CN110236971A - A kind of bacteriostatic hand sanitizer of the quaternary ammonium salt containing counter ion and preparation method thereof - Google Patents
A kind of bacteriostatic hand sanitizer of the quaternary ammonium salt containing counter ion and preparation method thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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Abstract
The invention discloses bacteriostatic hand sanitizers of a kind of quaternary ammonium salt containing counter ion and preparation method thereof.The bacteriostatic hand sanitizer comprises the following raw materials by weight percent: amphoteric surfactant 1.0 ~ 7.0%；Poly glucoside 1.0 ~ 8.0%；Grease ethoxylate 0.5 ~ 3.0%；Counter ion quaternary ammonium salt 0.2 ~ 2.0%；Moisturizer 0.5 ~ 5.0%；Thickener 0.03 ~ 0.2%；PH adjusting agent 0 ~ 0.01%；Essence 0 ~ 0.1%；Pigment 0 ~ 0.01%；Surplus is water.The counter ion quaternary ammonium salt that the present invention uses, for microorganism to it without drug resistance, a little additive amount can reach excellent bactericidal and bacteriostatic effect, good with other composition compound properties, and preparation method operability is high；Product integral formula embodies greenization feature；Gained bacteriostatic hand sanitizer has good killing ability to Gram-negative bacteria, gram-positive bacteria, fungi.
Description
Technical field
The present invention relates to bacteriostatic hand sanitizer of a kind of quaternary ammonium salt containing counter ion and preparation method thereof, belong to bacteriostatic hand sanitizer and
Its preparation field.
Background technique
The major function of hand cleanser is cleaning both hands skin, some special components can also play the role of antibacterial, sterilization.
The bacteriostatic hand sanitizer commodity sold on the market now, main bactericidal substance are that p-chloro-m-xylol etc. disappears containing chlorine
Kill agent or phenol elimination agent etc..Such as Wei Lushi, droplet dew bacteriostatic hand sanitizer, main antipathogenic composition is parachlorometaxylenol；
The main antipathogenic composition of blue moon aloetic bacteriostatic hand cleanser is o-phenyl phenol；Antibacterial substance in Safeguard series of products is then normal
Select zinc pyrithione (zinc pyrithione) Ji Dibao skin triclocarban.But the such chemical substance in part has had been found or potential
With harmfulness, wherein U.S. FDA has prohibited the addition of triclocarban, triclosan substance；In addition, zinc pyrithione is
Strong hormonal substance also has certain stimulation to human body.
Chinese invention patent CN108685733A discloses a kind of bacteriostatic hand sanitizer, and antibacterial substance therein is traditional Chinese medicine extraction
Polypeptide, polysaccharide, alkaloid effective component, but traditional Chinese medicine extraction relative difficulty, complicated component, and higher cost are applied to
In hand cleanser with other surfactants to compound stability poor, temperature and pH are sensitive, are not suitable with large-scale production.Chinese invention
Patent CN108567649A, CN108514533A etc. also proposed the side for adding that Chinese medical extract is antibacterial substance in hand cleanser
Method.
Quaternary ammonium salt has used for many years as a kind of wide-spectrum bactericide, and common model has 1227,1231, D1021 etc., tool
Have the advantages that sterilization is rapid-action, the continuous action time is long, cheap, when contacting with bacterium, cell knot can be acted on rapidly
Structure makes bacterolysis, death.But conventional quaternary ammonium salt has used for many years, most microorganisms generates it
Drug resistance, consequent are the decline of usage amount being continuously increased with mildness, and conventional quaternary ammonium salt biological degradability
Difference can generate pollution to environment, especially water body.
Summary of the invention
The object of the present invention is to provide bacteriostatic hand sanitizer of a kind of quaternary ammonium salt containing counter ion and preparation method thereof, the hand cleanser
Energy long-acting bacteriostatic, biodegradability is excellent, is not necessarily to outer adding preservative agent.
The present invention provides a kind of bacteriostatic hand sanitizers of quaternary ammonium salt containing counter ion, by the raw material group of following weight percent
At:
Amphoteric surfactant 1.0 ~ 7.0%；
Poly glucoside 1.0 ~ 8.0%；
Grease ethoxylate 0.5 ~ 3.0%；
Counter ion quaternary ammonium salt 0.2 ~ 2.0%；
Moisturizer 0.5 ~ 5.0%；
Thickener 0.03 ~ 0.2%；
PH adjusting agent 0 ~ 0.01%；
Essence 0 ~ 0.1%；
Pigment 0 ~ 0.01%；
Surplus is water.
In above-mentioned bacteriostatic hand sanitizer, described in counter ion quaternary ammonium salt be a kind of novel quaternary ammonium salt, general formula are as follows:
In formula: R1、R2For the alkyl chain of carbon atom number 1 ~ 18；X is NO3, HCOO or CH3(CH2)nCOO, n are whole between 0 ~ 6
Number.Wherein, counter ion quaternary ammonium salt can be any of which, be also possible to several mixing, R1, R2Preferred carbon atom number
It is 8 ~ 14.The weight percent 0.2 ~ 2.0% of the counter ion quaternary ammonium salt, preferred weight percent are 0.5 ~ 1.5%.
In above-mentioned bacteriostatic hand sanitizer, described in amphoteric surfactant be glycine betaine series of surfactants one kind
Or several mixing, including 1. alkyl betaine, alkyl carbon atoms number are 8 ~ 18；2. amido propyl betaine, amide groups
Carbon atom number is 8 ~ 22, comprising there is the unsaturated acyl amido of carbon-carbon double bond in amide groups；3. sulfobetaines.Preferably 10 ~
The beet alkali surface activator of 14 carbon atom numbers.The weight percent of beet alkali surface activator is 1.0 ~ 7.0%, preferred weight
Percentage is 3.0% ~ 5.0%.
In above-mentioned bacteriostatic hand sanitizer, described in poly glucoside be the compound with following general formula:
In formula: n is the integer between 1 ~ 3；R includes any one of following two: 1. carbon atom number is 8 ~ 22 straight chained alkyl
Chain or branched alkyl chain；2. shaped like-(CH2CH2O)mR1The fatty alcohol polyoxyethylene ether chain of structure, the integer between m=1 ~ 9, R1For
Carbon atom number is 8 ~ 22 straight chained alkyl or branched alkyl.Further, R includes any one of following two: 1. carbon atom
Linear alkyl chain or branched alkyl chain of the number for 8 ~ 14,2. shaped like-(CH2CH2O)mR1The fatty alcohol polyoxyethylene ether chain of structure, m
Integer between=1 ~ 9, R1It is 8 ~ 14 straight chained alkyl or branched alkyl for carbon atom number.Poly glucoside weight percent is
1.0 ~ 8.0%, preferred weight percent is 4.0 ~ 6.0%.
In above-mentioned bacteriostatic hand sanitizer, described in grease ethoxylate be palm-kernel oil ethoxylate, palm oil
Ethoxylate, castor oil ethoxylate, soybean oil ethoxylate, cottonseed oil ethoxylate, rapeseed oil ethoxylation
The composition of one or more of object, coconut oil ethoxylate, preferred grease ethoxylate are soybean oil ethyoxyl
The composition of one or more of compound, palm oil ethoxylate, castor oil ethoxylate.Grease ethoxylate
Weight percent is 0.5 ~ 3.0%, and preferred weight percent is 0.5% ~ 2.0%.
In above-mentioned bacteriostatic hand sanitizer, moisturizer are as follows: glycerol (glycerine), propylene glycol, butanediol, xylitol, sorb
Sugar alcohol is one or more of.
In above-mentioned bacteriostatic hand sanitizer, thickener are as follows: CMC(sodium carboxymethylcellulose), hydroxyethyl cellulose, card wave
Nurse, 6501 one or more.
In above-mentioned bacteriostatic hand sanitizer, pH adjusting agent are as follows: citric acid.
In above-mentioned bacteriostatic hand sanitizer, essence are as follows: one of green tea, lavender, jasmin, rose.
The pigment are as follows: one of amaranth pigment, light green pigment, lemon yellow pigment, uranidin.
The present invention provides the preparation methods of the bacteriostatic hand sanitizer of the above-mentioned quaternary ammonium salt containing counter ion, comprising the following steps:
Raw material melts in hot bath；First the water of total mass of raw material 50% is added in container, water temperature heating will increase to after 60 DEG C
Thick dose is added thereto and is uniformly mixed；Successively amphoteric surfactant, poly glucoside, grease ethoxylate are added again
In container, stirring is cooled to 30 ~ 40 DEG C after all raw materials all dissolution；Counter ion quaternary ammonium salt, moisturizer, pigment, perfume (or spice) is added
Essence, being adjusted to pH with pH adjusting agent is 6.3 ~ 6.7, and the water of surplus is added, obtains the bacteriostatic hand sanitizer after mixing evenly.
Above-mentioned preparation method, specifically includes the following steps:
Melt in hot bath (60 ~ 70 DEG C) 1. being formed by its weight percent raw material；
2. the water of total mass of raw material 50% is added in container, stirring is started, to after 60 DEG C it is added in thickener by water temperature heating
Middle stirring is extremely dissolved；
3. being successively added to the container amphoteric surfactant, poly glucoside, grease ethoxylate, stir to all originals
Material all after dissolution, is cooled to 30 ~ 40 DEG C；
4. counter ion quaternary ammonium salt, moisturizer, pigment, essence is added, being adjusted to pH with pH adjusting agent is 6.3 ~ 6.7, and surplus is added
Water obtains the bacteriostatic hand sanitizer after mixing evenly.
The bacteriostatic hand sanitizer of the quaternary ammonium salt of the present invention containing counter ion, the test of bacteriostasis property is according to light industry mark
Quasi- QB/T 2738-2012 " evaluation method of daily chemical products antibacterial bacteriostatic effect " test, selected method are suspension quantitative method,
The bacterial strain of selection is Escherichia coli, staphylococcus aureus, Candida albicans.
The bacteriostatic hand sanitizer of the quaternary ammonium salt of the present invention containing counter ion has following compared with existing bacteriostatic hand sanitizer
Advantage:
1. the present invention uses Chinese daily use chemicals institute newest research results counter ion quaternary ammonium salt (Hui-cheng Yan, Qiu-xiao
Li, Tao Geng, et al. Properties of the Quaternary Ammonium Salts with Novel
Counterions. Journal of surfactant and detergent. Journal of surfactants and
Detergents, 2012,15 (5): 953-959), for microorganism to it without drug resistance, a little additive amount can reach excellent kill
Bacterium fungistatic effect, good with other composition compound properties, preparation method operability is high；
2. primary surfactant composition-amphoteric surfactant, poly glucoside, grease ethoxylate that the present invention uses
It is green surfactant, good biocompatibility, green safe, fungicide counter ion quaternary ammonium salt is also that biodegradability is excellent
Different surfactant, product integral formula embody greenization feature；
3. bacteriostatic hand sanitizer provided by the present invention has good killing to Gram-negative bacteria, gram-positive bacteria, fungi
Ability.
Specific embodiment
The present invention is further illustrated below by embodiment, but is not limited to following embodiment.
Embodiment 1
Raw material composition: didecyl Dimethy ammonium formate (1.0wt% active matter) is 10g；Empgen BB BS-12 is
50g；Poly glucoside APG0810For 50g；Soybean oil ethoxylate is 15g；Glycerol is 10g；Carbomer is 1.0g；Citric acid
For 0g；Flavoring rose essence is 0.05g；Amaranth pigment is 0.01g；Water is 863.94g.
Preparation method:
First by didecyl Dimethy ammonium formate, empgen BB, APG0810, soybean oil ethoxylate, glycerol exists
Be preheated in hot bath 60 DEG C it is spare.500g water is added in 2000mL stirred tank and is heated to 60 DEG C, agitator speed is
300rpm/min, be added carbomer 1.0g continue stir 20min to be uniformly mixed.Dodecyl sweet tea is successively added into stirred tank
Dish alkali 50g, poly glucoside APG081050g, soybean oil ethoxylate 15g, feed midfeather 20min every time, adds big
20min is stirred after soya-bean oil ethoxylate, then is cooled to 35 DEG C.Didecyl Dimethy formic acid is successively added into stirred tank again
Ammonium 10g, glycerol 10g, flavoring rose essence 0.05g, amaranth pigment 0.01g, excess water 363.94g, system pH=6.5 continue to stir
60min.Uniform, shallow amaranth clear viscous shape liquid condition, band rose scent is presented in gained bacteriostatic hand sanitizer.
Embodiment 2
Raw material composition: didecyl Dimethy ammonium acetate (1.0wt% active matter) is 5g；Cocamidopropyl betaine CAB is
20g；Poly glucoside APG0810For 80g；Soybean oil ethoxylate is 10g；Propylene glycol is 15g；Sodium carboxymethylcellulose is
2.0g；Citric acid is 0.1g；Green tea essence is 0.05g；Light green pigment is 0.01g；Water is 867.84g.
Preparation method:
First by didecyl Dimethy ammonium acetate, cocamidopropyl betaine, APG0810, soybean oil ethoxylate,
Propylene glycol be preheated in hot bath 60 DEG C it is spare.500g water is added in 2000mL stirred tank and is heated to 60 DEG C, blender turns
Speed be 400rpm/min, be added sodium carboxymethylcellulose 2.0g continue stir 20min to be uniformly mixed.Successively add into stirred tank
Enter cocamidopropyl betaine 20g, poly glucoside APG081080g, soybean oil ethoxylate 10g, every time in charging
Between be spaced 20min, stir 20min after adding soybean oil ethoxylate, then be cooled to 35 DEG C.It is successively added again into stirred tank
Didecyl Dimethy ammonium acetate 5g, propylene glycol 15g, Green tea essence 0.05g, tender leaf marennin 0.01g, excess water 367.84g,
It is 6.5 with 0.1g citric acid regulation system pH, continues to stir 60min.Gained bacteriostatic hand sanitizer is presented uniform, greenish transparent and glues
Thick liquid state, band green tea fragrance.
Embodiment 3
Raw material composition: didecyl Dimethy ammonium formate (1.0wt% active matter) is 5g；Cocamidopropyl betaine CAB is
45g；Fatty alcohol ether poly glucoside AEG is 50g；Palm oil ethoxylate is 15g；Glycerol is 5g；Carbomer is 0.5g；Lemon
Lemon acid is 0.1g；Lemon extract is 0.05g；Lemon yellow pigment is 0.01g；Water is 879.34g.
Preparation method:
First by didecyl Dimethy ammonium formate, cocamidopropyl betaine, AEG, palm oil ethoxylate, glycerol
Be preheated in hot bath 60 DEG C it is spare.500g water is added in 2000mL stirred tank and is heated to 60 DEG C, agitator speed is
500rpm/min, be added carbomer 0.5g, continue stir 20min to be uniformly mixed.Coconut oleoyl amine is successively added into stirred tank
Base propyl betaine 45g, fatty alcohol ether poly glucoside AEG50g, palm oil ethoxylate 15g, feed midfeather every time
20min stirs 20min after adding palm oil ethoxylate, then is cooled to 35 DEG C.Double ten alkane are successively added into stirred tank again
Base dimethyl ammonium formate 5g, glycerol 5g, lemon extract 0.05g, lemon yellow pigment 0.01g, excess water 379.34g, with 0.1g lemon
Lemon acid regulation system pH is 6.5, continues to stir 60min.Uniform, yellow transparent sticky liquid shape is presented in gained bacteriostatic hand sanitizer
State, band citrus scented.
Embodiment 4
Raw material composition: didecyl Dimethy ammonium formate (1.0wt% active matter) is 10g；Empgen BB BS-12 is
20g；Fatty alcohol ether poly glucoside AEG is 80g；Palm oil ethoxylate is 10g；Propylene glycol is 5g；Carboxymethyl cellulose
Sodium is 2.0g；Citric acid is 0.1g；Cream jasmin france is 0.05g；Uranidin is 0.01g；Water is 872.84g.
Preparation method:
First by didecyl Dimethy ammonium formate, empgen BB, AEG, palm oil ethoxylate, propylene glycol in heat
Be preheated in water-bath 60 DEG C it is spare.500g water is added in 2000mL stirred tank and is heated to 60 DEG C, agitator speed 500rpm/
Min, be added sodium carboxymethylcellulose 2.0g, continue stir 20min to be uniformly mixed.Dodecyl is successively added into stirred tank
Glycine betaine 20g, fatty alcohol ether poly glucoside AEG80g, palm oil ethoxylate 10g, feed midfeather 20min every time,
20min is stirred after adding palm oil ethoxylate, then is cooled to 35 DEG C.Double ten alkyl-dimethyls are successively added into stirred tank again
Base ammonium formate 10g, propylene glycol 5g, cream jasmin france 0.05g, uranidin 0.01g, excess water 372.84g are adjusted with 0.1g citric acid
System pH is 6.5, continues to stir 60min.Uniform, yellow transparent sticky liquid state, band jasmine is presented in gained bacteriostatic hand sanitizer
Jasmine fragrance.
Embodiment 5
Raw material composition: didecyl Dimethy ammonium nitrate (1.0wt% active matter) is 20g；Sulfobetaines is 60g；Polydextrose
Glycosides APG1214For 10g；Castor oil ethoxylate is 30g；Xylitol is 30g；Alkanolamide 6501 is 1.0g；Citric acid is
0.1g；Green tea essence is 0.1g；Light green pigment is 0.1g；Water is 848.70g.
Preparation method:
First by didecyl Dimethy ammonium nitrate, sulfobetaines, APG1214, castor oil ethoxylate, xylitol is in warm
Be preheated in water-bath 60 DEG C it is spare.500g water is added in 2000mL stirred tank and is heated to 60 DEG C, agitator speed 500rpm/
The total 1.0g of alkanolamide 6501 is added in min, continues to stir 20min to uniformly mixed.Sulfobetaines are successively added into stirred tank
Alkali 60g, poly glucoside APG121410g, castor oil ethoxylate 30g, feed midfeather 20min every time, adds castor-oil plant
20min is stirred after oily ethoxylate, then is cooled to 35 DEG C.Didecyl Dimethy ammonium nitrate is successively added into stirred tank again
20g, xylitol 30g, Green tea essence 0.1g, light green pigment 0.1g, excess water 348.7g are with 0.1g citric acid regulation system pH
6.5, continue to stir 60min.Uniform, green transparent viscous liquid state, band green tea fragrance is presented in gained bacteriostatic hand sanitizer.
Embodiment 6
Raw material composition: didecyl Dimethy ammonium acetate (1.0wt% active matter) is 10g；Sulfobetaines is 10g；Polydextrose
Glycosides APG1214For 80g；Castor oil ethoxylate is 20g；Sorbierite is 50g；Alkanolamide 6501 is 2.0g；Citric acid is
0g；Flavoring rose essence is 0.05g；Amaranth pigment is 0.01g；Water is 827.94g.
Preparation method:
First by didecyl Dimethy ammonium acetate, sulfobetaines, APG1214, castor oil ethoxylate, sorbierite is in warm
Be preheated in water-bath 60 DEG C it is spare.500g water is added in 2000mL stirred tank and is heated to 60 DEG C, agitator speed 500rpm/
The total 2.0g of alkanolamide 6501 is added in min, continues to stir 20min to uniformly mixed.Sulfobetaines are successively added into stirred tank
Alkali 10g, poly glucoside APG121480g, castor oil ethoxylate 20g, feed midfeather 20min every time, adds castor-oil plant
20min is stirred after oily ethoxylate, then is cooled to 35 DEG C.Didecyl Dimethy ammonium acetate is successively added into stirred tank again
10g, sorbierite 50g, flavoring rose essence 0.05g, amaranth pigment 0.01g, excess water 327.94g, system pH are 6.5, continue to stir
Mix 60min.Uniform, light red clear viscous shape liquid condition, band rose scent is presented in gained bacteriostatic hand sanitizer.
Embodiment 7
Raw material composition: didecyl Dimethy ammonium acetate (1.0wt% active matter) is 2g；Empgen BB BS-12 is 70g；
Poly glucoside APG0810 is 20g；Castor oil ethoxylate is 5g；Xylitol is 40g；Carbomer is 2.0g；Citric acid is
0.1g；Cream jasmin france is 0.05g；Uranidin is 0.01g；Water is 860.84g.
Preparation method:
First by didecyl Dimethy ammonium acetate, empgen BB, APG0810, castor oil ethoxylate, xylitol
Be preheated in hot bath 60 DEG C it is spare.500g water is added in 2000mL stirred tank and is heated to 60 DEG C, agitator speed is
The total 2.0g of carbomer is added in 500rpm/min, continues to stir 20min to uniformly mixed.Dodecane is successively added into stirred tank
Base glycine betaine BS-12 is 70g, and poly glucoside APG0810 is 20g, and castor oil ethoxylate 5g, feed middle ware every time
Every 20min, 20min is stirred after adding castor oil ethoxylate, then is cooled to 35 DEG C.Double ten are successively added into stirred tank again
Alkyl dimethyl ammonium acetate 2g, xylitol 40g, cream jasmin france 0.05g, uranidin 0.01g, excess water 360.84g, with 0.1g lemon
Lemon acid regulation system pH is 6.5, continues to stir 60min.Uniform, yellow transparent sticky liquid shape is presented in gained bacteriostatic hand sanitizer
State, band jasmine fragrance.
Embodiment 8
Raw material composition: didecyl Dimethy ammonium nitrate (1.0wt% active matter) is 10g；Cocamidopropyl betaine CAB
For 10g；Poly glucoside APG1214For 50g；Palm oil ethoxylate is 20g；Sorbierite is 30g；Hydroxyethyl cellulose
1.0g；Citric acid is 0.05g；Lemon extract is 0.05g；Lemon yellow pigment is 0.01g；Water is 878.89g.
Preparation method:
First by didecyl Dimethy ammonium nitrate, cocamidopropyl betaine, APG1214, palm oil ethoxylate,
Sorbierite be preheated in hot bath 60 DEG C it is spare.500g water is added in 2000mL stirred tank and is heated to 60 DEG C, blender turns
Speed is 500rpm/min, and the total 1.0g of hydroxyethyl cellulose 1.0g is added, and continues to stir 20min to uniformly mixed.Successively to stirring
It is 10g, poly glucoside APG that cocamidopropyl betaine CAB is added in kettle1214For 50g, palm oil ethoxylate is
20g, feed midfeather 20min every time, stirs 20min after adding palm oil ethoxylate, then be cooled to 35 DEG C.Again successively
Didecyl Dimethy ammonium nitrate 10g, sorbierite 30g, lemon extract 0.05g, lemon yellow pigment are added into stirred tank
0.01g, excess water 378.89g are 6.5 with 0.05g citric acid regulation system pH, continue to stir 60min.Gained bacteriostatic hand sanitizer
Uniform, yellow transparent sticky liquid state, band citrus scented is presented.
Embodiment 9
Raw material composition: didecyl Dimethy ammonium nitrate (1.0wt% active matter) is 20g；Sulfobetaines is 40g；Fatty alcohol ether
Poly glucoside AEG is 20g；Soybean oil ethoxylate is 30g；Glycerol is 15g；Hydroxyethyl cellulose 0.3g；Citric acid is
0.05g；Green tea essence is 0.05g；Light green pigment is 0.01g；Water is 874.59g.
Preparation method:
First by didecyl Dimethy ammonium nitrate, sulfobetaines, AEG, soybean oil ethoxylate, glycerol in hot bath
Be preheated to 60 DEG C it is spare.500g water is added in 2000mL stirred tank and is heated to 60 DEG C, agitator speed 500rpm/min adds
Enter hydroxyethyl cellulose 0.3g, continue stir 20min to be uniformly mixed.Sulfobetaines 40g, rouge are successively added into stirred tank
Fat alcohol ether poly glucoside AEG 20g, soybean oil ethoxylate are 30g, and feed midfeather 20min every time, add soybean
20min is stirred after oily ethoxylate, then is cooled to 35 DEG C.Didecyl Dimethy ammonium nitrate is successively added into stirred tank again
20g, glycerol 15g, Green tea essence 0.05g, light green pigment 0.01g, excess water 374.59g, with citric acid 0.05g regulation system pH
It is 6.5, continues to stir 60min.Uniform, green transparent viscous liquid state, band green tea fragrance is presented in gained bacteriostatic hand sanitizer.
Embodiment 10
Raw material composition: didecyl Dimethy ammonium formate (1.0wt% active matter) is 5g；Didecyl Dimethy ammonium acetate
(1.0wt% active matter) is 5g；Empgen BB BS-12 is 50g；Poly glucoside APG0810For 50g；Soybean oil ethoxy
Glycolylate is 15g；Glycerol is 10g；Carbomer is 1.0g；Citric acid is 0g；Flavoring rose essence is 0.05g；Amaranth pigment is
0.01g；Water is 863.94g.
Preparation method:
First by didecyl Dimethy ammonium formate, didecyl Dimethy ammonium acetate, empgen BB, APG0810, it is big
Soya-bean oil ethoxylate, glycerol be preheated in hot bath 60 DEG C it is spare.500g water is added in 2000mL stirred tank to be heated to
60 DEG C, agitator speed 300rpm/min, be added carbomer 1.0g continue stir 20min to be uniformly mixed.Successively to stirring
Empgen BB 50g, poly glucoside APG are added in kettle081050g, soybean oil ethoxylate 15g, every time in charging
Between be spaced 20min, stir 20min after adding soybean oil ethoxylate, then be cooled to 35 DEG C.It is successively added again into stirred tank
Didecyl Dimethy ammonium formate 5g, didecyl Dimethy ammonium acetate 5g, glycerol 10g, flavoring rose essence 0.05g, three-coloured amaranth are red
Plain 0.01g, excess water 363.94g, system pH=6.5 continue to stir 60min.Uniform, shallow amaranth is presented in gained bacteriostatic hand sanitizer
Clear viscous shape liquid condition, band rose scent.
Embodiment 11
Raw material composition: didecyl Dimethy ammonium acetate (1.0wt% active matter) is 3g, didecyl Dimethy ammonium nitrate
(1.0wt% active matter) is 2g；Cocamidopropyl betaine CAB is 20g；Poly glucoside APG0810For 80g；Soybean oil
Ethoxylate is 10g；Propylene glycol is 15g；Sodium carboxymethylcellulose is 2.0g；Citric acid is 0.1g；Green tea essence is
0.05g；Light green pigment is 0.01g；Water is 867.84g.
Preparation method:
First by didecyl Dimethy ammonium acetate, didecyl Dimethy ammonium nitrate, cocamidopropyl betaine,
APG0810, soybean oil ethoxylate, propylene glycol be preheated in hot bath 60 DEG C it is spare.It is added in 2000mL stirred tank
500g water is heated to 60 DEG C, agitator speed 400rpm/min, and sodium carboxymethylcellulose 2.0g is added and continues to stir 20min extremely
It is uniformly mixed.Cocamidopropyl betaine 20g, poly glucoside APG are successively added into stirred tank081080g, soybean oil
Ethoxylate 10g, feed midfeather 20min every time, stirs 20min after adding soybean oil ethoxylate, then be cooled to
35℃.Didecyl Dimethy ammonium acetate 3g, didecyl Dimethy ammonium nitrate 2g, propylene glycol is successively added into stirred tank again
15g, Green tea essence 0.05g, tender leaf marennin 0.01g, excess water 367.84g are 6.5 with 0.1g citric acid regulation system pH,
Continue to stir 60min.Uniform, greenish transparent viscous liquid state, band green tea fragrance is presented in gained bacteriostatic hand sanitizer.
Embodiment 12
Raw material composition: 12/myristyl benzyl dimethyl ammonium chloride (1227,1.0wt% active matter) is 5g；Dodecyl sweet tea
Dish alkali BS-12 is 50g；Poly glucoside APG0810For 50g；Soybean oil ethoxylate is 15g；Glycerol is 10g；Carbomer is
1.0g；Citric acid is 0g；Flavoring rose essence is 0.05g；Amaranth pigment is 0.01g；Water is 868.94g.
Preparation method:
First by 12/myristyl benzyl dimethyl ammonium chloride, empgen BB, APG0810, soybean oil ethoxylation
Object, glycerol be preheated in hot bath 60 DEG C it is spare.500g water is added in 2000mL stirred tank and is heated to 60 DEG C, blender turns
Speed be 300rpm/min, be added carbomer 1.0g continue stir 20min to be uniformly mixed.Dodecane is successively added into stirred tank
Base glycine betaine 50g, poly glucoside APG081050g, soybean oil ethoxylate 15g, feed midfeather 20min every time, adds
20min is stirred after complete soybean oil ethoxylate, then is cooled to 35 DEG C.12/myristyl is successively added into stirred tank again
Dimethyl benzyl ammonium chloride 5g, glycerol 10g, flavoring rose essence 0.05g, amaranth pigment 0.01g, excess water 368.94g, system pH
=6.5 continue to stir 60min.Uniform, shallow amaranth clear viscous shape liquid condition, band rose fragrant is presented in gained bacteriostatic hand sanitizer
Taste.
Embodiment 13
Raw material composition: empgen BB BS-12 is 50g；Poly glucoside APG0810For 50g；Soybean oil ethoxylate
For 15g；Glycerol is 10g；Carbomer is 1.0g；Citric acid is 0g；Flavoring rose essence is 0.05g；Amaranth pigment is 0.01g；Water
For 873.94g.
Preparation method:
First by empgen BB, APG0810, soybean oil ethoxylate, glycerol be preheated in hot bath 60 DEG C it is standby
With.500g water is added in 2000mL stirred tank and is heated to 60 DEG C, agitator speed 300rpm/min, carbomer 1.0g is added
Continue stir 20min to be uniformly mixed.Empgen BB 50g, poly glucoside are successively added into stirred tank
APG081050g, soybean oil ethoxylate 15g, feed midfeather 20min every time, stirs after adding soybean oil ethoxylate
20min is mixed, then is cooled to 35 DEG C.Glycerol 10g, flavoring rose essence 0.05g, amaranth pigment is successively added into stirred tank again
0.01g, excess water 373.94g, system pH=6.5 continue to stir 60min.Gained bacteriostatic hand sanitizer is presented uniform, shallow three-coloured amaranth and is popular in
Bright viscous liquid state, band rose scent.
1 specific embodiment the performance test results statistical form of table
※ performance test methods:
1, heatproof experiment is tested according to the requirement of GB/T 34855-2017 " hand cleanser ", wherein high temperature resistant is tested at 40 ± 2 DEG C
Insulating box in place 24 hours, take out and restore to not stratified, transparent not muddy after room temperature；Cold test is at -5 ± 2 DEG C
It is placed 24 hours in insulating box, taking-up is not stratified after restoring to room temperature, does not crystallize, transparent not muddy.
2, the light industry standard QB/T 2738-2012 " evaluation of daily chemical products antibacterial bacteriostatic effect is pressed in bacteriostasis property test
Method " requirement.
3, storage stability: by product at room temperature continuously store 1 year it is not stratified, do not crystallize, be transparent not muddy.
Claims (10)
1. a kind of bacteriostatic hand sanitizer of quaternary ammonium salt containing counter ion, it is characterised in that comprise the following raw materials by weight percent:
Amphoteric surfactant 1.0 ~ 7.0%；
Poly glucoside 1.0 ~ 8.0%；
Grease ethoxylate 0.5 ~ 3.0%；
Counter ion quaternary ammonium salt 0.2 ~ 2.0%；
Moisturizer 0.5 ~ 5.0%；
Thickener 0.03 ~ 0.2%；
PH adjusting agent 0 ~ 0.01%；
Essence 0 ~ 0.1%；
Pigment 0 ~ 0.01%；
Surplus is water.
2. the bacteriostatic hand sanitizer of the quaternary ammonium salt according to claim 1 containing counter ion, it is characterised in that: the counter ion season
Ammonium salt general formula are as follows:
In formula: R1、R2For the alkyl chain of carbon atom number 1 ~ 18；X is NO3, HCOO or CH3(CH2)nCOO, n are whole between 0 ~ 6
Number；
Counter ion quaternary ammonium salt is the mixing of any compound therein or several compounds.
3. the bacteriostatic hand sanitizer of the quaternary ammonium salt according to claim 2 containing counter ion, it is characterised in that: the counter ion season
In ammonium salt general formula, R1, R2Carbon atom number be 8 ~ 14, the counter ion quaternary ammonium salt account for raw material total amount weight percent be 0.5
~1.5%。
4. the bacteriostatic hand sanitizer of the quaternary ammonium salt according to claim 1 containing counter ion, it is characterised in that: the amphoteric surface
Activating agent is the mixing of one or more of beet alkali surface activator, and the beet alkali surface activator includes alkyl betaines
One of alkali, amido propyl betaine, sulfobetaines；
Wherein, in alkyl betaine, alkyl carbon atoms number is 8 ~ 18；In amido propyl betaine, amide groups carbon atom
Number is 8 ~ 22, comprising there is the unsaturated acyl amido of carbon-carbon double bond in amide groups.
5. the bacteriostatic hand sanitizer of the quaternary ammonium salt according to claim 4 containing counter ion, it is characterised in that: the glycine betaine surface
Activating agent is the beet alkali surface activator of 10 ~ 14 carbon atom numbers, and beet alkali surface activator accounts for the percentage of raw material gross weight
It is 3.0% ~ 5.0%.
6. the bacteriostatic hand sanitizer of the quaternary ammonium salt according to claim 1 containing counter ion, it is characterised in that: the polydextrose
Glycosides is the compound with following general formula:
In formula: n is the integer between 1 ~ 3；R includes any one of following two: 1. carbon atom number is 8 ~ 22 straight chained alkyl
Chain or branched alkyl chain；2. shaped like-(CH2CH2O)mR1The fatty alcohol polyoxyethylene ether chain of structure, the integer between m=1 ~ 9, R1For
Carbon atom number is 8 ~ 22 straight chained alkyl or branched alkyl；
The weight percent that poly glucoside accounts for raw material is 1.0 ~ 8.0%.
7. the bacteriostatic hand sanitizer of the quaternary ammonium salt according to claim 1 containing counter ion, it is characterised in that: the polydextrose
Glycosides is the compound with following general formula:
In formula: n is the integer between 1 ~ 3；R includes any one of following two: the straight chained alkyl that 1. carbon atom number is 8 ~ 14
Chain or branched alkyl chain, 2. shaped like-(CH2CH2O)mR1The fatty alcohol polyoxyethylene ether chain of structure, the integer between m=1 ~ 9, R1For
Carbon atom number is 8 ~ 14 straight chained alkyl or branched alkyl；
The weight percent that poly glucoside accounts for raw material is 4.0 ~ 6.0%.
8. the bacteriostatic hand sanitizer of the quaternary ammonium salt according to claim 1 containing counter ion, it is characterised in that: the grease ethoxy
Glycolylate is palm-kernel oil ethoxylate, palm oil ethoxylate, castor oil ethoxylate, soybean oil ethoxylation
The composition of one or more of object, cottonseed oil ethoxylate, rapeseed oil ethoxylate, coconut oil ethoxylate；
The percentage that the grease ethoxylate accounts for raw material gross weight is 0.5% ~ 2.0%；
The moisturizer is one or more of glycerol, propylene glycol, butanediol, xylitol, D-sorbite；
The thickener be sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer, 6501 one or more；
The pH adjusting agent are as follows: citric acid；
The essence are as follows: one of green tea, lavender, jasmin, rose；
The pigment are as follows: one of amaranth pigment, light green pigment, lemon yellow pigment, uranidin.
9. a kind of preparation method of the bacteriostatic hand sanitizer of the described in any item quaternary ammonium salts containing counter ion of claim 1 ~ 8, feature
Be the following steps are included:
Raw material melts in hot bath；First the water of total mass of raw material 50% is added in container, water temperature heating will increase to after 60 DEG C
Thick dose is added thereto and is uniformly mixed；Successively amphoteric surfactant, poly glucoside, grease ethoxylate are added again
In container, stirring is cooled to 30 ~ 40 DEG C after all raw materials all dissolution；Counter ion quaternary ammonium salt, moisturizer, pigment, perfume (or spice) is added
The water of surplus is added with pH adjusting agent tune pH in essence, obtains the bacteriostatic hand sanitizer after mixing evenly.
10. the preparation method of the bacteriostatic hand sanitizer of the quaternary ammonium salt according to claim 9 containing counter ion, it is characterised in that including
Following steps:
Melt in hot bath 1. being formed by its weight percent raw material, the temperature of hot bath is controlled at 60 ~ 70 DEG C；
2. the water of total mass of raw material 50% is added in container, stirring is started, to after 60 DEG C it is added in thickener by water temperature heating
Middle stirring is extremely dissolved；
3. being successively added to the container amphoteric surfactant, poly glucoside, grease ethoxylate, stir to all originals
Material all after dissolution, is cooled to 30 ~ 40 DEG C；
4. counter ion quaternary ammonium salt, moisturizer, pigment, essence is added, being adjusted to pH with pH adjusting agent is 6.3 ~ 6.7, and surplus is added
Water obtains the bacteriostatic hand sanitizer after mixing evenly.
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