CN102205080A - External application medicinal composition for treating leukoplakia vulvae and preparation method thereof - Google Patents
External application medicinal composition for treating leukoplakia vulvae and preparation method thereof Download PDFInfo
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- CN102205080A CN102205080A CN2011101371062A CN201110137106A CN102205080A CN 102205080 A CN102205080 A CN 102205080A CN 2011101371062 A CN2011101371062 A CN 2011101371062A CN 201110137106 A CN201110137106 A CN 201110137106A CN 102205080 A CN102205080 A CN 102205080A
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Abstract
The invention discloses an external application medicinal composition for treating leukoplakia vulvae and a preparation method thereof, which are used for solving the problem of the treatment of leukoplakia vulvae. The external application medicinal composition is characterized by containing the following raw medicaments in parts by weight: 8-12 parts of root-bark of peony, 8-12 parts of ledebouriella root, 8-12 parts of stemona root, 8-12 parts of pine needle, 8-12 parts of colophony powder, 4-6 parts of peach tree glue, 1 part of fistrlar onion and 14-20 parts of siritch. The preparation method of the medicinal composition comprises the following steps of: frying the fistrlar onion in the siritch; filtering oil-bearing materials; adding the root-bark of peony, the ledebouriella root, the stemona root and the pine needle; filtering with oil; adding the colophony powder and the peach tree glue; stirring and decocting; removing infectious water; and performing cooling and split charging. As proved by clinical trial, the external application medicinal composition has the characteristics of good healing effect and high safety when being used for treating leukoplakia vulvae, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to externally-applied medicinal composition for the treatment of leukoplakia vulvae and preparation method thereof.
Background technology
Leukoplakia vulvae claims leukoplakia vulvae again, points out the limitation or the diffusivity white speckle of present women's genital skin, can spread to two preaxials, perineum and anus, but seldom invade urethral orifice and vestibule, and be a kind of chronic cysthus dystrophic disease.This disease can betide any age, and in each period of women: all there are report in juvenile stage, adolescence, climacteric and geratic period, but the climacteric person before and after 50 years old is in the majority, and the course of disease is different in size, and the elder can reach many decades.The cause of disease is unclear, may be relevant with the general factor, and as relevant with diabetes, endocrine regulation.Disease is seen pudendal pruritus, xerosis cutis, and plumpness bleaches, follows the string, in addition the atrophy ulceration, pain and burn feeling are arranged, vaginal orifice is narrow and small, elasticity disappears, even influence is urinated and sexual life.
Leukoplakia vulvae must be adhered to long-term treatment, regularly with examining.Because etiology unknown does not still have the specific therapy method.Present therapeutic modality mainly contains three kinds: 1. excision: because leukoplakia vulvae is a kind of precancerous lesion, may develop into carcinoma vulvae, so previously advocate surgical resection therapy, but shortcoming is to cause wound, the postoperative sexual life is subjected to very big influence, and the relapse rate height more than 80%, has not now been advocated operative treatment; 2. laser, thermotherapy: curative effect is unreliable, and atrophy is increased the weight of, and causes pudendum nutrition road barricade because primary disease is a various factors, the local nutrient that lacks, and thermotherapy, laser then increase the weight of the consume of nutrient, thereby the breach atrophy is increased the weight of; 3. external 2% hydrocortisone ointment, or be coated with 2% Testosterone Propionate cod liver oil ointment, its purpose is antipruritic, takes effect though short-term has necessarily, in case drug withdrawal will show effect repeatedly, causes the dependence to medicine, is difficult to fundamentally obtain medical treatment.Above therapeutic scheme all belongs to the refractory basis of taking stopgap measures, can't recover the blood circulation and the nutrition supply of pudendum, can only suppress pruritus, fester, surface symptoms such as keratinization, can not fundamentally treat leukoplakia vulvae, cause bad mental pressure and serious financial burden to extensive patients, allow the patient miss best occasion for the treatment.
And the use of Chinese medicine at present mostly is decoction oral, to close the XIAOFENG SAN sanction with SIWU TANG be main prescription: Radix Angelicae Sinensis, the Radix Rehmanniae, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, each 15g of Herba Spirodelae, Rhizoma Chuanxiong, Radix Saposhnikoviae, Herba Schizonepetae, Periostracum Cicadae, each 10g of Radix Achyranthis Bidentatae as disclosed in " Jiangxi Chinese medicine " 2002 the 33rd volume the 1st phase " the nourishing blood to expel wind method is main treatment leukoplakia vulvae 38 examples ".1 dose of every day, be decocted in water for oral dose for 2 times sooner or later.30 days is a course of treatment, treats 1～2 course of treatment.After but oral drugs absorbed by the intestines and stomach, active ingredient was difficult to arrive pudendum, and drug effect is had a greatly reduced quality, and influences therapeutic effect, therefore can't thoroughly cure leukoplakia vulvae.The exterior-applied formulation report is also arranged, as disclosed female peaceful (Radix Salviae Miltiorrhizae, Fructus Cnidii, Cortex Dictamni, Fructus Psoraleae, each 15g of Herba Epimedii) external wad part of itching in " the Shaanxi traditional Chinese medical science " calendar year 2001 the 22nd volume o. 11th " female itching rather controlled leukoplakia vulvae 285 examples " with 24h after the fumigation in treating primary disease, but medicated cushion and fumigation and wash method complex operation, fumigation and wash method medicament Local Residence Time is short, drug effect can't continue, and uses inconvenience.
Summary of the invention
Technical assignment of the present invention is at above the deficiencies in the prior art, provides a kind of curative effect certainly and the externally-applied medicinal composition of the little treatment leukoplakia vulvae of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of externally-applied medicinal composition for the treatment of leukoplakia vulvae is characterized in that being made up of following materials of weight proportions medicine: 14 ~ 20 parts of 8 ~ 12 parts of Cortex Moutans, 8 ~ 12 parts of Radix Saposhnikoviaes, 8 ~ 12 parts of the Radixs Stemonae, 8 ~ 12 parts in Folium Pini, 8 ~ 12 parts of Colophonium powder, 4 ~ 6 parts of gumshiraz, very light blue 1 part, siritch.
Chinese medicine of the present invention is prepared from by following optimum weight part proportion raw material:
16 parts of 10 parts of Cortex Moutans, 10 parts of Radix Saposhnikoviaes, 10 parts of the Radixs Stemonae, 10 parts in Folium Pini, 10 parts of Colophonium powder, 5 parts of gumshiraz, very light blue 1 part, siritch.
Chinese medicine of the present invention can be prepared from by following method:
(1), with Cortex Moutan, Radix Saposhnikoviae, the Radix Stemonae, Folium Pini clean, dry, pulverize, become compound standby after 100 mesh sieves;
(2), get siritch and be heated to 200 ℃ ~ 220 ℃, fry in shallow oil very light blue the adding withered by root, take out the Herba Alii fistulosi slag, the oil plant filtering is heated to 200 ℃ ~ 220 ℃, drops into the compound that step 1 produced, stir, heat after 10 ~ 15 minutes the oil plant filtering, be heated to 80 ℃ ~ 100 ℃, add Colophonium powder, gumshiraz, continue to stir, boil when dripping beading, spray cold water in surface is removed noxious water, is cooled to room temperature and is distributed into bottle and gets final product.
Wherein said: Cortex Moutan is the dry root bark of ranunculaceae peony, but the merit clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.
Radix Saposhnikoviae is the dry root of Umbelliferae herbaceos perennial Radix Saposhnikoviae, but the merit expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.
The Radix Stemonae is the dried root of Stemonaceae plant Radix Stemonae, Radix stemonae japonicae or radix stemonae tuberosae, but the merit parasite killing.
Folium Pini is the dry needle of Folium seu Strobilus Pini sibiricae, Pollen pini thunbergii, Pinus tabuliformis, Pinus koraiensis, Pinus armandi Franch-P. Komavovii Lavl., pinus yunnanensis faranch, Pinus kesiya Royle ex Gordon var. langbianensis (A.Chev) Gaussen, Pinus massoniana Lamb in the Pinaceae pine genus plant etc.But the merit dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching.
Colophonium powder is the oleoresin of obtaining in pinaceae plant Pinus massoniana Lamb or its congener trunk, the powder that the legacy after volatile oil is removed in distillation is made.But the merit dispeiling pathogenic wind and removing dampness, evacuation of pus is drawn out pus by applying a plaster to the affected part, the granulation promoting pain relieving.
Gumshiraz is gone up effusive resin for the rosaceous plant peach tree does.But the merit removing heat from blood and promoting blood circulation, benefiting qi for promoting granulation.
Very light blue is the cauloid of Liliaceae allium Herba Alii fistulosi, and merit can be detoxified to loose and be coagulated.
Siritch is the fatty oil that Pedaliaceae plant sesame seed squeezes, and merit can be moisturized, detoxifcation, pain relieving, detumescence.
Composition principle: leukoplakia vulvae card belongs to deficiency in origin and excess in superficiality, and deficiency of the kidney, deficiency of liver-blood be in interior, " turbid damp ", " wind-dryness " in outside.The Liver and kidney deficiency of YIN-blood, pudendum wind syndrome due to blood-deficiency dryness-transformation and arrive and very itch unbearably deficiency of vital energy insufficiency of blood, can not nourish pudendum, insufficiency of the spleenly can give birth to wetly again, multiple abscess is in pudendum, form insufficiency of vital energy and blood and simulataneous insufficiency and excessive situation that turbid damp is stagnated, or because of containing in damp and hot, heat is accumulate the pudendum skin and the pudendal pruritus that arrives, pachylosis; Disease is gone into network, and QI-blood circulation does not freely form stasis, hands over knot mutually with turbid damp, and see lichen, very itch, the eczema sample changes the nobility, and prolongedly do not heal.
The present invention is directed to etiology and pathogenesis, outward in order to dispeiling pathogenic wind and removing dampness, invigorate blood circulation antipruritic, to eliminate symptom.So we get Radix Saposhnikoviae, Folium Pini, Colophonium powder dispeiling pathogenic wind and removing dampness; Cortex Moutan, gumshiraz removing heat from blood and promoting blood circulation dissipating blood stasis improve local microcirculation; The Radix Stemonae, Folium Pini are with antipruritic; Gumshiraz, Colophonium powder have the effect of removing toxic substances and promoting tissue regeneration simultaneously, impel the local mucous membrane reparation; Very light blue merit can be detoxified to loose and be coagulated, and is used for making too sticking together of Colophonium, gumshiraz.Siritch decocts medicament, granulation promoting meat is arranged, the effect of the pain that relieves the pain, subduing inflammation, benefit rhagades of the skin.All medicine reinforcement and elimination in combination, evident in efficacy.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: 14 parts of 8 parts of Cortex Moutans, 8 parts of Radix Saposhnikoviaes, 8 parts of the Radixs Stemonae, 8 parts in Folium Pini, 8 parts of Colophonium powder, 4 parts of gumshiraz, very light blue 1 part, siritch.
Embodiment 2, the crude drug weight proportion: 20 parts of 12 parts of Cortex Moutans, 12 parts of Radix Saposhnikoviaes, 12 parts of the Radixs Stemonae, 12 parts in Folium Pini, 12 parts of Colophonium powder, 6 parts of gumshiraz, very light blue 1 part, siritch.
Embodiment 3, the crude drug weight proportion: 16 parts of 10 parts of Cortex Moutans, 10 parts of Radix Saposhnikoviaes, 10 parts of the Radixs Stemonae, 10 parts in Folium Pini, 10 parts of Colophonium powder, 5 parts of gumshiraz, very light blue 1 part, siritch.
Chinese medicine of the present invention can be prepared from by following method:
(1), with Cortex Moutan, Radix Saposhnikoviae, the Radix Stemonae, Folium Pini clean, dry, pulverize, become compound standby after 100 mesh sieves;
(2), get siritch and be heated to 200 ℃ ~ 220 ℃, fry in shallow oil very light blue the adding withered by root, take out the Herba Alii fistulosi slag, the oil plant filtering is heated to 200 ℃ ~ 220 ℃, drops into the compound that step 1 produced, stir, heat after 10 ~ 15 minutes the oil plant filtering, be heated to 80 ℃ ~ 100 ℃, add Colophonium powder, gumshiraz, continue to stir, boil when dripping beading, spray cold water in surface is removed noxious water, is cooled to room temperature and is distributed into bottle and gets final product.
All medicine compositions are coordinated mutually, dispeiling pathogenic wind and removing dampness, invigorate blood circulation antipruritic, effectively reach the treatment leukoplakia vulvae purpose.Outward appearance is yellow semi-solid ointment, uniform and smooth, and stretchability is good, and is easy to use.The above results is that clinical data proves that fully interrelated data is as follows, wherein studies drug use and is the crude drug weight proportion among the embodiment 3.
1 object and method.
1.1 object.
1.1.1 the standard of including in is my out-patient of gynecological of institute of in January, 2004 ~ 2010 year October, clinical manifestation is a pruritus vulvae companion hypopigmentation.
1.1.2 except the clear and definite cause of disease persons such as exclusion standard psoriasis, colpitis mycotica.
1.1.3 ordinary circumstance has 220 examples and enters research, 17 years old ~ 68 years old age, and the course of disease 2 months ~ 30 years, the lichen type that wherein hardens 66 examples, hypertrophy type 84 examples, mixed type 70 examples are not in the mood for, liver, kidney disease on inspection.Pathological changes is in the labium majus inboard and nympha person's 198 examples, pruritus vulvae 180 examples, and skin lesion 182 examples, coarse 89 examples, 68 examples of chapping, atrophy 62 examples all have hypopigmentation, bleach.
1.2 method.
1.2.1 research method gives the invention treatment of this Chinese medicine, decrease district local external use in disease and smear, before sleeping every day once.Be 8 weeks the course of treatment.Variation and the skin lesion of observing pudendum mucous membrane white spot skin lesion in the treatment dwindles, pruritus situation and have or not situation such as secretions.
1.2.2 the efficacy assessment standard therapeutic process is observed the variation of skin lesion, is mainly the color change of mucosa, the variation of skin lesion scope.Recovery from illness is all disappeared near normal mucosa for mucous membrane white spot.Produce effects is that mucous membrane white spot reddens, and the skin lesion area dwindles, and pruritus transference cure major part is near normal structure.Effectively be that 50% skin lesion is in white macula and reddens and disappear, do not see that tangible skin lesion changes.Invalid for treating the former skin lesion no change in back.Total effective rate=cure rate+obvious effective rate+effective percentage.
1.2.3 statistical analysis SPSS 11.0 carries out statistical analysis.Measurement data adopts mean ± standard deviation to carry out descriptive statistics.
2 results.
2.1 10 days aftersensations of efficacy evaluation most of patients treatment take a turn for the better, and do not itch, and are moist.After the treatment of 8 weeks, treatment is organized in 220 examples, 22 examples of fully recovering (cure rate 10.00%), produce effects 86 examples (obvious effective rate 39.09%), effective 94 examples (effective percentage 42.73%), invalid 18 examples (inefficiency 8.19%), total effective rate 91.82%.
2.2 untoward reaction except that the skin lesion position have tangible improvement and the recovery from illness, the basic no change of normal skin.Indivedual case skin lesion mucous membrane white spots are rubescent, have no adverse reaction.
3. this result of study of conclusion shows, the present invention can directly improve blood circulation and the lymph circulation that disease is decreased the district, promotes the recovery of pigment and skin elasticity, quickens the improvement of skin mucosa tissue, alleviates pruritus.And exterior-applied formulation treatment leukoplakia vulvae is simple to operate, and curative effect is reliable and be difficult for recurrence, is the reliable and safe Therapeutic Method of curative effect.
Claims (3)
1. externally-applied medicinal composition for the treatment of leukoplakia vulvae is characterized in that being made up of following materials of weight proportions medicine: 14 ~ 20 parts of 8 ~ 12 parts of Cortex Moutans, 8 ~ 12 parts of Radix Saposhnikoviaes, 8 ~ 12 parts of the Radixs Stemonae, 8 ~ 12 parts in Folium Pini, 8 ~ 12 parts of Colophonium powder, 4 ~ 6 parts of gumshiraz, very light blue 1 part, siritch.
2. a kind of externally-applied medicinal composition for the treatment of leukoplakia vulvae according to claim 1 is characterized in that being made up of following materials of weight proportions medicine: 16 parts of 10 parts of Cortex Moutans, 10 parts of Radix Saposhnikoviaes, 10 parts of the Radixs Stemonae, 10 parts in Folium Pini, 10 parts of Colophonium powder, 5 parts of gumshiraz, very light blue 1 part, siritch.
3. claim 1 or 2 described a kind of preparation methoies for the treatment of the externally-applied medicinal composition of leukoplakia vulvae are made up of following steps:
(1), with Cortex Moutan, Radix Saposhnikoviae, the Radix Stemonae, Folium Pini clean, dry, pulverize, become compound standby after 100 mesh sieves;
(2), get siritch and be heated to 200 ℃ ~ 220 ℃, fry in shallow oil very light blue the adding withered by root, take out the Herba Alii fistulosi slag, the oil plant filtering is heated to 200 ℃ ~ 220 ℃, drops into the compound that step 1 produced, stir, after 10 ~ 15 minutes, the oil plant filtering, be heated to 80 ℃ ~ 100 ℃, add Colophonium powder, gumshiraz, continue to stir, boil when dripping beading, spray cold water in surface is removed noxious water, is cooled to room temperature and is distributed into bottle and gets final product.
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| CN201110137106A CN102205080B (en) | 2011-05-25 | 2011-05-25 | External application medicinal composition for treating leukoplakia vulvae |
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| CN201210048598.2A Division CN102526571B (en) | 2011-05-25 | 2011-05-25 | Preparation method of externally used drug combination for curing genitalia leukoplakia |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370742A (en) * | 2011-11-09 | 2012-03-14 | 花莉 | Medicine for treating eczema of children and preparation method thereof |
| CN104013782A (en) * | 2014-06-14 | 2014-09-03 | 王红新 | Bath agent for treating blood vacuity and wind-dryness pudendal dryness |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1370576A (en) * | 2002-01-10 | 2002-09-25 | 胡井夫 | Medicine ointment for treating women's leukoplakia vulvae and valval pruritus |
| CN101450156A (en) * | 2007-12-05 | 2009-06-10 | 吴彦勇 | Traditional Chinese medicine composition for treating female genitalia leukoplakia |
-
2011
- 2011-05-25 CN CN201110137106A patent/CN102205080B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1370576A (en) * | 2002-01-10 | 2002-09-25 | 胡井夫 | Medicine ointment for treating women's leukoplakia vulvae and valval pruritus |
| CN101450156A (en) * | 2007-12-05 | 2009-06-10 | 吴彦勇 | Traditional Chinese medicine composition for treating female genitalia leukoplakia |
Non-Patent Citations (2)
| Title |
|---|
| 《吉林中医药》 19220901 孟东红 外阴白斑的中医治疗 570-571 1-2 第29卷, 第07期 * |
| 孟东红: "外阴白斑的中医治疗", 《吉林中医药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370742A (en) * | 2011-11-09 | 2012-03-14 | 花莉 | Medicine for treating eczema of children and preparation method thereof |
| CN102370742B (en) * | 2011-11-09 | 2013-03-20 | 花莉 | Medicine for treating eczema of children and preparation method thereof |
| CN104013782A (en) * | 2014-06-14 | 2014-09-03 | 王红新 | Bath agent for treating blood vacuity and wind-dryness pudendal dryness |
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| CN102205080B (en) | 2012-09-05 |
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