CN107468545A - A kind of antibacterial green skin care hand cleaning liquid and preparation method thereof - Google Patents

A kind of antibacterial green skin care hand cleaning liquid and preparation method thereof Download PDF

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Publication number
CN107468545A
CN107468545A CN201710687608.XA CN201710687608A CN107468545A CN 107468545 A CN107468545 A CN 107468545A CN 201710687608 A CN201710687608 A CN 201710687608A CN 107468545 A CN107468545 A CN 107468545A
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skin care
cleaning liquid
green skin
hand cleaning
antibacterial green
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CN201710687608.XA
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CN107468545B (en
Inventor
智丽飞
王远洋
薛永斌
姚树山
李晓明
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Taiyuan University of Science and Technology
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Taiyuan University of Science and Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48—Thickener, Thickening system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/596—Mixtures of surface active compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)

Abstract

The invention belongs to personal daily cleaning nursing article technical field, and in particular to a kind of hand cleanser of antibacterial green skin care and preparation method thereof.A kind of antibacterial green skin care hand cleaning liquid, is made up of the component of following weight percentage：Modified grease ethoxylate 15, APG 5 10, glycosyl amide cationic surfactant 0.5 3, methyl glucamine 0.5 1, edible glycerol 0.1 1, flavoring rose essence 0.01 0.1, surplus are deionized water.The antibiotic skincare hand cleanser of the present invention, energy deep-pollution-removing, antimicrbial power is strong, and foam is fine and smooth, easily rinses, easily biological-degradable, and have the effect of skin-moisturizing, skin.

Description

A kind of antibacterial green skin care hand cleaning liquid and preparation method thereof
Technical field
The invention belongs to personal daily cleaning nursing article technical field, and in particular to a kind of antibacterial green skin care is washed one's hands Liquid and preparation method thereof.
Background technology
With the improvement of people ' s living standards and consumption idea transformation, hand cleanser has been increasingly becoming traditional hand-washing article Substitute, it is a market clusters length, contains the product of abundant market potential, and application prospect is very wide.From mesh From the point of view of preceding demand, the product function of hand cleanser should be based on " taking out stains, disinfection ", " using health, conveniently ".Simultaneously " warding off taste, only hand perspiration, moist, moisturizing, anti-decortication, crease-resistant, anti-aging and whitening " etc. is also the auxiliary appeal point being considered as.
Also occurring some in the market has the hand cleanser of sterilizing function, mainly with the addition of some disinfectants and sun Ionic surface active agent etc., make it have certain bactericidal effect.But the bactericide in these hand cleanser is usually triclosan, chlorine For xylenols and 2,4,4- tri- chloro- 2- hydroxyls phenylates and cationic surfactant etc., these disinfectants, to human body uneasiness Entirely, if drift does not wash clean, there is certain stimulation to the skin of people, and these compositions do not have moist, moisturizing and other effects, use effect Rate reduces；Generally contain poisonous and harmful impurity content using multiclass active matter in traditional hand sanitizer formula, such as alkanolamide 6501 contains There are nitrosamine, ether alcohol sulfate AES to contain dioxane, alkyl betaine contains chloroethene acids carcinogenic substance etc.；Part hand cleanser is matched somebody with somebody Side is easily remained on skin after use due to surfactant improper use, has and rinse sordid sensation, made skin dry It is astringent, skin is damaged；In the market, which also has, contains substantial amounts of ethanol in some hand cleanser, sense of discomfort is had after use, especially It is not suitable for women use.So existing hand cleanser can not meet people to health, antibacterial, health, beauty, environmental protection etc. Many demands, it is badly in need of a kind of green, environmentally friendly, multi-functional hand cleanser of exploitation.
The content of the invention
Have it is an object of the invention to provide a kind of green, environmentally friendly, safe and non-stimulating, antibacterial strong detergency while to skin There is antibiotic skincare hand cleanser of preserving moisture and protecting skin effect and preparation method thereof.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of antibacterial green skin care hand cleaning liquid, is made up of the component of following weight percentage：
Modified grease ethoxylate 1-5, APG 5-10, glycosyl amide cationic surfactant 0.5-3, alkyl Glucose amide 0.5-1, edible glycerol 0.1-1, flavoring rose essence 0.01-0.1, surplus are deionized water.
Preferably, modified grease ethoxylate SOE of the present invention is the production of Zhong Qing daily use chemicals Science and Technology Ltd. Model SOE-S-60, SOE-N-60, SOE-P-60 or SOE-C-60 modified grease ethoxylate.
Preferably, the formula of APG of the present invention is：
In formula：R1The alkyl for being 8-18 for carbon number, m 1.2-1.8.
Preferably, the structural formula of glycosyl amide cationic surfactant of the present invention is：
Or
R is C in formula10-C18Long chain hydrocarbon groups, y 10-18.
Preferably, the structural formula of methyl glucamine of the present invention is：
N is 10-18 in structural formula.
A kind of preparation method of antibacterial green skin care hand cleaning liquid, at 70-80 DEG C, by deionized water and modified grease ethoxy Glycolylate is well mixed, and sequentially adds APG, glycosyl amide cationic surfactant, alkyl glucose acyl under agitation Amine and edible glycerol, stir transparent, be then cooled to room temperature, add flavoring rose essence and stir, that is, antibacterial shield is made Skin hand cleanser.
The present invention has the following advantages that compared with prior art：
1. material modification grease ethoxylate, APG, glycosyl amide cation surface activating that the present invention uses Agent and methyl glucamine are prepared by natural reproducible resource natural oil and sugar, raw material green, environmental protection, can be again It is raw, nontoxic, non-stimulated, it is safe to the human body, environment-friendly.
2. the bactericide that the present invention uses is new glycosyl amide cationic surfactant, such surfactant will The mildness of glycosyl surfactant active and the high efficiency of quaternary ammonium salt cationic surfactant are combined together, non-stimulated to skin, kill Bacterium property is strong, biological degradability is good and strong with the compatibility of cloudy (non-) ionic surface active agent.And amido link therein is similar to Peptide bond in protein, there can be more preferable compatibility with skin, hair, skin natural gloss can be assigned, and be allowed to soft and moist.
3. for the present invention using methyl glucamine as scrubbed component, it is not only a kind of preferably thickener (thickening 6501) effect is better than, and itself also has the characteristics of dirt-removing power is strong, and compatibility is good.
4th, antibiotic skincare hand cleanser of the invention, energy deep-pollution-removing, antimicrbial power is strong, and foam is fine and smooth, easily rinses, easily biological drop Solution, and there is the effect of skin-moisturizing, skin.
Embodiment：
The present invention is described further with reference to embodiments, and embodiment is only used for explaining the present invention rather than limit The scope of the present invention processed.
Embodiment 1：
At 70 DEG C, deionized water and modified palm-kernel oil ethoxylate are well mixed, sequentially added under agitation C12-14APG (degree of polymerization DP=1.8), C12DGPB、C10Methyl glucamine and edible glycerol, stir transparent； Room temperature is cooled to, flavoring rose essence is added and is stirred until homogeneous transparency liquid, discharge.
Embodiment 2：
At 72 DEG C, deionized water and modified walnut oil ethoxylate are well mixed, sequentially added under agitation C16-18APG (degree of polymerization DP=1.2), C16DGPB、C12Methyl glucamine and edible glycerol, stir transparent； Room temperature is cooled to, flavoring rose essence is added and is stirred until homogeneous transparency liquid, discharge.
Embodiment 3：
At 75 DEG C, deionized water and modified olive oil ethoxylate are well mixed, sequentially added under agitation C8-10APG (degree of polymerization DP=1.4), C14DGPB、C14Methyl glucamine and edible glycerol, stir transparent；It is cold But room temperature is arrived, flavoring rose essence is added and is stirred until homogeneous transparency liquid, discharge.
Embodiment 4：
At 76 DEG C, deionized water and modipied natural apatite ethoxylate are well mixed, sequentially added under agitation C12-14APG (degree of polymerization DP=1.6), C14DLPB、C16Methyl glucamine and edible glycerol, stir transparent； Room temperature is cooled to, flavoring rose essence is added and is stirred until homogeneous transparency liquid, discharge.
Embodiment 5：
At 78 DEG C, deionized water and modified palm-kernel oil ethoxylate are well mixed, sequentially added under agitation C12-14APG (degree of polymerization DP=1.2), C12MHGPB、C12Methyl glucamine and edible glycerol, stir transparent； Room temperature is cooled to, flavoring rose essence is added and is stirred until homogeneous transparency liquid, discharge.
Embodiment 6：
At 80 DEG C, deionized water and modified walnut oil ethoxylate are well mixed, sequentially added under agitation C12-14APG (degree of polymerization DP=1.6), C18MHGPB、C12Methyl glucamine and edible glycerol, stir transparent； Room temperature is cooled to, flavoring rose essence is added and is stirred until homogeneous transparency liquid, discharge.
To further demonstrate that the bactericidal effect of the present invention, the present invention is according to National Standard of the People's Republic of China Antibacterial impact of performance evaluation method has carried out the detection of antibacterial base to the embodiment of the present application in GB19877.1-2005 special type hand cleanser,
The embodiment of the present application prepares the sterilizing rate testing result such as following table of sample：
According to GB 19877.1-2005 requirement, sterilizing rate >=90% is qualified.Can from the experimental result of upper table Go out, the sample that the embodiment of the present application obtains can reach the requirement of standard.

Claims (6)

  1. A kind of 1. antibacterial green skin care hand cleaning liquid, it is characterized in that being made up of the component of following weight percentage：
    Modified grease ethoxylate 1-5, APG 5-10, glycosyl amide cationic surfactant 0.5-3, alkyl grape Sugared acid amides 0.5-1, edible glycerol 0.1-1, flavoring rose essence 0.01-0.1, surplus are deionized water.
  2. A kind of 2. antibacterial green skin care hand cleaning liquid according to claim 1, it is characterized in that described modified grease ethyoxyl Compound is model SOE-S-60, SOE-N-60, SOE-P-60 or SOE-C-60 of Zhong Qing daily use chemicals Science and Technology Ltd. production Modified grease ethoxylate.
  3. A kind of 3. antibacterial green skin care hand cleaning liquid according to claim 1, it is characterized in that the formula of described APG For：
    In formula：R1The alkyl for being 8-18 for carbon number, m 1.2-1.8.
  4. A kind of 4. antibacterial green skin care hand cleaning liquid according to claim 1, it is characterized in that described glycosyl amide cation The structural formula of surfactant is：
    Or
    R is C in formula10-C18Long chain hydrocarbon groups, y 10-18.
  5. A kind of 5. antibacterial green skin care hand cleaning liquid according to claim 1, it is characterized in that described methyl glucamine Structural formula be：
    N is 10-18 in structural formula.
  6. A kind of 6. preparation method of antibacterial green skin care hand cleaning liquid described in any one in claim 1-5, it is characterized in that in 70- At 80 DEG C, deionized water and modified grease ethoxylate are well mixed, sequentially add APG, glycosyl acyl under agitation Amine cation surfactant, methyl glucamine and edible glycerol, stir transparent, be then cooled to room temperature, then add Enter flavoring rose essence to stir, that is, antibiotic skincare hand cleanser is made.
CN201710687608.XA 2017-08-11 2017-08-11 Green antibacterial skin-care hand sanitizer and preparation method thereof Active CN107468545B (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110236971A (en) * 2019-04-17 2019-09-17 中国日用化学研究院有限公司 A kind of bacteriostatic hand sanitizer of the quaternary ammonium salt containing counter ion and preparation method thereof
CN114230481A (en) * 2021-12-29 2022-03-25 太原科技大学 Low-toxicity bactericidal glycosyl amide ionic liquid and preparation method and application thereof
CN115531278A (en) * 2022-09-22 2022-12-30 中轻日化科技有限公司 Fat-endowing no-clean hand sanitizer and preparation method thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110236971A (en) * 2019-04-17 2019-09-17 中国日用化学研究院有限公司 A kind of bacteriostatic hand sanitizer of the quaternary ammonium salt containing counter ion and preparation method thereof
CN110236971B (en) * 2019-04-17 2022-05-20 中国日用化学研究院有限公司 Antibacterial hand sanitizer containing counter ion quaternary ammonium salt and preparation method thereof
CN114230481A (en) * 2021-12-29 2022-03-25 太原科技大学 Low-toxicity bactericidal glycosyl amide ionic liquid and preparation method and application thereof
CN114230481B (en) * 2021-12-29 2023-09-22 太原科技大学 Low-toxicity sterilizing glycosylamide ionic liquid and preparation method and application thereof
CN115531278A (en) * 2022-09-22 2022-12-30 中轻日化科技有限公司 Fat-endowing no-clean hand sanitizer and preparation method thereof

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