CN112773885A - Zein disinfectant and preparation method thereof - Google Patents
Zein disinfectant and preparation method thereof Download PDFInfo
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- CN112773885A CN112773885A CN202110316946.9A CN202110316946A CN112773885A CN 112773885 A CN112773885 A CN 112773885A CN 202110316946 A CN202110316946 A CN 202110316946A CN 112773885 A CN112773885 A CN 112773885A
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- 239000005019 zein Substances 0.000 title claims abstract description 79
- 229920002494 Zein Polymers 0.000 title claims abstract description 73
- 229940093612 zein Drugs 0.000 title claims abstract description 73
- 239000000645 desinfectant Substances 0.000 title claims abstract description 63
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- KPZNAIJVCZDUKU-UHFFFAOYSA-N ethanol;propan-2-ol;hydrate Chemical compound O.CCO.CC(C)O KPZNAIJVCZDUKU-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000006366 phosphorylation reaction Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 claims abstract description 9
- 230000004048 modification Effects 0.000 claims abstract description 7
- 238000012986 modification Methods 0.000 claims abstract description 7
- 239000002904 solvent Substances 0.000 claims abstract description 6
- 230000008014 freezing Effects 0.000 claims description 12
- 238000007710 freezing Methods 0.000 claims description 12
- 239000003755 preservative agent Substances 0.000 claims description 8
- 230000002335 preservative effect Effects 0.000 claims description 8
- 239000012488 sample solution Substances 0.000 claims description 8
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- 230000026731 phosphorylation Effects 0.000 claims description 4
- 231100000252 nontoxic Toxicity 0.000 claims description 3
- ZIOLTJBZBPZMDC-UHFFFAOYSA-N ethanol;propan-1-ol;hydrate Chemical compound O.CCO.CCCO ZIOLTJBZBPZMDC-UHFFFAOYSA-N 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 5
- 239000002612 dispersion medium Substances 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 241000700605 Viruses Species 0.000 abstract description 2
- 230000002045 lasting effect Effects 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 34
- 239000000243 solution Substances 0.000 description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
- 239000000047 product Substances 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 229910019213 POCl3 Inorganic materials 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl chloride Substances ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 3
- 239000012088 reference solution Substances 0.000 description 3
- 206010067482 No adverse event Diseases 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000002715 modification method Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010040849 Skin fissures Diseases 0.000 description 1
- PPWHTZKZQNXVAE-UHFFFAOYSA-N Tetracaine hydrochloride Chemical compound Cl.CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 PPWHTZKZQNXVAE-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- AINBZKYUNWUTRE-UHFFFAOYSA-N ethanol;propan-2-ol Chemical compound CCO.CC(C)O AINBZKYUNWUTRE-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 208000001875 irritant dermatitis Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
The invention relates to a disinfection product, in particular to a zein disinfectant and a preparation method thereof. POCl is used in the present application3Phosphorylation modification is carried out, a dispersion medium of the zein is changed, the solubility of the zein is increased, the zein is dissolved in an isopropanol-ethanol-water solvent, and the properties of film forming, water drainage and the like are utilized to realize the disinfection effect of the zein disinfectant, reduce the damage of the disinfectant to the skin and develop the zein disinfectant. The invention can be diluted into various concentrations, can kill various bacteria and viruses, and has the advantages of quick and lasting sterilization, good safety and convenient use.
Description
Technical Field
The present invention relates to a disinfecting product.
Background
The disinfectant is an agent that disinfects or sterilizes by killing microorganisms on the transmission medium. It can be divided into skin disinfectant, air disinfectant, epidemic focus disinfectant, etc. The skin disinfectant is a disinfection product for preventing and controlling germ infection and is used for skin, mucous membrane, wound, burn wound and other parts. Damaged skin is also easy to irritate and corrode, and the requirement on safety of disinfectant is higher. At present, most of skin disinfectants for protection are neutral disinfectants, can be used for whole skin, and are mainly sprayed and smeared. Currently, most of the skin disinfectants used in daily hand protection in the market comprise alcohols, iodides, surfactants, phenols and peroxides.
The ethanol disinfectant is ethanol with the concentration of 70-80% and a compound product thereof, the recommended concentration is 75%, and the ethanol disinfectant is mainly used for disinfecting hands and skins of other parts. Alcohols are neutral disinfectants which act by destroying the bacterial cell wall, denaturing proteins, and destroying the microbial enzyme system. But ethanol is highly volatile, so its disinfection duration is not good. Moreover, the alcohol disinfectant can dissolve lipid membranes on the skin surface, so that physical barriers of the skin are easily damaged, chapped skin is generated, the skin permeability is increased, and the alcohol disinfectant can permeate into active epidermal layers to induce irritant dermatitis and generate symptoms of skin itch, erythema, pimple, blister and the like by continuously using the disinfectant. In addition, skin disinfectants can affect the normal flora structure of the skin, cause the pH of the skin to rise, affect the formation of natural moisturizing factors and intercellular lipids in the skin, and cause skin barrier damage.
When the skin disinfectant is used for disinfection, the skin disinfectant has certain damage to the skin of hands of a human body, the skin disinfectant can take away skin moisture due to volatility, skin chaps are caused, skin barriers are damaged, the risk of contact dermatitis caused by irritation exists, and therefore different people need to use the skin disinfectant scientifically and normatively according to occupation and use environments, moisturize and moisten the skin, and prevent allergy.
Zein is insoluble in water and absolute alcohol, but can be dissolved in an alcohol aqueous solution with the volume fraction of 60-95%. Although the amino acid composition of the zein is unbalanced, the zein has unique solubility, molecular shape and molecular structure, can form a transparent, soft and uniform preservative film, and is an ideal natural preservative film material. Zein films are renewable and degradable, and their potential value has been deeply explored at present. In addition, the zein also has good emulsifying property, water retention property, extensibility, elasticity and the like, and has wide application prospect in cosmetics and skin care products.
In view of the current situation of skin disinfectants, the screening of the skin disinfectants which are safe, efficient, free of toxic and side effects, moist and pleasant in smell is of great significance. The water holding capacity, ductility and elasticity of zein make it possible to prepare an improved disinfectant with low damage and strong disinfection duration. The amino acid composition of zein is special, and lysine and tryptophan are lacked, so that the zein has low nutritional value, and the non-nutritional function becomes an important direction for development and utilization. More than half of zein is hydrophobic amino acid, insoluble in water and therefore difficult to be utilized by organisms, and these disadvantages lead to its limited application. With the progress of science and technology and the increasing demand of people, the functional properties of natural proteins can not be met, the proteins need to be modified manually, and simply, different experimental methods are adopted to influence the molecular structure and aggregation mode of the proteins, so that the functional properties of the proteins are correspondingly improved.
POCl is used in the present application3The phosphorylation modification is carried out to change the dispersion medium of the zein, the solubility of the zein is increased, the zein is easy to dissolve in an ethanol-isopropanol solvent, and the properties of film forming, water drainage and the like are utilized to realize the disinfection effect of the zein, reduce the damage of the traditional disinfectant to the skin and have a certain protection effect on the skin. The zein disinfectant is developed, and theoretical basis is provided for widening the application range of zein in industrial production.
Disclosure of Invention
The object of the invention is to use POCl3Phosphorylation modification is carried out, a dispersion medium of the zein is changed, the solubility of the zein is increased, the zein is dissolved in an isopropanol-ethanol-water solvent, and the properties of film forming, water drainage and the like are utilized to realize the disinfection effect of the zein disinfectant, reduce the damage of the disinfectant to the skin and develop the zein disinfectant. The invention can diluteThe disinfectant has various concentrations, can kill various bacteria and viruses, and has the advantages of quick and lasting sterilization, good safety and convenient use.
The method of the invention comprises the following steps:
the zein disinfectant and the preparation method thereof are characterized in that the method comprises the following steps: (1) use of POCl for zein3Phosphorylation, which improves zein solubility and water absorption; (2) taking the modified zein solution as background, preparing 1%, 2% and 3% mass concentration zein disinfectant standard sample solution by using 3 types of isopropanol-ethanol-water solutions (10% -80% -10%, 20% -70% -10% and 30% -60% -10%) with different mass concentrations; (3) placing a rotor at normal temperature, covering a preservative film, and mixing and stirring by a magnetic stirrer, wherein the rotating speed is controlled at 40 revolutions for 6 minutes; (4) the volatility and the freezing point of the zein disinfectant are measured, and the zein disinfectant has low volatility and freezing point, moderate viscosity, strong skin affinity and good coexistence with other components; (5) packaging and inspecting the finished product, and storing at normal temperature in dark.
The modification method is POCl3And (4) phosphorylation modification.
The disinfectant is zein which has no toxic effect in food.
The basic concentration of the components of the disinfection solution corresponds to that the zein solution and 3 isopropanol-ethanol-water solutions (10% -80% -10%, 20% -70% -10% and 30% -60% -10%) with different mass concentrations are prepared into zein disinfection solution standard sample solutions with mass concentrations of 1%, 2% and 3%.
The optimal formula of the disinfection solution is based on an isopropanol-ethanol-water solution with the mass concentration of 20% -70% -10% as a solvent, and the prepared zein disinfection solution with the mass concentration of 1%.
Drawings
FIG. 1 is a technical flow diagram of the present invention;
FIG. 2 is a graph of the dissolution characteristics of zein after modification;
Detailed Description
The zein disinfectant and the preparation method thereof are characterized in that the method comprises the following steps: (1) use of POCl for zein3Phosphorylation, which improves zein solubility and water absorption; (2) taking the modified zein solution as background, preparing 1%, 2% and 3% mass concentration zein disinfectant standard sample solution by using 3 types of isopropanol-ethanol-water solutions (10% -80% -10%, 20% -70% -10% and 30% -60% -10%) with different mass concentrations; (3) placing a rotor at normal temperature, covering a preservative film, and mixing and stirring by a magnetic stirrer, wherein the rotating speed is controlled at 40 revolutions for 6 minutes; (4) the volatility and the freezing point of the zein disinfectant are measured, and the zein disinfectant has low volatility and freezing point, moderate viscosity, strong skin affinity and good coexistence with other components; (5) packaging and inspecting the finished product, and storing at normal temperature in dark.
The modification method is POCl3And (4) phosphorylation modification.
The disinfectant is zein which has no toxic effect in food.
The basic concentration of the components of the disinfection solution corresponds to that the zein solution and 3 isopropanol-ethanol-water solutions (10% -80% -10%, 20% -70% -10% and 30% -60% -10%) with different mass concentrations are prepared into zein disinfection solution standard sample solutions with mass concentrations of 1%, 2% and 3%.
The optimal formula of the disinfection solution is based on an isopropanol-ethanol-water solution with the mass concentration of 20% -70% -10% as a solvent, and the prepared zein disinfection solution with the mass concentration of 1%.
Example 1
(1) Use of POCl for zein3Phosphorylation, which improves zein solubility and water absorption;
(2) preparing a standard sample solution of the zein disinfectant with the mass concentration of 1%, 2% and 3% by using a reference solution with the mass concentration of an isopropanol-ethanol-water solution of 10% -80% -10% as background;
(3) placing a rotor at normal temperature, covering a preservative film, and mixing and stirring by a magnetic stirrer, wherein the rotating speed is controlled at 40 revolutions for 6 minutes;
(4) the volatility and the freezing point of the zein disinfectant are measured, and the zein disinfectant has low volatility and freezing point, moderate viscosity, strong skin affinity and good coexistence with other components;
(5) packaging and inspecting the finished product, and storing at normal temperature in dark.
Example 2
(1) Use of POCl for zein3Phosphorylation, which improves zein solubility and water absorption;
(2) preparing a standard sample solution of the zein disinfectant with the mass concentration of 1%, 2% and 3% by using a reference solution with the mass concentration of an isopropanol-ethanol-water solution of 20% -70% -10% as background; (ii) a
(3) Placing a rotor at normal temperature, covering a preservative film, and mixing and stirring by a magnetic stirrer, wherein the rotating speed is controlled at 40 revolutions for 6 minutes;
(4) the volatility and the freezing point of the zein disinfectant are measured, and the zein disinfectant has low volatility and freezing point, moderate viscosity, strong skin affinity and good coexistence with other components;
(5) packaging and inspecting the finished product, and storing at normal temperature in dark.
Example 3
(1) Use of POCl for zein3Phosphorylation, which improves zein solubility and water absorption;
(2) preparing a standard sample solution of the zein disinfectant with the mass concentration of 1%, 2% and 3% by using a reference solution with the mass concentration of an isopropanol-ethanol-water solution of 30% -60% -10% as background; (ii) a
(3) Placing a rotor at normal temperature, covering a preservative film, and mixing and stirring by a magnetic stirrer, wherein the rotating speed is controlled at 40 revolutions for 6 minutes;
(4) the volatility and the freezing point of the zein disinfectant are measured, and the zein disinfectant has low volatility and freezing point, moderate viscosity, strong skin affinity and good coexistence with other components;
(5) packaging and inspecting the finished product, and storing at normal temperature in dark.
Claims (4)
1. The zein disinfectant is characterized in that the zein disinfectant with the mass concentration of 1% is prepared by taking an isopropanol-ethanol-water solution with the mass concentration of 20% -70% -10% as a solvent.
2. The method for developing a zein disinfectant as claimed in claim 1, comprising the following steps: (1) use of POCl for zein3Phosphorylation, which improves zein solubility and water absorption; (2) taking the modified zein solution as background, preparing 1%, 2% and 3% mass concentration zein disinfectant standard sample solution by using 3 propanol-ethanol-water solutions (10% -80%, 20% -70% and 30% -60%) with different mass concentrations, (3) placing a rotor at normal temperature, covering a preservative film, mixing and stirring through a magnetic stirrer, controlling the rotating speed at 40 revolutions for 6 minutes, (4) measuring the volatility and the freezing point of the zein disinfectant, wherein the volatility and the freezing point are lower, the zein disinfectant has moderate viscosity and stronger skin affinity, and has good coexistence with other components, and (5) packaging and inspecting the finished product, and keeping the product at normal temperature in a dark place.
3. The zein disinfectant as claimed in claim 1, wherein POCl is used as a carrier3And (4) phosphorylation modification.
4. The zein disinfectant of claim 1 and its preparation, wherein the zein disinfectant is a non-toxic zein from food.
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| CN202110316946.9A CN112773885A (en) | 2021-03-19 | 2021-03-19 | Zein disinfectant and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114656548A (en) * | 2022-04-13 | 2022-06-24 | 练文飞 | Antihypertensive peptide, and preparation method and application thereof |
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| CN109265706A (en) * | 2018-09-20 | 2019-01-25 | 河南科技学院 | A kind of modified corn alcohol soluble protein and preparation method thereof and antibacterial film preparation |
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| CN112209998A (en) * | 2020-10-10 | 2021-01-12 | 国投生物科技投资有限公司 | Ultrasonic-assisted extraction method of corn protein |
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2021
- 2021-03-19 CN CN202110316946.9A patent/CN112773885A/en active Pending
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| CN109265706A (en) * | 2018-09-20 | 2019-01-25 | 河南科技学院 | A kind of modified corn alcohol soluble protein and preparation method thereof and antibacterial film preparation |
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| 银燕，等: "醇类消毒剂及其制剂的发展", 《中国消毒学杂志》 * |
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| CN114656548A (en) * | 2022-04-13 | 2022-06-24 | 练文飞 | Antihypertensive peptide, and preparation method and application thereof |
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