecological inflammation, is easy to relapse of the gynecological inflammation and cannot achieve the purpose of treating both symptoms and root causes.
Disclosure of Invention
The invention aims to provide gynecological inflammation gel and a preparation method thereof, overcomes the defects of the prior art, adopts a mild medicament formula, quickly sterilizes and relieves itching of gynecological inflammation patients, and is not easy to repeat.
The technical scheme adopted by the invention for solving the technical problems is as follows:
the gynecological inflammation gel mainly comprises the following raw materials in parts by weight: 2-5 parts of selenium malt, 20-35 parts of dandelion, 10-18 parts of motherwort, 10-15 parts of kudzu root, 16-18 parts of ailanthus bark, 8-12 parts of frankincense, 3-8 parts of hairyvein agrimonia herb and bud extract, 1-3 parts of sodium alginate, 4-5 parts of carboxymethyl cellulose, 1-3 parts of azone, 1-4 parts of a tween-80 and hydroxypropyl methyl cellulose compound, 3-5 parts of a natural moisturizing factor and 1-2 parts of sorbic acid, wherein the tween-80 and hydroxypropyl methyl cellulose compound is prepared from tween-80 and hydroxypropyl methyl cellulose according to the weight ratio (3-5): 1 is prepared by compounding.
Preferably, the material mainly comprises the following raw materials in parts by weight: 3 parts of malt selenium, 18 parts of dandelion, 15 parts of motherwort, 12 parts of kudzuvine root, 17 parts of ailanthus bark, 9 parts of frankincense, 6 parts of hairyvein agrimonia herb and bud extract, 2 parts of sodium alginate, 5 parts of carboxymethyl cellulose, 1 part of azone, 3 parts of a tween-80 and hydroxypropyl methyl cellulose compound, 4 parts of natural moisturizing factor and 1 part of sorbic acid, wherein the tween-80 and hydroxypropyl methyl cellulose compound is prepared from tween-80 and hydroxypropyl methyl cellulose according to the weight ratio (4): 1 is prepared by compounding.
Preferably, the preparation method of the agrimony extract comprises the following steps:
(1) extracting herba et Gemma Agrimoniae with 70-75% ethanol at 55-65 deg.C for 2-3 times (30-60 min for each time) 6-8 times of the weight of herba et Gemma Agrimoniae, filtering to obtain residue A and extractive solution, recovering ethanol from the extractive solution, concentrating, and drying to obtain extract A;
(2) extracting the residue A obtained in the step (1) with 55-60% ethanol at room temperature for 1-3 times (each time for 30-60 min) at 5-7 times of the weight of Chrysosplenium, filtering, recovering ethanol from the extractive solution, concentrating to relative density of 1.05-1.12, and filtering to obtain medicinal liquid A;
(3) passing the liquid medicine A obtained in the step (2) through a nonpolar macroporous adsorption resin column, eluting with water, directly passing the water eluent through the polar macroporous adsorption resin column, eluting the nonpolar macroporous adsorption resin column with 55-75% ethanol solution, collecting ethanol eluates with different concentrations, concentrating and drying to obtain an extract B;
(4) eluting the polar macroporous adsorbent resin column with 55-60% ethanol solution, collecting ethanol eluates with different concentrations, concentrating, and drying to obtain extract C;
(5) mixing extract A, extract B and extract C, and stirring to obtain herba et Gemma Agrimoniae extract.
A preparation method of gynecological inflammation gel comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) soaking herba Taraxaci, herba Leonuri, radix Puerariae, cortex Ailanthi and Olibanum in 6-8 times of water for 1.5-2 hr, decocting with slow fire for 2-3 hr, and filtering to remove residue;
(3) standing the liquid filtered and deslagged in the step (2) at normal temperature for 2-3h, filtering again, adding ethanol, adjusting to ethanol solubility of 65%, standing for 2-3h, filtering, and recovering ethanol at 40 deg.C to obtain a mixed solution A;
(4) adding the specified mass parts of the maltsium malt, the hairyvein agrimonia herb and bud extract, the sodium alginate, the carboxymethyl cellulose, the azone, the compound of the Tween-80 and the hydroxypropyl methyl cellulose, the natural moisturizing factor and the sorbic acid into the mixed solution A, and uniformly stirring to obtain the product.
The dandelion contains abundant vitamins A and C and various mineral substances, and the nutrient substances not only have the effects of promoting urination, promoting digestion and improving constipation, but also can relieve eczema, diminish inflammation and sterilize.
The motherwort herb is used as a medicine and has the functions of promoting blood circulation to remove blood stasis, regulating menstrual blood volume and eliminating edema.
The kudzu root contains isoflavone simulated estrogen, and long-term soaking and drinking of the kudzu root can regulate the secretion and supply of estrogen in the female body, and has good promotion effects on maintaining ovaries and relieving gynecological inflammation.
The cortex Ailanthi has effects of clearing heat, eliminating dampness, astringing, and stopping leukorrhagia.
Frankincense with frankincense has the effects of activating blood, promoting qi circulation, relieving pain, eliminating swelling and promoting granulation.
The hairyvein agrimony extract is extracted by the special process, and the prevention and treatment of irregular menstruation and red metrorrhagia leucorrhea of female women are promoted.
The selenium malted tea can prevent recurrence and has antioxidant effect on affected skin.
The Tween-80 and the hydroxypropyl methyl cellulose compound promote the gel stability through the optimized proportion.
The invention has the beneficial effects that: compared with the prior art, the gynecological inflammation gel and the preparation method thereof have the advantages of reasonable compatibility, synergistic effect among the components, obvious antibacterial, lubricating and moisturizing effects, good effect on treating vaginitis and difficulty in relapse.
Detailed Description
Example 1
The gynecological inflammation gel mainly comprises the following raw materials in parts by weight: 3 parts of malt selenium, 18 parts of dandelion, 15 parts of motherwort, 12 parts of kudzuvine root, 17 parts of ailanthus bark, 9 parts of frankincense, 6 parts of hairyvein agrimonia herb and bud extract, 2 parts of sodium alginate, 5 parts of carboxymethyl cellulose, 1 part of azone, 3 parts of a tween-80 and hydroxypropyl methyl cellulose compound, 4 parts of natural moisturizing factor and 1 part of sorbic acid, wherein the tween-80 and hydroxypropyl methyl cellulose compound is prepared from tween-80 and hydroxypropyl methyl cellulose according to the weight ratio (4): 1 is prepared by compounding.
In this embodiment, the method for preparing the agrimony extract includes:
(1) extracting herba et Gemma Agrimoniae with 72% ethanol at 60 deg.C for 3 times (50 min for each time, 7 times of solvent weight of herba et Gemma Agrimoniae), filtering to obtain residue A and extractive solution, recovering ethanol from the extractive solution, concentrating, and drying to obtain extract A;
(2) extracting the residue A obtained in the step (1) with 58% ethanol at room temperature for 2 times (50 min for each time), wherein the amount of the solvent is 6 times of the weight of the Chrysosplenium, filtering, recovering ethanol from the extractive solution, concentrating to relative density of 1.10, and filtering to obtain medicinal liquid A;
(3) passing the liquid medicine A obtained in the step (2) through a nonpolar macroporous adsorption resin column, eluting with water, directly passing the water eluent through the polar macroporous adsorption resin column, eluting the nonpolar macroporous adsorption resin column with 65% ethanol solution, collecting ethanol eluates with different concentrations, concentrating and drying to obtain an extract B;
(4) eluting the polar macroporous adsorption resin column with 58% ethanol solution, collecting ethanol eluates with different concentrations, concentrating, and drying to obtain extract C;
mixing extract A, extract B and extract C, and stirring to obtain herba et Gemma Agrimoniae extract.
The preparation method of the gynecological inflammation gel in the embodiment comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) adding herba Taraxaci, herba Leonuri, radix Puerariae, cortex Ailanthi and Olibanum into 7 times of water, soaking for 1.8h, decocting with slow fire for 3h, filtering to remove residue;
(3) standing the liquid filtered and deslagged in the step (2) at normal temperature for 3h, filtering again, adding ethanol, adjusting to ethanol solubility of 65%, standing for 33h, filtering, and recovering ethanol at 40 ℃ to obtain a mixed liquid A;
(4) adding the specified mass parts of the maltsium malt, the hairyvein agrimonia herb and bud extract, the sodium alginate, the carboxymethyl cellulose, the azone, the compound of the Tween-80 and the hydroxypropyl methyl cellulose, the natural moisturizing factor and the sorbic acid into the mixed solution A, and uniformly stirring to obtain the product.
Example 2
The gynecological inflammation gel mainly comprises the following raw materials in parts by weight: 2-5 parts of selenium malt, 20 parts of dandelion, 10 parts of motherwort, 10 parts of kudzu root, 16 parts of ailanthus bark, 8 parts of frankincense, 3 parts of hairyvein agrimony extract, 1 part of sodium alginate, 4 parts of carboxymethyl cellulose, 1 part of azone, 1 part of tween-80 and hydroxypropyl methyl cellulose compound, 3 parts of natural moisturizing factor and 1 part of sorbic acid, wherein the tween-80 and hydroxypropyl methyl cellulose compound is prepared from tween-80 and hydroxypropyl methyl cellulose according to the weight ratio of 3: 1 is prepared by compounding.
The preparation method of the agrimony extract in the embodiment comprises the following steps:
(1) extracting herba et Gemma Agrimoniae with 70% ethanol at 55 deg.C for 2 times (30 min for each time), filtering to obtain residue A and extractive solution, recovering ethanol from the extractive solution, concentrating, and drying to obtain extract A;
(2) extracting the residue A obtained in the step (1) with 55% ethanol at room temperature for 1 time (30 min for each time), wherein the amount of the solvent is 5 times of the weight of the Chrysosplenium, filtering, recovering ethanol from the extractive solution, concentrating to relative density of 1.05, and filtering to obtain medicinal liquid A;
(3) passing the liquid medicine A obtained in the step (2) through a nonpolar macroporous adsorption resin column, eluting with water, directly passing the water eluent through the polar macroporous adsorption resin column, eluting the nonpolar macroporous adsorption resin column with 55% ethanol solution, collecting ethanol eluates with different concentrations, concentrating and drying to obtain an extract B;
(4) eluting the polar macroporous adsorption resin column with 55% ethanol solution, collecting ethanol eluates with different concentrations, concentrating, and drying to obtain extract C;
(5) mixing extract A, extract B and extract C, and stirring to obtain herba et Gemma Agrimoniae extract.
The preparation method of the gynecological inflammation gel in the embodiment comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) soaking herba Taraxaci, herba Leonuri, radix Puerariae, cortex Ailanthi and Olibanum in 6 times of water for 1.5 hr, decocting with slow fire for 2 hr, and filtering to remove residue;
(3) standing the liquid filtered and deslagged in the step (2) at normal temperature for 2h, filtering again, adding ethanol, adjusting to ethanol solubility of 65%, standing for 2h, filtering, and recovering ethanol at 40 ℃ to obtain a mixed liquid A;
(4) adding the specified mass parts of the maltsium malt, the hairyvein agrimonia herb and bud extract, the sodium alginate, the carboxymethyl cellulose, the azone, the compound of the Tween-80 and the hydroxypropyl methyl cellulose, the natural moisturizing factor and the sorbic acid into the mixed solution A, and uniformly stirring to obtain the product.
Example 3
The gynecological inflammation gel mainly comprises the following raw materials in parts by weight: 5 parts of malt selenium, 35 parts of dandelion, 18 parts of motherwort, 15 parts of kudzu root, 18 parts of ailanthus bark, 12 parts of frankincense, 8 parts of hairyvein agrimonia herb and bud extract, 3 parts of sodium alginate, 5 parts of carboxymethyl cellulose, 3 parts of azone, 4 parts of tween-80 and hydroxypropyl methyl cellulose compound, 5 parts of natural moisturizing factor and 2 parts of sorbic acid, wherein the tween-80 and hydroxypropyl methyl cellulose compound is prepared from tween-80 and hydroxypropyl methyl cellulose in a weight ratio of 5: 1 is prepared by compounding.
The preparation method of the agrimony extract in the embodiment comprises the following steps:
(1) extracting herba et Gemma Agrimoniae with 75% ethanol at 65 deg.C for 3 times (60 min for each time), filtering to obtain residue A and extractive solution, recovering ethanol from the extractive solution, concentrating, and drying to obtain extract A;
(2) extracting the residue A obtained in the step (1) with 60% ethanol at room temperature for 3 times (60 min for each time) with 7 times of solvent, filtering, recovering ethanol from the extractive solution, concentrating to relative density of 1.12, and filtering to obtain medicinal liquid A;
(3) passing the liquid medicine A obtained in the step (2) through a nonpolar macroporous adsorption resin column, eluting with water, directly passing the water eluent through the polar macroporous adsorption resin column, eluting the nonpolar macroporous adsorption resin column with 75% ethanol solution, collecting ethanol eluates with different concentrations, concentrating and drying to obtain an extract B;
(4) eluting the polar macroporous adsorption resin column with 60% ethanol solution, collecting ethanol eluates with different concentrations, concentrating, and drying to obtain extract C;
(5) mixing extract A, extract B and extract C, and stirring to obtain herba et Gemma Agrimoniae extract.
The preparation method of the gynecological inflammation gel in the embodiment comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) soaking herba Taraxaci, herba Leonuri, radix Puerariae, cortex Ailanthi and Olibanum in 8 times of water for 2h, decocting with slow fire for 3h, and filtering to remove residue;
(3) standing the liquid filtered and deslagged in the step (2) at normal temperature for 2-3h, filtering again, adding ethanol, adjusting to ethanol solubility of 65%, standing for 3h, filtering, and recovering ethanol at 40 ℃ to obtain a mixed solution A;
(4) adding the specified mass parts of the maltsium malt, the hairyvein agrimonia herb and bud extract, the sodium alginate, the carboxymethyl cellulose, the azone, the compound of the Tween-80 and the hydroxypropyl methyl cellulose, the natural moisturizing factor and the sorbic acid into the mixed solution A, and uniformly stirring to obtain the product.
Experimental example 1
The clinical practice test of 300 gynecological patients is selected, one group is formed in every 100 cases, one dose is taken every day for each group, and 15 days are a treatment course.
The therapeutic criteria are as follows:
and (3) healing: the symptoms, physical signs and gynecological examination are recovered to be normal;
the effect is shown: symptoms, physical symptoms and gynecological examination are also obviously improved;
the method has the following advantages: symptoms, physical symptoms and examinations are improved;
and (4) invalidation: the symptoms and physical symptoms are not obviously improved, and the symptoms are as before.
The total effective rate is the cure rate + significant efficiency + effective rate.
The results of the experiment are shown in table 1:
TABLE 1
The above embodiments are only specific examples of the present invention, and the protection scope of the present invention includes but is not limited to the product forms and styles of the above embodiments, and any suitable changes or modifications made by those skilled in the art according to the claims of the present invention shall fall within the protection scope of the present invention.
Claims (4)
1. A gynecological inflammation gel, which is characterized in that: the material mainly comprises the following raw materials in parts by weight: 2-5 parts of selenium malt, 20-35 parts of dandelion, 10-18 parts of motherwort, 10-15 parts of kudzu root, 16-18 parts of ailanthus bark, 8-12 parts of frankincense, 3-8 parts of hairyvein agrimonia herb and bud extract, 1-3 parts of sodium alginate, 4-5 parts of carboxymethyl cellulose, 1-3 parts of azone, 1-4 parts of a tween-80 and hydroxypropyl methyl cellulose compound, 3-5 parts of a natural moisturizing factor and 1-2 parts of sorbic acid, wherein the tween-80 and hydroxypropyl methyl cellulose compound is prepared from tween-80 and hydroxypropyl methyl cellulose according to the weight ratio (3-5): 1 is prepared by compounding.
2. The gynecological inflammation gel according to claim 1, characterized in that: the material mainly comprises the following raw materials in parts by weight: 3 parts of malt selenium, 18 parts of dandelion, 15 parts of motherwort, 12 parts of kudzuvine root, 17 parts of ailanthus bark, 9 parts of frankincense, 6 parts of hairyvein agrimonia herb and bud extract, 2 parts of sodium alginate, 5 parts of carboxymethyl cellulose, 1 part of azone, 3 parts of a tween-80 and hydroxypropyl methyl cellulose compound, 4 parts of natural moisturizing factor and 1 part of sorbic acid, wherein the tween-80 and hydroxypropyl methyl cellulose compound is prepared from tween-80 and hydroxypropyl methyl cellulose according to the weight ratio (4): 1 is prepared by compounding.
3. The gynecological inflammation gel according to claim 1, characterized in that: the preparation method of the hairyvein agrimony extract comprises the following steps:
(1) extracting herba et Gemma Agrimoniae with 70-75% ethanol at 55-65 deg.C for 2-3 times (30-60 min for each time) 6-8 times of the weight of herba et Gemma Agrimoniae, filtering to obtain residue A and extractive solution, recovering ethanol from the extractive solution, concentrating, and drying to obtain extract A;
(2) extracting the residue A obtained in the step (1) with 55-60% ethanol at room temperature for 1-3 times (each time for 30-60 min) at 5-7 times of the weight of Chrysosplenium, filtering, recovering ethanol from the extractive solution, concentrating to relative density of 1.05-1.12, and filtering to obtain medicinal liquid A;
(3) passing the liquid medicine A obtained in the step (2) through a nonpolar macroporous adsorption resin column, eluting with water, directly passing the water eluent through the polar macroporous adsorption resin column, eluting the nonpolar macroporous adsorption resin column with 55-75% ethanol solution, collecting ethanol eluates with different concentrations, concentrating and drying to obtain an extract B;
(4) eluting the polar macroporous adsorbent resin column with 55-60% ethanol solution, collecting ethanol eluates with different concentrations, concentrating, and drying to obtain extract C;
(5) mixing extract A, extract B and extract C, and stirring to obtain herba et Gemma Agrimoniae extract.
4. A preparation method of gynecological inflammation gel is characterized in that: the method comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) soaking herba Taraxaci, herba Leonuri, radix Puerariae, cortex Ailanthi and Olibanum in 6-8 times of water for 1.5-2 hr, decocting with slow fire for 2-3 hr, and filtering to remove residue;
(3) standing the liquid filtered and deslagged in the step (2) at normal temperature for 2-3h, filtering again, adding ethanol, adjusting to ethanol solubility of 65%, standing for 2-3h, filtering, and recovering ethanol at 40 deg.C to obtain a mixed solution A;
(4) adding the specified mass parts of the maltsium malt, the hairyvein agrimonia herb and bud extract, the sodium alginate, the carboxymethyl cellulose, the azone, the compound of the Tween-80 and the hydroxypropyl methyl cellulose, the natural moisturizing factor and the sorbic acid into the mixed solution A, and uniformly stirring to obtain the product.
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| CN102485244A (en) * | 2010-12-06 | 2012-06-06 | 株洲千金药业股份有限公司 | Application of Chinese medicinal composition in preparing gel for treating gynecological inflammation |
| CN103585291A (en) * | 2013-10-31 | 2014-02-19 | 济南星懿医药技术有限公司 | Application of herba delphinii extract in preparation of drugs treating AIDS |
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| CN102485244A (en) * | 2010-12-06 | 2012-06-06 | 株洲千金药业股份有限公司 | Application of Chinese medicinal composition in preparing gel for treating gynecological inflammation |
| CN103585291A (en) * | 2013-10-31 | 2014-02-19 | 济南星懿医药技术有限公司 | Application of herba delphinii extract in preparation of drugs treating AIDS |
| CN106420974A (en) * | 2016-09-23 | 2017-02-22 | 毛里夏里甫·哈帕 | Fumigation preparation for treating gynopathy, preparing method and application method |
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