CN103768192A - Medicine for treating children eczema and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating children eczema and a preparation method thereof, and is used for solving a treatment problem of eczema. The medicine is characterized by being prepared through processing radix sileris, fructus arctii, wild chrysanthemum, fructus kochiae, cortex kadsurae radicis, radix salviae miltiorrhizae, prunus persica batsch and menthol, wherein the weight ratios of the components are in equal. The preparation method of the medicine comprises the following steps: extracting volatile oils from radix sileris, honeysuckle, wild chrysanthemum and fructus kochiae, adding prunus persica batsch into an aqueous extract liquid of dahurian angelica root, fructus arctii, cortex kadsurae radicis, radix salviae miltiorrhizae and menthol, stirring, heating, and mixing the volatile oils and the mixture. Clinical experiments prove that the medicine for treating children eczema has the characteristics of good curative effects and higher safety, and is worth of clinical application and popularization.

Description

A kind of medicine for the treatment of childhood eczema and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to medicine for the treatment of eczema and preparation method thereof.

Background technology

Eczema is common chronic, the recurrent of child, inflammatory skin disease, is caused by multiple internal and external factor, and the allergy of atopy body constitution, food and the enviromental allergen mediation of, infant unbalance with skin barrier function is relevant.This disease pruritus is obvious, Relapse rate, has a strong impact on infant and the head of a family's thereof quality of life, particularly sleep quality.Common western medicine is antihistaminic and glucocorticoid, and external glucocorticoid has non-specific antiinflammatory action, determined curative effect, but easily recurrence.And when infant is as excessive in the skin lesion region that needs long-term treatment or receive treatment, likely after external glucocorticoid systemic Absorption, cause the untoward reaction such as hypothalmus-pituitary-adrenal axis (HPA) axle inhibition.In addition, acute eczema belongs to inflammation acute stage, can not medicinal external emulsifiable paste agent or cream when oozing out, can only use water preparation soak, and also cause the inconvenience of external glucocorticoid.Research in recent years also shows, on the skin of eczema patients, the field planting rate of staphylococcus aureus is significantly higher than normal person, and the order of severity of skin lesion and the quantity of bacteria planting are proportionate, the extracellular toxin that gold Portugal bacterium discharges can bring out and add celsus' papules, and induce glucocorticoid beta receptor to express, thereby suppress glucocorticoid α receptor, make T cell insensitive to glucocorticoid, affect the treatment.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the medicine of the treatment eczema that side effect is little.

The technical scheme that the present invention solves its technical problem is: a kind of medicine for the treatment of eczema, is characterized in that being processed by Radix Saposhnikoviae, Fructus Arctii, Flos Chrysanthemi Indici, the Fructus Kochiae, Cortex cercis chinensis, Radix Salviae Miltiorrhizae, gumshiraz, Mentholum its weight proportion equal portions.

The preparation method of above-mentioned a kind of medicine for the treatment of eczema is made up of following steps:

(1) Radix Saposhnikoviae, Flos Chrysanthemi Indici, the Fructus Kochiae are pulverized, extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;

(2) Fructus Arctii, Cortex cercis chinensis, Radix Salviae Miltiorrhizae, Mentholum are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, left standstill and then in decocting liquid, adds gumshiraz, and agitating heating 0.5～1 hour is crossed leaching filtrate;

(3) gained volatile oil in step 1 is added in step 2 gained filtrate to sub-bottle fill.

Wherein said:

Radix Saposhnikoviae is the dry root of Umbelliferae herbaceos perennial Radix Saposhnikoviae, and merit can expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.

Fructus Arctii is the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..Nature and flavor are pungent, bitter, cold.Attach to the lung and stomach meridians.Merit can dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, removing toxic substances and promoting subsidence of swelling.

Flos Chrysanthemi Indici is the head inflorescence of Compositae herbaceos perennial Herba Dendranthematis indici, and merit can heat-clearing and toxic substances removing, detumescence.

The Fructus Kochiae is the dry mature fruit of chenopod Fructus Kochiae Kochia scoparia (L.) Schrad..Nature and flavor are pungent, bitter, cold.Return kidney, urinary bladder channel.Merit can clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.

Cortex cercis chinensis is Magnoliaceae Kadsura Fructus Schisandrae Sphenantherae Kadsuralongepedunculata Fin.et Gagnep.; The bark of Lythraceae plant of Lagerstroemia Lagerstroemia indica L. Lagerstroemia indica L. and pulse family redbud cercis Cercis chinensis Bunge etc.Nature and flavor hardship, flat.Merit can promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, removing toxic substances.

Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..Nature and flavor hardship, is slightly cold.GUIXIN, Liver Channel.Merit can stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and relieving restlessness clears away heart-fire.

Gumshiraz is the dry upper resin flowing out of rosaceous plant peach tree, is water-soluble gum.Merit can removing heat from blood and promoting blood circulation, benefiting qi for promoting granulation.

Composition principle: traditional medicine thinks, children's acute eczema for the heresy institute that is subject to rheumatism outward extremely.In the present invention, the pungent temperature of Radix Saposhnikoviae, Fructus Arctii is pungent cool, jointly disperses ailment said due to cold or exposure; The detumescence of Radix Angelicae Dahuricae dispeiling pathogenic wind and removing dampness; Flos Chrysanthemi Indici heat-clearing and toxic substances removing; The Fructus Kochiae, Cortex cercis chinensis are antipruritic; Radix Salviae Miltiorrhizae promoting blood circulation by removing blood stasis; Gumshiraz removing heat from blood and promoting blood circulation, benefiting qi for promoting granulation.Modern pharmacology research shows, Radix Saposhnikoviae volatile oil can obviously suppress CD54 expression, NF-κ B p65 activation and stop the increase of transcribing of NF-κ B p65mRNA, to reduce the synthetic of p65 albumen, and can antagonism leukotriene activity, jointly reach the object of its antiinflammatory.Cause rat paw edema and acetic acid and cause the acute inflammation of mice capillary permeability due to increasing and all have remarkable inhibitory action and Fructus Arctii extracting solution external xylol causes mice auricle swelling, carrageenin, can also significantly suppress allotransplantation in rats passive cutaneous anaphylaxis, PCA and the passive cutaneous anaphylaxis, PCA of mice xenogenesis, confirm that thus Fructus Arctii extracting solution has good antiinflammatory, anti-allergic effects.In addition the active component falcarindiol, containing in Flos Chrysanthemi Indici also has vitro antibacterial activity to staphylococcus aureus.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, crude drug: Radix Saposhnikoviae 10g, Fructus Arctii 10g, Flos Chrysanthemi Indici 10g, Fructus Kochiae 10g, Cortex cercis chinensis 10g, Radix Salviae Miltiorrhizae 10g, gumshiraz 10g, Mentholum 10g.All medicines mix, decoct with water 2 times, and collecting decoction, decocting liquid is applied to affected part.

1 materials and methods

1.1 physical data

Eczema infant 104 examples of in December, 2008～2010 year December the court outpatient clinic, are divided into 2 groups at random, treatment group 51 examples, male 28 examples, female's 23 examples, 0.5～5 years old age, average (2.1 ± 1.8) year; Matched group 53 examples, male 31 examples, female's 22 examples, 0.4～5.5 years old age, average (2 ± 2.1).Two groups of sexes, age differences not statistically significant.The diagnostic criteria of eczema, with reference to " clinical dermatology ", is treated in first 2 weeks and was not used glucocorticoid or antihistamine drug.

1.2 Therapeutic Method

Treatment group adopts the present invention's (embodiment 3 dosage and preparation method) affected part directly to smear, and oozes out obvious person stock solution is poured on a gauze pad and is applied at affected part, every day 2 times, each half an hour; Area the greater soaks whole body after stock solution and 1: 9 mixed diluting of pure water, every day 2 times.Matched group affected part hydrocortisone butyrate ointment (trade name: hydrocortisone butyrate, Tianjin Pharmaceutical Group Corp., Ltd produces, the accurate word H10940095 of traditional Chinese medicines) smear, every day 2 times, ooze out obvious person and add with 3% boric acid solution soak.Two groups for the treatment of times are 14 days.During two groups of infant treatments, stop using other for oral administration or external used medicine, avoid Exposure to Sunlight and pungent irritative food etc., in the time that the treatment later stage occurs that xerosis cutis, desquamation or rash are itched, can give Vitamin E Cream and put skin moistening outward on the skin.

1.3 curative effect determinate standards 3d, 7d, 14d after the first visit same day and treatment carry out observation of curative effect, and parameters for observation on effect comprises subjective symptoms and sign.

1.3.1 subjective symptoms adopts level Four method, and 0 is divided into without gargalesthesia, and the sleep of infant diet is normal; 1 to be divided into pruritus light, without crying and screaming; 2 are divided into rash itches and causes agitation, and time has and cries and screams, but does not affect sleep; 3 are divided into pruritus affects daily life and sleep.

1.3.2 sign adopts eczema skin lesion area and severity index (eczema area andseverity index, EASI) point system, be divided into 4, be erythema (erythema, E), firmly swollen or pimple (induration/papulation, I), exfoliation (excoriation, Ex), lichenization (lichenification, L), each sign performance order of severity divide in 0～3 point (0 point=without, 1 point=light, 2 points=in, 3 points=heavy).The ratio score value that skin lesion area accounts for each position area is 0～6 point: 0 is divided into without erythra, and 1 is divided into < 10%, 2 is divided into 10%～19%, 3 are divided into 20%～49%, 4 are divided into 50%～69%, and 5 are divided into 70%～89%, and 6 are divided into 90%～100%.Scoring × 100% before therapeutic index=(scoring after scoring-treatment before treatment)/treatment.Cure as therapeutic index >=90%; Effective for therapeutic index be 60%～89%; Progressive is therapeutic index 30%～59%; Invalidly increase the weight of for therapeutic index < 30% or symptom.Effective percentage=cure rate+obvious effective rate.

1.4 statistical method

Measurement data with

represent, between group, relatively with q check, before and after treatment, relatively adopt paired t-test; Enumeration data adopts χ ²check; P < 0.05 has statistical significance for difference.

2 results

Before and after 2.1 treatments, relatively the skin pruritus symptom comparing results in group of marking before and after two groups of treatments show in subjective symptoms scoring groups and between group, after treatment group treatment, before 3d and treatment more variant (P < 0.05), 7d and 14d symptom are extremely obviously improved (P < 0.01); After treatment of control group, before 7d, 14d and treatment, relatively symptom is extremely obviously improved (P < 0.01); Between two groups of groups, relatively, when the rear 3d for the treatment of, treatment group is better than matched group, and difference has statistical significance (P < 0.05), and this difference may be relevant with the effect of many target spots of Chinese medicine inflammation-resisting itch-stopping.In table 1.

Before and after 2.2 treatments, relatively the EASI comparison structure in group of marking before and after two groups of treatments show in EASI scoring groups and between group, after two groups for the treatment of 3d with before treatment, relatively there are differences (P < 0.05), treatment when 7d, 14d with treatment before all significantly (P < 0.01) of comparing difference.Between two groups of groups, compare difference not statistically significant (P > 0.05).In table 1.

3. conclusion

The demonstration of this result of study, external curing children's acute eczema of the present invention and glucocorticoid curative effect approach, and clinical efficacy is sure.

In sum, external curing children's acute eczema determined curative effect of the present invention, avoid the rebound phenomenon occurring after untoward reaction due to application glucocorticoid ointment and drug withdrawal, without obviously side reaction, and because it not only can have been put on the skin outward, soak but also can washout take a shower, especially be suitable for infant and the extensive person of skin lesion area, clinic is selected.

Claims (2)

1. treat a medicine for childhood eczema, it is characterized in that being processed by Radix Saposhnikoviae, Fructus Arctii, Flos Chrysanthemi Indici, the Fructus Kochiae, Cortex cercis chinensis, Radix Salviae Miltiorrhizae, gumshiraz, Mentholum, its weight proportion is equal portions.

2. a kind of preparation method for the treatment of childhood eczema medicine claimed in claim 1 is made up of following steps:

(1) Radix Saposhnikoviae, Flos Chrysanthemi Indici, the Fructus Kochiae are pulverized, extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;

(2) Fructus Arctii, Cortex cercis chinensis, Radix Salviae Miltiorrhizae, Mentholum are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, left standstill and then in decocting liquid, adds gumshiraz, and agitating heating 0.5～1 hour is crossed leaching filtrate;

(3) gained volatile oil in step 1 is added in step 2 gained filtrate to sub-bottle fill.