CN102370742B - Medicine for treating eczema of children and preparation method thereof - Google Patents
Medicine for treating eczema of children and preparation method thereof Download PDFInfo
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- CN102370742B CN102370742B CN 201110353932 CN201110353932A CN102370742B CN 102370742 B CN102370742 B CN 102370742B CN 201110353932 CN201110353932 CN 201110353932 CN 201110353932 A CN201110353932 A CN 201110353932A CN 102370742 B CN102370742 B CN 102370742B
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Abstract
The invention discloses a medicine for treating the eczema of children and a preparation method thereof so as to solve the problem of treatment of the eczema. The medicine is characterized by being formed through processing radix sileris, honeysuckle, dahurian angelica root, great burdock fruit, wild chrysanthemum flower, broom cypress fruit, kadsura rootbark, radix salviae miltiorrhizae and peach glue; and the components proportioned by weight are in equal amount. The preparation method of the medicine comprises the following steps: extracting volatile oil from the radix sileris, the honeysuckle, the wild chrysanthemum flower and the broom cypress fruit, adding the peach glue into the water extract of the dahurian angelica root, the great burdock fruit, the kadsura rootbark and the radix salviae miltiorrhizae, stirring, heating and mixing the volatile oil and the mixture. Clinical experiments prove that the medicine for treating the eczema of the children has the characteristics of good curative effects and higher safety for treating the eczema and is worth of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to medicine for the treatment of eczema and preparation method thereof.
Background technology
Eczema is that common chronic, the recurrent of child, inflammatory skin are sick, is caused by multiple internal and external factor, and the allergy of atopy body constitution, food and the enviromental allergen mediation of, infant unbalance with skin barrier function is relevant.This disease pruritus is obvious, Relapse rate, has a strong impact on infant and the head of a family's thereof quality of life, particularly sleep quality.Common western medicine is antihistaminic and glucocorticoid, and the external glucocorticoid has non-specific antiinflammatory action, determined curative effect, but easily recurrence.And when infant such as need long-term treatment or the skin lesion of receiving treatment zone are excessive, cause the untoward reaction such as hypothalmus-pituitary-adrenal axis (HPA) axle inhibition after then might external glucocorticoid systemic Absorption.In addition, acute eczema belongs to the inflammation acute stage, can not medicinal external emulsifiable paste agent or cream when oozing out, can only use the water preparation soak, and also caused the inconvenience of external glucocorticoid.Research in recent years also shows, the field planting rate of staphylococcus aureus is significantly higher than the normal person on the skin of eczema patients, and the order of severity of skin lesion and the quantity of bacteria planting are proportionate, the extracellular toxin that gold Portugal bacterium discharges can bring out and add celsus' papules, and induce the glucocorticoid beta receptor to express, thereby suppress glucocorticoid α receptor, make the T cell insensitive to glucocorticoid, affect the treatment.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the medicine of the treatment eczema that side effect is little.
The technical scheme that the present invention solves its technical problem is: a kind of medicine for the treatment of eczema is characterized in that being processed by Radix Saposhnikoviae, Flos Lonicerae, the Radix Angelicae Dahuricae, Fructus Arctii, Flos Chrysanthemi Indici, the Fructus Kochiae, Cortex cercis chinensis, Radix Salviae Miltiorrhizae, gumshiraz its weight proportion equal portions.
Above-mentioned a kind of preparation method for the treatment of the medicine of eczema is comprised of following steps:
(1) Radix Saposhnikoviae, Flos Lonicerae, Flos Chrysanthemi Indici, the Fructus Kochiae are pulverized, extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Radix Angelicae Dahuricae, Fructus Arctii, Cortex cercis chinensis, Radix Salviae Miltiorrhizae mixing are added 10 times of water yields, decoct with water 2 times, each 1 hour, then collecting decoction left standstill add gumshiraz in decocting liquid, and agitating heating 0.5～1 hour is crossed leaching filtrate;
(3) gained volatile oil in the step 1 is added in the step 2 gained filtrate sub-bottle fill.
Wherein said:
Radix Saposhnikoviae is the dry root of Umbelliferae herbaceos perennial Radix Saposhnikoviae, but the merit expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.
Flos Lonicerae is the flower that Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or band are just opened, but the merit heat-clearing and toxic substances removing reaches eliminating evilly thoroughly, and dispelling wind-heat is kind removing summer-heat blood poison also.
The Radix Angelicae Dahuricae is the root of samphire Yu Radix Angelicae Dahuricae, angelica anomala, Radix angelicae dahuricae, the merit cold expelling that can induce sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness detumescence and apocenosis.
Fructus Arctii is the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..Nature and flavor are hot, bitter, and are cold.Attach to the lung and stomach meridians.But the merit dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, removing toxic substances and promoting subsidence of swelling.
Flos Chrysanthemi Indici is the head inflorescence of Compositae herbaceos perennial Herba Dendranthematis indici, but the merit heat-clearing and toxic substances removing, detumescence.
The Fructus Kochiae is the dry mature fruit of chenopod Fructus Kochiae Kochia scoparia (L.) Schrad..Nature and flavor are hot, bitter, and are cold.Return kidney, urinary bladder channel.But the merit clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.
Cortex cercis chinensis is Magnoliaceae Kadsura Fructus Schisandrae Sphenantherae Kadsura longepedunculata Fin.et Gagnep.; The bark of Lythraceae plant of Lagerstroemia Lagerstroemia indica L. Lagerstroemia indica L. and pulse family redbud cercis Cercis chinensis Bunge etc.Nature and flavor are bitter, and are flat.But the merit promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, detoxifcation.
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..Nature and flavor are bitter, are slightly cold.GUIXIN, Liver Channel.But the merit stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.
Gumshiraz is that the rosaceous plant peach tree does the upper resin that flows out, and is water-soluble gum.But the merit removing heat from blood and promoting blood circulation, benefiting qi for promoting granulation.
Composition principle: traditional medicine thinks, children's acute eczema for the heresy institute that is subjected to rheumatism outward extremely.Among the present invention, Radix Saposhnikoviae, the hot temperature of the Radix Angelicae Dahuricae, ailment said due to cold or exposure is dispersed in Flos Lonicerae, the hot cold of Fructus Arctii jointly; The detumescence of Radix Angelicae Dahuricae dispeiling pathogenic wind and removing dampness; The Flos Chrysanthemi Indici heat-clearing and toxic substances removing; The Fructus Kochiae, Cortex cercis chinensis are antipruritic; The Radix Salviae Miltiorrhizae promoting blood circulation by removing blood stasis; The gumshiraz removing heat from blood and promoting blood circulation, benefiting qi for promoting granulation.Modern pharmacology studies show that, Radix Saposhnikoviae volatile oil can obviously suppress CD54 expression, NF-κ B p65 activation and stop the increase of transcribing of NF-κ B p65 mRNA, reducing the synthetic of p65 albumen, and can the antagonism leukotriene active, jointly reach the purpose of its antiinflammatory.Cause rat paw edema and acetic acid and cause the acute inflammation of mice capillary permeability due to increasing remarkable inhibitory action is all arranged and Fructus Arctii extracting solution external xylol causes mice auricle swelling, carrageenin, can also significantly suppress allotransplantation in rats passive cutaneous anaphylaxis, PCA and the passive cutaneous anaphylaxis, PCA of mice xenogenesis, confirm that thus the Fructus Arctii extracting solution has good antiinflammatory, anti-allergic effects.In addition, the active component falcarindiol that contains in the Flos Chrysanthemi Indici also has vitro antibacterial activity to staphylococcus aureus.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug: Radix Saposhnikoviae 10g, Flos Lonicerae 10g, Radix Angelicae Dahuricae 10g, Fructus Arctii 10g, Flos Chrysanthemi Indici 10g, Fructus Kochiae 10g, Cortex cercis chinensis 10g, Radix Salviae Miltiorrhizae 10g, gumshiraz 10g.All medicines mix, decoct with water 2 times, and collecting decoction, decocting liquid is applied to the affected part.
Embodiment 2, crude drug: Radix Saposhnikoviae 20g, Flos Lonicerae 20g, Radix Angelicae Dahuricae 20g, Fructus Arctii 20g, Flos Chrysanthemi Indici 20g, Fructus Kochiae 20g, Cortex cercis chinensis 20g, Radix Salviae Miltiorrhizae 20g, gumshiraz 20g.All medicines mixes, and decocts with water 2 times, and collecting decoction adds 9 times of volumes to the pure water of decocting liquid, and whole body soaks, twice of every day.
Embodiment 3, crude drug: etc. Radix Saposhnikoviae, Flos Lonicerae, the Radix Angelicae Dahuricae, Fructus Arctii, Flos Chrysanthemi Indici, the Fructus Kochiae, Cortex cercis chinensis, Radix Salviae Miltiorrhizae, the gumshiraz of weight.Preparation method is comprised of following steps:
(1) Radix Saposhnikoviae, Flos Lonicerae, Flos Chrysanthemi Indici, the Fructus Kochiae are pulverized, extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Radix Angelicae Dahuricae, Fructus Arctii, Cortex cercis chinensis, Radix Salviae Miltiorrhizae mixing are added 10 times of water yields, decoct with water 2 times, each 1 hour, then collecting decoction left standstill add gumshiraz in decocting liquid, and agitating heating 0.5～1 hour is crossed leaching filtrate;
(3) gained volatile oil in the step 1 is added in the step 2 gained filtrate sub-bottle fill.
Effective combination of said medicine is coordinated mutually, effectively reach the purpose for the treatment of eczema, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows, and wherein drugs uses and is crude drug weight proportion and preparation method among the embodiment 3.
1 materials and methods
1.1 physical data
Eczema infant 104 examples of in December, 2008～2010 year December the court outpatient clinic are divided into 2 groups at random, treatment group 51 examples, male 28 examples, women 23 examples, 0.5～5 years old age, average (2.1 ± 1.8) year; Matched group 53 examples, male 31 examples, women 22 examples, 0.4～5.5 years old age, average (2 ± 2.1).Two groups of sexes, age differences not statistically significant.The diagnostic criteria of eczema is treated in front 2 weeks and was not used glucocorticoid or antihistamine drug with reference to " clinical dermatology ".
1.2 Therapeutic Method
Treatment group adopts the present invention's (embodiment 3 dosage and preparation method) affected part directly to smear, and oozes out obvious person and stock solution is poured on the gauze pad applies at affected part every day 2 times, each half an hour; Area the greater with 1: 9 mixed diluting of stock solution and pure water after whole body soak every day 2 times.Matched group affected part hydrocortisone butyrate ointment (trade name: hydrocortisone butyrate, Tianjin Pharmaceutical Group Corp., Ltd produces, the accurate word H10940095 of traditional Chinese medicines) smear, every day 2 times, ooze out obvious person and add with 3% boric acid solution soak.Two groups for the treatment of times are 14 days.Stop using other for oral administration or external used medicine during the treatment of two groups of infants, avoid Exposure to Sunlight and pungent irritative food etc., when the treatment later stage xerosis cutis, desquamation or rash occur and itches, can give Vitamin E Cream and put skin moistening outward on the skin.
1.3 curative effect determinate standard 3d, 7d, 14d after the first visit same day and treatment carry out observation of curative effect, parameters for observation on effect comprises subjective symptoms and sign.
1.3.1 subjective symptoms adopts the level Four method, 0 is divided into without gargalesthesia, and the sleep of infant diet is normal; 1 to be divided into pruritus light, without crying and screaming; 2 are divided into rash itches and causes agitation, and time has and cries and screams, but does not affect sleep; 3 are divided into pruritus affects daily life and sleep.
1.3.2 sign adopts eczema skin lesion area and severity index (eczema area and severity index, EASI) point system, be divided into 4, be erythema (erythema, E), firmly swollen or pimple (induration/papulation, I), exfoliation (excoriation, Ex), lichenization (lichenification, L), each sign performance order of severity divide in 0～3 minute (0 minute=without, 1 minute=light, 2 minutes=in, 3 minutes=heavy).The ratio score value that the skin lesion area accounts for each position area is 0～6 minute: 0 is divided into without erythra, 1 is divided into＜10%, 2 be divided into 10%～19%, and 3 are divided into 20%～49%, and 4 are divided into 50%～69%, and 5 are divided into 70%～89%, and 6 are divided into 90%～100%.Scoring * 100% before therapeutic index=(scoring after scoring-treatment before the treatment)/treatment.Cure and be therapeutic index 〉=90%; Produce effects is that therapeutic index is 60%～89%; Progressive is therapeutic index 30%～59%; Invalid is therapeutic index＜30% or sx↑.Effective percentage=cure rate+obvious effective rate.
1.4 statistical method
Measurement data with
Expression relatively with the q check, is relatively adopted paired t-test between group before and after the treatment; Enumeration data adopts χ
2Check; There is statistical significance P＜0.05 for difference.
2 results
Comparing results show in the group 2.1 relatively the skin pruritus symptom is marked before and after two groups of treatments in the subjective symptoms scoring group and between group before and after the treatment, before 3d and the treatment more variant (P＜0.05), 7d and 14d symptom are extremely obviously improved (P＜0.01) after the treatment group treatment; Compare symptom after the treatment of control group before 7d, 14d and the treatment and extremely obviously improve (P＜0.01); Relatively, treatment group is better than matched group during the rear 3d for the treatment of between two groups of groups, and difference has statistical significance (P＜0.05), and this difference may be relevant with the effect of many target spots of Chinese medicine inflammation-resisting itch-stopping.See Table 1.
Comparison structure show in the group 2.2 relatively EASI marks before and after two groups of treatments in the EASI scoring group and between group before and after the treatment, relatively there are differences (P＜0.05) behind two groups for the treatment of 3d with before the treatment, treatment when 7d, 14d with treatment before comparing difference all significantly (P＜0.01).Compare difference not statistically significant (P＞0.05) between two groups of groups.See Table 1.
2.3 effective percentage is 58.82% during therapeutic evaluation treatment group 3d, matched group is to compare χ between 69.81%, two group of group
2=1.37, P=0.24; Effective percentage is 76.47% during treatment group 7d, and matched group is to compare χ between 73.58%, two group of group
2=0.11, P=0.73; Effective percentage is 86.27% during treatment group 14d, and matched group is to compare χ between 86.79%, two group of group
2=0.01, P=0.93.With comparing difference not statistically significant (P＞0.05) between two groups of time points, show two groups of therapeutic equivalences.See Table 1.
The therapeutic evaluation of table 1 infantile eczema and EASI scoring situation
It is relatively front with the treatment of this group,
#P＜0.05,
*P＜0.01; Compare between treatment group and matched group group,
△P＜0.05
2.4 in the recurrence 6 months, treatment group recurs 9 examples (17.65%), matched group recurs 10 examples (18.87%), comparing difference not statistically significant (χ between two groups
2=0.02, P=0.87).
3. conclusion
This result of study shows that external curing children's acute eczema of the present invention and glucocorticoid curative effect approach, and clinical efficacy is sure.
In sum, external curing children's acute eczema determined curative effect of the present invention, avoided using the rebound phenomenon that occurs after untoward reaction due to the glucocorticoid ointment and the drug withdrawal, without obviously side reaction, and because it not only can have been put on the skin outward, but soak but also washout are taken a shower, especially applicable infant and the extensive person of skin lesion area, clinic is selected.
Claims (1)
1. a medicine for the treatment of childhood eczema is characterized in that being processed by Radix Saposhnikoviae, Flos Lonicerae, the Radix Angelicae Dahuricae, Fructus Arctii, Flos Chrysanthemi Indici, the Fructus Kochiae, Cortex cercis chinensis, Radix Salviae Miltiorrhizae, gumshiraz, and its weight proportion is equal portions; The preparation method of described medicine is comprised of following steps:
(1) Radix Saposhnikoviae, Flos Lonicerae, Flos Chrysanthemi Indici, the Fructus Kochiae are pulverized, extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Radix Angelicae Dahuricae, Fructus Arctii, Cortex cercis chinensis, Radix Salviae Miltiorrhizae mixing are added 10 times of water yields, decoct with water 2 times, each 1 hour, then collecting decoction left standstill add gumshiraz in decocting liquid, and agitating heating 0.5 ~ 1 hour is crossed leaching filtrate;
(3) gained volatile oil in the step 1 is added in the step 2 gained filtrate sub-bottle fill.
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| CN103142741B (en) * | 2013-04-09 | 2014-03-19 | 袁夏 | Traditional Chinese medicine composition for treating infantile eczema and preparation method thereof |
| CN105796643A (en) * | 2016-03-24 | 2016-07-27 | 刘吉伟 | Traditional Chinese medicine lotion for treating infantile eczema and nursing method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1351876A (en) * | 2000-11-14 | 2002-06-05 | 深圳市中药总厂 | Chinese medicine external use lotion for treating skin diseases and its preparing method |
| CN101284082A (en) * | 2008-05-24 | 2008-10-15 | 李四牛 | Medicine for treating multiple skin diseases |
| CN102205080A (en) * | 2011-05-25 | 2011-10-05 | 栾艳 | External application medicinal composition for treating leukoplakia vulvae and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1351876A (en) * | 2000-11-14 | 2002-06-05 | 深圳市中药总厂 | Chinese medicine external use lotion for treating skin diseases and its preparing method |
| CN101284082A (en) * | 2008-05-24 | 2008-10-15 | 李四牛 | Medicine for treating multiple skin diseases |
| CN102205080A (en) * | 2011-05-25 | 2011-10-05 | 栾艳 | External application medicinal composition for treating leukoplakia vulvae and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 中药熏洗配合微波照射治疗肛门湿疹42例;蒋进广等;《湖南中医杂志》;20060131;第22卷(第1期);第35页2.1节 * |
| 蒋进广等.中药熏洗配合微波照射治疗肛门湿疹42例.《湖南中医杂志》.2006,第22卷(第1期),第35页2.1节. |
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