GB2597120A - Skin disinfectant - Google Patents

Abstract

Cosmetic product for hand disinfection comprising: 50-95 % C1-C4 alcohol; 2-15 % triethyl citrate; and 0.5-8 % glycerine; and/or 1,2-propanediol. The product may comprise: up to 45 % water; 50-95 % ethanol, isopropanol and/or n-propanol; 0.01-0.5 % non-greasing, non-film-forming skin care additive; 0.01-0.5 % ethylhexylglycerine; 0.1-1.5 % 2-butyloctanoic acid; and less than 0.1 % (preferably 0 %) perfume). Also disclosed is a cosmetic procedure for skin disinfection (preferably of hands) where the product is applied to skin and evenly distributed by rubbing. The product is used to combat/eliminate pathogenic microorganisms, preferably viruses, especially sheathed viruses. Also disclosed is the use of triethyl citrate in prolonging the antimicrobial (preferably antiviral) efficacy of a 50 % alcohol skin disinfector, and the use of triethyl citrate in improving skin compatibility, especially reducing skin dehydration, of such compositions.

Description

SKIN DISINFECTANT

TECHNICAL FIELD

100011 The invention is in the area of cosmetics and relates to alcohol-based skin disinfectant with a prolonged effect against pathogenic microorganisms, especially viruses.

BACKGROUND

[0002] Prevention of the transmission and/or spread of pathogenic germs and infectious diseases linked to them is extremely important in hospitals and foodstuff industry operations, but also in schools, kindergartens, hotels, restaurants as well as all areas of public life where many people come across each other.

[0003] A traditional and effect method for reducing and elimination of germs is regular and thorough handwashing with water and soap. Another known method is disinfection of the hands by means of a disinfectant. These are commercially available as lotions, creams, gels, pump or aerosol sprays and offer the advantage that they need not be rinsed off. They can be used quickly and without a problem in case water and soap are not available just then.

[0004] Commercial disinfectants usually comprise > 52% of weight of alcohol (ethanol) and effectively acting antimicrobial component. Alcohols such as ethanol evaporate quickly, which is desirable on the one hand, so that the hands dry quickly after disinfection without any aid, but on the other hand undesired, because there is no antimicrobial action when alcohol evaporates.

[0005] Besides disinfectants with excellent anti-bacterial and anti-fungal properties, disinfectants with higher efficacy against viruses are also increasingly needed due to the repeated global spread of viruses (such as corona viruses) in the recent decades [0006] Hand di sinfectants were disclosed in DE 3187165A 1, which, besides alcohols, al so contain glyceryl ether, glyceryl ester, aromatic alcohols and surfactants Compared with disinfectants containing alcohol as the only active ingredients, they exhibit a significantly improved anti-bacterial action.

[0007] Such preparations, however, show a rather bad skin compatibility due to their surfactant content, because surfactants do not get washed off, thus de-greasing and/or additionally drying the skin due to the high quantities of alcohol.

BRIEF SUMMARY

[0008] The object of the present disclosure is solved by the subject-matter of the independent claims, wherein further embodiments are incorporated in the dependent claims.

DETAILED DESCRIPTION

[0009] The following detailed description is merely exemplary in nature and is not intended to limit the disclosure or the application and uses of the subject matter as described herein. Furthermore, there is no intention to be bound by any theory presented in the preceding background or the following detailed description.

[0010] The task underlying present application is to make available hand disinfectants that exhibit an improved biocidal effect compared to the common commercially available disinfectants.

[0011] The products should be easily and quickly usable and be able to fight against and/or remove microbes of all kinds, especially viruses and particularly sheathed viruses, effectively and in a sustained manner.

[0012] It was possible to achieve these tasks by using the combination of higher quantities of Ci-C4-alcohols, with specific quantities of triethyl citrate as well as glycerin and/or 1,2-Propan edi ol.

[0013] A first object of the invention is, therefore, a cosmetic product for hand disinfection, preferably for disinfection of the hand, which contains (in relation to the total weight of the product) a) 50 to 95% by weight of at least one CI-C4 alcohol, b) 2 to 15 % by weight of Triethyl citrate, c) 0.5 to 8% by weight of glycerin and/or 1,2 propane diol.

[0014] The products as invented, compared with the common commercially available hand disinfectants (which mostly contain alcohol as the only antimicrobial active ingredient), showed a better and more prolonged biocidal effect [0015] They can be equally used for combating and/or eliminating bacteria and/or viruses, especially sheathed viruses and are effective for at least one to two hours after use [0016] The products can be easily manufactured, have better storage stability and have, due to their -preferably fluid -consistency, for the application by means of a pump dispenser, which can be an advantage especially for use in public areas.

[0017] Another advantage is the improved skin compatibility of the products as invented, because they dry the skin (the hands) to a much lower extent than the common commercially available products and they do not leave behind any sticky feel.

[0018] For some application forms, it can be advantageous if the products as invented contain water, besides the components a) to c) The content of water should, however, not be too high, as the products as invented would otherwise be too heavily diluted and their efficacy reduced.

[0019] In a first preferred embodiment, products as invented contain maximum 45% by weight (in relation to their total weight).

[0020] A first essential ingredient in the products as invented is at least one CI-Ca-alcohol Cl-C4-alcohols are easily accessible, have excellent antimicrobial properties and have a refreshing and toning action on the skin [0021] The at least one CI-Ca-alcohol is used in the products as invented in a weight proportion of from about 50 to about 95% by weight, preferably from about 52.5 to about 92.5% by weight and particularly preferably from about 55 to about 90% by weight of the total weight of the product.

[0022] Ethanol, n-propanol and/or isopropanol are considered as suitable C1-C4-alcohols in the context of the present invention.

[0023] For optimization or/or increase in the disinfection effect, it can be advantageous if mixtures of Cl-C4-alcohols are used in the products as invented.

100241 Particularly preferred are mixtures of ethanol and isopropanol in a weight proportion of from about 10: 1 to about 1: 10, preferably from about 7: 3 to about 1: 1.

[0025] In a second preferred embodiment, products as invented contain ethanol, isopropanol and/or n-propanol in a weight proportion of from about 50 to about 95% by weight, preferably from about 52.5 to about 92.5% by weight and particularly preferably from about 55 to about 90% by weight of the total weight of the product.

[0026] Within this embodiment, it is particularly preferred if the product contains ethanol and/or isopropanol in a weight ratio of about 10: Ito about 1: 10, preferably from about 7:3 to about 1: 1.

[0027] Within these embodiments, it is furthermore especially preferred, if the products contain ethanol as the only component a).

[0028] A second essential ingredient in the products as invented as triethyl citrate.

It was found that triethyl citrate - reduces the vapor pressure of Ci-C4-alcohols (especially of ethanol), due to which the alcohols remain on the skin for a longer period and their antimicrobial action can develop for a longer time.

- is split on the skin through hydrolases, due to which citric acid is created and local pH value on the skin is lowered. With lower pH value, viruses, especially sheathed viruses, are destroyed Triethyl citrate supports and accordingly raises the antimicrobial, particularly the anti-viral action of the product, - can be incorporated well into the alcoholic or alcohol-aqueous base of the products as invented and improves their skin compatibility.

Triethyl citrate is used in the products as invented in a weight proportion of about 2 to about 15% by weight, preferably from about 2 to about 12.5% by weight, more preferably from about 2.50 to about 10% by weight, particularly preferably from about 3 to about 10% by weight and especially from about 3 to about 8% by weight on the total weight of the product.

[0029] In a third preferred embodiment, products as invented contain triethyl citrate in a weight proportion of from about 2 to about 12.5% by weight, preferably from about 2.5 to about 10% by weight, more preferably from about 3 to about 10% by weight and especially from about 3 to about 8% by weight of the total weight of the product.

100301 A third essential ingredient in the products as invented is glycerin and/or 1,2-propane diol.

[0031] Glycerin and/or 1,2 propanediol are used in the products as invented, individually or as an arbitrary mixture, in a weight proportion of from about 0.5 to about 8 % by weight, preferably from about 0.5 to about 7% by weight, more preferably from about 0.75 to about 6% by weight, particularly preferably from about 0.75 to about 5% by weight and especially from about 1 to about 5% by weight on the total weight of the product.

100321 Glycerin and/or 1,2 propane diol reduce the skin dehydration accompanying the treatment with alcoholic compositions and contribute towards the conservation of suppleness and elasticity of the skin (especially with frequent disinfection).

100331 Another advantage of glycerin and/or 1,2 propane diol as active skin care ingredient is that they do not leave behind any sticky and/or fatty film on the skin, which is above all important in hospitals, if hand gloves need to be worn immediately after disinfection.

[0034] For further increase in the antimicrobial and/or skin-care properties, the products as invented can contain more optional active ingredients [0035[ Preferred optional active ingredients in the context of the invention are: i. Other non-greasing and non-film-forming skin care additives and/or Other anti-bacterial, antimycotic and/or anti-viral active ingredients.

[0036] Considered under suitable skin care additives ii) are polyols such as propylene glycol, sorbitol, ethylhexyl glycerin, hyaluronic acid and/or their salted forms, urea and/or plant extracts such as aloe vera, which can be used in the products as invented in a weight proportion of from about 0.01 to about 0.5% by weight of the total weight of the product.

100371 In a further preferred embodiment, the products as invented contain at least one non-greasing and non-film-forming skin care additive in a weight proportion of from about 0.01 to about 0.5% by weight of the total weight of the product.

[0038] Within this embodiment, products as invented are particularly preferred, which contain the ethyl hexyl glycerin in the above-mentioned quantities.

[0039] Other suitable anti-bacterial, antimycotic and/or anti-viral active ingredients. ii), are taken to mean preferably 2-butyl octanoic acid, benzalkonium chloride, benzethonium chloride, benzyl alcohol, dehydroacetic acid, parabens, phenoxyethanol, ethylhexyl glycerin, sodium hydroxy methyl glycinate and/or propionic acid, benzoic acid, sorbic acid as well as the salted forms of these acids, which can be used in the products as invented solely or as mixture in a total quantity of from about 0.1 to about 1.5 % by weight On relation to the total weight of the product).

[0040] In a further preferred embodiment, the products as invented contain 2-butyl octanic acid in a weight proportion of from about 0.1 to about 0.5% by weight of the total weight of the product, in weight proportion of from about 0.1 to about 1.5 % by weight of the total weight of the product.

[0041] For some embodiments, it can be advantageous, if the products as invented contain perfumes, in which case, it must be ensured that the perfumes are used in very small quantities and/or do not leave too strong a fragrance behind on the skin (the hands) A fragrance resulting from the separation of perfume oils, which stays on the skin (the hands) and can be sensed for longer than five hours could give the user a false impression that the antimicrobial -preferably antiviral -action is also effective, which impression is not desirable.

[0042] Over and above that, it was established that perfumes show a tendency to hamper the antiviral efficacy of the compositions as invented. It is assumed that some components of commercially available perfume mixtures can react with the citric acid formed on the skin through hydrolases (triethyl citrate), which reduces the pH fall needed for the antiviral action.

[0043] In the case where the products as invented contain a perfume, it is therefore advantageous if they contain the perfume in a weight proportion of less than 0.1% by weight of the total weight of the product. It is preferred to limit the maximum content of perfumes to less than 0.05% by weight, more preferably to 0.025% by weight and especially 0% by weight (in relation to the total weight of the products as invented).

[0044] In a further preferred embodiment, the products as invented (in relation to their total weight) contain less than 0.1 % by weight, preferably less than 0.05% by weight, more preferably less than 0.025% by weight and especially preferably 0% by weight of one or more perfumes.

[0045] Besides the above-mentioned essential and optional ingredients, the products as invented can contain yet more active ingredients, which lend them advantageous properties or reinforce their properties, as the case may be.

In order to avoid negative interactions with the essential components a) to c), above-mentioned optional ingredients are added -if at all -to the products as invented in quantities of maximum 0.001 to 0.5% by weight (in relation to the total weight of the products as invented).

Among the suitable ingredients that are optionally added to the products as invented axe: - Thickeners, such as polyacrylate and/or cellulose derivatives (such as hydroxyethyl cellulose), - Fatty acid esters such as cetyl myristate, isopropyl myristate, glyceryl (di)oleate, isopropyl palmitate, myristyl myristate, - Natural (herbal) oils such as almond oil, sesame oil, sunflower oil, olive oil, avocado oil, walnut oil, Allantoin, Bisabolol.

[0046] The disinfectants as invented for the skin, especially for the hands can be produced by mixing the described ingredients at room temperature (20°C) [0047] The ready-to-use products as invented can preferably be stored in a container with manually operated pump (what are called pump dispensers or pump atomizers) or with electrically activated pump (called sensor dispenser) Alternatively, the products as invented -possibly with higher viscosity in the range of about 300 to 3000 mPas (measured with Brookfield Instrument RVF; 20 revolutions per minute, spindle no. 3, at 25°C) in a container with lid; from which the products can be taken out by pressing or squeezing.

[0048] In this case, suitable thickeners and/or gelling agents can be added to the products as invented.

[0049] As further packing possibilities, containers can be considered, wherein - The products as invented can be combined with air before exiting from a pump, so that they come out as foam, - The products as invented, mixed with a propellant, filled in aerosol cans and taken out as spray. A mixture of propane/butane (15/85) can be considered, for example, as a propellant. The products as invented can be mixed with the propellants, for example, in a weight ratio of I. 3.

[0050] Products for skin disinfection in the context of the present invention, which can be assembled in a pump dispenser, a sensor dispenser or as Aerosol, are preferred.

[0051] A second object of the invention is a cosmetic process for skin disinfection, preferably for disinfection of the hands, in the case of which, a) an effective quantity of a preferably fluid product as invented is applied -preferably sprayed -on the skin surface and optionally b) evenly distributed by rubbing.

[0052] "Fluid" is understood as preferably a viscosity of the products as invented in the range of from 10 to 3000 mPas (measured on the Brookfield Instrument RVF; 20 revolutions per minute, spindle no. 3 at 25°C).

[0053] "Effective quantity" is understood preferably as that quantity of disinfectant as invented, wherein at least 99% of the microbes (also including viruses) on the skin are killed. An effective quantity of the disinfectant as invented is, for example, 0.05 to 5g per cm2 of skin.

[0054] A third object of the invention is the usage of a cosmetic agent for disinfection as invented for combating or elimination of pathogenic microorganisms, preferably viruses and especially sheathed viruses.

[0055] A fourth object of the invention is the usage of tri ethyl citrate in cosmetic products for skin disinfection, which contain at least 50% by weight of at least one Ci-C1-alcohol (in relation to its total weight), for prolongation of the antimicrobial, preferably antiviral, efficacy of the alcohol(s), [0056] A fifth object of the invention is the usage of a combination of triethyl citrate in cosmetic agents for skin disinfection, which contain (in relation to their total weight) 50% by weight of at least one CI-C4-alcohol, for improving the skin compatibility, especially for reducing or avoiding skin dehydration.

[0057] For the method as invented and the usages as Invented, the same applies as for the products as invented.

[0058] The following examples are intended to further explain the objects of the present invention without, however, being limitative.

Examples:

[0059] The following cosmetic disinfectant as invented for the hands have been manufactured (the quantities given are based on weight %]): a) Formulations for pump dispensers P1 P2 P3 P4 Ethanol (96%) 55 75 62 60 Tri ethyl citrate 3 6 5 3 Glycerin 1 - 2 3 1.2-propanediol 2 1 Ethylhexyl glycerin 0.1 0.3 - 0.5 2-Butyloctanoic acid 0.3 0.7 Polyglycery1-3 caprylate - - - 0.5 Perfume 0.1 0.05 Water ad 100 ad 100 ad 100 ad 100 b) Formulations for Aerosol AS A6 A7 A8 Ethanol (99%) 91.5 92.9 86.3 88 Tri ethyl citrate 6.0 3 8 10 Glycerin 1.0 2 - 0.5 1.2-propanediol - - 5 - 2-Butyloctanoic acid 0.3 0.5 0.3 0.3 Polyglyceryl -3 capryl ate 0.4 0.7 0.4 0.4 Phenoxyethanol 0.8 0.8 0.7 Perfume - 0.1 - 0.1 100601 The recipes 5 to 8 were bottled respectively in the weight ratio of 1 3 with the propellant mixture propane/butane (15/85) in Aerosol cans.

[0061] The antibacterial efficacy of the formulations P1 and AS was determined in accordance with EN 1276. Staphylococcus aureus, Pseudomonas Aeruginosa, Escherischa Coli and Enterococcis Hirae were selected as test germs in conformance with EN 1276 and 1 minute and 5 minutes were selected as contact time.

[0062] The tables below show that the required germ count reduction was achieved by a factor of I 05 under all conditions.

Staphylococcus aureus Formula Test concentration Reduction after 1 Reduction after 1 minute (log Levels) (%) minute (log Levels) P1 80 >5.35 >5.35 AS 80 >5.35 >5.35 Pseudomonas aeruginosa Formula Test concentration Reduction after I Reduction after 1 minute (log Levels) (°10) minute (log Levels) P1 80 >5.44 >5.44 AS 80 >5.44 >5.44 Escherischa coli Formula Test concentration Reduction after 1 Reduction after 1 minute (log Levels) (%) minute (log Levels) P1 80 >5.57 >5.57 AS 80 >5.57 >5.57 Enterodoccus hirae Formula Test concentration Reduction after 1 Reduction after 1 minute (log Levels) (%) minute (log Levels) P1 80 >5.48 >5.48 AS 80 >5.48 >5.48 [0063] The antiviral efficacy of the formulations P1 and AS was determined in accordance with EN 14476:2012-10. In the case of this test procedure, a reduction of the virus organism

II

by a factor of 104 for antiviral products. This efficacy level was reached by means of the formulas PI and AS.

Modified-Vaccinia-Ankara Voris, clone 6 Formula Test concentration Reduction after 30 Reduction after 60 seconds (log Levels) (%) seconds (log Levels) PI 80 >4.0 >4.0 AS 80 >4.0 >4.0 [0064] While at least one exemplary embodiment has been presented in the foregoing detailed description, it should be appreciated that a vast number of variations exist. It should also be appreciated that the exemplary embodiment or exemplary embodiments are only examples, and are not intended to limit the scope, applicability, or configuration of the various embodiments in any way. Rather, the foregoing detailed description will provide those skilled in the art with a convenient road map for implementing an exemplary embodiment as contemplated herein. It being understood that various changes may be made in the function and arrangement of elements described in an exemplary embodiment without departing from the scope of the various embodiments as set forth in the appended claims.

Claims (4)

1. Patent claims: 1. Cosmetic product for hand disinfection, preferably for disinfection of the hands, comprising On relation to the total weight of the product) a) about 50 to 95% by weight of at least one Ci-C4 alcohol, b) about 2 to 15 % by weight of Methyl citrate, c) about 0.5 to 8% by weight of glycerin and/or 1,2 propane diol.
2. 2 Cosmetic product for skin disinfection as claimed in Claim 1, comprising up to 45% by weight of water (in relation to the total weight of the product).
3. Cosmetic product for skin disinfection, as claimed in Claim 1 or Claim 2, comprising ethanol, isopropanol and/or n-propanol in a weight proportion of from about 50 to about 95% by weight, preferably from about 52.5 to about 92.5% by weight and particularly preferably from about 55 to about 90% by weight of the total weight of the product.
4. 4 Cosmetic product for skin disinfection as claimed in Claim 3, comprising ethanol and/or isopropanol, particularly preferably ethanol 5. Cosmetic product for skin disinfection as claimed in any one of the preceding claims, comprising triethyl citrate in a weight proportion of from about 2 to about 12.5% by weight, preferably from about 2.5 to about 10% by weight, more preferably from about 3 to about 10% by weight, and especially from about 3 to about 8% by weight of the total weight of the product.6. Cosmetic product for hand disinfection as claimed in any one of the preceding claims, comprising at least one non-greasing and non-film-forming skin care additive in a weight proportion of from about 0.01 to about 0.5% by weight of the total weight of the product.7. Cosmetic product for skin disinfection as claimed in any one of the preceding claims, comprising Ethylhexyl glycerin in a weight proportion of from about 0.01 to about 0.5% by weight of the total weight of the product. I 38. Cosmetic product for hand disinfection as claimed in any one of the preceding claims, comprising 2-butyl octanoic acid in a weight proportion of from about 0.1 to about 1.5 % by weight of the total weight of the product.9. Cosmetic product for skin disinfection as claimed in any one of the preceding claims, comprising On relation to their total weight) less than 0.1 % by weight, preferably less than 0.05% by weight, more preferably less than 0.025% by weight and especially preferably 0% by weight of one or more perfumes 10. Cosmetic procedure for skin disinfection, preferably for disinfection of the hands, in which a) an effective quantity of a preferably fluid agent as claimed in any one of the preceding claims is applied on the skin surface -preferably sprayed -and optionally b) evenly distributed by rubbing 11. Use of a cosmetic product for skin disinfection as claimed in any one of Claims 1 to 9 for combating or elimination of pathogenic microorganisms, preferably viruses and especially sheathed viruses.U. Use of triethyl citrate in cosmetic products for skin disinfection, wherein the cosmetic products contain at least 50% by weight of at least one CI-C4-alcohol (in relation to its total weight), for prolongation of the antimicrobial, preferably antiviral, efficacy of the alcohol(s), 13. Use of triethyl citrate in cosmetic agents for skin disinfection, wherein the cosmetic products contain (in relation to their total weight) at least 50% by weight of at least one CI-Ca-alcohol, for improving the skin compatibility, especially for reducing or avoiding skin dehydration