Summary of the invention
The technical problem to be solved in the present invention is for the weak point existing for prior art, the non-stimulated disinfection hand cleanser of a kind of medical skin moisturizing and preparation method are provided, handwashing liquid prepared by the method is soft, non-stimulated, and there is effect of skin moistening moisture-keeping function, the handwashing liquid utilizing the method to prepare is soft, to human body skin nonirritant, add skin protection Moisture factor, moisture preserving time is long, and effect of killing virus is than effective containing spirituous handwashing liquid.
Technical solution of the present invention is, following a kind of medical skin disinfection nursing handwashing liquid is provided, calculate by weight, comprise carbomer gel 0.1 ~ 0.5 part, glucose hibitane 0.06 ~ 0.1 part, triclosan 0.07 ~ 1.0 part, glycerol 2.0 ~ 6.0 parts, propylene glycol 2.0 ~ 5.5 parts, stearic acid 1.5 ~ 3.5 parts, PEG400 3 ~ 5 parts, Herba Lysimachiae foenum-graeci quintessence oil 0.02 ~ 0.1 part, vitamin B5 1.0 ~ 3.0 parts, 1.0 ~ 3.0 parts, tocopherol acid fat, stearin 3 ~ 7 parts, Coconut Fatty Acid Monoethanolamide 1 ~ 5 part, two imidazolidinyl urea 1 ~ 5 part, virgin olive oil 2 ~ 6 parts, triethanolamine 0.1 ~ 3 part and deionized water 85 ~ 96 parts.
A preparation method for medical skin disinfection nursing handwashing liquid, comprises the following steps:
(1) remove ionized water 48 ~ 53 parts, heating is also constantly stirred and is added carbomer gel 0.1 ~ 0.5 part, makes it to dissolve after repeating stirring;
(2) separately remove ionized water 19 ~ 22 parts, add stearic acid 1.5 ~ 3.5 parts, propylene glycol 2.0 ~ 5.5 parts, glycerol 2.0 ~ 6.0 parts and stearin 3 ~ 7 parts, and constantly stirring makes it to dissolve;
(3) ionized water 18 ~ 21 parts is removed again, add PEG400 3 ~ 5 parts of stirrings to make it to dissolve, add triclosan 0.07 ~ 1.0 part, glucose hibitane 0.06 ~ 0.1 part, Herba Lysimachiae foenum-graeci quintessence oil 0.02 ~ 0.1 part, vitamin B5 1.0 ~ 3.0 parts, 1.0 ~ 3.0 parts, tocopherol acid fat, Coconut Fatty Acid Monoethanolamide 1 ~ 5 part, two imidazolidinyl urea 1 ~ 5 part and virgin olive oil 2 ~ 6 parts again, constantly stir and make it to dissolve;
(4) solution that above-mentioned steps 1 ~ 3 is prepared respectively is poured in reactor, successively with homogenizer to viscous solution;
(5) PH to 6.5 ~ 7.0 are regulated with triethanolamine 0.1 ~ 3 part, obtained medical skin disinfection nursing handwashing liquid.
As preferably, in step (1), heating-up temperature is 55 ~ 70 DEG C; In step (4), homogenizer rotating speed is 2800rpm.
Adopt the beneficial effect of the technical program:
The present invention has selected the triclosan with broad-spectrum sterilization effect to be aided with glucose hibitane and natural lavender quintessence oil, for disinfectant, substitute ethanol, alcohol disinfecting is avoided to sterilize simultaneously to the stimulation of human body skin, add vitamin skin being had to skin moistening and moisture-keeping function simultaneously, tocopherol acid fat, virgin olive oil and glycerol.This product is soft, not only has nontoxic, nonirritant, high-effective disinfecting effect, and have good skin moistening to skin again, skin protection, nursing role, be a kind of brand-new disinfectant solution integrating sterilization, skin nursing, sterilizing ability is up to 96 ~ 97% simultaneously.
Stearic acid, stearin is good emulsifying agent and softening agent, tool Dimethicone Copolyol; Coconut Fatty Acid Monoethanolamide has excellent thickening property and foam stability and excellent skin moistening, lasting effect; Two imidazolidinyl urea has the breeding effect suppressing microorganism, and to Gram positive bacteria, Gram negative bacterium, comprising pseudomonas has fungistatic effect, suppresses selectively yeast, mycete.
In addition, owing to increasing natural lavender quintessence oil, virgin olive oil, while playing sterilization, also have effect of fragrance and whitening, glucose hibitane replaces ethanol, while raising virus killing effect, avoids the stimulation of ethanol to human body skin.
Detailed description of the invention
For ease of illustrating, below a kind of medical skin disinfection nursing handwashing liquid of the present invention and preparation method are elaborated.
Embodiment 1:
A kind of medical skin disinfection nursing handwashing liquid, calculate by weight, comprise carbomer gel 0.1 part, glucose hibitane 0.06 part, triclosan 0.07 part, glycerol 2.0 parts, propylene glycol 2.0 parts, stearic acid 1.5 parts, PEG400 3.0 parts, Herba Lysimachiae foenum-graeci quintessence oil 0.02 part, vitamin B5 1.0 parts, 1.0 parts, tocopherol acid fat, stearin 3 parts, Coconut Fatty Acid Monoethanolamide 1 part, two imidazolidinyl urea 1 part, virgin olive oil 2 parts, triethanolamine 0.3 part and deionized water 85 parts.
Prepare the non-stimulated disinfection hand cleanser of medical skin moisturizing, comprise the following steps:
(1) remove ionized water 48 parts, be heated to 60 DEG C, and constantly stirring adds carbomer gel 0.1 part, make it after repeating stirring to dissolve;
(2) separately remove ionized water 19 parts, add stearic acid 1.5 parts, propylene glycol 2.0 parts, glycerol 2.0 parts and stearin 3 parts, and constantly stirring makes it to dissolve;
(3) ionized water 18 parts is removed again, add PEG400 3.0 parts of stirrings to make it to dissolve, add triclosan 0.07 part, glucose hibitane 0.06 part, Herba Lysimachiae foenum-graeci quintessence oil 0.02 part, vitamin B5 1.0 parts, 1.0 parts, tocopherol acid fat, Coconut Fatty Acid Monoethanolamide 1 part, two imidazolidinyl urea 1 part, virgin olive oil 2 parts again, constantly stir and make it to dissolve;
(4) solution that above-mentioned steps 1 ~ 3 is prepared respectively is poured in reactor successively, stir with the rotating speed of 2800rpm with homogenizer, to the viscous solution of homogenizing;
(5) PH to 6.5 ~ 7.0 are regulated with triethanolamine 0.3 part, the obtained non-stimulated disinfection hand cleanser of medical skin moisturizing.
Embodiment 2:
The non-stimulated disinfection hand cleanser of a kind of medical skin moisturizing, calculate by weight, comprise carbomer gel 0.3 part, glucose hibitane 0.08 part, triclosan 0.09 part, glycerol 4.0 parts, propylene glycol 3.5 parts, stearic acid 2 parts, PEG400 4 parts, Herba Lysimachiae foenum-graeci quintessence oil 0.06 part, vitamin B5 2.0 parts, 2.0 parts, tocopherol acid fat, stearin 5 parts, Coconut Fatty Acid Monoethanolamide 3 parts, two imidazolidinyl urea 3 parts, virgin olive oil 4 parts, triethanolamine 0.6 part and deionized water 90 parts.
Prepare the non-stimulated disinfection hand cleanser of medical skin moisturizing, comprise the following steps:
(1) remove ionized water 50 parts, be heated to 60 DEG C, and constantly stirring adds carbomer gel 0.3 part, make it after repeating stirring to dissolve;
(2) separately remove ionized water 20 parts, add stearic acid 2 parts, propylene glycol 3.5 parts, glycerol 3 parts and stearin 5 parts, and constantly stirring makes it to dissolve;
(3) ionized water 20 parts is removed again, add Polyethylene Glycol 4 parts of stirrings to make it to dissolve, add triclosan 0.09 part, glucose hibitane 0.08 part, Herba Lysimachiae foenum-graeci quintessence oil 0.06 part and vitamin B5 2.0 parts, 2.0 parts, tocopherol acid fat, Coconut Fatty Acid Monoethanolamide 3 parts, two imidazolidinyl urea 3 parts, virgin olive oil 4 parts again, constantly stir and make it to dissolve;
(4) solution that above-mentioned steps 1 ~ 3 is prepared respectively is poured in reactor successively, stir with the rotating speed of 2800rpm with homogenizer, to the viscous solution of homogenizing;
(5) PH to 6.5 ~ 7.0 are regulated with triethanolamine 0.6 part, the obtained non-stimulated disinfection hand cleanser of medical skin moisturizing.
Embodiment 3:
The non-stimulated disinfection hand cleanser of a kind of medical skin moisturizing, calculate by weight, comprise carbomer gel 0.5 part, glucose hibitane 0.1 part, triclosan 1.0 parts, glycerol 6.0 parts, propylene glycol 5.5 parts, stearic acid 3.5 parts, PEG400 5 parts, Herba Lysimachiae foenum-graeci quintessence oil 0.1 part, vitamin B5 3.0 parts, 3 parts, tocopherol acid fat, stearin 7 parts, Coconut Fatty Acid Monoethanolamide 5 parts, two imidazolidinyl urea 5 parts, virgin olive oil 6 parts, triethanolamine 1 part and deionized water 96 parts.
Prepare the non-stimulated disinfection hand cleanser of medical skin moisturizing, comprise the following steps:
(1) remove ionized water 53 parts, be heated to 60 DEG C, and constantly stirring adds carbomer gel 0.5 part, make it after repeating stirring to dissolve;
(2) separately remove ionized water 22 parts, add stearic acid 3.5 parts, propylene glycol 5.5 parts, glycerol 6.0 parts and stearin 7 parts, and constantly stirring makes it to dissolve;
(3) ionized water 21 parts is removed again, add Polyethylene Glycol 5 parts of stirrings to make it to dissolve, add triclosan 1.0 parts, glucose hibitane 0.1 part, Herba Lysimachiae foenum-graeci quintessence oil 0.1 part and vitamin B5 3.0 parts, 3.0 parts, tocopherol acid fat, Coconut Fatty Acid Monoethanolamide 5 parts, two imidazolidinyl urea 5 parts, virgin olive oil 6 parts again, constantly stir and make it to dissolve;
(4) solution that above-mentioned steps 1 ~ 3 is prepared respectively is poured in reactor successively, stir with the rotating speed of 2800rpm with homogenizer, to the viscous solution of homogenizing;
(5) PH to 6.5 ~ 7.0 are regulated with triethanolamine 1 part, the obtained non-stimulated disinfection hand cleanser of medical skin moisturizing.
Embodiment 4:
The non-stimulated disinfection hand cleanser of a kind of medical skin moisturizing, calculate by weight, comprise carbomer gel 0.2 part, glucose hibitane 0.1 part, triclosan 0.07 part, glycerol 4.0 parts, propylene glycol 5 parts, stearic acid 1 part, PEG400 3 parts, Herba Lysimachiae foenum-graeci quintessence oil 0.1 part, vitamin B5 3.0 parts, 1.0 parts, tocopherol acid fat, seaweed extract liquid 2.0 parts, virgin olive oil 6 parts, triethanolamine 3 parts and deionized water 95 parts.
Prepare the non-stimulated disinfection hand cleanser of medical skin moisturizing, comprise the following steps:
(1) remove ionized water 53 parts, be heated to 60 DEG C, and constantly stirring adds carbomer gel 0.2 part, make it after repeating stirring to dissolve;
(2) separately remove ionized water 22 parts, add stearic acid 1 part, propylene glycol 5 parts, stearin 4 parts and glycerol 4 parts, and constantly stirring makes it to dissolve;
(3) ionized water 20 parts is removed again, add Polyethylene Glycol 5 parts of stirrings to make it to dissolve, add triclosan 0.07 part, glucose hibitane 0.1 part, Herba Lysimachiae foenum-graeci quintessence oil 0.1 part and vitamin B5 3.0 parts, 1.0 parts, tocopherol acid fat, Coconut Fatty Acid Monoethanolamide 2.5 parts, two imidazolidinyl urea 4 parts, virgin olive oil 6 parts again, constantly stir and make it to dissolve;
(4) solution that above-mentioned steps 1 ~ 3 is prepared respectively is poured in reactor successively, stir with the rotating speed of 2800rpm with homogenizer, to the viscous solution of homogenizing;
(5) PH to 6.5 ~ 7.0 are regulated with triethanolamine 3 parts, the obtained non-stimulated disinfection hand cleanser of medical skin moisturizing.
Embodiment 4:
The non-stimulated disinfection hand cleanser of a kind of medical skin moisturizing, calculate by weight, comprise carbomer gel 0.8 part, glucose hibitane 0.2 part, triclosan 0.05 part, glycerol 2.0 parts, propylene glycol 4.5 parts, stearic acid 4 parts, PEG400 4 parts, Herba Lysimachiae foenum-graeci quintessence oil 0.08 part, vitamin B5 2.5 parts, 3.0 parts, tocopherol acid fat, stearin 10 parts, Coconut Fatty Acid Monoethanolamide 4.5 parts, two imidazolidinyl urea 1 part, virgin olive oil 5 parts, triethanolamine 2.5 parts and deionized water 96 parts.
Prepare the non-stimulated disinfection hand cleanser of medical skin moisturizing, comprise the following steps:
(1) remove ionized water 53 parts, be heated to 60 DEG C, and constantly stirring adds carbomer gel 0.8 part, make it after repeating stirring to dissolve;
(2) separately remove ionized water 22 parts, add stearic acid 4 parts, propylene glycol 4.5 parts, stearin 10 parts and glycerol 2.0 parts, and constantly stirring makes it to dissolve;
(3) ionized water 21 parts is removed again, add Polyethylene Glycol 4 parts of stirrings to make it to dissolve, add triclosan 0.05 part, glucose hibitane 0.2 part, Herba Lysimachiae foenum-graeci quintessence oil 0.08 part and vitamin B5 2.5 parts, 3.0 parts, tocopherol acid fat, Coconut Fatty Acid Monoethanolamide 4.5 parts, two imidazolidinyl urea 1 part, virgin olive oil 5 parts again, constantly stir and make it to dissolve;
(4) solution that above-mentioned steps 1 ~ 3 is prepared respectively is poured in reactor successively, stir with the rotating speed of 2800rpm with homogenizer, to the viscous solution of homogenizing;
(5) PH to 6.5 ~ 7.0 are regulated with triethanolamine 2.5 parts, the obtained non-stimulated disinfection hand cleanser of medical skin moisturizing.
Through checking the non-stimulated disinfection hand cleanser of medical skin moisturizing prepared by above-described embodiment 1 ~ 5, specific as follows:
Get common pathogenic bacteria 6 kinds, be respectively staphylococcus aureus, escherichia coli, Candida albicans, Pseudomonas aeruginosa, Streptococcus viridans and tubercule bacillus, respectively getting 50 strains is placed in culture dish, when the condition such as temperature, humidity is identical, the handwashing liquid of the described preparation of this invention is used to carry out sterilization processing, after sterilization, all pathogenic bacterias are tested, then data form is made to the result after sterilization, as follows:
Note: in upper table, numerical value is the ratio that pathogenic bacteria kills quantity and total quantity.
Substantially although bactericidal effect can be completed containing spirituous handwashing liquid common on the market, but, due to use time high enrichment ethanol as main antibacterial, very serious to the stimulation of skin, nonalcoholic handwashing liquid prepared by the present invention is carried out Experimental Comparison with current containing spirituous handwashing liquid, specific as follows:
Test 1 ~ 5 group of corresponding handwashing liquid used prepared by embodiment 1 ~ 5 respectively, contrasting 1 ~ 5 group uses can buy in the market common to contain spirituous handwashing liquid, test 1 ~ 5 group and contrast 1 ~ 5 group are respectively used to this city three comparatively large-scale medical institutions, Mei Suo medical institutions choose 10 groups of medical personnel, often organize 10 people, amount to 100 people, wherein test 1 ~ 5 group and use handwashing liquid prepared by the present invention, contrast 1 ~ 5 group of 5 kinds of handwashing liquid using current market to have bought respectively, life cycle is one month.
Through the analysis to above-mentioned month, result is as follows:
Contrast 1 ~ 5 group: the market used has refrigerant sensation when at will the commercially available handwashing liquid containing highly enriched ethanol uses, but, if when not adding the continuous Reusability of other skin care item about 5 days, the medial surface of finger, palm can produce decortication phenomenon, peel in 50 subjects, xerosis cutis person reaches more than 46%.Along with the continuation of this type of handwashing liquid uses, most foaming, decortication person peel phenomenon more seriously, and alleviating appears in minority.During continuous use January, subjects skin becomes dry, coarse, stiff.
Test 1 ~ 5 group: use the handwashing liquid prepared by the embodiment of the present invention 1 ~ 5 respectively, peel in 50 subjects, dry only has three, use embodiment 1 and the handwashing liquid prepared by embodiment 5 respectively, all there is not the keratinization problems such as foaming, decortication in all the other personnel, after within continuous one month, using, subjects skin is moistening, flexible, surface is ruddy, soft, vigor is prosperous and powerful, and moistening effect is better, and finger, palm do not produce wrinkle, drying, the defect such as stiff, result of use is good, obtains the consistent favorable comment of numerous experimenters.
In sum; medical skin disinfection nursing handwashing liquid prepared by the present invention; not only there is good sterilization, bactericidal action; have more good moistening effect, non-stimulated to skin, effectively can protect finger, the palm of medical personnel; prevent the aging that skin is too early; lifting vigor, result of use is good, and the handwashing liquid prepared by this invention has significant result of use and outstanding substantive distinguishing features.Handwashing liquid bactericidal property described in integrated embodiment 1 ~ 5 is all higher than existing handwashing liquid bactericidal property, and described in embodiment 2, the bactericidal property of the handwashing liquid of preparation is higher than embodiment 1,3,4 and 5, is a kind of embodiment of optimum.
In the above-described embodiments, preferred forms of the present invention is described, obviously, under inventive concept of the present invention, still can make a lot of change.At this, should illustrate, any change made under inventive concept of the present invention all will fall within the scope of protection of the present invention.