CN103860526A - Disinfectant comprising hyaluronic acid as well as preparation method and use of disinfectant - Google Patents
Disinfectant comprising hyaluronic acid as well as preparation method and use of disinfectant Download PDFInfo
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- CN103860526A CN103860526A CN201310605971.4A CN201310605971A CN103860526A CN 103860526 A CN103860526 A CN 103860526A CN 201310605971 A CN201310605971 A CN 201310605971A CN 103860526 A CN103860526 A CN 103860526A
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Abstract
The invention belongs to the technical field of disinfection, and relates to a disinfectant with a skin protecting function and a preparation method of the disinfectant. The disinfectant is prepared from dichlorobenzyl alcohol, hyaluronate and other assistant matters. The disinfectant provided by the invention can be used in the fields of surgical hand disinfection, sanitary hand disinfection, skin disinfection, mucous membrane disinfection, mouth disinfection and the like. The disinfectant has the advantages of simple preparation process, quick and lasting disinfecting effect, excellent moisturizing and skin-protecting performance, high safety and low frequency of usage, and effectively has the double functions of disinfecting and protecting skins.
Description
technical field
The present invention relates to disinfectant technical field, particularly a kind of disinfectant with skin-care effect, also relates to the preparation method of described disinfectant.
background technology
Sterilization is to utilize chemicals or additive method to eliminate most of microorganism, makes common pathogenic bacterium decreased number to safe level.In the middle of the 19th century, start to draw attention in surgical operation, the use of sterilization has greatly reduced postoperative infection and has suffered from the probability of septicemia.Epidemiological study confirmation, hands is the important channel of hospital infection, accounts for the more than 30% of hospital infection.
The sterilization component of sterile products mainly contains ethanol, povidone iodine, hibitane, triclosan and quaternary ammonium salt etc. at present.But these current disinfection compositions all exist certain problem, affect the compliance of user, if povidone iodine is rufous, easily pollution clothes and skin, affect attractive in appearance; Hibitane and triclosan are water insoluble, need to add a large amount of ethanol or surfactant and increase dissolubility, thereby xerosis cutis is chapped, and skin is produced and stimulated.Although quaternary ammonium disinfectant water solublity is fine, it belongs to low effect disinfectants, needs and ethanol or the composite use of other disinfectant in practical application, also has the injury problem to skin.Ethanol is safe disinfectant, but the ethanol of high concentration can cause skin defat, water loss, prolonged and repeated contact easily causes xerosis cutis, desquamation, chaps and the side effect such as dermatitis occur, and after ethanol volatilization, just no longer there is disinfective action, therefore need frequent use.
DCBA is a kind of alcohols broad spectrum antimicrobicide, to gram negative bacteria, positive bacteria, and fungus, yeast and virus are all killed or inhibitory action.Known, DCBA is applied in lozenge the history of existing more than 40 years, is used for the treatment of the infection of oral cavity and throat, in antibiotic preparation for slight incised wound and abrasive sterilization and treatment, and enough with being used for the treatment of fungal infection in emulsifiable paste/lotion.
Hyaluronic acid is the straight chain polymer polysaccharide that disaccharidase unit forms by 2-Acetamido-2-deoxy-D-glucose and glucuronic acid, has strong moisture retention and viscoelasticity, is the nature moisturizing factor of generally acknowledging in the world.It acts on after skin surface, can increase skin lubrication sense, and maintenance skin is smooth, moist, high resilience.
A kind of gel for skin and the sterilization of other article surfaces is disclosed in Chinese patent CN1245012A, by non-ionic antibacterial type antibacterial halogenated diphenyl ether, be further 2,4,4 '-tri-chloro-2 '-dihydroxy diphenyl ethers (having another name called triclosan) and carrier composition, in disclosed carrier, contain wetting agent hyaluronate sodium.And the effect that hyaluronate sodium is brought into play in this disinfectant, just moisture-keeping function.And zoopery shows: Irgacare MP can hinder muscle contraction on cellular level, reduce the swimming rate of fish, weaken mouse muscle strength and infringement living animal cardiac systolic function (" scientific and technological wind " 2012,13:3).In recent years, in mud, surface water and sanitary sewage, all have triclosan to detect, its exposure also receives publicity day by day, triclosan to aquatile (as algae, water flea, fish etc.) there is stronger toxic action, in the situation such as ultraviolet light, sun exposure, triclosan can be degraded and be changed dioxin and phenolic compound into (as 2,4-chlorophenesic acid) etc. the stronger material of toxicity, have potential ecology and health risk (wait quietly in river. analytical chemistry research report, 2012,40(8): 1257-1261; US2004/0131578A1).
In addition, in patent CN1245012A, also disclose, time prepared by disinfecting gel, hyaluronate sodium need be dissolved in the water in advance for subsequent use, and then mix mutually with alcohol, fixed heavy.But this preparation method, hyaluronate easily lumps agglomerating, not soluble, causes the problems such as preparation time prolongation.
summary of the invention
In order to solve the problem that the problem and the Disinfection Effect that exist in above existing disinfectant preparation process are brought into play slowly, effect duration is short, skin is had to injury, the invention provides a kind of Disinfection Effect fast, effect is lasting, preserving moisture and protecting skin performance is good, safe, frequency of usage reduces, and can effectively play the disinfectant of sterilization, skin protection double effects.
The present invention is achieved by the following measures:
There is a disinfectant for skin-care effect, the raw material that contains following weight proportion:
Dybenal 0.01-5.0 part, hyaluronic acid or hyaluronate 0.001-5.0 part, low mass molecule alcohol class 5-70 part, surfactant 0-10 part.
Described disinfectant, preferably contains the raw material of following percentage by weight:
Dybenal 0.05-1.0 part, 0.001 ~ 3.0 part of hyaluronic acid or hyaluronate, 10 ~ 60 parts of low mass molecule alcohol classes, surfactant 0-5.0 part.
Described disinfectant, preferably also contains pH value regulator and essence.
Described disinfectant, preferably dybenal is DCBA.
Described disinfectant, preferred described hyaluronate is hyaluroni, potassium salt, zinc salt or calcium salt.
Described disinfectant, preferably low mass molecule alcohol class is ethanol, isopropyl alcohol, propylene glycol, glycerol or butanediol.
Described disinfectant, preferred surface active substance is more than one in Cremophor RH40, Tween 80, betanin and butylol polyether.
Described disinfectant, preferably pH value regulator is more than one of sodium hydroxide, potassium hydroxide, triethanolamine, Borax, sodium acetate, sodium citrate, hydrochloric acid, citric acid, boric acid, acetic acid etc.
The present invention also provides a kind of preparation method of the disinfectant with skin-care effect, comprises the following steps:
(1) by low mass molecule alcohol class, surfactant, essence mix homogeneously;
(2) drop into dybenal, until completely dissolved;
(3) drop into hyaluronic acid or hyaluronate, pH value regulator, after fully disperseing, add water to ormal weight;
(4) after stirring and dissolving, filter, obtain the disinfectant of pH value at 4-9.
Described preparation method, preferably makes solution, spray or gel.
Described preparation method, in preferred solution agent, the weight percent concentration of hyaluronic acid or hyaluronate is 0.1% ~ 0.5%, in described spray, the weight percent concentration of hyaluronic acid or hyaluronate is 0.001% ~ 0.2%, and in described gel, the weight percent concentration of hyaluronic acid or hyaluronate is 0.5% ~ 3.0%.
The present invention has the disinfectant of skin-care effect, is applicable to the fields such as the sterilization of surgery hands, the sterilization of health hands, skin degerming, mucosa sterilization, oral disinfecting.
Beneficial effect of the present invention:
1, the disinfectant with skin-care effect provided by the invention, mainly utilize the bactericidal property of dybenal, adopt hyaluronate as matrix components, in safe and efficient sterilization, make full use of the preserving moisture and protecting skin effect of hyaluronate, adding of hyaluronic acid or hyaluronate, can make Disinfection Effect better, it is more lasting to act on, and has overcome existing disinfectant and has easily caused xerosis cutis and the unabiding defect of bactericidal effect;
2, the disinfectant with skin-care effect of the present invention, through Germicidal test, volatilize test, irritation test, moisturizing test and continue bacteriostatic test checking, prove that it has excellent instantaneous sterilization effect, rapid draing, non-stimulated to skin, moistening effect is remarkable compared with reference product, and bacteriostasis is lasting, is that desirable hands is used, skin is used, mucosa is used, oral cavity disinfectant products;
3, in preparation process of the present invention, hyaluronic acid is first distributed in low mass molecule alcohol kind solvent, after being uniformly dispersed, is dissolved in water again, solve the hyaluronic acid problem agglomerating and that dissolution time is long of easily condensing, there is the advantages such as simple to operation, shortening preparation time, the saving energy.
The specific embodiment
Below enumerate specific embodiment further to set forth the present invention, should be understood that example is not for limiting the scope of the invention.
embodiment 1
The preparation method of solution: take 5 parts of ethanol, 5 parts of glycerol, 1.0 parts of Tween 80s, essence in appropriate vessel, is uniformly mixed in right amount, drops into 2,0.3 part of 4-dybenal, until completely dissolved, drops into 0.1 part of HA, and 0.01 part of sodium citrate, after being uniformly dispersed, add water to 100 parts, after stirring and dissolving, filter subpackage.Recording pH is 7.3.
embodiment 2
The preparation method of solution: take 5 parts of butanediols, 1.9 parts of betanins, essence in appropriate vessel, is uniformly mixed in right amount, drops into 2,0.5 part of 4-dybenal, until completely dissolved, drops into 0.5 part of HA, after being uniformly dispersed, add water to 100 parts, after stirring and dissolving, filter subpackage.Recording pH is 5.9.
embodiment 3
The preparation method of solution: take 30 parts of ethanol, 5 parts of glycerol, 0.5 part of betanin, essence are in right amount in appropriate vessel, be uniformly mixed, drop into 1.0 parts of DCBAs, until completely dissolved, drop into 0.3 part of HA, and Borax 0.0012g, after being uniformly dispersed, add water to 100 parts, after stirring and dissolving, filter subpackage.Recording pH is 6.9.
embodiment 4
The preparation method of spray: take 55 parts of ethanol, 5 parts of butanediols, 0.7 part of butylol polyether, essence are in appropriate vessel, be uniformly mixed, drop into 0.05 part of DCBA, until completely dissolved, drop into 0.001 part of HA, after being uniformly dispersed, add water to 100 parts, after stirring and dissolving, filter subpackage.Recording spray pH value is 6.2.
embodiment 5
The preparation method of spray: take 60 parts of ethanol, 5 parts of butanediols, 2.0 parts of Tween 80s, essence in appropriate vessel, is uniformly mixed in right amount, drops into 2,0.01 part of 4-dybenal, until completely dissolved, drops into 0.01 part of HA, after being uniformly dispersed, add 0.01 part of acetic acid, add water to 100 parts, after stirring and dissolving, filter subpackage.Recording spray pH value is 4.5.
embodiment 6
The preparation method of spray: take 45 parts of ethanol, 5 parts of propylene glycol, 1.5 parts of Tween 80s, essence are in appropriate vessel, be uniformly mixed, drop into 0.7 part of DCBA, until completely dissolved, drop into 0.2 part of HA, after being uniformly dispersed, add water to 100 parts, after stirring and dissolving, filter subpackage.Recording spray pH value is 6.5.
embodiment 7
The preparation method of gel: take 30 parts of isopropyl alcohols, 15 parts of propylene glycol, 3.0 parts of Cremophor RH40s, essence are in appropriate vessel, be uniformly mixed, drop into 5.0 parts of DCBAs, until completely dissolved, drop into 0.5 part of HA, after being uniformly dispersed, add 0.1 part of the hydrochloric acid of 0.1mol/L, add water to 100 parts, after stirring and dissolving, filter subpackage.Recording gel pH value is 5.0.
embodiment 8
The preparation method of gel: take ethanol 10g, propylene glycol 8 g, betanin 5.0g, essence, in appropriate vessel, is uniformly mixed, and drops into 2,2.0 parts of 4-dybenals, 0.5 part of sodium sulfite, until completely dissolved, drop into HA 1.5g, after being uniformly dispersed, add water to 100 parts, after stirring and dissolving, filter subpackage.Recording gel pH value is 7.1.
embodiment 9
The preparation method of gel: take 35 parts of ethanol, 5 parts of glycerol, 0.3 part of betanin, essence, in appropriate vessel, is uniformly mixed, and drops into 2,0.4 part of 4-dybenal, until completely dissolved, drops into 3.0 parts of HA, 0.05 part of triethanolamine, after being uniformly dispersed, add water to 100 parts, after stirring and dissolving, filter subpackage.Recording gel pH value is 8.7.
reference examples 1
According to the disinfectant that in patent CN1245012A, disclosed content prepares.
reference examples 2
Compared with embodiment 1, do not contain hyaluronic acid, the shared amount of hyaluronic acid is by water polishing, and all the other are in full accord with embodiment 1.
reference examples 3
Compared with embodiment 2, do not contain hyaluronic acid, the shared amount of hyaluronic acid is by water polishing, and all the other are in full accord with embodiment 2.
disinfection Effect experimental verification
1, Germicidal test
The disinfectant of prepared by embodiment 1-9 have skin-care effect, to escherichia coli, staphylococcus aureus, Candida albicans and bacillus pyocyaneus all can effectively be killed.According to the check of " disinfection technology standard " (version in 2002) 2.1.1 method, with the stock solution in embodiment 1-9 to escherichia coli (8099), staphylococcus aureus (ATCC6538), Candida albicans (ATCC10231) and bacillus pyocyaneus (ATCC15442) the 5th generation effect 30 seconds, 60 seconds and 90 seconds, result showed: it is to four kinds of bacterium killing rate at the appointed time (in Table 1-table 4) more than 99.99%.
Table 1 is to colibacillary killing effect
The killing effect of table 2 to staphylococcus aureus
The killing effect of table 3 to Candida albicans
The killing effect of table 4 to bacillus pyocyaneus
2, moistening effect test
The disinfectant with skin-care effect of preparing with embodiment 1-9, carries out moistening effect check.Method is: take the solution of embodiment 1-9 or spray or gel as given the test agent.Select 30 volunteers, inside its right-hand man's forearm, labelling length and width are the square area of 4cm respectively, and sample size is by 3.0 ± 0.1 mg/cm
2consumption, evenly coat in trial zone.Use respectively Corneometer CM825 and Tewanmeter TM300 measurement to smear rear 0min, 10min, 30min, the moisture content of skin of tested region and control zone and moisture of skin number of dropouts when 1h, 2h, 4h.
Be calculated as follows skin moisture content rate of increase:
Φ=?
-----moisture of skin rate of increase in formula: Φ;
MMV
0-----smears the water content of front skin;
MMVt------smears the water content of t period skin.
Use SPSS software to carry out date processing, analyze its significance.Observe the performance of keeping humidity of embodiment 1-9 disinfectant.
Result shows: the moisture of skin increment rate of smearing embodiment 1-9 given the test agent is significantly higher than reference examples 1,2, equal tool significant difference in 4 hours that investigate.The moisture of skin evaporation capacity of smearing after embodiment 1-9 given the test agent was all significantly less than reference examples 1,2 in 4 hours, equal tool significant difference in 4 hours that investigate.Show that skin protection disinfectant prepared by embodiment 1-9 has moistening effect, and be significantly better than reference examples 1,2.The results are shown in Table 5.
Table 5 moistening effect result of the test
3, volatilize test
The disinfectant with skin-care effect of preparing with embodiment 1-9, volatilizes test.Method is: at 20 ℃ and 35 ℃ of temperature, get about 1.0g disinfectant, by standard hand washing rubbing 30 seconds, then both hands were spread beginning timing out, write down the time used during to bone dry.
Result shows: ambient temperature is between 20 ℃～35 ℃, and the disinfectant with skin-care effect of the present invention can reach and volatilize requirement in 3 ~ 35 seconds, shows that disinfectant of the present invention can meet disposable needs fast.The results are shown in Table 6.
Table 6 volatilizes result of the test
4, skin irritation test
The disinfectant of preparing with embodiment 1-9, reference examples 1 and reference examples 2, carry out irritation test by the regulation of " disinfection technology standard " (version in 2002) 2.3.3, result shows: smearing continuously after 14 days, the skin irritation index of embodiment 1-9, reference examples 1 and reference examples 2 test group all, between 0-0.5, shows the equal nonirritant of above-mentioned disinfectant.But find in experiment, all there is not erythema and edema in embodiment 1-9 experimental group animal, and reference examples 1 and reference examples 2 experimental group animals have and occur individually erythema and edema, and the result of the test of embodiment 1-9 is similar, only list the result of the test of embodiment 1 herein, in table 7.
Table 7 skin irritation result of the test
5, vaginal mucomembranous irritant test
The disinfectant of preparing with embodiment 2 and reference examples 3, carry out vaginal mucomembranous irritant test by the regulation of " disinfection technology standard " (version in 2002) 2.3.5, result shows: at successive administration after 5 days, the vaginal mucosa irritation index of embodiment 2, reference examples 3 is respectively 0 and 2.7, show as non-stimulated and extremely slightly stimulate, in table 8, can reduce the stimulation of other compositions to vaginal mucosa after showing to add hyaluronic acid.
Table 8 vaginal mucomembranous irritant test result
6, acute eye irritation test
The disinfectant of preparing with embodiment 2 and reference examples 3, carry out acute eye irritation test by the regulation of " disinfection technology standard " (version in 2002) 2.3.4, result shows: 2 groups of normal saline group and embodiment are all non-stimulated to rabbit eyes, and 3 groups of reference examples show as subexcite, in table 9, show that hyaluronic acid can alleviate the zest of other components to rabbit eyes.
Table 9 acute eye irritation test result
7, continue bacteriostatic test
The disinfectant with skin-care effect of preparing with embodiment 1-9, smears the rear bacteriostatic test that continues respectively 4 hours, and its method is: take the solution of embodiment 1-9 or spray or gel as given the test agent, and reference examples 1 in contrast 1, reference examples 2 in contrast 2.30 of collection volunteers, men and women does not limit.Before sterilization, after the mutually abundant rubbing of experimenter's both hands, make its left hand refer to close up, wipe soaking containing in 10ml diluent test tube with sterile cotton, after extracting, bend face finger tip to referring to root at the five fingers on tube wall, double rub 2 times, often embrocates one time, and cotton is wiped to rotation once.After sampling, in sterile working's mode, cotton is wiped to sampling end and cut into nertralizer in vitro, as positive controls sample.Separately get appropriate disinfectant the right hand is smeared, after volatilizing, make volunteer freely movable, after 4 hours, wipe containing soaking in 10ml and in diluent test tube with sterile cotton, after extracting, bend face finger tip to referring to root at the five fingers on tube wall, double rub 2 times, often embrocates one time, and cotton is wiped to rotation once.After sampling, in sterile working's mode, cotton is wiped to sampling end and cut into nertralizer in vitro, as test group sample.Same batch nertralizer, diluent are as negative control.Get respectively test group, positive controls and the each 1ml of negative control group sample, with agar tilt-pour process inoculation plate, 2 plates of each sample inoculation, put in 37 ℃ of calorstats and cultivate 48h, observe final result, calculate and kill logarithm value.
Result of the test shows: the feminine gender of embodiment 1-9 and matched group is organized equal asepsis growth, 30 person-times of embodiment 1-9 groups on hand natural bacteria on average kill logarithm value between 1.16 ~ 1.85, all be greater than 1.00, the logarithm value of on average killing of contrast 1 is 0.63, the logarithm value of on average killing of contrast 2 is 0.80, is all less than 1.00, shows that the disinfectant with skin-care effect is applied to after hand skin, in 4 hours, have lasting bacteriostasis, and contrast 1 and contrast 2 are continuing to be inferior to disinfectant of the present invention in bacteriostasis.The comparative test result of embodiment 1 and contrast 2 also illustrates, hyaluronate continues to play a key effect in bacteriostasis at this prescription.
The result of the test of embodiment 1-9 is similar, only lists the result of the test of embodiment 1 and matched group herein, in table 10.
Table 10 embodiment 1 and matched group continue bacteriostatic test result
8, the application's preparation technology and traditional preparation technology's comparative study
To prepare 100g gel as example by embodiment 9, relatively two kinds of preparation technologies' quality.Concrete grammar is as follows:
Traditional handicraft: get HA 2.0g, be scattered in 40g water under stirring, dissolve; Separately get ethanol 35g, glycerol 5g, essence is appropriate, after being uniformly mixed, dropping into 0.4g DCBA and dissolves; After two solution all dissolve completely, mix, stir, with triethanolamine 0.05g adjusting pH value, excess water is surely heavy, stirs and get final product.
This technique: get ethanol 35g, glycerol 5 g, essence, in appropriate vessel, is uniformly mixed, and drops into DCBA 0.4g, until completely dissolved, drops into HA 2.0g, and triethanolamine 0.05g, after being uniformly dispersed, adds water to 100g, stirs and get final product.
The parameter comparison of two kinds of techniques is in table 11.
This technique of table 11 and traditional handicraft preparation parameter contrast table
| Parameter | Traditional handicraft | This technique |
| HA dissolution phenomena | Condense agglomerating | Dispersed |
| HA dissolution time | 4-6 hour | 0.5-1 hour |
| Dissolving tank and mixing situation | 2 dissolving tanks, need mixed processes | 1 dissolving tank, without mixing |
| Preparation technology's deadline | Approximately 8 hours | Approximately 2 hours |
| Finished product outward appearance | Colorless transparent gel | Colorless transparent gel |
Experimental result shows: two kinds of techniques all obtain colorless transparent gel.Under these process conditions, HA dissolves rapidly, and preparation technology is simple, and without mixed processes, work efficiency improves 4 times.
Although, above, with general explanation and embodiment, the present invention is done to detailed explanation, on basis of the present invention, can make some modifications or improvement, this it will be apparent to those skilled in the art that.Therefore, modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (12)
1. containing a hyaluronic disinfectant, it is characterized in that the raw material that contains following weight proportion:
Dybenal 0.01-5.0 part, hyaluronic acid or hyaluronate 0.001-5.0 part, low mass molecule alcohol class 5-70 part, surfactant 0-10 part.
2. disinfectant according to claim 1, is characterized in that the raw material that contains following percentage by weight:
Dybenal 0.05-1.0 part, 0.001 ~ 3.0 part of hyaluronic acid or hyaluronate, 10 ~ 60 parts of low mass molecule alcohol classes, surfactant 0-5.0 part.
3. disinfectant according to claim 1, is characterized in that also containing pH value regulator and essence.
4. according to the disinfectant described in any one in claim 1-3, it is characterized in that dybenal is DCBA.
5. according to the disinfectant described in any one in claim 1,3,4, it is characterized in that described hyaluronate is more than one in hyaluroni, potassium salt, zinc salt or calcium salt.
6. according to the disinfectant described in any one in claim 1,3,4,5, it is characterized in that described low mass molecule alcohol class is more than one in ethanol, isopropyl alcohol, propylene glycol, glycerol or butanediol.
7. according to the disinfectant described in any one in claim 1,3,4,5,6, it is characterized in that described surfactant is more than one in Cremophor RH40, Tween 80, betanin and butylol polyether.
8. a preparation method for the disinfectant described in claim 3-7, is characterized in that comprising following steps:
(1) by low mass molecule alcohol class, surfactant, essence mix homogeneously;
(2) drop into dybenal, until completely dissolved;
(3) add hyaluronic acid or hyaluronate, pH value regulator, after fully disperseing, add water to ormal weight;
(4) after stirring and dissolving, filter, obtain the disinfectant of pH value at 4-9.
9. preparation method according to claim 8, is characterized in that making solution, spray or gel.
10. preparation method according to claim 9, the weight percent concentration that it is characterized in that hyaluronic acid in described solution or hyaluronate is 0.1% ~ 0.5%, in described spray, the weight percent concentration of hyaluronic acid or hyaluronate is 0.001% ~ 0.2%, and in described gel, the weight percent concentration of hyaluronic acid or hyaluronate is 0.5% ~ 3.0%.
11. disinfectant that obtain according to the preparation method described in any one in the disinfectant described in any one in claim 1,3,4,5,6 or claim 8-10 for skin degerming, have skin care effect in the sterilization of surgery hands, the sterilization of health hands simultaneously.
12. disinfectant that obtain according to the preparation method described in any one in the disinfectant described in any one in claim 1,3,4,5,6 or claim 8-10, for mucosa sterilization, oral disinfecting.
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| WO2023123421A1 (en) * | 2021-12-31 | 2023-07-06 | 振德医疗用品股份有限公司 | Long-acting antibacterial disinfectant, preparation method therefor and application thereof |
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| CN111249176A (en) * | 2020-02-21 | 2020-06-09 | 华熙生物科技股份有限公司 | No-clean disinfectant, preparation method and application thereof |
| WO2021261916A1 (en) * | 2020-06-24 | 2021-12-30 | 주식회사 진우바이오 | Alcohol-based disinfectant composition having moisturizing effect, and preparation method therefor |
| WO2023123421A1 (en) * | 2021-12-31 | 2023-07-06 | 振德医疗用品股份有限公司 | Long-acting antibacterial disinfectant, preparation method therefor and application thereof |
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Application publication date: 20140618 |