CN101803611A - Citric acid iodine disinfectant and method for preparing same - Google Patents
Citric acid iodine disinfectant and method for preparing same Download PDFInfo
- Publication number
- CN101803611A CN101803611A CN201010163683A CN201010163683A CN101803611A CN 101803611 A CN101803611 A CN 101803611A CN 201010163683 A CN201010163683 A CN 201010163683A CN 201010163683 A CN201010163683 A CN 201010163683A CN 101803611 A CN101803611 A CN 101803611A
- Authority
- CN
- China
- Prior art keywords
- citric acid
- iodine
- disinfectant
- iodine disinfectant
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses a citric acid iodine disinfectant. The citric acid iodine disinfectant is characterized by consisting of the following components in percentage by weight: 10 to 50 percent of citric acid, 0.5 to 2.5 percent of iodine, 10 to 50 percent of ethanol, and 1 to 65 percent of water. The preparation method comprises the following steps of: dissolving citric acid and iodine in ethanol to obtain uniform liquid, pouring the uniform liquid in a reaction kettle, adding water, stirring the mixed solution for about 2 to 5 hours to obtain solution which is homogeneous, clear and bright. The citric acid iodine disinfectant has the advantages of broad disinfection spectrum, high disinfecting capability, high acting speed, good stability, safety to people and animals and low environmental pollution, so that the citric acid iodine disinfectant is an environmentally-friendly citric acid iodine disinfectant.
Description
Technical field
The invention belongs to the disinfectant field, particularly a kind of compound lemon acid iodine disinfectant that is used for livestock and poultry, aquaculture and public place sterilization and preparation method thereof.
Background technology
In recent years; because of factors such as environment and drug abuses; cause the various infectious diseases of livestock and poultry breeding industry to take place frequently; to such an extent as to relevant industries such as livestock and poultry breeding industry, veterinary drug production and operation are subjected to great impact; along with the layer of food security incident goes out, the propagation of zoonosis, the development of large-scale cultivation; and people " prevent overweighting controlling " continually strengthening of medication idea; press for and be used to improve feeding environment, prophylactic green safety disinfectant; should effectively kill virus, again livestock and poultry, aquatic products not had stress.
Iodine is used for the history in existing 150 years of body sterilizing, and since latter half in 19th century, many people have spoken highly of the usefulness of iodine as antibacterial agent, and this mainly is because it has the unexistent and inaccessiable bactericidal effect of many bactericide.Its has a broad antifungal spectrum, little to tissue toxicity, be widely used, that its sterilizing scope relates to is clinical, health, daily life, livestock and poultry cultivation, aquaculture, public place and drinking water etc., the iodine sterilizing medicine of different classes of, different dosage form, different efficacies just is being widely used in practice, as be used for the sterilization of human body skin, wound surface, mucomembranous surface, surgical instruments, Chi Shui, drinking water and the sanitized of tableware, be used for treating various human various diseases etc.
Citric acid has another name called citric acid, is first acid in the organic acid, because the performance of physical property, chemical property, derivative is to be widely used in the most important organic acids of industry such as food, medicine, daily use chemicals.Be mainly used in food, beverage industry as acid, flavor enhancement and preservative, antistaling agent; In chemical industry, cosmetic industry and washing industry, be used as antioxidant, plasticizer, washing agent etc.; All have been widely used at aspects such as environmental protection, fowl poultry, aquaculture sterilization, medicine.
Iodine and citric acid all are distributed widely in occurring in nature, all contain iodine in air, water, soil, rock and the animal and plant body, all contain more citric acid in the fruit of a variety of fruits and vegetables, especially Citrus.Citric acid has pleasant tart flavour, the mouthfeel frankness, and tart flavour without issue, safety non-toxic, the solvability in water is high, can directly be absorbed metabolism by organism.How the two combination being utilized, is a problem of great practical value.
Summary of the invention
The purpose of this invention is to provide a kind of new disinfectant, have that fungicidal spectrum is wide, sterilizing ability is strong, speed of action is fast, good stability, to humans and animals safety, the environmental pollution degree is low, citric acid iodine disinfectant of advantages such as environmentally friendly type and preparation method thereof.
The present invention adopts following technical scheme to realize above-mentioned purpose:
Citric acid iodine disinfectant of the present invention is characterized in that: it contains following component, and the percentage by weight of each component is as follows:
Citric acid 10-50%,
Iodine 0.5-2.5%,
Ethanol 10-50%,
Water 1-65%.
Citric acid iodine disinfectant preparation method of the present invention is, at first flow into reactor with the uniform liquid after each component of dissolve with ethanol, adds an amount of water then, mixes about 2-5 hour, becomes the clear and bright liquid of homogeneous phase.
The beneficial effect that the present invention adopts above technical scheme to reach is:
Citric acid iodine disinfectant of the present invention is a kind of with citric acid, iodine, ethanol, the formulated liquid sterilization disinfectant of water, it has the double sterilization effect of citric acid and Operand, sterilizing ability is strong, speed of action is fast, good stability, and to humans and animals safety, the environmental pollution degree is low; Its preparation method is simple, and production cost is low, and product has use value widely.
Embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1:
Citric acid iodine disinfectant of the present invention, it contains following component, citric acid 10%, iodine 1%, ethanol 29%, water 60%, at first use citric acid and iodine in the dissolve with ethanol component, the uniform liquid that forms is flow into reactor, add water then and mix about 2 hours, become the clear and bright liquid of homogeneous phase and get final product.
Embodiment 2:
Citric acid iodine disinfectant of the present invention, it contains following component, citric acid 20%, iodine 0.5%, ethanol 29.5%, water 50% flow into reactor with the uniform liquid after each component of dissolve with ethanol, add an amount of water, mix then about 3 hours, become the clear and bright liquid of homogeneous phase.
Embodiment 3:
Citric acid iodine disinfectant of the present invention, it contains following component, citric acid 40%, iodine 1.5%, ethanol 10%, water 48.5% flow into reactor with the uniform liquid after each component of dissolve with ethanol, add an amount of water, mix then about 4 hours, become the clear and bright liquid of homogeneous phase.
Citric acid iodine disinfectant bactericidal effect of the present invention can embody from following bactericidal assay:
1 material and method
1.1 test equipment
1.1.1 citric acid iodine disinfectant is provided by Zhengdian Biological Tech. Co., Ltd., Foshan City.
1.1.2 test strain Escherichia coli (8099) and staphylococcus aureus (ATCC6538) cultivated for the 6th～8 generation; Bacillus subtilis var (ATCC9372) cultivated for the 4th generation, the preparation brood cell.
1.2 method
1.2.1 staphylococcus aureus (ATCC6538) and Escherichia coli (8099) 24h fresh cultured thing and bacillus subtilis var (ATCC9372) brood cell suspension are got in the preparation of bacteria suspension, to be mixed with the bacteria suspension of experimental concentration standby with containing 10g/L peptone phosphate buffer dilution.
1.2.2 it is representative with Escherichia coli that neutralizer is selected test.Under 20 ℃ of conditions, establish parallel 6 groups of tests, undertaken by suspension quantitative disinfecting test program.1. thimerosal+bacteria suspension; 2. (thimerosal+bacteria suspension)+neutralizer; 3. neutralizer+bacteria suspension; 4. (thimerosal+neutralizer)+bacteria suspension; 5. dilution+bacteria suspension (normal bacterium contrast); 6. dilution+neutralizer+medium is as negative control.Result of the test is not grown bacterium or the only a few colony growth is only arranged with the 1st group; The 2nd group has colony growth, than the 1st group be many, but than the 3rd, 4,5 group for few; 3rd, 4,5 groups of bacterium numbers are similar, error rate≤10%; The 6th group of asepsis growth, for selected neutralizer and concentration thereof suitable.Test repeats 3 times.
1.2.3 the suspension quantitative disinfecting test is under 20 ℃ of conditions, 1: 1 mixing of organic chaff interference and bacteria suspension is standby, mix with the ratio (positive control is a hard water) of 4ml disinfectant in every test tube 1ml bacteria suspension, act on, draw 0.5ml bacterium medicine and add mixing in the 4.5ml neutralizer to the scheduled time.Neutralization 10min gets this liquid 1ml inoculation plate, pours into corresponding agar medium, cultivates 48h (bacillus subtilis black variety bud cell is 72h) for 37 ℃, calculates clump count, calculates and kills logarithm value.Test repeats 3 times.
2 results
2.1 neutralizer selects the test result of the test to show, under 20 ℃ of conditions, the aseptic PBS solution of 1% lecithin+1% Tween 80+0.5% sodium thiosulfate, the thimerosal residual action that can effectively neutralize residual, and neutralizer and neutralized reaction product do not have obvious influence to test bacterial growth and medium.
2.2 suspension quantitative disinfecting test result of the test shows that under 20 ℃ of conditions, available iodine is that 100mg/L thimerosal dilution acts on 3min respectively to Escherichia coli, staphylococcus aureus, kills logarithm value 〉=5.0; Available iodine be 500mg/L thimerosal dilution to bacillus subtilis black variety bud cell effect 5min, kill logarithm value 〉=5.0, see Table 1.
Table 1 citric acid iodine disinfectant bactericidal effect
Annotate: test temperature is 20 ℃, the negative control asepsis growth, and the result is 3 test mean values.
3 discuss
This experimental study citric acid iodine disinfectant available iodine is that the dilution of 500mg/L has good killing effect to microorganism.
Above embodiment is only in order to illustrate that technical scheme of the present invention is not intended to limit; Although with reference to preferred embodiment the present invention is had been described in detail, those of ordinary skill in the field are to be understood that.Still can make amendment or the part technical characterictic is equal to replacement the embodiment of invention; And not breaking away from the spirit of technical solution of the present invention, it all should be encompassed in the middle of the technical scheme scope that the present invention asks for protection.
Claims (2)
1. citric acid iodine disinfectant, it is characterized in that: it contains following component, and the percentage by weight of each component is as follows:
Citric acid 10-50%,
Iodine 0.5-2.5%,
Ethanol 10-50%,
Water 1-65%, more than each component sum be absolutely.
2. the preparation method of the described citric acid iodine disinfectant of claim 1, it is characterized in that, at first use citric acid and iodine in the dissolve with ethanol component, the uniform liquid that forms is flow into reactor, add water then and mix about 2-5 hour, become the clear and bright liquid of homogeneous phase.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010163683.4A CN101803611B (en) | 2010-05-06 | 2010-05-06 | Citric acid iodine disinfectant and method for preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010163683.4A CN101803611B (en) | 2010-05-06 | 2010-05-06 | Citric acid iodine disinfectant and method for preparing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101803611A true CN101803611A (en) | 2010-08-18 |
| CN101803611B CN101803611B (en) | 2015-01-28 |
Family
ID=42605698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010163683.4A Active CN101803611B (en) | 2010-05-06 | 2010-05-06 | Citric acid iodine disinfectant and method for preparing same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101803611B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107501078A (en) * | 2016-06-14 | 2017-12-22 | 佛山市正典生物技术有限公司 | A kind of citric acid iodo-complexes and preparation method thereof |
| CN110937937A (en) * | 2019-12-03 | 2020-03-31 | 杭州三得农业科技有限公司 | Special tea fertilizer process for improving theanine content |
| CN112640913A (en) * | 2020-12-30 | 2021-04-13 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with long-term component stability and preparation method thereof |
| CN112704080A (en) * | 2020-12-30 | 2021-04-27 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with stable component content and preparation method thereof |
| CN112806387A (en) * | 2020-12-31 | 2021-05-18 | 佛山市正典生物技术有限公司 | Preparation method of iodine-containing disinfectant with stable component content |
| CN112841181A (en) * | 2020-12-31 | 2021-05-28 | 佛山市正典生物技术有限公司 | Stable iodine-containing disinfectant and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193484A (en) * | 1997-03-14 | 1998-09-23 | 烟台开发区天和科技有限责任公司 | Composition containing iodine and preparation thereof |
| WO2008005059A2 (en) * | 2006-07-05 | 2008-01-10 | Frio Technologies, Inc. | Treatment of mouth and urinary tract infections |
-
2010
- 2010-05-06 CN CN201010163683.4A patent/CN101803611B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193484A (en) * | 1997-03-14 | 1998-09-23 | 烟台开发区天和科技有限责任公司 | Composition containing iodine and preparation thereof |
| WO2008005059A2 (en) * | 2006-07-05 | 2008-01-10 | Frio Technologies, Inc. | Treatment of mouth and urinary tract infections |
Non-Patent Citations (6)
| Title |
|---|
| 刘梅和 等: "0.5%与2%碘酊抑菌效果分析", 《药学实践杂志》 * |
| 北京中苏友谊医院药房: "碘酊处方及其配制法的研讨", 《中国药学杂志》 * |
| 李忠铭 等: "聚醚碘制备工艺研究", 《武汉理工大学学报》 * |
| 李清禄 等: "新型水产养殖消毒剂的制备、性能及其临床应用I碘伏", 《福建农业大学学报》 * |
| 温旺荣: "常用消毒剂对念珠菌最小杀菌浓度的测定", 《中国消毒学杂志》 * |
| 邝煜宏: "水杨酸碘搽剂含量测定的试验", 《现代食品与药品杂志》 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107501078A (en) * | 2016-06-14 | 2017-12-22 | 佛山市正典生物技术有限公司 | A kind of citric acid iodo-complexes and preparation method thereof |
| CN110937937A (en) * | 2019-12-03 | 2020-03-31 | 杭州三得农业科技有限公司 | Special tea fertilizer process for improving theanine content |
| CN112640913A (en) * | 2020-12-30 | 2021-04-13 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with long-term component stability and preparation method thereof |
| CN112704080A (en) * | 2020-12-30 | 2021-04-27 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with stable component content and preparation method thereof |
| CN112640913B (en) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with long-term component stability and preparation method thereof |
| CN112704080B (en) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with stable component content and preparation method thereof |
| CN112806387A (en) * | 2020-12-31 | 2021-05-18 | 佛山市正典生物技术有限公司 | Preparation method of iodine-containing disinfectant with stable component content |
| CN112841181A (en) * | 2020-12-31 | 2021-05-28 | 佛山市正典生物技术有限公司 | Stable iodine-containing disinfectant and preparation method thereof |
| CN112806387B (en) * | 2020-12-31 | 2022-02-25 | 佛山市正典生物技术有限公司 | Preparation method of iodine-containing disinfectant with stable component content |
| CN112841181B (en) * | 2020-12-31 | 2022-06-17 | 佛山市正典生物技术有限公司 | Stable iodine-containing disinfectant and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101803611B (en) | 2015-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101803611B (en) | Citric acid iodine disinfectant and method for preparing same | |
| CN101810198B (en) | Salicylic acid-iodine disinfector and preparation method thereof | |
| CN104872205B (en) | The mixture and its application method prevented and treated for soil-borne disease of tobacco | |
| CN102835424A (en) | Water disinfectant for aquiculture and use method thereof | |
| CN107836466A (en) | A kind of tea tree ethereal oil natural disinfectant agent for animals and preparation method thereof | |
| Li et al. | Stabilizing the bactericidal activity of hydrogen peroxide: a brandnew function of certain chinese herbs | |
| Qiao et al. | Management of bacterial spot of tomato caused by copper-resistant Xanthomonas perforans using a small molecule compound carvacrol | |
| CN104957189A (en) | Disinfectant for water in grass carp and prawn mixed aquaculture ponds and method for applying disinfectant | |
| CN101700011A (en) | Compound disinfectant for livestock and poultry raising environment | |
| CN103039491A (en) | Composition containing chitosan oligosaccharide and prochloraz | |
| CN104824040A (en) | Biological insecticidal rooting dual protective agent and preparation method and application method thereof | |
| Dong et al. | Control Escherichia coli O157: H7 growth on sprouting brassicacae seeds with high acoustic power density (APD) ultrasound plus mild heat and calcium-oxide antimicrobial spray | |
| CN105010401A (en) | Seed treating agent adopting microorganisms | |
| CN116210728B (en) | Bactericide and preparation method and application thereof | |
| CN102106347A (en) | Cinnamaldehyde, eugenol, thymol and tannin compound bactericide | |
| CN104383324A (en) | Compound fulvate drug for silkworms | |
| CN104207956A (en) | Compound antiseptic containing natamycin and application of compound antiseptic | |
| CN104351180B (en) | A kind of micro-capsule suspension for preventing and treating rice green smut | |
| CN101032244B (en) | Disinfectant formulation and producing method thereof | |
| CN100361584C (en) | Broad-spectrum antiseptics and production thereof | |
| CN109221223A (en) | A kind of safe and efficient composite disinfectant | |
| CN102939966B (en) | A kind of compound disinfectant, its preparation method and application | |
| CN107518001A (en) | A kind of new disinfectant of alcohol containing iodo-salicylic acid and preparation method thereof | |
| CN106489990A (en) | Application of the ozonized surfactant in chicken cultivation | |
| CN111109289A (en) | Stable solid hydrogen peroxide adduct and application thereof in livestock and poultry and aquaculture fields |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |