CN109602667B

CN109602667B - Antibacterial hand sanitizer and preparation method thereof

Info

Publication number: CN109602667B
Application number: CN201910118975.7A
Authority: CN
Inventors: 王德富; 龙丹丹; 牛颜冰; 申少斐; 王舒婷; 王宝霞; 武亚婧
Original assignee: Shanxi Agricultural University
Current assignee: Shanxi Agricultural University
Priority date: 2019-02-18
Filing date: 2019-02-18
Publication date: 2021-12-24
Anticipated expiration: 2039-02-18
Also published as: CN109602667A

Abstract

The invention belongs to the technical field of skin care products, and discloses an antibacterial hand sanitizer and a preparation method thereof, wherein the antibacterial hand sanitizer comprises the following raw materials in parts by weight: 2 to 5 percent of traditional Chinese medicine extracting solution, 6 to 10 percent of surfactant, 0.5 to 1.5 percent of thickening agent, 1 to 4 percent of humectant and the balance of distilled water; the traditional Chinese medicine extracting solution is a coptis extracting solution with the concentration of 12mg/mL and a honeysuckle extracting solution with the concentration of 16mg/mL, and the volume ratio of the coptis extracting solution to the honeysuckle extracting solution is 1: 1.5-2.5. The hand sanitizer disclosed by the invention is uniform in quality, good in stability, good in foaming performance, strong in dirt-removing power and strong in bacteriostatic effect.

Description

Antibacterial hand sanitizer and preparation method thereof

Technical Field

The invention belongs to the technical field of skin care products, and particularly relates to an antibacterial hand sanitizer and a preparation method thereof.

Background

Bacteria, whether they present a degree of harm to the environment, humans or animals, include contact, airborne, food, water and bacteria-bearing microorganisms. Coli, a representative of gram-negative bacteria, often causes parenteral infection and acute diarrhea. However, the hazard of Staphylococcus aureus in human pathogenic bacteria is not of small concern, it is a gram-positive bacterium and it is the culprit responsible for many wound infections. In ordinary life, the hand is an important organ of the human body and is everywhere untouched. Many bacterial or parasitic eggs on the hands that are invisible to the naked eye are not included under a microscope. As a tie connecting the two hands with pathogenic bacteria microorganisms in the environment, a large number of sebaceous glands and epidermal cell aggregates exist on the two hands, and the tissues have physiological metabolism functions of secreting grease and sweat, so that the pathogenic bacteria are very easy to adhere to the tissues due to the functions. Meanwhile, the body skin temperature of 37 ℃ is a hotbed for the growth and survival of most bacteria and viruses. Therefore, when other parts such as hands are wounded, wound infection and difficult healing can be caused, and bacteria enter a blood circulation system in severe cases to cause septicemia and tissue necrosis. The hand washing is the most convenient method for preventing germ pollution, can effectively cut off the disease transmission way, and has outstanding effects on preventing the transmission of influenza, preventing infectious diseases, reducing the morbidity and the like by using the hand washing solution. The effect of twice the result with half the effort can be achieved only by mastering the correct use frequency and method of the hand sanitizer and selecting the effective hand sanitizer.

In 1977, Robert Taylor manufacturers invented a pressure pump type soap solution, which was introduced as a precursor of hand washing solutions and was widely popular. The hand sanitizer is mild and has no irritant decontamination effect, is rich in foamability, is slightly acidic and has fresh fragrance similar to the pH value of skin, has antibacterial effect, far exceeds the traditional hand sanitizer such as soap, perfumed soap, washing powder and the like, and has wide market prospect. The development of the times brings the progress of novel surfactants, active ingredients with special functions and functional auxiliary agent technologies, and simultaneously causes the change of the concept of people, and the gradual transition from the initial cleaning to the coexistence of multiple functions is required. With the high pursuit of green, safe, healthy and reassuring life of consumer groups, the hand sanitizer is changed from disinfection and bacteriostasis by adding irritant components to the main direction of natural and harmless plant bacteriostasis.

Disclosure of Invention

The invention aims to provide an antibacterial hand sanitizer and a preparation method thereof, aiming at the problems of the existing hand sanitizer.

In order to achieve the purpose, the technical scheme adopted by the application is as follows:

an antibacterial hand sanitizer comprises the following raw materials in parts by weight:

2 to 5 percent of traditional Chinese medicine extracting solution, 6 to 10 percent of surfactant, 0.5 to 1.5 percent of thickening agent, 1 to 4 percent of humectant and the balance of distilled water;

the traditional Chinese medicine extracting solution is a coptis extracting solution with the concentration of 12mg/mL and a honeysuckle extracting solution with the concentration of 16mg/mL, and the volume ratio of the coptis extracting solution to the honeysuckle extracting solution is 1: 1.5-2.5.

Further, the surfactant is a mixture of sodium alpha-alkenyl sulfonate and sodium fatty alcohol ether sulfate;

the volume ratio of the alpha-sodium alkenyl sulfonate to the fatty alcohol ether sodium sulfate is that the thickening agent is sodium carboxymethyl cellulose;

the humectant is glycerol.

Further, the antibacterial hand sanitizer also comprises essential oil and citric acid for adjusting the pH value of the antibacterial hand sanitizer; the pH value of the antibacterial hand sanitizer is 5.5-6.5.

Further, the coptis chinensis extract is prepared by the following method:

weighing coptis chinensis, grinding the coptis chinensis into powder, and sieving the powder by a 100-200-mesh medicine sieve to obtain coptis chinensis powder;

adding coptis chinensis powder into a mixed solution of ethanol and water, leaching for 13 hours, and then carrying out flash extraction for 2min under the voltage of 140-160150V to obtain a first extraction primary liquid;

wherein the ratio of the coptis powder to the mixed solution is 1g:15mL, and the volume ratio of ethanol to water in the mixed solution is 13: 7;

centrifuging the first extractive solution at 6000r/min for 10min, collecting supernatant, repeating twice, mixing the supernatants, and rotary evaporating to obtain Coptidis rhizoma extract;

and dissolving the coptis chinensis extract and distilled water to obtain coptis chinensis extract, wherein the concentration of the coptis chinensis extract is 12 mg/mL.

Further, the honeysuckle extract is prepared by the following method:

weighing honeysuckle, grinding into powder, and sieving with a 100-200 mesh sieve to obtain honeysuckle powder;

adding Coptidis rhizoma powder into mixed solution of ethanol and water, leaching for 13h, and performing flash extraction at 150V for 3min to obtain second primary extractive solution; wherein the ratio of the honeysuckle powder to the mixed solution is 1g:50mL, and the volume ratio of ethanol to water in the mixed solution is 7: 3;

centrifuging the second extractive solution at 6000r/min for 10min, collecting supernatant, repeating twice, mixing the supernatants, and rotary evaporating to obtain flos Lonicerae extract;

and dissolving the honeysuckle extract and distilled water to obtain a honeysuckle extracting solution, wherein the concentration of the honeysuckle extracting solution is 16 mg/mL.

The invention also provides a preparation method of the antibacterial hand sanitizer, which comprises the following steps:

uniformly stirring humectant, thickener, Coptidis rhizoma extract, flos Lonicerae extract and distilled water to obtain water phase;

mixing the surfactant and the water phase, placing the mixture in an environment of 60-80 ℃, uniformly stirring the mixture until no suspended matters exist to obtain a mixed phase, and cooling the mixed phase to obtain the antibacterial hand sanitizer.

Surfactants play an extremely important role as agents that change the surface tension of substances to function. It can not only wet and emulsify, but also can test the functions of permeation and foaming by rubbing with both hands. Because of its existence, the detergent can remove stains and keep hands clean in cleaning, and is an indispensable component in the hand sanitizer. AOS (alpha-sodium alkenyl sulfonate) is an anionic surfactant with strong comprehensive performance. Can generate a large amount of foam, and the strong detergency is shown in the aspects of basically not reducing the dirt removing capability in hard water, not greatly changing the foaming capability in hard water and soft water, and the like. The biological degradability is good, the AOS is safe for both human bodies and the environment, mice are used as test objects to find that the oral toxicity is slightly small, the stimulation effect on the eye mucosa can be almost eliminated under the condition of low concentration, and the rinsing method can be used for testing if the irritation is eliminated completely. It can produce rich creamy foam and has the soap-like feeling characteristic of fitting the Chinese habit of washing both hands, so that AOS can be used as a high-quality alternative of surfactant. AES (sodium fatty alcohol ether sulfate), also an anionic surfactant. In terms of acute oral toxicity, it is consistent with the very widespread use of edible salts and baking soda in daily life. The water solubility is good, and the detergent has the general performance of the reagent and has outstanding effects on the aspects of decontamination and hard water resistance. The use condition is mild, and the skin can not be damaged. The two reagents can thoroughly and rapidly remove dirt, have safe and reassuring health guarantee and meet the national standard requirements of the hand sanitizer.

The principle of CMC (sodium carboxymethylcellulose) is that the fluid volume of the polymer is enlarged to reduce the space through the chemical reaction of hydrogen bond association, thereby inhibiting the free movement of particles, and finally leading to the increase of the viscosity of the whole system. It is advantageous for thickening the aqueous phase and also for thickening the food product, which proves safe and reliable in use characteristics. The special functions of water solubility and emulsification and water retention and film formation make it popular in the fields of daily use chemicals, medicine and the like, and is called industrial monosodium glutamate.

After the hands are washed, the moisture on the surfaces of the hands can be slowly volatilized, and if a layer of protective film is left after the moisture disappears, the moisture in the hands can be prevented from continuously losing, so that the moisturizing and moisture retention of the skin can be tried. The advent of humectants prompted the trial of this idea. The formula of the test selects glycerol as the humectant, has the characteristics of good water solubility and no boiling at high temperature, and can play a role in preventing skin dryness. It should be noted that the addition of excess emollient for the purpose of obtaining good moisturizing effect may result in a thick and sticky hand, and the product may not achieve the desired detergency, and may also reduce the generation of foam. The moisturizing emollient has obvious effects on caring and maintaining skin, improving skin metabolism and preventing chapping. Is suitable for people with dry skin, the elderly with skin lack of water, and workers with skin condition deterioration caused by outdoor.

The effective components in the coptis chinensis and honeysuckle extract can play a natural bacteriostatic role, the coptis chinensis and the honeysuckle which are used as broad-spectrum antibacterial drugs have good bacteriostatic effect on common bacteria, the traditional Chinese medicine antibiosis is safe, healthy and pollution-free, not only exerts the advantages of the traditional Chinese medicine discipline, but also meets the requirements of consumers, and has high value and popularization.

Compared with the prior art, the invention has the beneficial effects that: the hand sanitizer disclosed by the invention is uniform in quality, good in stability, good in foaming performance, strong in dirt-removing power and strong in bacteriostatic effect.

Drawings

FIG. 1 shows the results of bacteriostasis tests, wherein FIG. 1(a) shows the results of bacteriostasis tests on E.coli in test groups and control groups in bacteriostasis tests; FIG. 1(b) is the result of the bacteriostasis test of Staphylococcus aureus in the test group and the control group.

Detailed Description

In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the technical scheme of the invention is clearly and completely described below by combining the specific embodiment of the invention and the attached drawings.

The coptis root extract used in the following examples is prepared by the following method:

adding Coptidis rhizoma powder into mixed solution of ethanol and water, leaching for 13h, and performing flash extraction at 150V for 2min to obtain first primary extractive solution; wherein the ratio of the coptis powder to the mixed solution is 1g:15mL, and the volume ratio of ethanol to water in the mixed solution is 13: 7;

The honeysuckle extract used in the following examples was prepared by the following method:

Example 1

2% of traditional Chinese medicine extracting solution, 6% of surfactant, 0.5% of thickening agent, 1% -4% of humectant and the balance of distilled water; and adjusting the pH of the hand sanitizer to 5.5-6.5 by using citric acid, adding a small amount of mint essential oil, and adjusting the smell of the hand sanitizer, wherein the ratio of the weight of the mint essential oil to the total weight of the antibacterial hand sanitizer is 1: 50.

The traditional Chinese medicine extracting solution is a coptis extracting solution with the concentration of 12mg/mL and a honeysuckle extracting solution with the concentration of 16mg/mL, and the volume ratio of the coptis extracting solution to the honeysuckle extracting solution is 1: 1.5.

The surfactant is a mixture of alpha-sodium alkenyl sulfonate AOS and fatty alcohol ether sodium sulfate AES;

the volume ratio of the alpha-sodium alkenyl sulfonate AOS to the fatty alcohol ether sodium sulfate AES is 1: 0.5;

the thickening agent is sodium carboxymethyl cellulose CMC;

the humectant is glycerol.

The preparation method of the antibacterial hand sanitizer comprises the following steps:

mixing alpha-sodium alkenyl sulfonate AOS and fatty alcohol ether sodium sulfate AES to form an oil phase for later use;

uniformly stirring glycerol, sodium carboxymethylcellulose (CMC), coptis chinensis extract, honeysuckle extract and distilled water to obtain a water phase for later use;

mixing the oil phase and the water phase, placing the mixture in an environment of 60 ℃, uniformly stirring the mixture until no suspended matters exist to obtain a mixed phase, and cooling the mixed phase to obtain the antibacterial hand sanitizer.

Example 2

5% of traditional Chinese medicine extracting solution, 10% of surfactant, 1.5% of thickening agent, 4% of humectant and the balance of distilled water; and adjusting the pH of the hand sanitizer to 5.5-6.5 by using citric acid, adding a small amount of mint essential oil, and adjusting the smell of the hand sanitizer, wherein the ratio of the weight of the mint essential oil to the total weight of the antibacterial hand sanitizer is 1: 30.

The traditional Chinese medicine extracting solution is a coptis extracting solution with the concentration of 12mg/mL and a honeysuckle extracting solution with the concentration of 16mg/mL, and the volume ratio of the coptis extracting solution to the honeysuckle extracting solution is 1: 2.5.

the volume ratio of the alpha-sodium alkenyl sulfonate AOS to the fatty alcohol ether sodium sulfate AES is 1: 2;

the thickening agent is sodium carboxymethyl cellulose (CMC);

the humectant is glycerol.

mixing the oil phase and the water phase, placing the mixture in an environment of 80 ℃, uniformly stirring the mixture until no suspended matters exist to obtain a mixed phase, and cooling the mixed phase to obtain the antibacterial hand sanitizer.

Example 3

3% of traditional Chinese medicine extracting solution, 8.5% of surfactant, 1% of thickening agent, 3% of humectant and the balance of distilled water; and adjusting the pH of the hand sanitizer to 5.5-6.5 by using citric acid, adding a small amount of mint essential oil, and adjusting the smell of the hand sanitizer, wherein the ratio of the weight of the mint essential oil to the total weight of the antibacterial hand sanitizer is 1: 25.

The traditional Chinese medicine extracting solution is a coptis extracting solution with the concentration of 12mg/mL and a honeysuckle extracting solution with the concentration of 16mg/mL, and the volume ratio of the coptis extracting solution to the honeysuckle extracting solution is 1:2.

the thickening agent is sodium carboxymethyl cellulose (CMC);

the humectant is glycerol.

mixing the oil phase and the water phase, placing the mixture in an environment of 70 ℃, uniformly stirring the mixture until no suspended matters exist to obtain a mixed phase, and cooling the mixed phase to obtain the antibacterial hand sanitizer.

Comparative example 1

The hand sanitizer comprises the following raw materials in parts by weight:

8.5% of surfactant, 1% of thickening agent, 3% of humectant and the balance of distilled water; and adjusting the pH of the hand sanitizer to 5.5-6.5 by using citric acid, adding a small amount of mint essential oil, and adjusting the smell of the hand sanitizer, wherein the ratio of the weight of the mint essential oil to the total weight of the antibacterial hand sanitizer is 1: 25.

the thickening agent is sodium carboxymethyl cellulose (CMC);

the humectant is glycerol.

Comparative example 2

An extracting solution comprises 3% of a traditional Chinese medicine extracting solution and 97% of distilled water, wherein the traditional Chinese medicine extracting solution comprises a coptis extracting solution with the concentration of 12mg/mL and a honeysuckle extracting solution with the concentration of 16mg/mL, and the volume ratio of the coptis extracting solution to the honeysuckle extracting solution is 1:2.

In addition, the performance and bacteriostatic performance of the bacteriostatic hand sanitizer prepared in example 3 are tested as follows.

(I) stability measurement

Test groups: 5g of the antibacterial hand sanitizer prepared in example 3 is placed in a thermostat, treated for 24 hours, taken out, and observed after the temperature is returned to room temperature.

As shown in table 1, the results of the experiments show that the hand sanitizer of example 3 has no change in odor and color, no precipitation or suspended matter, and uniform texture, and thus the hand sanitizer of the present invention has a stable state.

Table 1 stability test results

(II) measurement of bubble Performance

Adding 0.5mL of prepared sample and 20mL of distilled water into a test tube, plugging the opening of the test tube by a thumb to ensure that the strength of the direction is consistent, shaking for 30 times, adding 20mL of distilled water along the tube wall, and flushing the foam. Two values need to be recorded, the first is the stable height of the foam which does not drop after shaking, the height is used for measuring the foaming performance of the hand sanitizer, and the second is the time consumed by destroying the foam to half of the original height after adding the clean water slowly, and is used for representing whether the generated foam is stable or not. Repeating the operation for three times, recording the data and the average value of each group, and obtaining a result shown in table 2, wherein the average value of the height after the foam is stabilized is 143 mm; the average of the time required for the foam to fall to half of its original height was 35 s.

According to the requirements of national standards, the height of the foam is more than or equal to 100mm, the time for the foam to be damaged to half of the original height is more than 25s, and the test liquid soap meets the requirements, so that the finished liquid soap has good foam performance.

TABLE 2 foaming Capacity test results

(III) measurement of detergency

Test groups:

selecting a small piece of white and clean gauze, dripping a drop of edible vegetable oil on the gauze, adding a proper amount of the hand sanitizer on the oil stain part, kneading with clear water until the oil stain disappears, and recording the time required for decontamination for 28 s.

Control group: selecting a small piece of white and clean gauze, dripping a drop of edible vegetable oil on the gauze, adding a hand-washing solution which is sold in the market and has the same amount as that of the test group on the oil stain part, kneading the hand-washing solution with clear water until the oil stain disappears, and recording the time required for decontamination for 35 s.

The result shows that the hand sanitizer is shorter in use, and the experimental hand sanitizer is higher in stain removal and decontamination capability.

(IV) determination of bacteriostatic Activity

The test adopts a paper diffusion method as a determination test of antibacterial performance, and the principle of the method is as follows: the concentration gradient is generated by diffusion after the medicine round paper sheet absorbs water, so that bacteria around the paper sheet cannot survive, and a transparent bacteriostatic ring is formed at the periphery of the round paper sheet after the medicine round paper sheet is cultured for a period of time. The method can be used for intuitively judging the antibacterial action of the medicament, has simple and convenient operation means and low cost, and is widely used in the antibacterial test at present.

Test strains of the invention: gram bacteria include Staphylococcus aureus (Staphylococcus aureus), Escherichia coli (Escherichia coli).

(1) Preparation of solid culture medium

The experiment requires the preparation of a solid medium: the corresponding drug was added to a beaker according to the formulation in table 3 below, and dissolved with an appropriate amount of distilled water. In order to achieve the purpose of uniform mixing, a magnetic stirrer is used for auxiliary operation. Adding water to constant volume of 1L, adjusting pH to 7.0, packaging the solution in triangular flask (500 mL/bottle), adding agar 10g/L, sealing, and sterilizing with high temperature steam. After the medium is cooled slightly, the medium is poured into a clean culture dish in a ventilated superclean bench, and after the medium is completely solidified, the culture dish is covered with a dish cover to keep sterile for later use.

TABLE 3 culture formula

(2) Preparation of test strains

Activating bacteria: picking dry escherichia coli colonies stored in an EP tube for a long time, putting the colonies into a triangular flask filled with an LB liquid culture medium, sealing the opening, placing the triangular flask into a 37 ℃ shaking table, shaking the shaking table until the colonies are turbid, obtaining turbid liquid, paying attention to prevent the colonies from being too long, and otherwise, causing bacteria to die. The colonies were diluted in an ultraclean bench and 900. mu.L LLB broth, and 100. mu.L of shaken turbid liquid, were added to the same EP tube as dilution 10 using 1000. mu.L pipette^-1The bacterial liquid is further diluted and released 10 times by using LB liquid culture medium^-2、10^-3、10^-4、10^-5、10^-6、10^-7、10^-8A bacterial liquid of the double. Dip dilution 10 by sterile inoculating Loop^-5、10^-6、10^-7、10^-8And uniformly coating 200 mu L of each multiplied bacterial solution on different solid culture mediums, sealing after the completion, placing in an incubator at 37 ℃, inverting the culture mediums after 0.5h, and culturing for 14 h. Picking out single colony from solid culture medium with grown colony, placing into EP tube filled with LB liquid culture medium 500 μ L, sealing, shaking at 37 deg.C for 1.5h, and standing at 4 deg.C after turbidity.

Activation of Staphylococcus aureus was as above.

(3) Bacteriostasis test

Test groups: to the bacteriostatic hand sanitizer of example 3, 0, 1, 2, and 3 times of distilled water was added, respectively, to obtain 5 test groups, which were recorded as 1, 2, 3, and 4 groups, respectively.

Control group 1: the hand sanitizer of comparative example 1 was used without dilution with distilled water and recorded as 5 groups.

Control group 2: the antibacterial performance of the traditional Chinese medicine extract of comparative example 2 was directly tested and recorded as 6 groups.

Sterilizing and drying filter paper discs with diameter of 1cm punched by a puncher, and soaking in solutions of 1 group, 2 groups, 3 groups, 4 groups, 5 groups and 6 groups for a long time. Taking culture dishes No. 1 and No. 2 filled with solid culture medium, evenly dividing the bottom of each culture dish into 6 areas by using a marker pen, inoculating Escherichia coli No. 1 and Staphylococcus aureus No. 2, uniformly coating, and respectively sticking the soaked wafers to the central position of each area. Sealing and culturing bacteria. Parallel control experiment 3 groups are performed to avoid test contingency and improve accuracy. The mean value was obtained after measuring the zone diameter for each group and the test data were recorded as in table 4 and figure 1. As is clear from table 4 and fig. 1, the bacteriostatic hand sanitizer of the present invention has a good bacteriostatic effect.

TABLE 4 bacteriostatic effect of test group and control group

In conclusion, the hand sanitizer disclosed by the invention is uniform in quality, good in stability, good in foaming performance, strong in decontamination capability and strong in bacteriostatic effect.

The above disclosure is only for the preferred embodiments of the present invention, but the embodiments of the present invention are not limited thereto, and any variations that can be made by those skilled in the art are intended to fall within the scope of the present invention.

Claims

1. The antibacterial hand sanitizer is characterized by comprising the following raw materials in parts by weight:

the traditional Chinese medicine extracting solution is a mixed solution of a coptis extracting solution with the concentration of 12mg/mL and a honeysuckle extracting solution with the concentration of 16mg/mL, and the volume ratio of the coptis extracting solution to the honeysuckle extracting solution is 1: 1.5-2.5;

the coptis chinensis extracting solution is prepared by the following method:

adding Coptidis rhizoma powder into mixed solution of ethanol and water, leaching for 13h, and performing flash extraction at 150V for 2min to obtain first primary extractive solution;

dissolving the coptis chinensis extract and distilled water to obtain coptis chinensis extract, wherein the concentration of the coptis chinensis extract is 12 mg/mL;

the honeysuckle extracting solution is prepared by the following method:

adding honeysuckle powder into a mixed solution of ethanol and water, leaching for 13h, and then carrying out flash extraction for 3min under the voltage of 150V to obtain a second extraction primary liquid;

wherein the ratio of the honeysuckle powder to the mixed solution is 1g:50mL, and the volume ratio of ethanol to water in the mixed solution is 7: 3;

centrifuging the second extraction primary liquid at 6000r/min for 10min, collecting supernatant, repeating twice, mixing the supernatants, and rotary evaporating to obtain flos Lonicerae extract;

2. The bacteriostatic hand sanitizer according to claim 1, which comprises the following raw materials in parts by weight:

3% of traditional Chinese medicine extracting solution, 8.5% of surfactant, 1% of thickening agent, 3% of humectant and the balance of distilled water;

the traditional Chinese medicine extracting solution is a mixed solution of a coptis extracting solution with the concentration of 12mg/mL and a honeysuckle extracting solution with the concentration of 16mg/mL, and the volume ratio of the coptis extracting solution to the honeysuckle extracting solution is 1:2.

3. The bacteriostatic hand sanitizer according to claim 1,

the surfactant is a mixture of alpha-sodium alkenyl sulfonate and fatty alcohol ether sodium sulfate;

the volume ratio of the alpha-sodium alkenyl sulfonate to the fatty alcohol ether sodium sulfate is 1: 0.5-2;

the thickening agent is sodium carboxymethyl cellulose;

the humectant is glycerol.

4. The bacteriostatic hand sanitizer according to claim 1, further comprising essential oil and citric acid for adjusting the pH of the bacteriostatic hand sanitizer; the pH value of the antibacterial hand sanitizer is 5.5-6.5.

5. The preparation method of the bacteriostatic hand sanitizer according to any one of claims 1 to 4, which comprises the following steps: