JP2006089388A - Quick-drying germicide having excellent skin protection and moisture retaining effects - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a quick-drying germicide that provides a concentration and an action time most suitable for the germicidal action of alcohol and has an excellent protection action on chapped skin. <P>SOLUTION: This quick-drying germicide is obtained by dissolving acetylated sodium hyaluronate in a high-concentration alcohol, exhibits quick-drying properties by the high-concentration alcohol and strong germicidal power in a short time and protects fingers from defatting action and water separation action of the alcohol and protects chapped skin by the acetylated sodium hyaluronate. The number of substitutions of acetyl groups of the acetylated sodium hyaluronate is 2.5-4.5 so as to readily dissolve the acetylated sodium hyaluronate in the alcohol. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a quick-drying fungicide, and more particularly, by combining acetylated sodium hyaluronate and a lower alcohol, while having a strong bactericidal power due to a high concentration of alcohol, an excellent water retention effect and skin protection effect It relates to a quick-drying disinfectant having

Examples of conventional quick-drying fungicides include an example in which a lower alcohol and sodium hyaluronate as a water-soluble polymer are used in combination, or an example in which hyaluronic acid itself is used (see Patent Document 2 below).
JP-A-10-130173 JP-A-6-199700

  However, in the conventional quick-drying disinfectant, sodium hyaluronate as the water-soluble polymer is insolubilized and deposited when the proportion of alcohol increases, and the blending proportion of lower alcohol is about 50% by weight at maximum. There is a problem that the bactericidal action of alcohol is insufficient and the drying speed is also slow.

  Hyaluronic acid itself may be used, but this has problems in storage stability, dissolution stability, etc., and there is a problem in use as a cosmetic.

  As described above, the conventional quick-drying disinfectant has problems in the disinfecting power of alcohol, the protective action of the skin, and the stability, and is not satisfactory. In order to solve the above-described problems, an object of the present invention is to provide a quick-drying fungicide that is excellent in a rough skin protection action while obtaining a concentration and an action time that are most suitable for an alcohol bactericidal action.

  As a means for solving the above-mentioned problems, the quick-drying fungicide of the invention according to claim 1 is a combination of acetylated sodium hyaluronate and a lower alcohol.

  The quick-drying disinfectant of the invention according to claim 2 is a combination of a high-pressure gas such as dimethyl ether, carbon dioxide gas or LPG (liquefied petroleum gas).

  The quick-drying disinfectant of the invention according to claim 3 is further characterized in that the acetylated sodium hyaluronate is an alcohol-soluble sodium acetylated hyaluronate having an acetyl group substitution number of 2.5 to 4.5. .

  The quick-drying disinfectant of the invention according to claim 4 further has a lower alcohol content of 30 to 90% by weight.

  The quick-drying fungicide of the invention according to claim 5 is a combination of one or more of fungicides, antibacterial agents, antifungal agents, antiviral agents and deodorants. Commonly used bactericides include acrinol, benzalkonium chloride, hydrogen peroxide and the like. Commonly used antibacterial, antifungal and antiviral components include fatty acid esters such as isopropyl palmitate and diisopyr It can be combined with plant-derived extracts such as auren extract, garlic extract, sicon extract, docami extract, and grapefruit seed extract, or biological components such as propolis.

  According to the quick-drying disinfectant of the invention according to claim 1, since the acetylated sodium hyaluronate has both hydrophilic and hydrophobic properties due to the acetyl group, the stratum corneum of the skin partially having a hydrophobic surface Uniform film can be formed on the surface, preventing moisture transpiration from the skin, maintaining water retention of skin more than twice that of sodium hyaluronate used in the past, softening skin keratin, rough skin It is superior to sodium hyaluronate in improving effect. For this reason, according to the quick-drying fungicide of the present invention, the alcohol concentration is sufficiently increased to about 70 to 80% to exhibit quick-drying, and almost all bacteria except spores are killed in a short time. It exerts an effective bactericidal power, and further protects the fingers from the strong degreasing and water-removing effects of alcohol by acetylated sodium hyaluronate and has a rough skin protection effect.

  According to the quick-drying disinfectant of the invention according to claim 2, a stable alcohol concentration can be maintained by aerosolizing in a pressurized container by further combining a high-pressure gas such as dimethyl ether, carbon dioxide gas or LPG. If the alcohol concentration is high as in the conventional case, problems such as a gradual change in the alcohol concentration will not occur depending on the material and storage state of the storage container. It is also possible to uniformly diffuse alcohol over a wide range.

  According to the quick-drying disinfectant of the invention according to claim 3, since the acetylated sodium hyaluronate has an acetyl group substitution number of 2.5 to 4.5, it dissolves well in alcohol and has an excellent quick-drying disinfectant. Become an agent.

  According to the quick-drying disinfectant of the invention according to claim 4, since the blending ratio of the lower alcohol can be sufficiently high at 30 to 90% by weight, sufficient disinfecting power can be obtained.

  According to the quick-drying disinfectant of the invention according to claim 5, since the alcohol having quick-drying disinfectant is further combined with a disinfectant, an antibacterial agent, an antifungal agent, an antiviral agent, and a deodorant, Even after transpiration, the effect of maintaining the bactericidal power for a long time can be provided.

  Hereinafter, although an example is given and demonstrated about the quick-drying fungicide of this invention, this invention is not limited to these Examples.

The quick-drying fungicide of Example 1 was obtained by adding 0.5 parts by weight of acetylated sodium hyaluronate to 70 parts by weight of ethanol and dissolving it, and further adding 29.5 parts by weight of purified water.
[Comparative Example 1]

To 60 parts by weight of purified water, 0.5 part by weight of sodium hyaluronate was added and dissolved, and 39.5 parts by weight of ethanol was further added.
[Comparative Example 2]

  It was obtained by adding 30 parts by weight of purified water to 70 parts by weight of ethanol.

  The evaluation test of skin protection and moisturizing effect will be described. Thirty volunteers are divided into three groups, the first group 10 people use the adjustment liquid of Example 1, the second group 10 people use the adjustment liquid of Comparative Example 1, and the third group 10 people use the adjustment liquid of Comparative Example 2. Skin protection and moisturizing effect tests were conducted.

  The first group, the second group, and the third group were rubbed on one hand four times a day, and one week later, both hands were compared, and the sensory test of (A) test side hand and (B) untested side hand Classification was performed based on the criteria, and the skin roughness and moisture retention were compared. The results are shown in Table 2.

  As shown in Table 2, in Example 1 group using acetylated sodium hyaluronate, the sodium hyaluronate of Comparative Example 1 was blended in 39.5 parts by weight ethanol even though 70 parts by weight ethanol was blended. The result was superior in terms of skin protection and moisturizing effect. Normally, rough skin, water separation, etc. tend to increase in proportion to the alcohol concentration, but this example is excellent in skin protection and moisturizing effects to such an extent that the influence of the alcohol concentration can be ignored.

  In general, the bactericidal power of alcohol is determined by the alcohol concentration and the action time. When the alcohol concentration is 70 to 80 parts by weight, there is a bactericidal power that kills most bacteria except spores within 1 second. Therefore, the quick-drying disinfectant of the present example has a sufficient disinfecting effect.

Claims (5)

  A quick-drying disinfectant excellent in skin protection and moisturizing effect comprising acetylated sodium hyaluronate and one or a combination of two or more alcohols selected from the group of ethyl alcohol, modified ethyl alcohol, isopropanol or propanol as a lower alcohol.   The quick-drying disinfectant according to claim 1, wherein a high-pressure gas such as dimethyl ether, carbon dioxide or LPG is combined with the combination.   The quick-drying fungicide according to claim 1 or 2, wherein the acetylated sodium hyaluronate is alcohol-soluble acetylated sodium hyaluronate having an acetyl group substitution number of 2.5 to 4.5.   The quick-drying disinfectant according to claim 1, 2 or 3, wherein the proportion of the lower alcohol is 30 to 90% by weight.   5. The quick according to claim 1, 2, 3 or 4, wherein the composition of the quick-drying fungicide comprises one or a combination of two or more of a fungicide, an antibacterial agent, an antifungal agent, an antiviral agent and a deodorant. Dry germicide.