CN102793742B - Film coating agent for disinfecting dairy cow breasts and preparation method of film coating agent - Google Patents
Film coating agent for disinfecting dairy cow breasts and preparation method of film coating agent Download PDFInfo
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- CN102793742B CN102793742B CN201210332804.2A CN201210332804A CN102793742B CN 102793742 B CN102793742 B CN 102793742B CN 201210332804 A CN201210332804 A CN 201210332804A CN 102793742 B CN102793742 B CN 102793742B
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Abstract
The invention relates to a film coating agent for disinfecting dairy cow breasts for preventing dairy cow mastitis and a preparation method of the film coating agent. The film coating agent is prepared from sophora alopecuroide extracts, honeysuckle extracts, lycium barbarum polysaccharide, dried alum, a film forming material, a plasticizer and a penetration enhancer. According to the invention, the sophora alopecuroide extracts and the honeysuckle extracts have the bacteriostatic and antiphlogistic effects, the lycium barbarum polysaccharide has the effect of improving body immunity and the dried alum has the effects of enhancing dairy cow milk duct heating and shortening the milk duct opening time. The film coating agent is prepared from the above traditional Chinese medicine formulas, is used for preventing dairy cow mastitis, can form a protective film on the dairy cow breast to reduce secondary pollution of disinfectants, can effectively kill pathogenic microorganisms attaching to the dairy cow breast, can prevent dairy cow mastitis and then improve the yield and quality of milk and has the characteristics that use is convenient, safe and effective.
Description
Technical field
The invention belongs to the veterinary drug technical field, particularly relate to a kind of for preventing cow breast sterilization liniment and preparation method thereof of mammitis of cow.
Background technology
Mammitis of cow is that dairy harm is maximum, one of modal disease, and mammitis of cow not only reduces lactation amount, and affects milk quality.For tackling this problem, herd peasant association and add antibiotic in feedstuff, once add excessively, will cause in raw milk having antibiotic remains, cause that milk pollutes.From the news that of State General Administration for Quality Supervision, a demonstration of the testing result to northern China market, in nearly 800 portions of milks sampling, " antibiotic remains exceeds standard " occupies first of defective item.And Chinese herbal medicine cow breast sterilizing nursing agent not only can effectively go out except being attached to the pathogenic microorganism on cow breast, can also prevent and treat the breast inflammation of milch cow, obviously improve the health status of milch cow, be expected to allow raw milk away from antibiotic, make people drink safer milk.
Summary of the invention
The object of the present invention is to provide a kind of cow breast of Chinese medicine safely and effectively sterilization liniment;
Another object of the present invention is to provide the preparation method of above-mentioned cow breast sterilization with liniment.
The technical scheme taked for achieving the above object is:
Liniment is used in a kind of cow breast sterilization, it is characterized in that constituent and prescription are than as follows:
Herba Sophorae alopecuroidis extract 150g-200g,
Flos Lonicerae extract 100g-200g,
Lycium barbarum polysaccharide 20g-50g,
Dried Alumen 10g-50g,
Filmogen 50g-100g,
Plasticizer 10ml-30ml,
Penetration enhancer 5g-30g,
Purified water 400ml-500ml,
95% ethanol adds to overall 1000ml.
Described filmogen is chitosan or polyvinyl alcohol or sodium alginate.
Described plasticizer is glycerol or propylene glycol or ethyl phthalate.
Described penetration enhancer is Mentholum or Borneolum Syntheticum or laurocapram.
The preparation method of liniment for above-mentioned cow breast sterilization, its technical process is:
A. filmogen is dissolved in water, then adds the plasticizer mix homogeneously as blank film forming liquid;
B. the Herba Sophorae alopecuroidis extract of formula ratio, lycium barbarum polysaccharide, Flos Lonicerae extract and dried Alumen are added in blank film forming liquid, standby as solution 1 after stirring and dissolving;
C. using penetration enhancer with standby as solution 2 after 95% dissolve with ethanol;
D. by above-mentioned solution 1 and solution 2 mix homogeneously, add 95% ethanol and get final product to ormal weight.
Above-mentioned Herba Sophorae alopecuroidis extract adopts following method to obtain: sophora alopecuroide is ground into to coarse powder, adds 65% ethanol continuous circumfluence extraction 4 hours, filter, concentration and recovery ethanol is to the thick paste shape, and vacuum drying, to Powdered, obtains Herba Sophorae alopecuroidis extract.
During described reflux, extract,, pH value of solution 3-4, solid-liquid ratio is 1:12.
Above-mentioned Flos Lonicerae extract adopts following method to obtain: Flos Lonicerae is measured to 65% ethanol continuous circumfluence extractions 5 hours with 8 times, filter, concentration and recovery ethanol is to the thick paste shape, and vacuum drying, to Powdered, obtains Flos Lonicerae extract.
The present invention is that pathogeny and pharmaceutical preparation theory theoretical according to Chinese veterinarian, mammitis of cow are developed; there is inhibiting bacteria and diminishing inflammation, promote the healing of milch cow milk duct; shorten the effect of milk duct the first transaction of a day's business time and raising immunity of organisms; liniment can form layer protecting film at the mammilla of milk cattle place, nipple is had to certain protective effect.
Herba Sophorae alopecuroidis extract in prescription of the present invention has antipyretic-antalgic, inhibiting bacteria and diminishing inflammation, the effect of raising immunity; Flos Lonicerae extract has the effects such as eliminating pestilence and relieving toxicity, anti-inflammation; Lycium barbarum polysaccharide has the chemotaxis that improves M7, the effect of enhancing body to the phagocytic activity of external pathogenic microorganism; That dried Alumen has is antibacterial, the effect of convergence; Chitosan and sodium alginate have good biocompatibility and degradability as filmogen, in vitro the Main Pathogenic Bacteria be separated to is had to fungistatic effect preferably from the clinic mastitis case, polyvinyl alcohol has the characteristics such as the film property tack is good, easy cleaning simultaneously.All medicine compatibilities, have inhibiting bacteria and diminishing inflammation, promote the healing of milch cow milk duct, shorten milk duct open a business the time and improve immunity of organisms effect.
The present invention makes liniment by Chinese prescription, for preventing mammitis of cow, can form layer protecting film at the mammilla of milk cattle place, reduces the secondary pollution of disinfectant solution, has effective characteristics easy to use, safe.
Bacteriostatic test effect: adopt the drug sensitive test paper agar diffusion method, staphylococcus aureus, streptococcus agalactiae, escherichia coli, streptococcus dysgalactiae on each culture medium identified of learning from else's experience respectively are inoculated on corresponding culture medium, gripping is impregnated with the drug paper disk of above-mentioned membrane, be affixed on respectively on flat board, put 37 ℃ and cultivate taking-up after 24 hours, measure antibacterial circle diameter, and compare with ciprofloxacin, the results are shown in following table.
The average bacteriostatic diameter mm (meansigma methods ± standard error) of liniment to 3 kinds of pathogen
| Medicine name | Staphylococcus aureus | Streptococcus agalactiae | Escherichia coli | Streptococcus dysgalactiae |
| Ciprofloxacin | 23.82±1.86 | 26.72±2.98 | 22.88±1.36 | 28.31±2.02 |
| Liniment | 21.41±2.45 | 22.15±1.54 | 23.68±2.64 | 24.02±2.64 |
Result shows, liniment of the present invention all has inhibitory action preferably to Identification of Major Pathogens in Bovine Mastitis staphylococcus aureus, streptococcus agalactiae, escherichia coli, streptococcus dysgalactiae.
The specific embodiment
Below with example, be explained the present invention, it should be understood that example is for the present invention rather than limitation of the present invention are described.Scope of the present invention and core content are determined according to claims.
Embodiment 1
According to following prescription proportioning:
Herba Sophorae alopecuroidis extract 200g,
Flos Lonicerae extract 100g,
Lycium barbarum polysaccharide 30g,
Dried Alumen 20g,
Chitosan 80g,
Glycerol 10ml,
Mentholum 15g,
Purified water 400ml,
95% ethanol adds to cumulative volume 1000ml.
Its preparation method is:
(1) sophora alopecuroide is ground into coarse powder, adds 65% ethanol (with 3% sulphuric acid, adjusting pH3-4) (solid-liquid ratio is 1:12) continuous circumfluence extraction 4 hours, filters, and concentration and recovery ethanol is to the thick paste shape, and vacuum drying, to Powdered, obtains Herba Sophorae alopecuroidis extract, standby.
(2) by 8 times of amount 65% ethanol continuous circumfluence extractions for Flos Lonicerae, filter, concentration and recovery ethanol is to the thick paste shape, and vacuum drying, to Powdered, obtains Flos Lonicerae extract standby.
(3) get the chitosan of recipe quantity, add purified water 400ml and dissolve, add recipe quantity glycerol 10ml, be uniformly mixed, as blank film forming liquid.
(4) Herba Sophorae alopecuroidis extract, Flos Lonicerae extract, lycium barbarum polysaccharide and the dried Alumen of getting recipe quantity are added in blank film forming liquid, are stirred into solution 1.
(5) get the Mentholum of recipe quantity, add after 95% ethanol 100ml dissolves and become solution 2 standby.
By above-mentioned 2 kinds of solution mix homogeneously, then add 95% ethanol to cumulative volume 1000ml.
Embodiment 2
According to following prescription proportioning:
Herba Sophorae alopecuroidis extract 150g,
Flos Lonicerae extract 200g,
Lycium barbarum polysaccharide 50g,
Dried Alumen 30g,
Sodium alginate 60g,
Propylene glycol 20ml,
Borneolum Syntheticum 15g,
Purified water 500ml,
95% ethanol adds to cumulative volume 1000ml.
Its preparation method is:
(1) sophora alopecuroide is ground into coarse powder, adds 65% ethanol (with 3% sulphuric acid, adjusting pH3-4) (solid-liquid ratio is 1:12) continuous circumfluence extraction 4 hours, filters, and concentration and recovery ethanol is to the thick paste shape, and vacuum drying, to Powdered, obtains Herba Sophorae alopecuroidis extract, standby.
(2) by 8 times of amount 65% ethanol continuous circumfluence extractions for Flos Lonicerae, filter, concentration and recovery ethanol is to the thick paste shape, and vacuum drying, to Powdered, obtains Flos Lonicerae extract standby.
(3) get the sodium alginate of recipe quantity, add purified water 400ml and dissolve, add recipe quantity propylene glycol 20ml, be uniformly mixed, as blank film forming liquid.
(4) Herba Sophorae alopecuroidis extract, Flos Lonicerae extract, lycium barbarum polysaccharide and the dried Alumen of getting recipe quantity are added in blank film forming liquid, are stirred into solution 1.
(5) get the Borneolum Syntheticum of recipe quantity, add after 95% ethanol 100ml dissolves and become solution 2 standby.
By above-mentioned 2 kinds of solution mix homogeneously, then add 95% ethanol to cumulative volume 1000ml.
Embodiment 3
According to following prescription proportioning:
Herba Sophorae alopecuroidis extract 200g,
Flos Lonicerae extract 100g,
Lycium barbarum polysaccharide 40g,
Dried Alumen 10g,
Polyvinyl alcohol 60g,
Ethyl phthalate 15ml,
Laurocapram 5g,
Purified water 400ml,
95% ethanol adds to cumulative volume 1000ml.
Its preparation method is:
(1) sophora alopecuroide is ground into coarse powder, adds 65% ethanol (with 3% sulphuric acid, adjusting pH3-4) (solid-liquid ratio is 1:12) continuous circumfluence extraction 4 hours, filters, and concentration and recovery ethanol is to the thick paste shape, and vacuum drying, to Powdered, obtains Herba Sophorae alopecuroidis extract, standby.
(2) by 8 times of amount 65% ethanol continuous circumfluence extractions for Flos Lonicerae, filter, concentration and recovery ethanol is to the thick paste shape, and vacuum drying, to Powdered, obtains Flos Lonicerae extract standby.
(3) get the polyvinyl alcohol of recipe quantity, add purified water 400ml and dissolve, add the recipe quantity ethyl phthalate, be uniformly mixed, as blank film forming liquid.
(4) Herba Sophorae alopecuroidis extract, Flos Lonicerae extract, lycium barbarum polysaccharide and the dried Alumen of getting recipe quantity are added in blank film forming liquid, are stirred into solution 1.
(5) get the laurocapram of recipe quantity, add after 95% ethanol 100ml dissolves and become solution 2 standby.
By above-mentioned 2 kinds of solution mix homogeneously, then add 95% ethanol to cumulative volume 1000ml.
Embodiment 4
According to following prescription proportioning:
Herba Sophorae alopecuroidis extract 160g,
Flos Lonicerae extract 150g,
Lycium barbarum polysaccharide 50g,
Dried Alumen 40g,
Chitosan 50g,
Glycerol 15ml,
Borneolum Syntheticum 30g,
Purified water 500ml,
95% ethanol adds to cumulative volume 1000ml.
The other the same as in Example 1.
Embodiment 5
According to following prescription proportioning:
Herba Sophorae alopecuroidis extract 180g,
Flos Lonicerae extract 150g,
Lycium barbarum polysaccharide 20g,
Dried Alumen 50g,
Polyvinyl alcohol 100g,
Ethyl phthalate 30ml,
Laurocapram 20g,
Purified water 450ml,
95% ethanol adds to cumulative volume 1000ml.
The other the same as in Example 1.
Claims (5)
1. liniment is used in a cow breast sterilization, it is characterized in that constituent and prescription are than as follows:
Herba Sophorae alopecuroidis extract 150g-200g,
Flos Lonicerae extract 100g-200g,
Lycium barbarum polysaccharide 20g-50g,
Dried Alumen 10g-50g,
Filmogen 50g-100g,
Plasticizer 10ml-30ml,
Penetration enhancer 5g-30g,
Purified water 400ml-500ml,
95% ethanol adds to overall 1000ml;
Described filmogen is chitosan or polyvinyl alcohol or sodium alginate,
Described plasticizer is glycerol or propylene glycol or ethyl phthalate,
Described penetration enhancer is Mentholum or Borneolum Syntheticum or laurocapram.
2. the preparation method of liniment for cow breast sterilization as claimed in claim 1, its technical process is:
A. filmogen is dissolved in water, then adds the plasticizer mix homogeneously as blank film forming liquid;
B. the Herba Sophorae alopecuroidis extract of formula ratio, lycium barbarum polysaccharide, Flos Lonicerae extract and dried Alumen are added in blank film forming liquid, standby as solution 1 after stirring and dissolving;
C. using penetration enhancer with standby as solution 2 after 95% dissolve with ethanol;
D. by above-mentioned solution 1 and solution 2 mix homogeneously, add 95% ethanol and get final product to ormal weight.
3. use the preparation method of liniment according to cow breast sterilization claimed in claim 2, it is characterized in that above-mentioned Herba Sophorae alopecuroidis extract adopts following method to obtain: sophora alopecuroide is ground into to coarse powder, add 65% ethanol continuous circumfluence extraction 4 hours, filter, concentration and recovery ethanol is to the thick paste shape, vacuum drying, to Powdered, obtains Herba Sophorae alopecuroidis extract.
4. use the preparation method of liniment according to cow breast sterilization claimed in claim 2, while it is characterized in that described reflux, extract,, pH value of solution 3-4, solid-liquid ratio is 1:12.
5. use the preparation method of liniment according to cow breast sterilization claimed in claim 2, it is characterized in that above-mentioned Flos Lonicerae extract adopts following method to obtain: Flos Lonicerae is measured to 65% ethanol continuous circumfluence extractions 5 hours with 8 times, filter, concentration and recovery ethanol is to the thick paste shape, vacuum drying, to Powdered, obtains Flos Lonicerae extract.
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| CN103142683B (en) * | 2013-03-12 | 2015-09-09 | 广东海纳川生物科技股份有限公司 | Be used for the treatment of Chinese medicinal perfusion liquid containing Herba Sophorae alopecuroidis total alkali of bovine mastitis and endometritis and preparation method thereof |
| CN104856977B (en) * | 2015-05-19 | 2017-10-27 | 中国农业科学院兰州畜牧与兽药研究所 | One kind treats the dermopathic external application plastics of cattle and sheep fungal infectious |
| CN105287667A (en) * | 2015-11-04 | 2016-02-03 | 南京美凯生物科技有限公司 | Traditional Chinese medicine liquid patch for treating arthritis and rheumatism |
| CN105596235B (en) * | 2016-01-11 | 2019-02-12 | 西安汉隆化工科技有限公司 | A kind of milk cow nipple medicated bath liquid and preparation method thereof |
| CN105998051A (en) * | 2016-05-12 | 2016-10-12 | 成都易创思生物科技有限公司 | Plastics capable of dispersing blood stasis and relieving pain |
| CN105997947A (en) * | 2016-05-12 | 2016-10-12 | 成都易创思生物科技有限公司 | Preparing method of plastics capable of dispersing blood stasis and relieving pain |
| CN110013472A (en) * | 2019-04-30 | 2019-07-16 | 扬州大学 | A kind of mammilla of milk cattle film forming Medicatedbath lotion, preparation method and its application method |
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