CN105596235B - A kind of milk cow nipple medicated bath liquid and preparation method thereof - Google Patents
A kind of milk cow nipple medicated bath liquid and preparation method thereof Download PDFInfo
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- CN105596235B CN105596235B CN201610014841.7A CN201610014841A CN105596235B CN 105596235 B CN105596235 B CN 105596235B CN 201610014841 A CN201610014841 A CN 201610014841A CN 105596235 B CN105596235 B CN 105596235B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
A kind of milk cow nipple medicated bath liquid and preparation method thereof, animal husbandry field more particularly to a kind of milk cow nipple medicated bath liquid.Being designed to provide one kind has good not dripping and bactericidal effect, while non-stimulated to skin and skin-moistening effect milk cow nipple medicated bath liquid.The dip by following mass parts material composition: 60-88 parts of purified water；4-32 parts of alcohols；0.8-1.2 parts of mobility stabilizer；0.2-0.4 parts of guanidine disinfectant；4-6 parts of emollient；0.1-0.2 parts of emulsifier；0.1-0.2 parts of detergent；Emollient is made of vegetable oil and natural moisturizing factor, and vegetable oil is olive oil, the linseed oil naturally extracted, and at least one of Jojoba Oil, shea butter, natural moisturizing factor is at least one of sodium lactate, amino acid, fatty acid, trehalose.The milk cow nipple medicated bath liquid is non-stimulated to skin, while will not solidify under cryogenic, and moisturizing moisture-keeping function is good, while having good not dripping and bactericidal effect.
Description
Technical field
The present invention relates to animal husbandry field more particularly to a kind of milk cow nipple medicated bath liquid.
Background technique
Milk since ancient times, is known as " white blood ", the milk of the good milk cow ability output high-quality of health.Mesh
Before, for dairy just in extensive development, prospect is considerable.But mammitis is one of four big diseases of milk cow, it is special
It is not that recessive mastitis disease incidence is high, harm is big, which not only influences the health of milk cow, endangers consumer's interests, and directly
The economic interests for reducing the output of milk and milk cattle cultivating seriously affect the development of dairy.The precautionary measures being usually taken are done
Milking health, the good hygienic conditions of creation, enhancing milk cow immunity etc. well do milking health is then mostly important one well
The step of a aspect, persistently dipping sterilizes after dipping 30s, milking before milking is indispensable.Therefore, scientific and effective nipple
Dipping disinfection is to prevent an important link of mammitis, can be effectively reduced the incidence of mammitis, reduces economic loss, protects
Demonstrate,prove former milk quality.
Traditional dip has iodine, povidone iodine, hydrogen peroxide and quaternary ammonium salts disinfectant, and bactericidal effect is good, in market
Upper prevalence is for a long time.These dipping products can probably be divided into several classes: one kind is dip of the alcohol as disinfectant solvent；It is a kind of
It is the dip containing film forming substance；It is also the Operand dip using glycerol as Emollient materials mostly.
The current above-mentioned generally existing some defects of dip, such as dip of the alcohol as disinfectant solvent, can stimulate
Skin of nipple causes skin degreasing phenomenon occur, to influence former milk quality；And the dip containing film forming substance, freezing point
It is higher, it is easy solidification under cryogenic conditions, although there is certain barrier action to bacterium, wraps up in the film forming matter for being attached to mammilla of milk cattle
Often thicker and cause skin of nipple airtight, the effect of moisturizing moisturizing is had a greatly reduced quality.
Disinfectant of the povidone iodine as conventional milk cow nipple medicated bath liquid, bactericidal effect with higher, wherein glycerol
It is the mechanism with moisture absorption and plays the purpose of moisturizing, soothing effect is single, therefore contains Operand of the glycerol as Emollient materials
Dip skin effect is not ideal enough, and long-time dipping will cause the dry and cracked of cow papillary skin.
Vegetable oil and natural moisturizing factor are usually used in having the function of nourishing, moisturizing in makeup washing product, Chinese special
The use that olive oil, sodium lactate are mentioned in sharp 104013561 A of CN is played the role of nourishing conditioning hair and scalp, but its
The compounding for not mentioning olive oil and sodium lactate and the use in disinfectant system, and find vegetable oil and iodine, povidone iodine
Compounding can occur slowly to chemically react, so that system does not have moisturizing and disinfection after compounding.
Hydroxypropyl guar gum, propylene glycol alginate, chitosan and its derivative are usually using the mechanism of reticular structure as increasing
Thick dose, thixotropic agent exclusive use, play the role of stabilising system mobility, however, it was found that being used in dipping liquid system to go out
Existing two kinds of extreme phenomenons, first is that guar gum class small using viscosity but big consistency, which is easy solidification, therefore does not have
Mobility is not only caused using difficulty, and be easy it is whole fallen from animal skin, second is that big using viscosity and consistency is small
Propylene glycol alginate, chitosan and its derivative, although having mobility, this mobility is unstable, is coated to skin
When upper, it was easy to appear drip phenomenon, causes the waste of dip, influences dipping effect indirectly.
It is that nipple has been closed in pervious this 30 minutes after having squeezed milk when mastitis for milk cows disease incidence highest, at present simultaneously
Do not have it is a kind of can avoid disadvantage mentioned above, while can play again excellent soothing effect, sterilizing and barrier bacterium intrusion work
Dip.
Summary of the invention
The purpose of the present invention is to provide one kind to have good not dripping and bactericidal effect, while non-stimulated to skin
And the milk cow nipple medicated bath liquid of skin-moistening effect.
The present invention provides a kind of milk cow nipple medicated bath liquid, by the material composition of following mass parts:
60-88 parts of purified water；
4-6 parts of emollient；
0.8-1.2 parts of mobility stabilizer；
0.2-0.4 parts of guanidine disinfectant；
4-32 parts of alcohols；
0.1-0.4 parts of detergent；
The emollient is made of vegetable oil and natural moisturizing factor, the mass ratio of the vegetable oil and natural moisturizing factor
For 9:2~6:5, the vegetable oil is olive oil, the linseed oil naturally extracted, at least one of Jojoba Oil, shea butter, institute
Stating natural moisturizing factor is at least one of sodium lactate, amino acid, fatty acid, trehalose.
The mobility stabilizer is by one of guar gum original powder, cation guar gum, hydroxypropyl guar gum and water
At least one of soluble chitosan, chitosan derivatives, propylene glycol alginate, bassora gum, lauric acid amide of ethanol press matter
Amount is compounded than 5:1~7:5.
The chitosan derivatives are chitosan hydrochloride, hydroxypropyl chitosan, hydroxyethyl chitosan, carboxymethyl chitosan
At least one of.
The guanidine disinfectant is cationic surfactant.
The cationic surfactant is acetic acid chlorhexidine, gluconic acid chlorhexidine, hexamethylene
(PHMB), polyhexamethylene list guanidine hydrochloride (PHMG), polyaminopropyl biguanide (PAPB), widow [2- (2- ethyoxyl)-ethyoxyl second
At least one of ester] chlorination guanidine.
The alcohol is 1,3- propylene glycol, 1,2- propylene glycol, polyethylene glycol, butanediol, glycerine, polypropylene glycol, sorbierite
At least one of.
The HLB value of the detergent is in 8~16 ranges.
The detergent is polysorbate, methyl glucamine, alkylolamides, alkyl glycosides (APG), poly alkyl alcohol
At least one of ethylene oxide ether.
It further include pigment, mass parts are 0.05-0.06 parts, and the pigment is fruit green, egg yolk, sunset yellow, brilliant blue
At least one of.
The present invention also provides the preparation methods of above-mentioned milk cow nipple medicated bath liquid, include the following steps:
(1) preparation of disinfectant premixed liquid: guanidine disinfectant is added in 10-13 mass parts purified water and is stirred
Uniformly；
(2) mobility stablizes the preparation of agent dispersing liquid: mobility stabilizer being mixed with 3-26 mass parts alcohols, is stirred
Uniformly obtain dispersion liquid；
(3) preparation of emollient emulsion: after emollient and 1-6 mass parts alcohols are mixed, it is then added to 10-13 matter
In the water for measuring part, it is homogenized to obtain emollient emulsion through colloid mill grinding 15min；
(4) it homogenizes: dispersion liquid that disinfectant premixed liquid that step (1) obtains, step (2) are obtained, step (3)
To emulsion, detergent, pigment be added sequentially in 40-62 mass parts purified water, at room temperature after mixing evenly, warp
After colloid mill grinds 30min, and continue to stir 2h, stands 2h to get milk cow nipple medicated bath liquid is arrived.
The invention has the following beneficial effects:
Dip of the present invention is non-stimulated to skin, while will not solidify under cryogenic, and moisturizing moisture-keeping function is good, simultaneously
With good not dripping and bactericidal effect.
Detailed description of the invention
Fig. 1 is measured object to moisture of skin influence curve figure.
Specific embodiment
Below by the specific embodiment provided, the present invention will be further described, but not as a limitation of the invention.
The present invention provides a kind of milk cow nipple medicated bath liquid, by the material composition of following mass parts:
60-88 parts of purified water；
4-6 parts of emollient；
0.8-1.2 parts of mobility stabilizer；
0.2-0.6 parts of guanidine disinfectant；
4-32 parts of alcohols；
0.1-0.4 parts of detergent；
Raw material is all food-grade or pharmaceutical grade in dip of the present invention.
Emollient is made of vegetable oil and natural moisturizing factor in dip of the present invention, vegetable oil and natural guarantor in emollient
The adding proportion range of the wet factor is 9:2~6:5.
The adding proportion range of vegetable oil and natural moisturizing factor is 9:2~6:5 in the emollient.In dipping liquid system
Under the premise of other components and dosage and emollient total amount are constant, the excessive (> of the adding proportion of vegetable oil and natural moisturizing factor
9:2), indicating that vegetable oil consumption is excessive, there is precipitation phenomenon in oil-in-water dipping liquid system in when low temperature, and under normal temperature condition
System liquidity becomes larger and serious drip phenomenon occurs；And ratio is too small (< 6:5), indicates that natural moisturizing factor dosage is excessive,
Although flowing sex expression is good under cryogenic, normal temperature condition can mobility be excessive drip phenomenon.
Vegetable oil of the present invention is olive oil, the linseed oil naturally extracted, at least one in Jojoba Oil, shea butter
Kind, permeability is strong but non-greasy, has the function of moistening skin-care.
Natural moisturizing factor (NMF) of the present invention, also known as moisturizer can help to repair damaged skin, improve skin
State, it is safe and non-stimulating.The natural moisturizing factor is at least one of sodium lactate, amino acid, fatty acid, trehalose.
The present invention uses at least one of sodium lactate, amino acid, fatty acid, trehalose, refers in dipping liquid system,
Play a dual role of system moisture preservative itself and keep cow papillary skin moisture, moisturizing effect can be further enhanced
Fruit.
Mobility stabilizer is guar gum original powder in the present invention, cation guar gum, hydroxypropyl guar gum, water soluble shells are gathered
Sugar, chitosan derivatives, propylene glycol alginate, bassora gum, at least two in lauric acid amide of ethanol, play improvement system
The effect of mobility is easy to dip and squeezes out from medicated bath cup, uniformly wrap up in and be attached on skin of nipple after dipping in, system drop is avoided to occur
Drippage and caused by waste.
Mobility stabilizer is by one of guar gum original powder, cation guar gum, hydroxypropyl guar gum in the present invention
With at least one of water soluble chitosan, chitosan derivatives, propylene glycol alginate, bassora gum, lauric acid amide of ethanol
It compounds, compound proportion range is 5:1~7:5.
Chitosan derivatives are chitosan hydrochloride, hydroxypropyl chitosan, hydroxyethyl chitosan, carboxymethyl shell in the present invention
At least one of glycan.
Guanidine disinfectant is all cationic surfactant in the present invention, is different from the advantages of Operand soluble easily in water
And without alcohol come that hydrotropy, thermal stability non-stimulated to skin be good and emollient is without any chemical reaction, has a broad antifungal spectrum, it can be with
There is killing effect to most Grain-positives and negative bacteria.
Guanidine disinfectant can prevent the corruption failure of the organic substances such as grease and carbohydrate and uniformly deposit in the present invention
It is in the reticular structure of mobility stabilizer, is finally reached the effect of stabilising system.
Cationic surfactant is hexamethylene (PHMB), acetic acid chlorhexidine, grape in the present invention
Saccharic acid chlorhexidine, polyhexamethylene list guanidine hydrochloride (PHMG), polyaminopropyl biguanide (PAPB), few [2- (2- ethyoxyl)-ethoxy
At least one of base ethyl ester] chlorination guanidine.
Heretofore described alcohol is 1,3- propylene glycol, 1,2- propylene glycol, polyethylene glycol, butanediol, glycerine, poly- the third two
At least one of alcohol, sorbierite.
The HLB value of heretofore described detergent is in 8~16 ranges.
Detergent is polysorbate, methyl glucamine, alkylolamides, alkyl glycosides (APG), fat in the present invention
There is emulsification, solubilising, decontamination etc. to make at least one of the nonionics such as alcohol polyoxyethylene ether or the surfactant of cationic
With, the surface tension of dirt can be effectively reduced, keep dirt more easy to remove, nipple more cleans, make disinfectant be easier contact skin
Simultaneously kill bacterium in skin surface.
Pigment is additionally added in the present invention, mass parts are 0.05-0.06 parts, and the pigment is fruit green, egg yolk, sunset
At least one of Huang, brilliant blue, sodium zinc chlorophyllin, all in skin surface noresidue, it is therefore an objective to convenient for the identification of no dipping.
Embodiment 1
The component of milk cow nipple medicated bath liquid described in the present embodiment and the preparation method is as follows:
1 component and proportion:
62.5 parts of purified water
4.5 parts of olive oil
1.0 parts of sodium lactate
1.0 parts of hydroxypropyl guar gum
0.2 part of water soluble chitosan
0.5 part of PHMB
30 parts of 1,3- propylene glycol
0.24 part of alkyl glycosides
0.06 part of light green pigment
2 ingredients explanation:
Emollient is that olive oil and sodium lactate are composed in the present invention, and the additional proportion of olive oil and sodium lactate is 9:2.
In the present invention although olive oil is the common substance of skin conditioner, is rich in unsaturated fatty acid, phenols antioxidant
And various vitamins etc., it is easily absorbed by the skin, can increase the gloss and elasticity of skin, chapped skin can be prevented.But often
It needs to carry out water-soluble processing, it is therefore desirable to which adding surfactant could be compounded with other water-soluble skin care substances
It uses, can be also stabilized in the dip containing disinfectant.
Sodium lactate is as a kind of natural moisturizing factor (NMF) in the present invention, can dissolve each other with water, alcohols etc., be skin moisture
Retention agent, the soothing effect of system can be improved jointly with plant oil skin care material mixing.
Hydroxypropyl guar gum is a kind of derivative of guar gum in the present invention, can be used as high viscosity liquid, can be effectively steady
Determine oil-in-water type emulsion system.It can keep not dripping when it is individually added into a certain amount of (>=1.2 mass parts), but system at this time
It can seem very thick, it is difficult to squeeze out in the medicated bath cup that never flows back and influence practicability.
Water soluble chitosan in the present invention is that the chitin (chitin) being widely present by nature passes through deacetylation
It obtaining, chemical name is Chitosan (1-4) -2- amino-B-D glucose, it can be used as adhesive, thickener, stabilizer,
Transparent protective layer can be formed, has preferable affinity interaction to skin, meanwhile, a certain amount of water soluble chitosan, which is added, has collaboration
Antibacterial effect.
The present invention needs one kind to have both low consistency and highly viscous compound mobility stabiliser system to optimize dip
Viscosity, to improve the practicability of dip.When mobility stabilizer total amount be 1.2 mass parts, hydroxypropyl guar gum with
When water soluble chitosan compound proportion is 5:1, system viscosity is not dripped properly, and not thick, in addition, hydroxypropyl guar gum is direct
Reunion caking phenomenon can be generated by being added to the water, and be unfavorable for the homogenization effect of system, therefore the present invention is made using 1,3-PD
This is solved the problems, such as the decentralized medium of compound mobility stabiliser system.
PHMB in the present invention, the entitled hexamethylene of chemistry, colorless and odorless are non-stimulated to skin and mucosa
Property, Mlc is low, work fast, and can continue antibacterial effect in material surface long-time one layer of cationic of formation
Fruit does not occur to chemically react and be stable in the presence of in system with other components.Because of the guanidine in hexamethylene
Base activity with higher, polymer is at electropositive.And virus, all kinds of bacteriums be generally in elecrtonegativity, so polyhexamethylene guanide
Salt is easy to be adsorbed, so make bacterium, virus can not schizogamy, loss of activity achievees the purpose that sterilizing.
PHMB is clearly superior to Operand dip as disinfectant in the present invention, and iodine easily distils and unstable, and as halogen
Plain atom easily reacts with unsaturated fatty acid in vegetable oil and causes system unstable.
The effect of 1,3- propylene glycol is: one contributes to hydroxypropyl guar gum and water soluble chitosan in water molten
Solution；Second is that the freezing point of dipping liquid system can be effectively reduced, prevents dip from freezing under cryogenic and destroy system character.
Alkyl glycosides in the present invention, English write a Chinese character in simplified form APG, also referred to as " APG decontamination factor ", are a kind of green safe property
The more comprehensive nonionic surfactant of energy, has high surface, good ecological security and intermiscibility, in the present invention
Play the role of solubilising, emulsification, decontamination, the present invention using one of APG06, APG0810, APG0814, APG1214 etc. or
Several, the HLB value of alkyl glycosides is in 10~16 ranges.
Addition pigment facilitate whether the identification of dipping, addition is more can be in skin deposits, and addition, which has been lacked, can not distinguish and be
No dipping.The present invention uses light green pigment, is a kind of combined food grade pigment, stablizes under the solubilization of surfactant
In the presence of, it is bright-colored, convenient for identification.
3 preparation methods:
(1) preparation of disinfectant premixed liquid:
The PHMB of 0.5 mass parts is added in 10 mass parts purified waters and is uniformly mixed；
(2) mobility stablizes the preparation of agent dispersing liquid:
1.0 mass parts hydroxypropyl guar gum, 0.2 mass of water-soluble chitosan and the 1,3- propylene glycol of 25 mass parts are mixed
It closes, is uniformly mixing to obtain dispersion liquid；
(3) preparation of emollient emulsion:
After 4.5 mass parts olive oil, 1.0 mass parts sodium lactates and 5 mass parts 1,3-PDs are mixed, it is then added to
In the water of 12.5 mass parts, it is homogenized to obtain emollient emulsion through colloid mill grinding 15min；
(4) it homogenizes:
By (1) disinfectant premixed liquid, (2) dispersion liquid, (3) emulsion, 0.24 mass parts alkyl glycosides, 0.06 mass parts fruit
Marennin is added sequentially in 40 mass parts purified waters, at room temperature after mixing evenly, after colloid mill grinds 30min,
Plastic barrel is squeezed into, and is continued after stirring 2h, stands 2h to get a kind of milk cow nipple medicated bath liquid finished product of transparent green.
Embodiment 2
The component of milk cow nipple medicated bath liquid described in the present embodiment and the preparation method is as follows:
1 component and proportion:
72.5 parts of purified water
4.5 parts of olive oil
1.0 parts of trehalose
0.84 part of hydroxypropyl guar gum
0.24 part of propylene glycol alginate
0.12 part of chitosan hydrochloride
0.3 part of PHMB
0.15 part of gluconic acid chlorhexidine
10.0 parts of 1,2- propylene glycol
10.0 parts of sorbierite
0.3 part of compound detergent
0.05 part of brilliant blue pigment
2 ingredients explanation:
Trehalose is by two glucose molecules with a, a, 1 in the present invention, and 1- glycosidic bond constitutes nonreducing sugar, can be used as
The antistaling agent of food, usually in cosmetic field as skin conditioning agent.But its aqueous solution has certain viscosity, this goo
Matter has good water retentivity, so cannot generally use in the system for destroying its cohesive structure, especially oxidisability
In system, or in the system of high viscosity and wrapping up it cannot play a role, it is therefore desirable to reacted with olive oil without any, carry out
It can be added in dipping liquid system after first compound emulsion, improve skin and reach reparation damage skin to the absorption of trehalose
Purpose.
Propylene glycol alginate is white or pale yellow powder in the present invention, is basic by the alginic acid extracted in natural seaweed
Material modification forms, and aqueous solution is at clear viscous shape colloid, because having lipophilic and hydrophily two in its molecular structure simultaneously
Kind group, can be used as emulsifier, thickener and stabilizer, be a kind of additive of common improvement food mouthfeel.But alginic acid
Propylene glycol ester thickening effect (>=1.2 mass parts) in the case where measuring on an equal basis in addition is not so good as hydroxypropyl guar gum, but the performance of its viscosity is on the contrary.
Chitosan hydrochloride of the present invention is a kind of chitosan derivatives with strong cation, white amorphous powder
End, it is tasteless, nontoxic.Aqueous solution is weakly acidic, clear, and property is stablized.Because maintaining the quality of chitosan, can make
The stability of dipping liquid system is improved for thickener, but cannot be individually added into, and needs to be compounded with other materials.
The present invention uses compound rheological property stabilizing agent, including three kinds of substances, i.e. hydroxypropyl guar gum, propylene glycol alginate
And chitosan hydrochloride.When additional proportion is hydroxypropyl guar gum: propylene glycol alginate: when chitosan hydrochloride=7:2:1, body
The viscosity and consistency of system have reached stationary value, squeeze out in the medicated bath cup that is easy to never flow back, and formed after dipping in skin surface
Wet protective layer and keep not dripping, there is contact metamorphism and improve the practicability of dip of the present invention.
Compound guanidine disinfectant is two kinds of Fungicidal substances, i.e. PHMB and gluconic acid chlorhexidine, sterilization effect in the present invention
Fruit is better than single substance, and dosage is few, and gluconic acid chlorhexidine is also a kind of guanidine disinfectant, soluble easily in water, living without surface
Property agent improve water solubility, most of Gram-negative bacteria and gram-positive bacteria can be inhibited, suppression to skin and mucosa nonirritant
Bacteria concentration is low, work fast, preferable with PHMB compatibility.
Sorbierite in the present invention, white crystalline powder is odorless, there is refrigerant sweet taste, can be miscible with water, propylene glycol.Sorbierite
Polyhydroxy structure make it have the property in conjunction with water, have the effects that control system viscosity, keep humidity.1,2- the third two
The moistening effect of the composite strengthening system of pure and mild sorbierite, while increasing dissolubility of the mobility stabilizer in system.
The present invention, as compound detergent, belongs to nonionic surfactant using APG0810 and AEO-7.AEO-7 is
A kind of fatty alcohol polyoxyethylene ether, it is good to compound synergisticing performance with APG0810, has good wetting power, detergency, and biology can drop
Solution property is good, and APG0810 and AEO-7 adding proportion are 2:1.
The present invention uses brilliant blue pigment, is a kind of Natural Food grade pigment, stablizes under the solubilization of surfactant
In the presence of, it is bright-colored, convenient for identification.
3 preparation methods:
(1) preparation of disinfectant premixed liquid:
The PHMB of 0.3 mass parts and 0.15 mass parts gluconic acid chlorhexidine are added in 10 mass parts purified waters and are stirred
It is uniformly mixed；
(2) mobility stablizes the preparation of agent dispersing liquid:
By 0.84 mass parts hydroxypropyl guar gum, 0.24 mass parts propylene glycol alginate, 0.12 mass parts chitosan hydrochloric acid
Salt is mixed with the sorbierite of the 1,2-PD of 5 mass parts and 10 mass parts, is uniformly mixing to obtain dispersion liquid；
(3) preparation of emollient emulsion
After mixing by 4.5 mass parts olive oil, 1.0 mass parts trehaloses and 5 mass parts 1,2-PDs, it adds
Into the water of 12.5 mass parts, it is homogenized to obtain emollient emulsion through colloid mill grinding 15min；
(4) it homogenizes:
By (1) disinfectant premixed liquid, (2) dispersion liquid, (3) emulsion, the compound detergent of 0.3 mass parts, 0.05 mass parts
Brilliant blue pigment is added sequentially in 50 mass parts purified waters, at room temperature after mixing evenly, grinds 30min through colloid mill
Afterwards, plastic barrel is squeezed into, and is continued after stirring 2h, stands 2h to get a kind of milk cow nipple medicated bath liquid finished product of transparent blue.
Embodiment 3
The main pathogenic bacteria of mastitis for milk cows includes Escherichia coli, staphylococcus aureus etc., and the present invention will be of the invention real
It applies the dip mechanism for testing that example 1 and 2 is prepared and has carried out anti-(suppression) bacterium product bacteriostasis property test test survey of stripping property
Examination, antibacterial the results are shown in Table 1.
Table 1
Illustrate that dip of the present invention has excellent bacteriostasis to Escherichia coli, staphylococcus aureus.
Embodiment 4
Skin surface moisture value is the one important finger of emollient effect for investigating milk cow nipple medicated bath liquid and related skin conditioner
Mark, can be tested by moisture of skin analyzer.Moisture of skin tester mainly uses capacitance principle, i.e., according to water and other objects
The difference of the dielectric constant of matter carries out the measurement of moisture content of skin.
Test condition: 20 ± 2 DEG C of room temperature, humidity 50 ~ 60%.
Test position: the back of the hand tiger's jaw position, 3 × 3 ㎝ 2 of area size are basically unchanged through clear water wiped clean to moisture value.
Criterion: skin is relatively dry, and moisture value is less than 35%；Dry skin, moisture value 35 ~ 50%；Moisture of skin is sufficient,
Moisture value is greater than 50%.
Testing procedure: its moisture value is tested at the tested position after cleaning before smearing；In specified tested region, smear tested
Sample (usage amount: 0.2g) starts timing afterwards, at regular intervals by probe of tester it is vertical be pressed in tested skin surface, 1
The numerical value of moisture of skin is just shown in second on host.It is every to have surveyed a sample, it wipes clean, to skin nature rest and reorganization 1h, side
It can carry out the test of next sample.In parallel three times, it is averaged, will be surveyed on the market with dip of the present invention Related product
Examination, as a result as shown in Figure 1, as seen from the figure, its moistening effect is much higher than existing under the dip same time that the present invention is prepared
There is product.
The main component of Related product on the market:
1 glycerine water solution: glycerol (20%), water；
Dip before 2 Operands: Iodophor, glycerol, water；
3 non-Operand prodrug bath foams: chlorohexidene or bromogeramine, alcohol, glycerol, water；
4 Operand film forming dips: macromolecule film former, Iodophor, alcohol, glycerol, water etc.；
5 non-Operand film forming dips: chlorohexidene, film forming agent, alcohol, glycerol, water etc..
Embodiment 5
Dip of the present invention is prepared using food-grade and pharmaceutical grade raw material, and irritation and anaphylaxis are to investigate dip
There is important indicator without side-effects to skin.At room temperature, the dip prepared by embodiment 1,2 is smeared respectively in health
People left and right the back of the hand tiger's jaw position, after action time 1h, wipe dip observation skin with hygienic non-woven fabrics, with smear before ratio
Compared with as a result without any irritation and allergic reaction.
Embodiment 6
Dip of the present invention is different from rear dipping product in the market, can form a kind of wet guarantor in skin surface after dipping
Sheath, and keep not dripping, it can avoid the waste of dip in this way, livestock farm management cost be effectively reduced, accumulation drippage number is inspection
An intuitive index of dip mobility is tested, and judges mobility stabilizer type and dosage to dip system liquidity
Influence size, indoors under conditions of 20 ± 2 DEG C of temperature, humidity 50~60%, the nipple of healthy cow dip length be 5 ±
After 0.5cm, the rear dip sample that quality is 3 ± 0.2g, starts timing, observe and count drippage number, each sample is done three times
Parallel test is averaged, and accumulation drippage number statistical result is shown in Table 2.
Table 2
The main component of other dipping liquid products in the market:
1 Operand film forming dip: macromolecule film former, Iodophor, alcohol, glycerol, water etc.；
2 non-Operand film forming dips: chlorohexidene or bromogeramine, film forming agent, alcohol, glycerol, water etc..
Because being that nipple has been closed in pervious this 30 minutes after having squeezed milk when mastitis for milk cows disease incidence highest, table
2 to illustrate that dip of the present invention has relative to existing product good not dripping.
The above content is combine specific embodiment to the further description of the invention done, and it cannot be said that this hair
Bright specific implementation is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, it is not taking off
Under the premise of from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to protection of the invention
Range.
Claims (9)
1. a kind of milk cow nipple medicated bath liquid, it is characterised in that by the material composition of following mass parts:
60-88 parts of purified water；
4-6 parts of emollient；
0.8-1.2 parts of mobility stabilizer；
0.2-0.4 parts of guanidine disinfectant；
4-32 parts of alcohols；
0.1-0.4 parts of detergent；
The emollient is made of vegetable oil and natural moisturizing factor, and the mass ratio of the vegetable oil and natural moisturizing factor is 9:
2~6:5, the vegetable oil are olive oil, the linseed oil naturally extracted, at least one of Jojoba Oil, shea butter, the day
The right damping factor is at least one of sodium lactate, amino acid, fatty acid, trehalose；
The mobility stabilizer is by one of guar gum original powder, cation guar gum, hydroxypropyl guar gum and water solubility
At least one of chitosan, chitosan derivatives, propylene glycol alginate, bassora gum, lauric acid amide of ethanol are in mass ratio
5:1~7:5 is compounded.
2. milk cow nipple medicated bath liquid as described in claim 1, it is characterised in that: the chitosan derivatives are chitosan hydrochloric acid
At least one of salt, hydroxypropyl chitosan, hydroxyethyl chitosan, carboxymethyl chitosan.
3. milk cow nipple medicated bath liquid as described in claim 1, it is characterised in that: the guanidine disinfectant is living for cationic surface
Property agent.
4. milk cow nipple medicated bath liquid as claimed in claim 3, it is characterised in that: the cationic surfactant is acetic acid chlorine
Determine, gluconic acid chlorhexidine, hexamethylene (PHMB), polyhexamethylene list guanidine hydrochloride (PHMG), gathered
At least one of aminopropyl biguanides (PAPB), few [2- (2- ethyoxyl)-ethoxy ethyl ester] chlorination guanidine.
5. milk cow nipple medicated bath liquid as described in claim 1, it is characterised in that: the alcohol is 1,3-PD, 1,2- the third two
At least one of alcohol, polyethylene glycol, butanediol, glycerine, polypropylene glycol, sorbierite.
6. milk cow nipple medicated bath liquid as described in claim 1, it is characterised in that: the HLB value of the detergent is in 8~16 ranges
It is interior.
7. milk cow nipple medicated bath liquid as claimed in claim 6, it is characterised in that: the detergent is polysorbate, alkyl Portugal
At least one of grape sugar amide, alkylolamides, alkyl glycosides (APG), fatty alcohol polyoxyethylene ether.
8. milk cow nipple medicated bath liquid as described in claim 1, it is characterised in that: further include pigment, mass parts 0.05-
0.06 part, the pigment is at least one of fruit green, egg yolk, sunset yellow, brilliant blue.
9. a kind of milk cow nipple medicated bath liquid as claimed in claim 8, it is characterised in that the preparation side of the milk cow nipple medicated bath liquid
Method includes the following steps:
(1) preparation of disinfectant premixed liquid: guanidine disinfectant is added in 10-13 mass parts purified water and is uniformly mixed；
(2) mobility stablizes the preparation of agent dispersing liquid: mobility stabilizer being mixed with 3-26 mass parts alcohols, is stirred evenly
Obtain dispersion liquid；
(3) after emollient and 1-6 mass parts alcohols are mixed, 10-13 mass parts the preparation of emollient emulsion: are then added to
Water in, through colloid mill grinding 15min be homogenized to obtain emollient emulsion；
(4) it homogenizes: dispersion liquid that disinfectant premixed liquid that step (1) obtains, step (2) obtain, step (3) is obtained
Emulsion, detergent, pigment are added sequentially in 40-62 mass parts purified water, at room temperature after mixing evenly, through colloid
After mill grinding 30min, and continue to stir 2h, stands 2h to get milk cow nipple medicated bath liquid is arrived.
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| CN110420257B (en) * | 2019-08-30 | 2021-08-17 | 陕西汉隆清洁消毒产品有限公司 | Composite cow nipple medicated bath liquid and preparation method thereof |
| CN114376940B (en) * | 2022-02-21 | 2023-03-31 | 佛山嘿黑科技有限公司 | Amino acid ice crystal shower gel and preparation method thereof |
| CN115869260B (en) * | 2023-02-22 | 2023-05-12 | 四川科宏达集团有限责任公司 | Dairy cow nipple medicated bath liquid and preparation method thereof |
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| CN101590075A (en) * | 2008-05-26 | 2009-12-02 | 烟台绿叶动物保健品有限公司 | The application of polycation disinfectant in disinfecting nipple skins of dairy cows |
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| CN102793742A (en) * | 2012-09-11 | 2012-11-28 | 冷晓红 | Film coating agent for disinfecting dairy cow breasts and preparation method of film coating agent |
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