CN111249176A - No-clean disinfectant, preparation method and application thereof - Google Patents
No-clean disinfectant, preparation method and application thereof Download PDFInfo
- Publication number
- CN111249176A CN111249176A CN202010182859.4A CN202010182859A CN111249176A CN 111249176 A CN111249176 A CN 111249176A CN 202010182859 A CN202010182859 A CN 202010182859A CN 111249176 A CN111249176 A CN 111249176A
- Authority
- CN
- China
- Prior art keywords
- disinfectant
- solution
- clean
- film
- low molecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 126
- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 71
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 26
- 239000003906 humectant Substances 0.000 claims abstract description 22
- 239000003623 enhancer Substances 0.000 claims abstract description 21
- 239000003899 bactericide agent Substances 0.000 claims abstract description 20
- 239000003381 stabilizer Substances 0.000 claims abstract description 19
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims abstract description 17
- 229940014041 hyaluronate Drugs 0.000 claims abstract description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 48
- 238000002156 mixing Methods 0.000 claims description 40
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 38
- 238000003756 stirring Methods 0.000 claims description 33
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 20
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 20
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 20
- DBHODFSFBXJZNY-UHFFFAOYSA-N 2,4-dichlorobenzyl alcohol Chemical compound OCC1=CC=C(Cl)C=C1Cl DBHODFSFBXJZNY-UHFFFAOYSA-N 0.000 claims description 19
- 229960004698 dichlorobenzyl alcohol Drugs 0.000 claims description 19
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical group O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims description 16
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 16
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- 235000019438 castor oil Nutrition 0.000 claims description 11
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- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 10
- 229960003500 triclosan Drugs 0.000 claims description 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 9
- 150000001298 alcohols Chemical class 0.000 claims description 9
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 9
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
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- 235000011083 sodium citrates Nutrition 0.000 claims description 7
- 239000001540 sodium lactate Substances 0.000 claims description 7
- 229940005581 sodium lactate Drugs 0.000 claims description 7
- 235000011088 sodium lactate Nutrition 0.000 claims description 7
- 229960002233 benzalkonium bromide Drugs 0.000 claims description 6
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- 239000005017 polysaccharide Substances 0.000 claims description 6
- -1 acetyl chitosamine Chemical compound 0.000 claims description 5
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 5
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 5
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- WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Natural products CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 claims description 4
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 230000000249 desinfective effect Effects 0.000 claims description 3
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A—HUMAN NECESSITIES
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- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
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- A—HUMAN NECESSITIES
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- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/34—Alcohols
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Abstract
The invention discloses a no-clean disinfectant, a preparation method and application thereof, wherein the no-clean disinfectant comprises 5-60% of low molecular alcohol, 1-10% of humectant, 0.01-2% of stabilizer, 0.01-2% of hyaluronate, 0.02-1.0% of bactericide, 0.01-2% of film-forming enhancer and the balance of water by weight percentage in the disinfectant. The non-washing disinfectant provided by the invention has the advantages that as the hyaluronate and the film-forming enhancer are mixed in proportion, a relatively tough film is formed on hands, the hand protection can be improved, and the bacteriostatic time can be prolonged. In addition, the provided no-clean disinfectant can improve the barrier function of skin and has the function of treating eczema.
Description
Technical Field
The invention relates to the technical field of disinfectants, in particular to a no-clean disinfectant, a preparation method and application thereof.
Background
Disinfection is the use of chemicals or other means to destroy most microbes and reduce the number of common pathogenic bacteria or viruses to safe levels. In the middle of the 19 th century, attention was paid to surgical procedures, and the use of disinfection measures greatly reduced the chances of surgical infection and sepsis. Epidemiological investigations have confirmed that hands are an important route for nosocomial infections, accounting for over 30% of nosocomial infections.
The sterilization components of the existing sterilization products mainly comprise ethanol, povidone iodine, chlorhexidine, triclosan, quaternary ammonium salts and the like. Ethanol (70-80%) disinfectant has excellent bactericidal effect and quick volatilization, but loses the long-acting antibacterial effect after volatilization, has degreasing effect in the volatilization process, and easily causes damages such as dryness, chap, dermatitis, even eczema and the like to skin; the povidone iodine disinfectant has good sterilizing and antiviral effects, but is yellow brown, is yellow when being applied to the skin, and is not suitable for sanitary disinfection in daily life.
CN103860526A discloses a disinfectant containing hyaluronic acid, a preparation method and application thereof, wherein the disinfectant containing hyaluronic acid comprises the following raw materials in parts by weight: 0.01-5.0 parts of dichlorobenzyl alcohol, 0.001-5.0 parts of hyaluronic acid or hyaluronate, 5-70 parts of low molecular alcohols and 0-10 parts of surface active substances.
The existing disinfectant technology has the advantages of colored finished product, complex components, damage to skin and no long-acting antibacterial effect.
Disclosure of Invention
The invention provides a no-clean disinfectant, a preparation method and application thereof, aiming at solving the problems of poor continuous antibacterial effect and poor film forming property in the prior art.
The technical scheme of the invention is as follows:
the invention provides a no-clean disinfectant, which comprises 5-60% of low molecular alcohols, 1-10% of humectant, 0.01-2% of stabilizer, 0.01-2% of hyaluronate, 0.02-1.0% of bactericide, 0.01-2% of film-forming enhancer and the balance of water.
Preferably, the non-washing disinfectant is prepared from 10 to 50 percent of low molecular alcohols, preferably 15 to 45 percent of low molecular alcohols, by weight percentage in the disinfectant; the humectant is 1-8%, preferably 2-5%; the stabilizer is 0.05-1%, preferably 0.1-0.8%; the hyaluronic acid salt is 0.05-1%, preferably 0.1-0.8%; the bactericide is 0.1-0.8%, preferably 0.2-0.5%; the film-forming enhancer is 0.1-1%, preferably 0.1-0.5%.
Preferably, the non-washing disinfectant is a disinfectant prepared by mixing the hyaluronic acid salt with sodium hyaluronate, potassium hyaluronate and zinc hyaluronate.
Preferably, the non-washing disinfectant is one or more selected from ethanol, propylene glycol, butylene glycol, isopropanol, hexylene glycol and phenoxyethanol.
Preferably, for the no-clean disinfectant, the humectant is one or more selected from butanediol, propylene glycol, pentanediol, glycerol, betaine, cellulose, carbomer, tremella polysaccharide, acetyl chitosamine, ectoine and trehalose.
Preferably, the non-washing disinfectant is one or more of PPG-26-Butanethol-26, PEG-40 hydrogenated castor oil, Tween 80, sodium dihydrogen phosphate, disodium hydrogen phosphate, citric acid, sodium citrate, Tween 20, lactic acid and sodium lactate.
Preferably, the leave-on disinfectant is one or more selected from the group consisting of 2, 4-dichlorobenzyl alcohol, benzalkonium bromide, triclosan, benzalkonium chloride and polyhexamethylene guanide.
Preferably, the no-clean disinfectant is prepared by adding a film-forming enhancer, namely galactomannan and/or sulfated galactan into the disinfectant.
Preferably, the no-clean disinfectant comprises a pH value regulator; preferably, the pH value regulator accounts for 0.01-0.1 percent of the weight percentage of the washing-free disinfectant, and preferably 0.01-0.05 percent of the weight percentage of the washing-free disinfectant.
Preferably, the non-washing disinfectant is one or more selected from sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium citrate, sodium lactate, citric acid and lactic acid.
Preferably, the no-clean disinfectant further comprises essence.
The invention provides a preparation method of a no-clean disinfectant, which comprises the following steps:
mixing a stabilizer, hyaluronate, a film-forming enhancer, an optional pH value regulator, water and an optional essence to obtain a first solution;
mixing low molecular alcohol, humectant and bactericide to obtain a second solution;
dripping the second solution into the first solution to obtain the no-clean disinfectant;
the washing-free disinfectant comprises, by weight, 5-60% of low molecular alcohol, 1-10% of humectant, 0.01-2% of stabilizer, 0.01-2% of hyaluronate, 0.02-1.0% of bactericide, 0.01-2% of film-forming enhancer and the balance of water.
Preferably, in the above production method, wherein, in the step of obtaining the first solution, the stirring is performed at a temperature of 40 to 50 ℃; preferably, the heating is followed by incubation at 40-50 ℃ for 4-6 hours.
Preferably, in the preparation method, the low molecular alcohol accounts for 10 to 50 percent of the disinfectant by weight percent, and is preferably 15 to 45 percent; the humectant is 1-8%, preferably 2-5%; the stabilizer is 0.05-1%, preferably 0.1-0.8%; the hyaluronic acid salt is 0.05-1%, preferably 0.1-0.8%; the bactericide is 0.1-0.8%, preferably 0.2-0.5%; the film-forming enhancer is 0.1-1%, preferably 0.1-0.5%.
Preferably, in the above production method, the low molecular alcohol is one or more selected from the group consisting of ethanol, propylene glycol, butylene glycol, isopropanol, hexylene glycol and phenoxyethanol.
Preferably, in the above preparation method, the humectant is one or more selected from butylene glycol, propylene glycol, pentylene glycol, glycerin, betaine, cellulose, carbomer, tremella polysaccharide, acetylcysteine, ectoine, and trehalose.
Preferably, in the above preparation method, the stabilizer is one or more selected from PPG-26-butyether-26, PEG-40 hydrogenated castor oil, tween 80, sodium dihydrogen phosphate, disodium hydrogen phosphate, citric acid, sodium citrate, tween 20, lactic acid, and sodium lactate.
Preferably, in the above production method, the bactericide is one or more selected from the group consisting of 2, 4-dichlorobenzyl alcohol, benzalkonium bromide, triclosan, benzalkonium chloride and polyhexamethylene guanide.
Preferably, in the above production method, the filming enhancer is galactomannan and/or sulfated galactan.
Preferably, in the preparation method, the pH regulator is 0.01 to 0.1%, preferably 0.01 to 0.05%, by weight, based on the weight of the disinfectant.
Preferably, in the above production method, the pH adjuster is one or more selected from the group consisting of sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium citrate, sodium lactate, citric acid, and lactic acid.
The invention provides a disinfection method, which comprises the step of smearing the no-clean disinfectant or the no-clean disinfectant prepared by the preparation method on the surface of an object in need or the skin surface of a subject.
ADVANTAGEOUS EFFECTS OF INVENTION
The non-washing disinfectant provided by the invention has the advantages that as the hyaluronate and the film-forming enhancer are mixed in proportion, a relatively tough film is formed on hands, the hand protection can be improved, and the bacteriostatic time can be prolonged. In addition, the provided no-clean disinfectant can improve the barrier function of skin and has the function of treating eczema.
Detailed Description
The present invention will be described in detail with reference to the following embodiments. While specific embodiments of the invention have been shown, it should be understood that the invention may be embodied in various forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
It should be noted that certain terms are used throughout the description and claims to refer to particular components. As one skilled in the art will appreciate, various names may be used to refer to a component. This specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. The description which follows is a preferred embodiment of the invention, however, the description is given for the purpose of illustrating the general principles of the invention and not for the purpose of limiting the scope of the invention. The scope of the present invention is defined by the appended claims.
The invention provides a no-clean disinfectant, which comprises 5-60% of low molecular alcohols, 1-10% of humectant, 0.01-2% of stabilizer, 0.01-2% of hyaluronate, 0.02-1.0% of bactericide, 0.01-2% of film-forming enhancer and the balance of water.
For example, the low molecular alcohol may be 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60% or any range therebetween by weight percentage in the disinfectant;
the humectant may be 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, or any range therebetween;
the stabilizer may be 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 2%, or any range therebetween;
the hyaluronic acid salt may be 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 2%, or any range therebetween;
the bactericide may be 0.02%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, or any range therebetween;
the film-forming enhancer may be 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 2%, or any range therebetween.
Preferably, the non-washing disinfectant is prepared from 10 to 50 percent of low molecular alcohols, preferably 15 to 45 percent of low molecular alcohols, by weight percentage in the disinfectant; the humectant is 1-8%, preferably 2-5%; the stabilizer is 0.05-1%, preferably 0.1-0.8%; the hyaluronic acid salt is 0.05-1%, preferably 0.1-0.8%; the bactericide is 0.1-0.8%, preferably 0.2-0.5%; the film-forming enhancer is 0.1-1%, preferably 0.1-0.5%.
The hyaluronate can be sodium hyaluronate, potassium hyaluronate or zinc hyaluronate and similar salts.
In a preferred embodiment of the present invention, the low molecular alcohol is one or more selected from ethanol, propylene glycol, butylene glycol, isopropanol, hexylene glycol and phenoxyethanol.
The butanediol may be butanediol having a 1,2 structure, butanediol having a 1,3 structure, butanediol having a 2,3 structure, butanediol having a 1,4 structure, and preferably 1, 3-butanediol.
In a preferred embodiment of the present invention, the humectant is one or more selected from butylene glycol, propylene glycol, pentanediol, glycerin, betaine, cellulose, carbomer, tremella polysaccharide, acetyl chitosamine, ectoine and trehalose.
In the case where propylene glycol and butylene glycol are used as both the low molecular alcohol and the humectant in the leave-on disinfectant, the propylene glycol and butylene glycol are respectively contained in amounts calculated in the range of 5 to 60% when propylene glycol is used as the low molecular alcohol and in the range of 1 to 10% when propylene glycol is used as the humectant, as is the case with butylene glycol.
The butanediol may be butanediol having a 1,2 structure, butanediol having a 1,3 structure, butanediol having a 2,3 structure, butanediol having a 1,4 structure, and preferably 1, 3-butanediol.
The pentanediol can be pentanediol with a structure of 1,2, pentanediol with a structure of 1,3, pentanediol with a structure of 1,4, pentanediol with a structure of 1,5, pentanediol with a structure of 2,3 or pentanediol with a structure of 2,4, and 1, 2-pentanediol is preferred.
The betaine is also called betaine, trimethylamine B lactone and glycine trimethylamine inner salt, is an alkaloid and has strong moisture absorption performance.
The trehalose is a non-reducing sugar formed by two glucose molecules through 1, 1-glycosidic bonds, has three isomers, namely trehalose, iso-trehalose and new trehalose, and is an important component of the moisturizing cosmetics.
In a preferred embodiment of the present invention, the stabilizer is one or more selected from PPG-26-butyether-26, PEG-40 hydrogenated castor oil, tween 80, sodium dihydrogen phosphate, disodium hydrogen phosphate, citric acid, sodium citrate, tween 20, lactic acid and sodium lactate.
The PPG-26-butanol polyether-26 is also called polyethylene oxide polypropylene oxide monobutyl ether, and is mainly used as an emulsifier and a solubilizer in cosmetics and skin care products.
The PEG-40 hydrogenated castor oil is a viscous liquid or paste, and is an excellent nonionic solubilizer and emulsifier.
In a preferred embodiment of the present invention, the bactericide is one or more selected from the group consisting of 2, 4-dichlorobenzyl alcohol, benzalkonium bromide, triclosan, benzalkonium chloride and polyhexamethylene guanide.
The benzalkonium bromide is also called dodecyl dimethyl benzyl ammonium bromide, is a yellow white waxy solid or colloid, has the property of a typical cationic surfactant, and is mainly used for disinfecting skin, mucous membranes, wounds, surfaces of articles and indoor environment.
The triclosan is also called triclosan or triclosan, is a broad-spectrum antibacterial agent and is widely applied to daily chemicals such as soap, toothpaste and the like.
The benzalkonium chloride is a white waxy solid or yellow colloid, is an important cationic quaternary ammonium salt surfactant, and can be used for disinfection and sterilization of skin, mucous membrane, wound, medical apparatus and the like.
The polyhexamethylene guanidine is a bactericide formula for broad-spectrum and rapid disinfection of sanitary articles, and can be used for skin, mucosa, wound, industry, public facilities, agriculture, food, beverage, household disinfection and the like.
In a preferred embodiment of the present invention, the filming enhancing agent is galactomannan and/or sulfated galactan.
The galactomannan, also called galactomannan, is a polysaccharide comprising a mannose backbone and galactose side groups, which is soluble in water, neutral and has a very low viscosity, and is often used in food products to increase the viscosity of the aqueous phase.
The sulfated galactan, also known as carrageenan, is mostly present in seaweed and other invertebrate marine organisms, and is mainly used as food pigment and fresh keeping. The sulfated galactan molecules are formed by connecting galactose through glycosidic bonds, and the properties of the glycosidic bonds, the specificity of isomers and the degree of substitution by other polysaccharides endow the sulfated galactan molecules with different biological activities, such as immune regulation, antitumor activity and the like.
In a preferred embodiment of the present invention, wherein the no-clean disinfectant further comprises a pH adjuster; preferably, the pH value regulator accounts for 0.01-0.1 percent of the weight percentage of the washing-free disinfectant, and preferably 0.01-0.05 percent of the weight percentage of the washing-free disinfectant.
For example, the pH adjuster may be 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, or any range therebetween, by weight percent of the sanitizer.
In a preferred embodiment of the present invention, the pH adjuster is one or more selected from the group consisting of sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium citrate, sodium lactate, citric acid, and lactic acid.
In a preferred embodiment of the present invention, wherein the no-clean disinfectant further comprises essence, which is used in a proper amount according to the requirement.
In a preferred embodiment of the invention, the leave-on disinfectant may be of the gel type or may be a liquid formulation.
The invention provides a preparation method of a no-clean disinfectant, which comprises the following steps:
mixing a stabilizer, hyaluronate, a film-forming enhancer, an optional pH value regulator, water and an optional essence to obtain a first solution;
mixing low molecular alcohol, humectant and bactericide to obtain a second solution;
dripping the second solution into the first solution to obtain the no-clean disinfectant,
the washing-free disinfectant comprises, by weight, 5-60% of low molecular alcohol, 1-10% of humectant, 0.01-2% of stabilizer, 0.01-2% of hyaluronate, 0.02-1.0% of bactericide, 0.01-2% of film-forming enhancer and the balance of water.
The term "optionally" refers to the fact that the starting material may or may not be used in the manufacturing process.
In a preferred embodiment of the present invention, it comprises the following steps:
mixing the stabilizer, the hyaluronate, the film-forming enhancer, an optional pH value regulator, the water and an optional essence, slowly stirring at a speed of 200rpm under the environment of 40-50 ℃, and preserving heat for 4-6 hours to obtain a first solution;
mixing and dissolving the low molecular alcohol, the humectant and the bactericide to obtain a second solution;
and slowly dripping the second solution into the first solution to obtain the no-clean disinfectant.
The pH value of the no-clean disinfectant is 5-8.
The invention provides a disinfection method, which comprises the step of smearing the no-clean disinfectant or the no-clean disinfectant prepared by the preparation method on the surface of an object in need or the skin surface of a subject.
The invention is described generally and/or specifically for the materials used in the tests and the test methods, in the following examples,% means wt%, i.e. percent by weight, unless otherwise specified. The reagents or instruments used are not indicated by manufacturers, and are all conventional reagent products which can be obtained commercially.
TABLE 1 raw material information used in examples and comparative examples
| Name of raw materials | Type/purity | Manufacturer of the product |
| PPG-26-Butaneth-26 | Cosmetic grade | Is commercially available |
| Hyaluronic acid sodium salt | Food grade or cosmetic grade | BLOOMAGE BIOTECH Co.,Ltd. |
| Galactomannan | Cosmetic grade | Is commercially available |
| 1, 3-butanediol | Cosmetic grade | Is commercially available |
| 2, 4-dichlorobenzyl alcohol | Pharmaceutical grade | Is commercially available |
| PEG-40 hydrogenated Castor oil | Cosmetic grade | Is commercially available |
| Sulfated galactan | Cosmetic grade | Is commercially available |
| Carbomer | Pharmaceutical grade | Is commercially available |
| Propylene glycol | Cosmetic grade | Is commercially available |
| Triclosan | Pharmaceutical grade | Is commercially available |
| Betaine | Cosmetic grade | Is commercially available |
EXAMPLE 1 preparation of No-clean disinfectant
(1) Mixing PPG-26-butanol polyether-260.8 g, sodium hyaluronate 0.4g, galactomannan 0.1g, sodium dihydrogen phosphate 0.05g and the balance of water, slowly stirring at the speed of 200rpm under the environment of heat preservation of 40 ℃, and preserving the heat for 5 hours to obtain a first solution;
(2) uniformly mixing 40g of ethanol, 5g of 1, 3-butanediol and 0.5g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 6.32.
EXAMPLE 2 preparation of No-clean disinfectant
(1) Mixing 0.8g of PEG-40 hydrogenated castor oil, 0.3g of sodium hyaluronate, 0.1g of sulfated galactan, 0.03g of sodium dihydrogen phosphate and the balance of water, slowly stirring at the speed of 200rpm under the environment of heat preservation of 40 ℃, and preserving the heat for 5 hours to obtain a first solution;
(2) uniformly mixing 40g of ethanol, 4g of 1, 3-butanediol and 0.2g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 6.84.
EXAMPLE 3 preparation of No-clean disinfectant
(1) Mixing 0.5g of PEG-40 hydrogenated castor oil, 0.1g of sodium hyaluronate, 0.2g of sulfated galactan, 0.05g of sodium dihydrogen phosphate and the balance of water, slowly stirring at the speed of 200rpm under the environment of keeping the temperature at 60 ℃, and keeping the temperature for 6 hours to obtain a first solution;
(2) uniformly mixing 45g of ethanol, 3g of 1, 3-butanediol and 0.3g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 6.33.
EXAMPLE 4 preparation of No-clean disinfectant
(1) Mixing PPG-26-butanol polyether-260.8 g, sodium hyaluronate 0.2g, galactomannan 0.1g, sodium dihydrogen phosphate 0.01g and the balance of water, adding a proper amount of essence, slowly stirring at the speed of 200rpm under the environment of heat preservation of 40 ℃, and preserving heat for 5 hours to obtain a first solution;
(2) uniformly mixing 40g of ethanol, 5g of 1, 3-butanediol and 0.3g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 6.26.
EXAMPLE 5 preparation of No-clean disinfectant
(1) Mixing PPG-26-butanol polyether-260.1 g, sodium hyaluronate 0.5g, galactomannan 0.3g, sodium dihydrogen phosphate 0.01g and the balance of water, adding a proper amount of essence, slowly stirring at the speed of 200rpm under the environment of keeping the temperature at 40 ℃, and keeping the temperature for 5 hours to obtain a first solution;
(2) uniformly mixing 15g of ethanol, 2g of 1, 3-butanediol and 0.3g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 6.99.
EXAMPLE 6 preparation of No-clean disinfectant
(1) Mixing 0.3g of PEG-40 hydrogenated castor oil, 0.8g of sodium hyaluronate, 0.5g of sulfated galactan, 0.04g of sodium dihydrogen phosphate and the balance of water, adding a proper amount of essence, slowly stirring at the speed of 200rpm under the environment of heat preservation of 40 ℃, and preserving the heat for 5 hours to obtain a first solution;
(2) uniformly mixing 30g of ethanol, 3g of 1, 3-butanediol and 0.4g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 7.42.
EXAMPLE 7 preparation of No-clean disinfectant
(1) Mixing 0.05g of PEG-40 hydrogenated castor oil, 1g of sodium hyaluronate, 1g of galactomannan, 0.03g of sodium dihydrogen phosphate and the balance of water, slowly stirring at the speed of 200rpm under the environment of heat preservation of 40 ℃, and preserving the heat for 5 hours to obtain a first solution;
(2) uniformly mixing 50g of ethanol, 8g of 1, 3-butanediol and 0.8g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 7.28.
EXAMPLE 8 preparation of No-clean disinfectant
(1) Mixing PPG-26-butanol polyether-261 g, sodium hyaluronate 0.05g, sulfated galactan 0.1g, sodium dihydrogen phosphate 0.05g and the balance of water, slowly stirring at 200rpm in an environment with the temperature of 40 ℃, and preserving the temperature for 5 hours to obtain a first solution;
(2) uniformly mixing 10g of ethanol, 1g of 1, 3-butanediol and 0.1g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 7.51.
EXAMPLE 9 preparation of No-clean disinfectant
(1) Mixing PPG-26-butanol polyether-262 g, sodium hyaluronate 2g, galactomannan 2g, sodium dihydrogen phosphate 0.05g and the balance of water, adding a proper amount of essence, slowly stirring at the speed of 200rpm under the environment of heat preservation of 50 ℃, and preserving heat for 4 hours to obtain a first solution;
(2) uniformly mixing 60g of ethanol, 10g of 1, 3-butanediol and 0.02g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 6.50.
EXAMPLE 10 preparation of No-clean disinfectant
(1) Mixing PPG-26-butanol polyether-262 g, sodium hyaluronate 0.01g, galactomannan 2g, sodium dihydrogen phosphate 0.05g and the balance of water, adding a proper amount of essence, slowly stirring at the speed of 200rpm under the environment of heat preservation of 50 ℃, and preserving heat for 4 hours to obtain a first solution;
(2) uniformly mixing 5g of ethanol, 10g of 1, 3-butanediol and 0.05g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 6.25.
EXAMPLE 11 preparation of No-clean disinfectant
(1) Mixing PPG-26-butanol polyether-261.5 g, sodium hyaluronate 0.05g, sulfated galactan 0.01g, citric acid 0.05g and the balance of water, adding a proper amount of essence, slowly stirring at a speed of 200rpm under the environment of heat preservation of 50 ℃, and preserving heat for 5 hours to obtain a first solution;
(2) uniformly mixing 10g of ethanol, 1g of propylene glycol and 0.02g of triclosan to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 5.89.
EXAMPLE 12 preparation of No-clean disinfectant
(1) Mixing 2g of PEG-40 hydrogenated castor oil, 1.2g of sodium hyaluronate, 1.8g of sulfated galactan, 0.1g of sodium dihydrogen phosphate and the balance of water, slowly stirring at a speed of 200rpm in an environment with the temperature of 40 ℃, and preserving the temperature for 4 hours to obtain a first solution;
(2) uniformly mixing 55g of propylene glycol, 10g of betaine and 0.08g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 6.21.
EXAMPLE 13 preparation of No-clean disinfectant
(1) Mixing 800.01 g of Tween, 1.5g of sodium hyaluronate, 2g of galactomannan, 0.08g of lactic acid and the balance of water, slowly stirring at the speed of 200rpm in the environment with the temperature of 50 ℃, and preserving the temperature for 4 hours to obtain a first solution;
(2) uniformly mixing 60g of 1, 3-butanediol, 9g of propylene glycol and 0.05g of benzalkonium bromide to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 6.11.
Comparative example 1 preparation of ordinary No-clean disinfectant
(1) Mixing PPG-26-butanol polyether-260.8 g, carbomer 0.4g, sodium dihydrogen phosphate 0.05g and the balance of water, slowly stirring at 200rpm in an environment with the temperature of 40 ℃, and keeping the temperature for 5 hours to obtain a first solution;
(2) uniformly mixing 40g of ethanol, 5g of butanediol and 0.5g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 5.54.
Comparative example 2 preparation of ordinary No-clean disinfectant
(1) Mixing PPG-26-butanol polyether-260.8 g, sodium hyaluronate 0.4g, sodium dihydrogen phosphate 0.05g and the balance of water, slowly stirring at the speed of 200rpm in an environment with the temperature of 40 ℃, and keeping the temperature for 5 hours to obtain a first solution;
(2) uniformly mixing 40g of ethanol, 5g of butanediol and 0.5g of 2, 4-dichlorobenzyl alcohol to obtain a second solution;
(3) and slowly dripping the second solution into the first solution, uniformly stirring and filtering to obtain the no-clean disinfectant, wherein the pH value of the no-clean disinfectant is 6.55.
TABLE 2 Components and quality tables for the examples and comparative examples
Description of the drawings:
1. the total mass of the other components except the essence is 100 g.
2. - "means that the corresponding component was not added
Experimental example 1 film-forming stability and continuous bacteriostasis test of product
Experiment 1 film Forming stability
5g of each of the no-clean disinfectants prepared in comparative example 1, comparative example 2 and example 1 was slowly poured into a dish having a diameter of 13cm, dried in a desiccator, and the properties of the film in the dish were observed after the liquid components were completely volatilized, and the results of the observation are shown in the following table.
TABLE 3 film formation Properties after drying of the three samples
| Sample (I) | Film appearance | Membrane softToughness of |
| Comparative example 1 | Is brittle, not shaped, and almost transparent | Is free of |
| Comparative example 2 | Intact and almost transparent | Soft, tearable and tearable |
| Example 1 | Intact and almost transparent | Soft and not easy to crack by tearing |
As can be seen from table 3, the film forming property of sodium hyaluronate is superior to that of carbomer, and compared to the film forming property of sodium hyaluronate, the film formed by the sample added with galactomannan or sulfated galactan is more flexible and less breakable, resulting in a significant improvement in the sustained antibacterial performance.
The leave-on disinfectants obtained in examples 2-13 have similar film-forming properties, i.e., the film is tough and not easily broken.
Experiment 2 continuous bacteriostasis test
Randomly selecting 30 volunteers, wiping the inner middle section and the rear section of the left forearm and the right forearm of the volunteers sufficiently before disinfection, transversely wiping the surface of the middle section of the inner side of the left forearm of the volunteers repeatedly for 3 times in a longitudinal direction for 10 times in a longitudinal direction, rotating the cotton swab once for sampling, shearing the sampling end of the cotton swab into an original diluent test tube in an aseptic operation mode, uniformly mixing the sampling end of the cotton swab with an electric mixer in an oscillating way for 20 seconds or vibrating the cotton swab with a palm for 200 times, properly diluting with diluent, taking proper dilution as a positive control sample, disinfecting the inner side of the right forearm with a proper amount of a disinfectant to be tested for 1-3 minutes, then replacing the diluent with a neutralizer solution, sampling natural bacteria remaining on the inner side surface of the forearm in the same method as the positive control group once, taking a test sample ①, respectively wiping the inner side of the left forearm and the rear section of the left forearm for 6 hours, respectively inoculating the residual bacteria on the surface of the positive control sample in a constant-temperature culture dish, respectively inoculating the positive test sample, inoculating the residual bacteria in a constant-temperature test sample culture dish, respectively for 6 hours, and inoculating the residual bacteria on the culture medium in a constant-temperature test dish, respectively, and observing the test results of the positive control dish, respectively, and a ④, respectively, and a 3648, respectively, and a test medium.
The samples of example 1, comparative example 1 and comparative example 2 were all measured using the method described above.
According to the technical Specification for Disinfection 2008 edition: 2.2.8 the method for identifying and testing the sterilizing effect of the disinfectant on the hand site comprises the steps of respectively calculating the logarithmic value of the natural bacteria reduction, taking an average value and calculating the sterilization rate. The results are shown in Table 4 below.
TABLE 4 results of continuous bacteriostasis
The above results show that the same bactericidal composition is used, but since the sodium hyaluronate and galactomannan are used in example 1 and carbomer is used in comparative example 1, and the sodium hyaluronate is used in comparative example 2, namely the product uses different matrixes, the effect of obtaining the continuous bacteriostasis of the product is slightly different, the analysis reason may be related to the flexibility of the film formed on the skin surface of the product, when the flexibility of the film is high, the invisible protective film is not easy to break, so that the skin can be protected for a long time, and once the formed film is broken, the bacteriostasis composition cannot be uniformly distributed on the skin, so that natural bacteria fall on the skin for permanent planting to different degrees.
Experimental example 2 the results of evaluating the sterilizing effects of the leave-on disinfectants obtained in examples 2-13 in the same manner as in the experiment of example 1 are shown in Table 5.
Table 5 examples 2-13 sustained bacteriostatic results for leave-on disinfectants
As can be seen from the above table, the no-clean disinfectants obtained in examples 2-13 all have strong continuous bacteriostatic effects, and the natural bacteria inhibition rate is over 91% 6 hours after the no-clean disinfectants are applied, which indicates that the no-clean disinfectants of the invention have good bacteriostatic effects.
Experimental example 3 test for improving eczema symptom
Bank clerks 1, woman, age 35, teller, checking banknotes frequently, using common disinfectant products, had eczema, peeling and redness on hands, and the symptoms of eczema disappeared after using the leave-on disinfectant prepared in any one of examples 1-6.
The imaging doctor, female, age 42, hospital frequently disinfected, dry hands, peeled hands and itching, and after the washing-free disinfectant prepared in any one of examples 1-6 is used, the hands become moist and smooth, the peeling phenomenon is avoided, and the itching feeling disappears.
The foregoing is directed to preferred embodiments of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow. However, any simple modification, equivalent change and modification of the above embodiments according to the technical essence of the present invention are within the protection scope of the technical solution of the present invention.
Claims (10)
1. The no-clean disinfectant comprises, by weight, 5-60% of low molecular alcohols, 1-10% of humectants, 0.01-2% of stabilizers, 0.01-2% of hyaluronate, 0.02-1.0% of bactericides, 0.01-2% of film-forming enhancers and the balance of water.
2. A leave-on disinfectant according to claim 1, wherein the low molecular alcohols are present in an amount of 10-50%, preferably 15-45% by weight of the disinfectant; the humectant is 1-8%, preferably 2-5%; the stabilizer is 0.05-1%, preferably 0.1-0.8%; the hyaluronic acid salt is 0.05-1%, preferably 0.1-0.8%; the bactericide is 0.1-0.8%, preferably 0.2-0.5%; the film-forming enhancer is 0.1-1%, preferably 0.1-0.5%.
3. The no-clean disinfectant as set forth in claim 1 or 2, wherein the low molecular alcohol is one or more selected from ethanol, propylene glycol, butylene glycol, isopropyl alcohol, hexylene glycol and phenoxyethanol.
4. A leave-on disinfectant according to any one of claims 1 to 3 wherein the humectant is selected from one or more of butylene glycol, propylene glycol, pentylene glycol, glycerin, betaine, cellulose, carbomer, tremella polysaccharide, acetyl chitosamine, ectoine and trehalose.
5. The no-clean disinfectant as set forth in any one of claims 1-4, wherein the stabilizer is one or more selected from the group consisting of PPG-26-Butaneth-26, PEG-40 hydrogenated castor oil, Tween 80, sodium dihydrogen phosphate, disodium hydrogen phosphate, citric acid, sodium citrate, Tween 20, lactic acid and sodium lactate.
6. A leave-on disinfectant according to any one of claims 1 to 5 wherein the bactericide is selected from one or more of 2, 4-dichlorobenzyl alcohol, benzalkonium bromide, triclosan, benzalkonium chloride and polyhexamethylene guanide.
7. A leave-on disinfectant according to any of claims 1 to 6 wherein the filming enhancer is galactomannan and/or galactosulfate.
8. A preparation method of a no-clean disinfectant comprises the following steps:
mixing a stabilizer, hyaluronate, a film-forming enhancer, an optional pH value regulator, water and an optional essence to obtain a first solution;
mixing low molecular alcohol, humectant and bactericide to obtain a second solution;
dripping the second solution into the first solution to obtain the no-clean disinfectant;
the washing-free disinfectant comprises, by weight, 5-60% of low molecular alcohol, 1-10% of humectant, 0.01-2% of stabilizer, 0.01-2% of hyaluronate, 0.02-1.0% of bactericide, 0.01-2% of film-forming enhancer and the balance of water.
9. The production method according to claim 8, wherein in the step of obtaining the first solution, stirring is performed at a temperature of 40 to 50 ℃; preferably, the heating is followed by incubation at 40-50 ℃ for 4-6 hours.
10. A method of disinfecting comprising applying the leave-on disinfectant of any one of claims 1-7 or prepared according to the preparation method of any one of claims 8-9 to a surface of an object in need thereof or a skin surface of a subject.
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| CN112773885A (en) * | 2021-03-19 | 2021-05-11 | 东北农业大学 | Zein disinfectant and preparation method thereof |
| CN115531254A (en) * | 2022-09-20 | 2022-12-30 | 安徽达尔美生物科技有限公司 | Hand washing-free disinfectant |
| WO2023123421A1 (en) * | 2021-12-31 | 2023-07-06 | 振德医疗用品股份有限公司 | Long-acting antibacterial disinfectant, preparation method therefor and application thereof |
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