CN106726956A - A kind of antibacterial skin moistening liquid soap and preparation method thereof - Google Patents

A kind of antibacterial skin moistening liquid soap and preparation method thereof Download PDF

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Publication number
CN106726956A
CN106726956A CN201611208760.7A CN201611208760A CN106726956A CN 106726956 A CN106726956 A CN 106726956A CN 201611208760 A CN201611208760 A CN 201611208760A CN 106726956 A CN106726956 A CN 106726956A
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Prior art keywords
liquid soap
antibacterial
moistening liquid
skin moistening
nmf
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CN201611208760.7A
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Chinese (zh)
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严志海
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Individual
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Priority to CN201611208760.7A priority Critical patent/CN106726956A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • A61K8/355Quinones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/733Alginic acid; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/736Chitin; Chitosan; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations

Abstract

The invention belongs to daily chemical product technical field, and in particular to a kind of antibacterial skin moistening liquid soap and preparation method thereof.The antibacterial skin moistening liquid soap that the present invention is provided, including following components and its mass percent:Sodium lauroyl glutamate 5~10%, sodium cocoyl glycinate 10~15%, NMF 10~16%, shitosan 4~10%, Tea Polyphenols 6~10%, antiseptic 3~6%, chelating agent 2~3% and water 30~60%.It is of the invention it is a technical advantage that:The gentle pro-skin soil release performance of amino acid surfactant is good, and antibacterial components can dispel the bacterium of hand, and the addition of the component such as NMF and shitosan has moisturizing and soothing effect, and each component mutual cooperation collective effect is used for decontamination, antibacterial and the moisturizing of both hands.

Description

A kind of antibacterial skin moistening liquid soap and preparation method thereof
Technical field
The invention belongs to daily chemical product technical field, and in particular to a kind of antibacterial skin moistening liquid soap and preparation method thereof.
Background technology
Hand cleanser is a kind of daily articles for washing, and species is various, but hand cleanser is all closed containing a certain amount of chemistry at present Into composition, the materials such as excessive synthetic surfactant, preservative, organic solvent are contacted, easily stimulate skin, trigger skin The problems such as skin allergy, contact dermatitis, skin is damaged, and health can also be produced certain direct or indirect Influence, then have environment can be polluted, so existing hand cleanser can not meet people for health, antibacterial, health, Many demands such as beauty, environmental protection towards green, environmentally friendly, renewable direction, it is necessary to develop.
Chinese patent application CN102871930A discloses a kind of hand cleanser, including cocounut oil 2-5%, dodecanamide propyl are sweet The pure ether sodium sulfate 8-15% of dish alkali 3-8%, bay, citric acid 1-3%, EDETATE SODIUM 1-3%, sodium chloride 0.5-1%, essence 1- 3%th, lemon extract 20-25%, ethanol 30-40%, remaining is water.The hand cleanser has a skin-protecting function, but the hand cleanser Dirt-removing power is poor, easily residual, and environment is polluted after discharge, and due to containing a large amount of ethanol, sense of discomfort being had after use, especially It is not suitable for women to use.
Chinese patent CN103655361B discloses a kind of Traditional Chinese medicinal hand lotion, by ethoxylated alkyl sulfate 40-60 parts, Sodium alkyl benzene sulfonate 6-10 parts, cocoanut fatty acid diethanolamide 1-2 parts, glycerine 2-3 parts, littlefruit heartseed fruit 2-4 parts, purple swallow grass 2- 4 parts of compositions, although the hand cleanser has good antibacterial effect, soothing effect is poor.
Therefore researching and developing a kind of had both had decontamination and antibacterial effect and the hand cleanser with moisturizing effect is a current weight Want task.
The content of the invention
Only consider to solve some being irritating to the skin property of component present in existing hand cleanser and some hand cleanser Dirty and antibacterial effect and have ignored the problem of moisturizing effect, the present invention provides a kind of antibacterial skin moistening liquid soap and preparation method thereof.
Antibacterial skin moistening liquid soap of the present invention, including following components and its mass percent:
Sodium lauroyl glutamate 5~10%, sodium cocoyl glycinate 10~15%, NMF 10~16%, shitosan 4~ 10%th, Tea Polyphenols 6~10%, antiseptic 3~6%, chelating agent 2~3% and water 30~60%.
Preferably, described antibacterial skin moistening liquid soap, is made up of following components and its mass percent:
Sodium lauroyl glutamate 7.5%, sodium cocoyl glycinate 12.5%, NMF 13%, shitosan 7%, Tea Polyphenols 8%th, antiseptic 4.5%, chelating agent 2.5% and water 45%.
Preferably, described NMF be sodium alginate and trimethylglycine in one or two.
Preferably, described antiseptic is by TCC and aloe-emodin in mass ratio 2:3 compositions.
Further preferably, described chelating agent is ethylenediamine tetra-acetic acid.
In addition, present invention also offers a kind of preparation method of antibacterial skin moistening liquid soap, comprising the following steps:Add water to To in container, 60-80 DEG C is heated to, stirring is lower to add sodium lauroyl glutamate, sodium cocoyl glycinate, NMF, shitosan And Tea Polyphenols, to being completely dissolved, 40-50 DEG C is cooled to, antiseptic and chelating agent are added, stir and be down to room temperature and obtain final product.
Sodium lauroyl glutamate CAS:29923-31-7;Sodium cocoyl glycinate CAS:90387-74-9;Alginic acid Sodium CAS:9005-38-3;Trimethylglycine CAS:107-43-7;Shitosan CAS:9012-76-4;Tea Polyphenols CAS Number:84650-60-2;TCC CAS:101-20-2;Aloe-emodin CAS:481-72-1.
Sodium lauroyl glutamate and sodium cocoyl glycinate are amino acid type surfactant, and amino acid is to constitute protein Base substance, gentle, nonirritant, and have splendid detergency, gentle pro-skin, the cleaning that sensitive skin can also be safe to use Product.
Sodium alginate hydrophily is strong, can be dissolved in cold water and warm water, forms very sticky uniform solution, is formed True solution there are other analogs to be difficult to flexibility, homogeneity and other good characteristics for obtaining, with very strong Protection glue The effect of body;Trimethylglycine is natural moisture preserving agent, tool high biological compatibility, for that can change rapidly in personal care product The water holding capacity of kind skin, activated cell vigor makes that skin is moist, smooth, prevents from drying and obfuscation.
Shitosan is unique basic amine group polysaccharide for largely existing in natural polysaccharide, and Chitosan-phospholipid complex can also suppress The growth and breeding of fungi, bacterium and virus, with good spectrum bactericidal properties.
Tea Polyphenols is water-soluble substances, and with sterilization, sterilizing, resisting age of skin, with very strong antioxidation, it resists Oxidability is artificial synthesized antioxidant BHT, 4-6 times of BHA, 6-7 times of VE, 5-10 times of VC, and consumption is few, 0.01- 0.03% can act, and the potential toxic and side effect without synthetic.
TCC is a kind of household chemicals bacteriostatic agent, be added to perfumed soap, shower cream, hand cleanser, mildy wash, In beautifying liquid, acne eliminating cream, washing powder etc., with sterilized, antibacterial and deodorant effect;Aloe-emodin is effective for the resistance of rheum officinale Composition, is the chemical substance of a kind of orange needle-like crystals or khaki crystalline powder, can be extracted from aloe, with antitumor work Property, antibacterial activity and immunosuppressive action, are widely used as medicine, cosmetic material.
Ethylenediamine tetra-acetic acid is a kind of organic compound, and it is a six tooth ylidene ligands, can with huge legendary turtle and many kinds of metal ions, Its 4 acid and 2 parts of amine all can be as the teeth of part, with the metal ion composition chelate such as manganese, copper, iron, cobalt.
Compatibility of the present invention is reasonable, science, and each component is cooperated, synergy, and decontamination, antibacterial and moisturizing effect are played jointly Really.
Compared with prior art, it is of the invention it is a technical advantage that:The gentle pro-skin soil release performance of amino acid surfactant is good, Antibacterial components can dispel the bacterium of hand, and the addition of the component such as NMF and shitosan has moisturizing and soothing effect, each group Split-phase interworking amounts to same-action is used for decontamination, antibacterial and the moisturizing of both hands.
Specific embodiment
The present invention is described in further details below by specific embodiment, these embodiments are only used for the mesh of illustration , it is in no way intended to limit protection scope of the present invention.
Embodiment 1-3, comparative example 1-2
Table 1 lists the component and quality hundred of the specific embodiment 1-3 and comparative example 1-2 of hand cleanser provided by the present invention Divide ratio.
The embodiment of table 1 and comparative example hand cleanser component and mass percent
Comparative example 1 is with the difference of embodiment 2:Chitosan-containing, does not increase the content of NMF and Tea Polyphenols.
Comparative example 2 is with the difference of embodiment 2:Antiseptic is by TCC and aloe-emodin in mass ratio 1: 1 composition.
The preparation method of the antibacterial skin moistening liquid soap of embodiment 1:Add water in container, be heated to 60 DEG C, stirring is lower to be added Enter sodium lauroyl glutamate, sodium cocoyl glycinate, NMF, shitosan and Tea Polyphenols, to being completely dissolved, be cooled to 40 DEG C, Antiseptic and chelating agent are added, is stirred and is down to room temperature and obtains final product.
The preparation method of the antibacterial skin moistening liquid soap of embodiment 2:Add water in container, be heated to 70 DEG C, stirring is lower to be added Enter sodium lauroyl glutamate, sodium cocoyl glycinate, NMF, shitosan and Tea Polyphenols, to being completely dissolved, be cooled to 45 DEG C, Antiseptic and chelating agent are added, is stirred and is down to room temperature and obtains final product.
The preparation method of the antibacterial skin moistening liquid soap of embodiment 3:Add water in container, be heated to 80 DEG C, stirring is lower to be added Enter sodium lauroyl glutamate, sodium cocoyl glycinate, NMF, shitosan and Tea Polyphenols, to being completely dissolved, be cooled to 50 DEG C, Antiseptic and chelating agent are added, is stirred and is down to room temperature and obtains final product.
The preparation method of comparative example 1-2 hand cleanser is similar to Example 2.
Properties of product evaluation test
Test example 1:Detergency test
Test material:Hand cleanser prepared by embodiment 1-3 and comparative example 1-2.
Subjects:Health 300 people of group, men and women half and half, age 18-60 Sui;Health status:Hand skin without allergies, Meet subject's aspiration inclusion criteria.
Test method:Subject is randomly divided into 5 groups, every group of 60 people, i.e. embodiment 1-3 groups and comparative example 1-2 groups, selection Representative dirt smears the palm of the hand, the back of the hand, and dirt area is identical, and the pollution time is continuous tested half an hour and 1 hour Time is 30 days, and using the cleaning composition prepared by embodiment 1-3 and comparative example 1-2 twice daily, test clean effect is entered Row scoring.Standards of grading:Ten point system is taken, 1 point worst, 10 points best, and fraction more high effect is better.
Result of the test:Hand cleanser decontamination evaluation effect is as shown in table 2.
The embodiment of table 2 and comparative example hand cleanser decontamination evaluation effect
The hand cleanser dirt-removing power of present invention offer, skin mildness are preferable as shown in Table 2, and prepared by comparative example 1-2 The clean effect of hand cleanser is poorer than hand cleanser effect prepared by embodiment of the present invention 1-3, illustrate hand cleanser compatibility of the present invention rationally, Science, each component synergy enhancing dirt-removing power.
Test example 2:Quantitative disinfecting test
Strain:Staphylococcus aureus (ATCC6538);Pseudomonas aeruginosa (ATCC15442);Escherichia coli (8099); Candida albicans (ATCC10231);Salmonella typhi.
The preparation of bacteria suspension:Sterile distilled water 5mL is used, staphylococcus aureus (ATCC6538), the verdigris that 24h is cultivated Pseudomonad (ATCC15442), Escherichia coli (8099), Candida albicans (ATCC10231) and Salmonella typhi are respectively with containing The phosphate buffer (PBS) of the 0.03mol/L of 1% (weight) peptone is diluted to bacteria suspension, and PH is 7.2-7.4.
Suspension quantitative bactericidal test:Bacteria suspension 1.0mL is taken in sterile test tube, the constant temperature in 19~21 DEG C of water-baths, then add Enter the mixing of 4.0mL thimerosals.Effect takes bacterium medicine mixed liquor 0.5mL and is mixed in 4.5mL nertralizers to the stipulated time.Neutralization The liquid or dilution 1.0mL inoculation sterilized petri dishes are taken after 10min, ordinary nutrient agar culture medium is poured into, in 37 DEG C of incubator cultures 48h, counts flat-plate bacterial colony number, and empirical average three times is averaged, and calculates sterilizing rate, and experiment effect 1min sterilizing rate results are shown in Table 3.
The hand cleanser fungistatic effect of table 3 tests table
Bacteriostasis rate % Embodiment 1 Embodiment 2 Embodiment 3 Comparative example 1 Comparative example 2
Staphylococcus aureus 91.23 99.26 92.03 82.23 80.36
Pseudomonas aeruginosa 90.36 98.95 91.05 81.23 79.23
Escherichia coli 89.68 98.26 91.05 80.67 78.69
Candida albicans 90.78 98.69 90.18 80.28 76.89
Salmonella typhi 91.28 98.61 88.96 78.69 80.46
The hand cleanser that as can be seen from Table 3 prepared by embodiment of the present invention 1-3 is compared with comparative example 1-2 hand cleanser for golden yellow Portugal The killing rate of grape coccus, pseudomonas aeruginosa, Escherichia coli, Candida albicans and Salmonella typhi is higher, illustrates that the present invention is washed Hand liquid compatibility rationally, science, each component synergy enhancing bactericidal action, and the antibacterial skin moistening liquid soap of embodiment 2 for this five The killing rate for planting strain is the preferred embodiments of the present invention more than 98%.
The above is only the preferred embodiment of the present invention, it is noted that it is right that above-mentioned preferred embodiment is not construed as Limitation of the invention, protection scope of the present invention should be defined by claim limited range.For the art For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change Enter and retouch and also should be regarded as protection scope of the present invention.

Claims (6)

1. a kind of antibacterial skin moistening liquid soap, it is characterised in that including following components and its mass percent:
Sodium lauroyl glutamate 5~10%, sodium cocoyl glycinate 10~15%, NMF 10~16%, shitosan 4~ 10%th, Tea Polyphenols 6~10%, antiseptic 3~6%, chelating agent 2~3% and water 30~60%.
2. antibacterial skin moistening liquid soap according to claim 1, it is characterised in that by following components and its mass percent group Into:It is sodium lauroyl glutamate 7.5%, sodium cocoyl glycinate 12.5%, NMF 13%, shitosan 7%, Tea Polyphenols 8%, anti- Microbial inoculum 4.5%, chelating agent 2.5% and water 45%.
3. antibacterial skin moistening liquid soap according to claim 1 and 2, it is characterised in that described NMF is sodium alginate With one or two in trimethylglycine.
4. antibacterial skin moistening liquid soap according to claim 1 and 2, it is characterised in that described antiseptic is by trichlorine equal two Phenylurea and aloe-emodin in mass ratio 2:3 compositions.
5. antibacterial skin moistening liquid soap according to claim 1 and 2, it is characterised in that described chelating agent is ethylenediamine tetraacetic Acetic acid.
6. the preparation method of the antibacterial skin moistening liquid soap according to claim any one of 1-5, it is characterised in that including following Step:In adding water to container, be heated to 60-80 DEG C, stirring is lower add sodium lauroyl glutamate, sodium cocoyl glycinate, NMF, shitosan and Tea Polyphenols, to being completely dissolved, are cooled to 40-50 DEG C, add antiseptic and chelating agent, stir Room temperature is down to obtain final product.
CN201611208760.7A 2016-12-23 2016-12-23 A kind of antibacterial skin moistening liquid soap and preparation method thereof Pending CN106726956A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107456401A (en) * 2017-08-14 2017-12-12 泉州亚林新材料科技有限公司 A kind of chitosan hand cleanser
CN107854369A (en) * 2017-12-21 2018-03-30 湖南华莱生物科技有限公司 A kind of black tea cleaning solution of long-acting bacteriostatic and preparation method thereof
CN111437206A (en) * 2020-05-27 2020-07-24 珠海纳金科技有限公司 Antibacterial and disinfectant hand sanitizer containing nano-silver and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103505384A (en) * 2012-06-25 2014-01-15 江苏天一健消毒剂有限公司 Antibacterial skin-moisturizing hand-washing liquid
CN105342932A (en) * 2015-12-11 2016-02-24 中华全国供销合作总社南京野生植物综合利用研究院 All-natural multifunctional hand sanitizer containing carboxymethyl chitosan and production method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103505384A (en) * 2012-06-25 2014-01-15 江苏天一健消毒剂有限公司 Antibacterial skin-moisturizing hand-washing liquid
CN105342932A (en) * 2015-12-11 2016-02-24 中华全国供销合作总社南京野生植物综合利用研究院 All-natural multifunctional hand sanitizer containing carboxymethyl chitosan and production method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107456401A (en) * 2017-08-14 2017-12-12 泉州亚林新材料科技有限公司 A kind of chitosan hand cleanser
CN107854369A (en) * 2017-12-21 2018-03-30 湖南华莱生物科技有限公司 A kind of black tea cleaning solution of long-acting bacteriostatic and preparation method thereof
CN111437206A (en) * 2020-05-27 2020-07-24 珠海纳金科技有限公司 Antibacterial and disinfectant hand sanitizer containing nano-silver and preparation method thereof

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