CN107106434A - Cosmetic composition comprising paraanisic acid and hydroxyacetophenone, its purposes and its cosmetic method - Google Patents
Cosmetic composition comprising paraanisic acid and hydroxyacetophenone, its purposes and its cosmetic method Download PDFInfo
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- CN107106434A CN107106434A CN201480084367.4A CN201480084367A CN107106434A CN 107106434 A CN107106434 A CN 107106434A CN 201480084367 A CN201480084367 A CN 201480084367A CN 107106434 A CN107106434 A CN 107106434A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The cosmetic composition of the combination comprising at least one aqueous phase and paraanisic acid and hydroxyacetophenone is provided, wherein the pH value of the composition is less than or equal to 6.Its purposes and cosmetic method are also provided.
Description
The present invention relates to the combination of paraanisic acid and hydroxyacetophenone, its use in skin nursing aqueous cosmetics composition
On the way, particularly useful as cosmetic overlay film (mask), and the cosmetic method of the cosmetic composition is used.
In manufacture or consumer during use, cosmetic composition is sensitive to microorganism pollution.Therefore, preservative is used for
The microorganism contacted in cosmetic composition with kill with these compositions.The preservative can during protecting a product from manufacture
The microorganism pollution (also referred to as primary contact scar) that can occur, and dirt is protected a user from during use in cosmetic composition
Dye or infection (also referred to as secondary pollution).
Many different types of conventional preservatives are developed to provide enough antimicrobial acivities to cosmetic composition.
These preservatives allow to protect cosmetic composition well during primary contact scar and/or secondary pollution.
In addition, consumer seeks comfortable dermal sensation after cosmetic composition applies." comfortable dermal sensation " anticipates
It is intended to represent after cosmetic composition applies softness, moisturizing, the non-stimulated and/or sensation do not itched.Therefore, enough anti-micro- lifes
Thing is active and balances matching somebody with somebody in typically cosmetic field between comfortable dermal sensation after cosmetic composition application
The target to be realized of person processed.
Up to the present, the combination of such as phenoxetol, paraanisic acid and methyl p-hydroxybenzoate is used for routine
In cosmetic composition, for preventing them by microorganism pollution.
However, this combination is not fully satisfactory, because when in for any kind of cosmetic composition, especially
During skin overlay film (skin mask) form when in the composition for aqueous solution form, more particularly as an aqueous solution,
It may be without expected antimicrobial acivity.In addition, consumer expects the comfortable dermal sensation improved after applying, such as
Softness, moisturizing, the non-stimulated and/or sensation do not itched, especially when cosmetic composition will be applied on skin for a long time,
Such as skin overlay film.
Therefore exist and be in afterwards to during and/or after application, applying (such as 10 minutes) for a long time especially on skin
Existing effect and broad-spectrum anti-microbial activity and improved dermal sensation (that is, softness, moisturizing, the non-stimulated and/or sensation do not itched)
Cosmetic composition demand.Stable and comfortable cosmetic composition is also needed to be applied on skin.
One of target of the present invention is to provide composition, has during and/or after the composition is applied comfortable
Dermal sensation.
One of target of the present invention is to provide during primary contact scar and/or secondary pollution, that is, is manufacturing and/or consuming
Person has the composition of good antimicrobial acivity during use.
One of target of the present invention is to provide stable cosmetic composition, its group comprising paraanisic acid and hydroxyacetophenone
Close.
One of target of the present invention is to provide the Aquo-composition comprising combinations thereof, and its pH is less than or equal to 6.
One of target of the present invention is to provide the cosmetic composition comprising combinations thereof, and it is used as skin overlay film, preferably
Facial mask (face mask).
One of target of the present invention is to provide the cosmetic composition in aqueous solution form.
One of target of the present invention is to provide skin care compositions and methods, and it preferably has moistening effect.
Therefore, the present invention relates to the cosmetics group of the combination comprising at least one aqueous phase and paraanisic acid and hydroxyacetophenone
Compound, wherein the pH value of the composition is less than or equal to 6.
The invention further relates to purposes of the combination of paraanisic acid and hydroxyacetophenone in cosmetic composition is prepared.
The invention further relates to purposes of the cosmetic composition as defined above as skin overlay film.
The invention further relates to cosmetic care method, it include by according to the cosmetic composition of the present invention be applied to
Step on a few skin area.
Present inventor have found that when the local cosmetics group for applying the combination comprising paraanisic acid and hydroxyacetophenone
During compound, the combination used causes dermal sensation improve and/or comfortable in cosmetic composition of the invention.
Therefore, the combination of the paraanisic acid and hydroxyacetophenone in the cosmetic composition of the present invention is preventing microorganism
Grow and effective with skin-compatible aspect.
Term " preservative " can refer to the examination for being used to suppress microorganism growth purpose therein included in cosmetic composition
Agent.
When " comfortable dermal sensation " can represent to apply cosmetic composition of the invention in part and/or afterwards,
On skin selected from least one of softness, moisturizing, the non-stimulated and sensation do not itched sensation.
Therefore, the combination of cosmetic composition of the invention comprising paraanisic acid and hydroxyacetophenone.The invention further relates to right
The combination of anisic acid and hydroxyacetophenone.
Paraanisic acid is used in the cosmetic composition of the present invention.
Paraanisic acid, its No. CAS be 100-09-4, also referred to as 4- anisic acids, 4- methoxy benzoic acids, to methoxybenzene first
Acid or anisic acid (draconic acid).Paraanisic acid has lower formula (I)：
。
It can be mentioned that, this product for example sold by Merck companies with title 4- methoxy benzoic acids.
According to the present invention, the cosmetic composition also includes hydroxyacetophenone.
More particularly, cosmetic composition of the invention includes hydroxyacetophenone or parahydroxyacet-ophenone, and its No. CAS is 99-
93-4 and also known as 1- (4- hydroxy phenyls)-ethyl ketone.
Hydroxyacetophenone has lower formula (II)：
。
It can be mentioned that by Symrise companies with title Symsave®The product of H sale.
The cosmetic composition of the present invention has the pH less than or equal to 6.Preferably, the pH value of the cosmetic composition
Between 4 and 6, it is more preferably between (is comprised between) between 5 and 6.
The invention further relates to purposes of the combination of paraanisic acid and hydroxyacetophenone in cosmetic composition is prepared.
In one embodiment, relative to the gross weight of composition, cosmetic composition of the invention includes 0.01 weight
Measure % to 1 weight %, preferably 0.05 weight % to 0.5 weight %, more preferably 0.1 weight % to 0.2 weight % paraanisic acid.
In one embodiment, relative to the gross weight of composition, cosmetic composition of the invention includes 0.01 weight
Measure % to 1 weight %, preferably 0.1 weight % to 0.6 weight %, even more preferably 0.4 weight % to 0.6 weight % hydroxyacetophenone.
According to specific embodiment, relative to the gross weight of composition, cosmetic composition of the invention includes 0.05
Weight % to 0.5 weight % paraanisic acid and 0.1 weight % to 0.6 weight % hydroxyacetophenone.
In certain embodiments, relative to the gross weight of composition, cosmetic composition of the invention includes 0.1 weight
Measure % paraanisic acid and 0.5 weight % hydroxyacetophenone.
More particularly, relative to the gross weight of composition, cosmetic composition of the invention includes at least one aqueous phase, with
And following combination：
- 0.1 weight % to 0.5 weight % paraanisic acid, and
- 0.1 weight % to 0.6 weight % hydroxyacetophenone,
The pH value of wherein described composition is between 4 and 6.
In certain embodiments, the cosmetic composition further comprising at least one dihydric alcohol such as propane diols,
At least one hydrophily gelling agent and at least one NMF.
Physiologically acceptable medium
Physiologically acceptable medium can be included according to the cosmetic composition of the present invention.
Term " physiologically acceptable medium " is intended to represent to be particularly suitable for apply the composition of the present invention to skin
The medium of skin or lip.
The physiologically acceptable medium is generally suitable for the supporter that the composition should be applied thereto
(support) property, and the composition is also adapted to by packaged mode.
Aqueous phase
The cosmetic composition of the present invention includes aqueous phase.
In one embodiment, water is included according to the aqueous phase of the composition of the present invention.
According to an embodiment, at least 50 weight %, preferably at least 70 weights are accounted for according to the aqueous phase of the composition of the present invention
Measure %, more preferably at least 80 weight %, relative to the gross weight of the composition.
According to an embodiment, cosmetic composition of the invention is the aqueous solution." aqueous solution " can be represented comprising at least
The composition of 50% aqueous phase, the composition is in room temperature (between 20 °C and 25 °C) and atmospheric pressure (about 1 013,25 hPa)
Under be in a liquid state.
The aqueous phase can also include miscible organic solvents (under 20 DEG C -25 DEG C of environment temperature), such as, for example with
The monohydric alcohol of 2 to 6 carbon atoms, such as ethanol, isopropanol；Polyalcohol, especially has 2 to 20 carbon atoms, preferably with 2 to 10
Individual carbon atom, and preferably there are 2 to 6 carbon atoms, such as glycerine, propane diols, butanediol, pentanediol, hexylene glycol, pungent ethylene glycol
(caprylyl glycol), dipropylene glycol, diglycol；Glycol ethers (especially have 3 to 16 carbon atoms), such as
MPG-, dipropylene glycol-or tripropylene glycol (C1-C4) alkyl ether, monoethylene glycol-, diglycol-or two
Contracting triethylene glycol (C1-C4) alkyl ether and its mixture.
The aqueous phase can also gather comprising any water-soluble or dispersible compounds compatible with aqueous phase, such as gelling agent, film forming
Compound, thickener, surfactant and its mixture.
According to preferred embodiment, the present invention is that the cosmetics of the combination comprising paraanisic acid and hydroxyacetophenone are water-soluble
Liquid, wherein the pH value of the solution is less than or equal to 6.
Activating agent (actives)
In one embodiment, the cosmetic composition is preferably selected from moisturizing also comprising at least one cosmetic active agent
Agent, renovation agent (healing agents) and/or age resister, are chosen more particularly from NMF.
Therefore, the mixture of single-activity agent or some activating agents can be included according to the composition of the present invention.
In preferred embodiments, the NMF is selected from Sodium Hyaluronate, propane diols, D-sorbite and/or it is mixed
Compound.
In one embodiment, relative to the gross weight of composition, composition of the invention be included in 0.01 weight % and
Between 15 weight %, preferably between 1 weight % and 10 weight %, the activating agent more preferably between 1 weight % and 5 weight %.
NMF
According to an embodiment, the composition is also comprising at least one NMF (also referred to as wetting agent).
As wetting agent or NMF, D-sorbite, polyalcohol, preferably C especially can be mentioned that2-C8 Alcohol, and even more preferably
C3-C6Alcohol, such as preferably glycerine, propane diols, 1,3-BDO, dipropylene glycol, diglycerol and its mixture, glycerine and its spread out
Biological, urea and its derivative, the Hydrovance especially sold by National Starch (2- ethoxys urea), lactic acid, thoroughly
Bright matter acid, Sodium Hyaluronate, AHA, BHA, Pidolic Acid sodium, xylitol, serine, sodium lactate, Ectoin and its derivative,
Chitosan-phospholipid complex, collagen, planktonic organism (plankton), the cogongrass sold by Sederma with title Moist 24
(Imperata cylindrica) Lipidure-HM of extract, acrylate homopolymer such as from NOF Corporation®、
Beta glucan and especially from Mibelle-AG-Biochemistry carboxymethyl R-glucan sodium；By Nestle with title
NutraLipids®The passionflower of sale, apricot, the mixture of corn and rice bran；C- glycosides derivatives are as applied for WO 02/051828
Described in those and particularly C- β-D- xylopyranoses glucosides -2- hydroxy propanes, in 30 weight % active materials in water/propane diols
Solution form in mixture (60/40 weight %), such as by CHIMEX with trade name MEXORYL SBB®The product of preparation；
The rose hip oil sold by Nestle；By Vincience with title Algualane Zinc®The purple ball of the microalgae rich in zinc of sale
Algae (Porphyridium cruentum) extract；By Engelhard Lyon with title marine filling spheres
The collagen of the marine source of sale and the spheroid (lacking atelocollagen (Atelocollagen)) of chondroitin sulfate；Hyaluronic acid spheroid,
As sold by Engelhard Lyon；And arginine.
Preferably, by using selected from following NMF：Glycerine, urea and its derivative, especially by National Starch
The Hydrovance of sale®, hyaluronic acid AHA, BHA, acrylate homopolymer is as from NOF Corporation
Lipidure-HM®, beta glucan and especially from Mibelle-AG-Biochemistry carboxymethyl R-glucan sodium；By
Nestle is with title NutraLipids®The passionflower of sale, apricot, the mixture of corn oil and rice bran；C- glycosides derivatives such as Shen
Those and particularly C- β-D- xylopyranoses glucosides -2- hydroxy propanes that please be described in WO 02/051828, in 30 weight % active matters
Solution form of the matter in water/propylene glycol mixture (60/40 weight %), such as by CHIMEX with trade name MEXORYL SBB®
The product of preparation；The rose hip oil sold by Nestle；By Vincience with title Algualane Zinc®That sells is rich in
The purple ball algae extract of the microalgae of zinc；The ocean sold with title marine filling spheres by Engelhard Lyon Lai
The collagen in source and the spheroid (scarce atelocollagen) of chondroitin sulfate；Hyaluronic acid spheroid, such as sold by Engelhard Lyon that
A bit；And arginine.
In one embodiment, the NMF is selected from reed fragrant plant glue oily (Lubrajel oil), Sodium Hyaluronate, the third two
Alcohol, D-sorbite and its mixture.
Hydrophily gelling agent
In one embodiment, the cosmetic composition is also comprising at least one hydrophily gelling agent.
Hydrophily gelling agent that can be specifically mentioned includes water-soluble or water dispersible thickening polymer.These polymer can be outstanding
It is selected from：
- modified or unmodified carboxy vinyl polymer, such as by Goodrich companies with title Carbopol (CTFA：Card
Ripple nurse) sale product；
- polyacrylate；
- polymethacrylates such as by Guardian companies with title Lubrajel and the Norgel product sold or by
The product that Hispano Chimica companies are sold with title Hispagel；
- polyacrylamide；
- optionally be crosslinked and/or neutralize 2- acrylamide-2-methylpro panesulfonic acids polymer and copolymer, for example by
Clariant companies are with title Hostacerin AMPS®Poly- (2- the acrylamide-2-methylpro panesulfonic acids) (CTFA of sale
Name：Polypropylene acyl group dimethyltaurine ammonium)；
The crosslinked anionic copolymers of-acrylamide and 2- acrylamide-2-methylpro panesulfonic acids；It is in W/O (Water-In-Oil) breasts
Liquid form, such as by SEPPIC companies with title Sepigel 305 (CTFA：Polyacrylamide/C13-C14Isoparaffin/laruyl alcohol
Polyethers -7) and with title Simulgel 600 (CTFA：Acrylamide/acryloyl dimethyl tauric acid sodium copolymer/different
Hexadecane/polysorbate80) sale those；
- polysaccharide, such as xanthans, guar gum, tragon, gum arabic, scleroglucan, chitin and chitosan derivative
Thing, carrageenan, exocellular polysaccharide (gellan), alginates, for example, sold by CP Kelco companies with title Keltrol CG-T
Xanthans,
- cellulose, such as microcrystalline cellulose, carboxymethyl cellulose, hydroxymethyl cellulose and hydroxypropyl cellulose；And its mixture.
It is, in general, that may be selected from the polysaccharide produced by microorganism according to the polysaccharide of the present invention；From algae separate polysaccharide and
Polysaccharide from upper plant (upper plant), such as homogeneous polysaccharide, particularly cellulose and its derivates and levulan, it is non-
Homogeneous polysaccharide such as gum arabic, galactomannans, glucomannans, pectin and its derivative.
Especially, the polysaccharide may be selected from levulan, it is exocellular polysaccharide, glucan, amylose, amylopectin, glycogen, general
Lu Lan (pullulan), dextran (dextran), particularly cellulose and its derivates, methylcellulose, hydroxylalkyl
Element, ethylhydroxyethylcellulose and carboxymethyl cellulose, mannosan, xylan, lignin, araban, galactan,
Polygalacturonic acid, the compound based on alginates, chitin, chitosan, glucuronoxylan, arabinose sill gather
Sugar, xyloglucan, glucomannans, pectic acid and pectin, arabogalactan, carrageenan, agar, glycosaminoglycan, Ah
Uncle's natural gum, bassora gum, ghatti gum, karaya, tragon, galactomannans are drawn, such as guar gum and nonionic spread out
Biology, particularly HPG, and its ionic derivative, particularly microbe-derived biological polyoses glue, scleroglucan
Or xanthans, mucopolysaccharide, and particularly chondroitin sulfate and its mixture.
Advantageously, included according to the composition of the present invention and be used as hydrophily gelling agent selected from following at least one polysaccharide：
Carrageenan, particularly k- carrageenans, gellan gum, agar, xanthans, the compound based on alginates, particularly mosanom,
Scleroglucan glue, guar gum, inulin, Propiram and its mixture.
These polysaccharide can be chemically modified, especially by urea, carbamate groups or by hydrolysis, oxidation, ester
Change, etherificate, sulphation, phosphorylation, amination, amidatioon, alkylated reaction are modified by a variety of in these modifications.
The derivative of acquisition can be anion, cation, both sexes or non-ionic.
Advantageously, the polysaccharide may be selected from carrageenan, particularly k- carrageenans, gellan gum, agar, xanthans, base
In the compound of alginates, particularly mosanom, scleroglucan glue, guar gum, inulin, Propiram and its mixture.
It is, in general, that the such compound being suitable in the present invention is selected from " Encyclopedia of
Chemical Technology, Kirk-Othmer, the third edition, volume 1982,3, the 896-900 pages and volume 15,
439-458 pages " in, " Polymers in Nature, E. A. Mc GREGOR and C. T. GREENWOOD, John
Wiley ＆ Sons Editions, the 6th chapter, the 240-328 pages, in 1980 ", by Mc Graw Hill Book
Entitled " the Handbook of Water soluble gums and for the Robert L. DAVIDSON that Company is published
Resins " in the publication of (1980) and in Industrial Gums " Polysaccharides and their
Derivatives, Roy L. WHISTLER are compiled, second edition, are particularly described in Edition Academic Press Inc. "
Those.
According to a particular, the hydrophily gelling agent is the compound selected from xanthans, based on alginates,
The particularly polysaccharide of mosanom, scleroglucan glue, guar gum and its mixture.
According to a particularly preferred embodiment, the hydrophily gelling agent is xanthans.
Xanthans is with the molecular weight between 1,000,000 g/mol and 50,000,000 g/mol and for including 1%
For the Aquo-composition of xanthans, the viscosity between 0.6 and 1.65 Pa.s (uses Brookfield LVT under 25 °C
Viscosimeter is determined under 60 rpm).
Xanthans by for example by RHODIA CHIMIE with title Rhodicare, by Cargill Texturizing
Solutions with title SATIAXANE (be used for food, cosmetics and pharmaceuticals industry), by ADM with title NOVAXAN and
By CP-Kelco with title Kelzan®And Keltrol®The product of sale is represented.
In one embodiment, relative to the gross weight of composition, the hydrophily gelling agent between 0.01 weight % and
Between 10 weight %, it is preferably between 0.1 weight % and 5 weight %, is more preferably between 0.1 weight % between 1 weight %.
Additive
The cosmetic composition of the present invention can further include at least one physiologically acceptable additive.Therefore according to this
The cosmetic composition of invention can further include any additive commonly used in discussed field, be selected from extra
Glue, resin, dispersant, extra polymer, extra antioxidant, essential oil, preservative, spices, nertralizer, bactericide
(antiseptic agent), anti-UV protective agents and its mixture.
Those skilled in the art can adjust the class of the additive according to present in the composition of the present invention by routine operation
Type and amount so that the cosmetic property and stability property sought for these compositions are not influenceed by additive.
Using
In one embodiment, cosmetic composition as defined above is intended for local application.According to the group of the present invention
Compound can be the cosmetic composition for being intended for skin nursing.Therefore, these compositions may be intended to be applied on skin.
The invention further relates to purposes of the cosmetic composition as defined above as skin overlay film.In particular
In, composition defined above is used as body overlay film or facial mask, preferably facial mask and more particularly moisture saver mask.
" being used as skin overlay film " can be regarded as composition defined above being applied at least one skin area.Institute
Stating composition may need or may not be needed to be rinsed out with water.
" rinsing out " can refer to by rinsing composition (such as water) that (it is held as described below institute being applied on skin by composition
After the application time of definition) removed from skin.
" application time " can be regarded as the cosmetic composition has the effect of such as soft and/or moistening effect on skin
Fruit does not simultaneously cause skin irritatin or uncomfortable enough time optionally.In one embodiment, the application time is between 5
Minute and between 15 minutes, preferably 10 minutes.
In one embodiment, according to form of the composition of the present invention in the aqueous solution, frost, emulsion or gel, preferably
In the form of the aqueous solution.
In one embodiment, cosmetic composition of the invention is the overlay film for skin.
These compositions using the usual mode of such product to be used.
In one embodiment, it is in unit dose (single dose) form according to the cosmetic composition of the present invention.
At this point, there is enough antimicrobial acivities (especially during manufacture) to protect according to the composition of the present invention
The composition is protected from primary contact scar.
Optionally, composition of the invention is with being suitable for being applied topically on skin, and the substrate especially on face makes together
With.
At this point, then the substrate comprising the composition according to the present invention is removed from skin.
Especially, the substrate can be tectorial paper (mask tissue) or lamination patch (mask sheet), and it generally can be
In the market is obtained.
The invention further relates to cosmetic care method, it is included in application as defined aboveization at least one skin area
The step of cosmetic compositions.
In one embodiment, the cosmetic method is included during application time as defined above at least one
The step of applying cosmetic composition as defined above on skin area.
The application in the whole text in, unless otherwise expressly noted, term "comprising" or " comprising " represent " comprising at least one " or
" including at least one ".
Description above in the whole text in, unless otherwise expressly noted, term " between x and y " refers to inclusive scope, i.e.,
Value x and y are contained in the range of this.
Now by the example present invention in following non-limiting example.Unless otherwise expressly noted, % is expressed as with phase
For the weight meter of composition total weight.
Composition is prepared using conventional cosmetic composition compound method.
Embodiment
Embodiment 1：According to the cosmetic composition of the present invention
1. The composition of test：
The following composition A prepared according to the present invention：
。
The method compositions formulated A according to known in cosmetic field.
Composition A is facial mask.It can be used together with substrate or can not be used together with substrate.It can use water or can be without
Water is rinsed out.
Composition A has the pH value between 5.5 and 6.
According to technology compositions formulated A well known to the skilled person.
Antimicrobial research：
Carry out the test of the antimicrobial acivity according to composition A of the invention.
Various types of microorganisms are introduced into said composition, and the entitled Eddy Jet 2 produced using IUL companies spiral shell
Kind of an instrument (spiral instrument) and the entitled Flash ＆ Go image analyzer of spinning observes the numbers of these microorganisms
Change.
Following table shows the total change with contacting microorganism after certain period of time according to the composition A of the present invention
Change.
Think that antimicrobial acivity is enough when the sum for observing microorganism is reduced.
The result of antimicrobial test after 7 days：
。
The result of antimicrobial test after 1 month：
。
As a result show that according to the composition A of the present invention there is non-constant width (scope) and effective antimicrobial acivity.
Skin comfort degree is studied：
The comfort test of dermal sensation is carried out after the composition A according to the present invention is applied.
Composition A is combined with the substrate fabric that Nbond companies produce to obtain the sheet overlay film according to the present invention.
The above-mentioned sheet overlay film of 62 women panelists applications 2 times, every time 10 minutes, and then use during 5 days
Wash their face.
It is required that panelist votes the dermal sensation of overlay film, wherein passing through soft feeling, moisturizing, non-stimulated and do not itch
Sensory measurement dermal sensation.
As a result, 100% panelist votes the sheet overlay film according to the present invention " non-during and after application
It is often good dermal sensation, non-stimulated and do not itch ".
Thus, it is seen that composition A has effectively and improved after the antimicrobial acivity of wide spectrum and application and comfortable
Dermal sensation.
Therefore, comfortable dermal sensation is caused according to the composition A of the present invention after the application, specifically resulted in the absence of stimulation
And/or the sensation itched.
In addition, the present composition is stayed in 4 °C, room temperature (25 °C), under 40 °C and 45 °C after, said composition is 2
It is stable during individual month.
Claims (12)
1. a kind of cosmetic composition, its combination comprising at least one aqueous phase and paraanisic acid and hydroxyacetophenone, wherein institute
The pH value for stating composition is less than or equal to 6.
2. cosmetic composition according to claim 1, it is the aqueous solution.
3. the cosmetic composition according to any one of preceding claims 1 or 2, wherein the pH of the cosmetic composition
Value is preferably between 5 and 6 between 4 and 6.
4. the cosmetic composition according to any one of preceding claims 1 to 3, relative to the gross weight of the composition
Amount, it includes 0.01 weight % to 1 weight %, and preferably 0.05 weight % to 0.5 weight %, more preferably 0.1 weight % are to 0.2 weight %'s
Paraanisic acid.
5. the cosmetic composition according to any one of preceding claims 1 to 4, relative to the gross weight of the composition
Amount, it includes 0.01 weight % to 1 weight %, preferably 0.1 weight % to 0.6 weight % hydroxyacetophenone.
6. the cosmetic composition according to any one of preceding claims 1 to 5, relative to the gross weight of the composition
Amount, it includes at least one aqueous phase and following combination：
- 0.1 weight % to 0.5 weight % paraanisic acid,
- 0.1 weight % to 0.6 weight % hydroxyacetophenone, and
The pH value of wherein described composition is between 4 and 6.
7. the cosmetic composition according to any one of preceding claims 1 to 6, it also lives comprising at least one cosmetics
Property agent, preferably NMF.
8. the cosmetic composition according to any one of preceding claims 1 to 7, it is also comprising at least one hydrophilic gel
Solidifying agent, is preferably selected from polysaccharide, more preferably xanthans.
9. the cosmetic composition according to any one of preceding claims 1 to 8, wherein total relative to the composition
Weight, the hydrophily gelling agent is preferably between 0.1 weight % and 5 weight % between 0.01 weight % and 10 weight %,
0.1 weight % is more preferably between 1 weight %.
10. cosmetic composition according to any one of claim 1 to 9 is used as the purposes of skin overlay film.
11. the purposes of cosmetic composition according to claim 10, it is as facial mask, preferably as moisture saver mask.
12. a kind of cosmetic care method, it includes applying cosmetic composition according to any one of claim 1 to 9
It is added to the step at least one skin area.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211221418.6A CN115569081A (en) | 2014-12-26 | 2014-12-26 | Cosmetic composition comprising p-anisic acid and hydroxyacetophenone and cosmetic method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2014/095138 WO2016101264A1 (en) | 2014-12-26 | 2014-12-26 | Cosmetic compositions comprising p-anisic acid and hydroxyacetophenone, their uses and cosmetic methods thereof |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202211221418.6A Division CN115569081A (en) | 2014-12-26 | 2014-12-26 | Cosmetic composition comprising p-anisic acid and hydroxyacetophenone and cosmetic method thereof |
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| CN107106434A true CN107106434A (en) | 2017-08-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201480084367.4A Pending CN107106434A (en) | 2014-12-26 | 2014-12-26 | Cosmetic composition comprising paraanisic acid and hydroxyacetophenone, its purposes and its cosmetic method |
| CN202211221418.6A Pending CN115569081A (en) | 2014-12-26 | 2014-12-26 | Cosmetic composition comprising p-anisic acid and hydroxyacetophenone and cosmetic method thereof |
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| CN202211221418.6A Pending CN115569081A (en) | 2014-12-26 | 2014-12-26 | Cosmetic composition comprising p-anisic acid and hydroxyacetophenone and cosmetic method thereof |
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| CN (2) | CN107106434A (en) |
| WO (1) | WO2016101264A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176480A (en) * | 2016-08-30 | 2016-12-07 | 广州品赫化妆品有限公司 | A kind of food grade compositions with antiseptic activity and the application in cosmetics thereof |
| CN113163758A (en) * | 2018-12-20 | 2021-07-23 | 莱雅公司 | Antimicrobial mixture containing 4- (3-ethoxy-4-hydroxyphenyl) butan-2-one and alcohol compound and cosmetic composition containing the same |
| CN113194722A (en) * | 2018-12-20 | 2021-07-30 | 莱雅公司 | Antimicrobial mixtures containing 4- (3-ethoxy-4-hydroxyphenyl) butan-2-one and 4-hydroxyacetophenone and compositions containing the same |
| CN114222554A (en) * | 2019-06-28 | 2022-03-22 | 莱雅公司 | Cosmetic composition for making up and/or caring for keratin materials |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113710331B (en) | 2019-03-12 | 2024-03-22 | 西姆莱斯股份公司 | Antimicrobial mixture |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040167195A1 (en) * | 2002-01-07 | 2004-08-26 | Rainer Muller | Microbicidal agent and composition for cosmetic treatment containing it |
| CN104188874A (en) * | 2014-09-18 | 2014-12-10 | 湖南御家化妆品制造有限公司 | Mild moisturizing facial mask |
-
2014
- 2014-12-26 CN CN201480084367.4A patent/CN107106434A/en active Pending
- 2014-12-26 CN CN202211221418.6A patent/CN115569081A/en active Pending
- 2014-12-26 WO PCT/CN2014/095138 patent/WO2016101264A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040167195A1 (en) * | 2002-01-07 | 2004-08-26 | Rainer Muller | Microbicidal agent and composition for cosmetic treatment containing it |
| CN104188874A (en) * | 2014-09-18 | 2014-12-10 | 湖南御家化妆品制造有限公司 | Mild moisturizing facial mask |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176480A (en) * | 2016-08-30 | 2016-12-07 | 广州品赫化妆品有限公司 | A kind of food grade compositions with antiseptic activity and the application in cosmetics thereof |
| CN113163758A (en) * | 2018-12-20 | 2021-07-23 | 莱雅公司 | Antimicrobial mixture containing 4- (3-ethoxy-4-hydroxyphenyl) butan-2-one and alcohol compound and cosmetic composition containing the same |
| CN113194722A (en) * | 2018-12-20 | 2021-07-30 | 莱雅公司 | Antimicrobial mixtures containing 4- (3-ethoxy-4-hydroxyphenyl) butan-2-one and 4-hydroxyacetophenone and compositions containing the same |
| CN113163758B (en) * | 2018-12-20 | 2022-11-11 | 莱雅公司 | Antimicrobial mixture containing 4- (3-ethoxy-4-hydroxyphenyl) butan-2-one and alcohol compound and cosmetic composition containing the same |
| CN113194722B (en) * | 2018-12-20 | 2023-05-05 | 莱雅公司 | Antimicrobial mixtures containing 4- (3-ethoxy-4-hydroxyphenyl) butan-2-one and 4-hydroxyacetophenone, and compositions containing the same |
| CN114222554A (en) * | 2019-06-28 | 2022-03-22 | 莱雅公司 | Cosmetic composition for making up and/or caring for keratin materials |
| CN114222554B (en) * | 2019-06-28 | 2024-03-12 | 莱雅公司 | Cosmetic composition for making up and/or caring for keratin materials |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016101264A1 (en) | 2016-06-30 |
| CN115569081A (en) | 2023-01-06 |
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Application publication date: 20170829 |