CN105012399A - Chinese medicine film agent used for treating recessive mastitis of dairy cows and preparation method thereof - Google Patents
Chinese medicine film agent used for treating recessive mastitis of dairy cows and preparation method thereof Download PDFInfo
- Publication number
- CN105012399A CN105012399A CN201410182826.4A CN201410182826A CN105012399A CN 105012399 A CN105012399 A CN 105012399A CN 201410182826 A CN201410182826 A CN 201410182826A CN 105012399 A CN105012399 A CN 105012399A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- extract
- polyvinyl alcohol
- treatment
- fructus forsythiae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a Chinese medicine film agent used for treating recessive mastitis of dairy cows. The film agent is composed of honeysuckles, dandelions, fructus forsythiae, polyvinyl alcohol, glycerin, propylene glycol, distilled water and ethyl alcohol. Clinical tests show that the film agent can effectively treat the recessive mastitis of the dairy cows.
Description
Technical field
The invention belongs to field of traditional Chinese veterinary, relate to a kind of Chinese medicine membrane being used for the treatment of bovine subclinical mastitis and preparation method thereof.
Background technology
Mastitis is the most common in milk cattle cultivating process, the most difficult control, the larger development to dairy of cost hinders one of comparatively serious disease.Milch cow is during normal activity, and mammilla of milk cattle surface can contact and grow a large amount of antibacterial, if antibacterial falls into milk when milking, milk source will be caused to pollute.And milch cow after being milked, mammilla of milk cattle approximately needs 1-2 hour ability completely closed, is easy to the invasion and attack being subject to antibacterial therebetween, thus brings out the generation of mastitis.Pathogenic microorganism invades papillary duct, and to cause mastitis be the main path that people generally acknowledge, nipple mouth is unique passage of breast and extraneous UNICOM, and paying attention to nipple dipping is one very effectively and succinctly approach easily.At present, the clinical treatment of mammitis of cow is mainly based on antibiotic control, but life-time service antibiotic therapy can cause Resistant strain to produce, and reduces curative effect of medication, and the decline of milk antibiotic remains, milk-quality is also detrimental to health.Therefore development can prevent mammitis of cow and can not cause the active drug of milk antibiotic remains be current dairy in the urgent need to.
The Chinese medicine membrane for the treatment of bovine subclinical mastitis is disclosed for such situation the present invention, Chinese medicine belongs to pure natural substance, containing multiple bioactive ingredients, there is antibacterial, antiinflammatory, have no drug resistance, noresidue, toxic and side effects are little etc., and advantage highlights more and more important effect in the treatment of mammitis of cow.And Chinese medicine cow breast liniment not only can effectively go out except the pathogenic microorganism be attached on cow breast, the breast inflammation of milch cow can also be prevented and treated, obviously improve the health status of milch cow, be expected to allow raw milk away from antibiotic, make people drink safer milk.The invention belongs to the herbal mixture membrane for the treatment of mammitis of cow, prove, this prescription successful through clinical trial, pollution-free to milk, no drug residue, have curative effect fast, cure rate is high, without complication, not easily recurs, the advantages such as no drug residue.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine membrane for the treatment of bovine subclinical mastitis and preparation method thereof, there is the route of infection cutting off mastitis, reach the object for the treatment of mastitis.
Chinese medicine membrane of the present invention comprises Flos Lonicerae, Herba Taraxaci, Fructus Forsythiae, polyvinyl alcohol, glycerol, propylene glycol, distilled water, ethanol.
The formula of Chinese medicine membrane of the present invention is: Flos Lonicerae 150-200 gram, Herba Taraxaci 100-150 gram, Fructus Forsythiae 100-150 gram; Polyvinyl alcohol 50-80g, glycerol 50-70ml, propylene glycol 20-40ml, distilled water 500-600ml, ethanol is settled to 1000ml.
The formula of Chinese medicine membrane of the present invention is preferably: Flos Lonicerae 175 grams, Herba Taraxaci 125 grams, Fructus Forsythiae 125 grams, polyvinyl alcohol 65 grams, glycerol 60ml, propylene glycol 30ml, distilled water 550ml, ethanol is settled to 1000ml.
Described in Chinese medicinal film agent prescription of the present invention, polyvinyl alcohol is polyvinyl alcohol 124.
Described Chinese medicine membrane is completed by following preparation technology:
(1) each component of Chinese medicine membrane is taken by recipe quantity, for subsequent use;
(2) following method is adopted to extract Flos Lonicerae, Fructus Forsythiae: first Flos Lonicerae, Fructus Forsythiae powder to be broken to 40-60 order, then by crush Flos Lonicerae, Fructus Forsythiae 8 times amount 65% ethanol continuous circumfluence extraction 5 hours, filter, concentration and recovery ethanol is to paste, vacuum drying is to Powdered, obtain extract A, for subsequent use;
(3) following method is adopted by Herba Taraxaci to extract: first Herba Taraxaci to be crushed to 40-60 order, then the Herba Taraxaci crushed is added the water of 6 times amount as solvent, 100 DEG C of reflux, extract, after extracting liquid filtering, it is the extract of 1.2 that 50 DEG C of concentrating under reduced pressure obtain relative density density, obtain extract B, for subsequent use;
(4) added water by filmogen polyvinyl alcohol and stir, 120 DEG C of heating 30 minutes, make it all dissolve clarification as blank film forming liquid as solution C, for subsequent use;
(5) using adding as solution D after extract A, extract B stirring and dissolving in above-mentioned solution C, for subsequent use;
(6) by adding propylene glycol in above-mentioned solution D, after glycerol stirs, be settled to 1000ml with ethanol, both.
Beneficial effect of the present invention:
The present invention is that the pathogeny of, mammitis of cow theoretical according to Chinese veterinarian and pharmaceutical preparation are theoretical and develop; there is inhibiting bacteria and diminishing inflammation, promote the healing of milch cow milk duct; shorten effect of milk duct the first transaction of a day's business time and raising immunity of organisms; membrane can form layer protecting film at mammilla of milk cattle place, has certain protective effect to nipple.Treatments period Residue of Antibiotics in Milk problem can be solved, thus the waste that during reducing antibiotic medication, milk is outwelled, Chinese medicine liniment of the present invention belongs to Chinese medicine preparation in addition, has the advantages such as preparation technology is simple, easy to operate, noresidue.
Detailed description of the invention:
Embodiment 1
Embodiment 2
Embodiment 3
Embodiment 4
Embodiment 5
Usage and the consumption of Chinese medicine membrane of the present invention are: first milk is extracted before medication, first disease Lac Bovis seu Bubali district is cleaned with warm water, then dry, Chinese medicine membrane 20-30mL is smeared in each newborn district, be retained to and milk next time, twice daily (at 9 in the morning, once at 6 in afternoon once), it within 5-8 days, is a course for the treatment of.Should note during use: (1) breast gangrene, damaging mastorrhagia avoid use.(2) breast must be cleaned before using and dry by this product, otherwise will affect this agent film forming and drug transdermal, and finally affects the treatment
Preparation method:
(1) each component of Chinese medicine membrane is taken by recipe quantity, for subsequent use;
(2) following method is adopted to extract Flos Lonicerae, Fructus Forsythiae: first Flos Lonicerae, Fructus Forsythiae powder to be broken to 40-60 order, then by crush Flos Lonicerae, Fructus Forsythiae 8 times amount 65% ethanol continuous circumfluence extraction 5 hours, filter, concentration and recovery ethanol is to paste, vacuum drying is to Powdered, obtain extract A, for subsequent use;
(3) following method is adopted by Herba Taraxaci to extract: first Herba Taraxaci to be crushed to 40-60 order, then the Herba Taraxaci crushed is added the water of 6 times amount as solvent, 100 DEG C of reflux, extract, after extracting liquid filtering, it is the extractum of 1.2 that 50 DEG C of concentrating under reduced pressure obtain relative density, obtain extract B, for subsequent use;
(4) added water by filmogen polyvinyl alcohol and stir, 120 DEG C of heating 30 minutes, make it all dissolve clarification as blank film forming liquid as solution C, for subsequent use;
(5) using adding as solution D after extract A, extract B stirring and dissolving in above-mentioned solution C, for subsequent use;
(6) by adding propylene glycol in above-mentioned solution D, after glycerol stirs, be settled to 1000ml with ethanol, obtain final product.
In order to verify curative effect of the present invention further, spy carries out following clinical trial:
1. experimental animal:
Select Shanghai mastitis diagnostic reagent SMT to detect positive degree in Hebei province be latent mammitis case more than " ++ ".Have 55.The rearing conditions of all experimental animals is consistent, except test medication, does not all use other any medicines.
2. EXPERIMENTAL DESIGN
2.1 test medicines
Test drug: Chinese medicine membrane of the present invention.
2.2 test method
2.2.1 group technology:
Experimental animal is divided at random A, B two groups, A group test group (28); B group is drug control group (27).
2.2.2 dosage and method:
A group is test group Chinese medicine membrane of the present invention, B group is drug control group dipping iodine glycerol membrane, first milk is extracted before medication, then clean disease Lac Bovis seu Bubali district with warm water and dry, smear the embodiment of the present invention 3 Chinese medicine membrane 20-30mL in each newborn district, be retained to and milk next time, twice daily (at 9 in the morning once, at 6 in afternoon is once), within 5-8 days, be a course for the treatment of.Measure respectively and treat the same day, treatment the 5th day and the treatment measurement result of the 8th day.
2.3 curative effect judging standard
After treatment, detect with SMT, allly transfer "-" to from " +++ " (strong positive), "+" (negatively or suspicious is judged to healing; " +++ " → "+" is also for taking a turn for the better; All " +++ " " ++ " is constant is after the treatment invalid).Somatic cell measures: define without taking a turn for the better according to the size of somatic cell from milk number, milk must not more than 1,000,000/milliliter to somatic requirement.
3. result
Therapeutic effect:
A group: treat after 5 days, cure rate reaches 67.86%, effective percentage 85.71%; Treat cure rate and effective percentage after 8 days and reach 82.14% and 92.86% respectively.
B group: treat after 5 days, cure rate reaches 33.33%, and effective percentage is 44.44%; Treat cure rate and effective percentage after 8 days and reach 40.74% and 55.56% respectively.Result of the test sees the following form 1.
Table 1 " Chinese medicine membrane " is to recessive mastitis clinical therapeutic efficacy
As can be seen from Table 1, " Chinese medicine membrane " has good therapeutic effect to latent mammitis, and treat after 8 days, total cure rate reaches 82.14%, and total effective rate is 92.86%.
Treatment forebody-afterbody raji cell assay Raji result.
Contents in Cows cell number measurement result before and after the treatment of table 2 Chinese medicine membrane
**P＜0.01
As can be seen from Table 2, after the treatment of Chinese medicine membrane, the somatic number in dairy cow milk greatly reduces, and lower than 1,000,000/milliliter, reaches the requirement to raw milk.Chinese medicine membrane of the present invention has good therapeutic effect to treatment mammitis of cow.
Claims (5)
1. be used for the treatment of a Chinese medicine membrane for bovine subclinical mastitis, it is characterized in that, described membrane is by Flos Lonicerae, Herba Taraxaci, Fructus Forsythiae, polyvinyl alcohol, glycerol, propylene glycol, distilled water, and ethanol forms.
2. a kind of Chinese medicine membrane being used for the treatment of bovine subclinical mastitis according to claim 1, is characterized in that the prescription of described membrane is: Flos Lonicerae 150-200 gram, Herba Taraxaci 100-150 gram, Fructus Forsythiae 100-150 gram; Polyvinyl alcohol 50-80g, glycerol 50-70ml, propylene glycol 20-40ml, distilled water 500-600ml, ethanol is settled to 1000ml.
3. a kind of Chinese medicine membrane being used for the treatment of bovine subclinical mastitis according to claim 2, it is characterized in that the prescription of described compositions is: Flos Lonicerae 175 grams, Herba Taraxaci 125 grams, Fructus Forsythiae 125 grams, polyvinyl alcohol 65 grams, glycerol 60ml, propylene glycol 30ml, distilled water 550ml, ethanol is settled to 1000ml.
4. a kind of Chinese medicine membrane being used for the treatment of bovine subclinical mastitis according to claim 3, it is characterized in that, described polyvinyl alcohol is polyvinyl alcohol 124.
5., according to the arbitrary described a kind of Chinese medicine membrane being used for the treatment of bovine subclinical mastitis of claim 1-4, it is characterized in that, completed by following preparation technology:
(1) each component of Chinese medicine membrane is taken by recipe quantity, for subsequent use;
(2) following method is adopted to extract Flos Lonicerae, Fructus Forsythiae: first Flos Lonicerae, Fructus Forsythiae powder to be broken to 40-60 order, then by crush Flos Lonicerae, Fructus Forsythiae 8 times amount 65% ethanol continuous circumfluence extraction 5 hours, filter, concentration and recovery ethanol is to paste, vacuum drying is to Powdered, obtain extract A, for subsequent use;
(3) following method is adopted by Herba Taraxaci to extract: first Herba Taraxaci to be crushed to 40-60 order, then the Herba Taraxaci crushed is added the water of 6 times amount as solvent, 100 DEG C of reflux, extract, after extracting liquid filtering, it is the extractum of 1.2 that 50 DEG C of concentrating under reduced pressure obtain relative density, obtain extract B, for subsequent use;
(4) added water by filmogen polyvinyl alcohol and stir, 120 DEG C of heating 30 minutes, make it all dissolve clarification as blank film forming liquid as solution C, for subsequent use;
(5) using adding as solution D after extract A, extract B stirring and dissolving in above-mentioned solution C, for subsequent use;
(6) by adding propylene glycol in above-mentioned solution D, after glycerol stirs, be settled to 1000ml with ethanol, obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410182826.4A CN105012399A (en) | 2014-04-30 | 2014-04-30 | Chinese medicine film agent used for treating recessive mastitis of dairy cows and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410182826.4A CN105012399A (en) | 2014-04-30 | 2014-04-30 | Chinese medicine film agent used for treating recessive mastitis of dairy cows and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105012399A true CN105012399A (en) | 2015-11-04 |
Family
ID=54402944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410182826.4A Pending CN105012399A (en) | 2014-04-30 | 2014-04-30 | Chinese medicine film agent used for treating recessive mastitis of dairy cows and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105012399A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596235A (en) * | 2016-01-11 | 2016-05-25 | 西安汉隆化工科技有限公司 | Novel milk cow nipple medicated bath solution and preparing method thereof |
| CN110037177A (en) * | 2018-01-17 | 2019-07-23 | 内蒙古自治区农牧业科学院 | A kind of cow feed additive and its preparation and application |
-
2014
- 2014-04-30 CN CN201410182826.4A patent/CN105012399A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596235A (en) * | 2016-01-11 | 2016-05-25 | 西安汉隆化工科技有限公司 | Novel milk cow nipple medicated bath solution and preparing method thereof |
| CN105596235B (en) * | 2016-01-11 | 2019-02-12 | 西安汉隆化工科技有限公司 | A kind of milk cow nipple medicated bath liquid and preparation method thereof |
| CN110037177A (en) * | 2018-01-17 | 2019-07-23 | 内蒙古自治区农牧业科学院 | A kind of cow feed additive and its preparation and application |
| CN110037177B (en) * | 2018-01-17 | 2022-08-23 | 内蒙古自治区农牧业科学院 | Milk cow feed additive and preparation and use methods thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102793742B (en) | Film coating agent for disinfecting dairy cow breasts and preparation method of film coating agent | |
| CN102579662A (en) | Medicinal composition for treating dairy cattle mammitis | |
| CN103223021A (en) | Uterine infusion drug for preventing and treating endometritis of dairy cows and sows and preparation method of uterine infusion drug | |
| CN103316312B (en) | A kind of tonification clearing heat in the pericardium mixture and preparation technology thereof | |
| CN101700290A (en) | Pharmaceutical composition for preventing and treating warm-heat diseases of livestock and poultry and preparation method thereof | |
| CN105012399A (en) | Chinese medicine film agent used for treating recessive mastitis of dairy cows and preparation method thereof | |
| CN104435023A (en) | Traditional Chinese medicine extract and application thereof | |
| CN103251741A (en) | Chinese medicine composition for treating toxoplasmosisinswine, and preparation method and application thereof | |
| CN102670860B (en) | Organic cow breast anti-bacterial care solution and preparation method thereof | |
| CN109771595A (en) | A kind of Chinese medicine composition and preparation method thereof for treating gynaecological imflammation | |
| CN103251691A (en) | Chinese medicine formula for treating bovine mastitis as well as extract and preparation thereof | |
| CN103142702A (en) | Chinese herbal medicine injection liquid for treating porcine reproductive and respiratory syndrome and preparation method thereof | |
| CN103191232B (en) | Traditional Chinese medicine composition for preventing and treating mastitis of dairy cattle and preparation and application of composition | |
| CN101972451B (en) | Compound infusion preparation of Chinese herbal medicines and western medicines for treating cow hysteritis and preparation method thereof | |
| CN102670793A (en) | Chinese herba preparation for increasing cow immunity and reducing milk somatic number and preparation method | |
| CN111228428A (en) | Liquid traditional Chinese medicine preparation for preventing African swine fever and method thereof | |
| CN101780199B (en) | Traditional Chinese medicine breast perfusate for treating mastitis of dairy cattle and preparation method thereof | |
| CN111494509A (en) | A Chinese medicinal injection for treating mastitis of milk cow, and its preparation method | |
| CN109845697A (en) | A kind of cultural method of fructus lycii sheep | |
| CN103463224B (en) | Drug for colpitis and preparation method thereof | |
| CN102824440A (en) | Traditional Chinese medicine composition for treating dairy cow mastitis and preparation method thereof | |
| CN103285079B (en) | Preparation process of perfusion agent for treating dairy cow mastitis | |
| CN103893259A (en) | Novel traditional Chinese medicine composition for controlling recessive mastitis and preparation method thereof | |
| CN111544570B (en) | Antiviral preparation added with antibacterial peptide and preparation method thereof | |
| CN102302575A (en) | Oral medicament for treating white scour of piglets and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20151104 |
|
| WD01 | Invention patent application deemed withdrawn after publication |