KR20190067020A - The Tacky Hydrogel Composition - Google Patents

Abstract

The present invention relates to a viscous hydrogel composition comprising a gelation polymer, skin active components, polyvalent alcohol, a hydrophilic polymer, a crosslinker, a gelation speed regulator, and a solvent. The viscous hydrogel composition has desirable viscosity over repeated use, and causes little skin irritation.

Description

The tacky hydrogel composition {The Tacky Hydrogel Composition}

The present invention relates to a tacky hydrogel composition, and more particularly, to a tacky hydrogel composition composed of a tacky hydrogel composition comprising a gelling polymer, a skin active ingredient, a polyhydric alcohol, a hydrophilic polymer, a crosslinking agent, a gelation rate regulator and a solvent.

A hydrogel is basically a polymer having a high affinity for water swelled in an aqueous solvent. Hydrogels have various properties such as water absorbency, swelling property, tackiness, and conductivity, and are utilized in a wide range of fields such as civil engineering, agriculture, food, medicine, cosmetics and electricity.

For example, in a medical field, a sticky hydrogel is used as an electrode pad of a measuring device such as an electrocardiograph. Recently, sticky hydrogels have also been used as electrode pads for EMS (Electrical Muscle Stimulation) for weight loss and strength training. This EMS is a exercise device that shrinks the muscles by electrical stimulation by sticking an electrode pad made of a sticky hydrogel to the skin, and the opportunity to be used in general households is increasing.

The adhesive hydrogel used for such an electrode pad is required to have high adhesion to the skin.

For example, Patent Document 1 discloses a technique for improving adhesiveness by using a predetermined amount of a water-soluble polymer and a medical electrode using the same. Although the technique disclosed in Patent Document 1 can improve the adhesive force of the hydrogel, the adhesive strength is immediately lowered even if the application of the adhesive and peeling is repeated several times, that is, the adhesive force at the time of repeated use is not sufficient. There was also a problem that the skin became red after peeling off from the skin.

Here, as a main cause of deterioration of the adhesive force at the time of repeated use and a main cause of reddening of the skin, for example, when the electrode pad is peeled from the skin, the skin is detached from the skin surface and attached to the surface of the electrode pad, Is lowered.

As a method for maintaining the adhesive force at the time of repeated use, for example, Patent Document 2 discloses a technique of restoring the adhesive force by washing the adhesive surface where the adhesive strength is decreased by repeatedly applying and peeling the skin several times.

However, since the hydrogel described in Patent Document 2 requires work such as water washing, in order to reliably restore the adhesive force, the condition described in the manual or the like must be observed for the cleaning method, the drying method, etc., There was a problem.

In addition, the problem that the skin is prevented from reddening, that is, the stimulation to the skin is alleviated is not solved.

It is an object of the present invention to provide a composition for a sticky hydrogel which does not involve a special operation such as washing with water in view of the above-described present situation, has excellent adhesiveness at the time of repeated use, and particularly has less irritation to the skin, and its use.

In order to solve the above problems, the present invention provides a sticky hydrogel composition comprising a gel polymer, a skin active ingredient, a polyhydric alcohol, a hydrophilic polymer, a cross-linking agent, a gelation rate regulator and a solvent.

The present invention also relates to a method for producing a sticky hydrogel composition, comprising the steps of: 0.1 to 10% by weight of a gelled polymer, 0.1 to 15% by weight of a skin active ingredient, 5 to 35% by weight of a polyhydric alcohol, 0.5 to 10% by weight of a hydrophilic polymer, 0.01 to 5 wt% of a gelling rate modifier, and 45 to 80 wt% of a solvent.

Also, the present invention provides a sticky hydrogel composition comprising at least one selected from the group consisting of galactomannan, glucomannan, guar gum, locust bean gum, pluronic, agar, algin, carrageenan, xanthan and gellan do.

The present invention also relates to a method for producing a skin active ingredient, which comprises administering to the skin 1 component selected from the group consisting of arbutin, niacinamide, vitamin C, vitamin B5, vitamin E, retinol, coenzyme Q10, adenosine, elastin, collagen, hyaluronic acid, chitosan, By weight of the total weight of the composition.

The present invention also relates to the above-mentioned natural extracts, wherein the natural extracts are selected from the group consisting of aloe, green tea, ginseng, red ginseng, vinegar, pine leaves, ginkgo leaf, propolis, mulberry leaf, silkworm, snail slime, kakaduplum, camucam, yashiyaki, squalane, Berry, locust hanger, acerola, chlorella, mangosteen, guava, mountain demand, carrots, caffeine, hammamelis, spirulina, salmon roe, giant kelp, packing, packing, mugwort roots, raspberry, raspberry At least one kind selected from the group consisting of at least one selected from the group consisting of at least one kind of viscous hydrolyzate selected from the group consisting of atorvastatin, atorvastatin, edelwease, chamomile, lavender, peppermint, eucalyptus, lemon balm, oregano, tea tree, Gel composition.

The present invention also provides a sticky hydrogel composition wherein the polyhydric alcohol is at least one selected from the group consisting of glycerin, ethylene glycol, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol, and xylitol.

The hydrophilic polymer may be at least one selected from the group consisting of gelatin, polyacrylate or salt thereof, polymethacrylic acid, carboxyvinyl polymer, polyvinyl alcohol, polyacrylamide, polyethylene oxide, polyethyleneimine, polyvinylpyrrolidone, methylcellulose, cellulose. At least one selected from the group consisting of carboxymethyl cellulose, hydroxyethylcellulose, and hydroxyethylcellulose.

In the present invention, the gelling rate modifier is at least one selected from the group consisting of EDTA, acetic acid, lactic acid, oxalic acid, citric acid, tartaric acid, EDTA-2 sodium, calcium citrate, sodium citrate, and sodium nitrate. .

INDUSTRIAL APPLICABILITY The adhesive hydrogel made using the composition for a viscous hydrogel of the present invention has high adhesiveness to the skin, does not involve any special work such as washing with water, has excellent adhesiveness at the time of repeated use, and particularly has less irritation to the skin . Because of this, products such as electrode pads using the adhesive hydrogel of the present invention can withstand repeated use compared with conventional products, and therefore, the life of the product is long, which is economical and contributes to resource saving.

Hereinafter, preferred embodiments of the present invention will be described in detail. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted so as to avoid obscuring the subject matter of the present invention.

As used herein, the terms " about, " " substantially, " " etc. ", when used to refer to a manufacturing or material tolerance inherent in the stated sense, Accurate or absolute numbers are used to help prevent unauthorized exploitation by unauthorized intruders of the referenced disclosure.

 The present invention relates to a sticky hydrogel composition comprising a gelled polymer, a skin active ingredient, a polyhydric alcohol, a hydrophilic polymer, a cross-linking agent, a gelation rate regulator and a solvent. The present invention relates to a sticky hydrogel composition containing a hydrophilic polymer together with a gelled polymer, A stable tacky hydrogel sheet can be produced.

The adhesive hydrogel composition comprises 0.1 to 10 wt% of a gelled polymer, 0.1 to 15 wt% of a skin active ingredient, 5 to 35 wt% of a polyhydric alcohol, 0.5 to 10 wt% of a hydrophilic polymer, 0.01 to 5 wt% of a crosslinking agent, 0.01 By weight to 10% by weight and the solvent is 45 to 80% by weight.

More preferably, the adhesive hydrogel composition of the present invention comprises 0.5 to 5% by weight of a gelled polymer, 0.15 to 5% by weight of a skin active ingredient, 10 to 30% by weight of a polyhydric alcohol, 1 to 5% by weight of a hydrophilic polymer, 0.05 to 3% by weight of a gelling rate modifier, and 45 to 70% by weight of a solvent.

The gelling polymer contained in the adhesive hydrogel composition of the present invention acts to gelate the adhesive composition. For example, the gelling polymer may be selected from the group consisting of galactomannan, glucomannan, guar gum, locust bean gum, pluronic, agar, , Gellan and the like, but is not limited thereto.

The gelling polymer is preferably contained in an amount of 0.1 to 10% by weight, more preferably 0.5 to 5% by weight, based on the weight of the total adhesive hydrogel composition of the present invention. When the gel polymer is contained in an amount of less than 0.1% by weight, the hardness of the gel is low, flexibility is low, and skin adhesion is reduced, so that it is difficult to apply the gel to a skin having many bends. When the gel polymer is contained in an amount exceeding 10% There is a problem that the gel is stretched to make it difficult to maintain its shape, its elasticity is low, and its adhesive function is deteriorated.

The skin active ingredient contained in the skin adhesive composition of the present invention improves the affinity with the skin and enhances the skin absorption rate of the functional ingredient that can effectively act on the skin. The whitening ingredient, wrinkle function, antioxidant ingredient, Component, an antibacterial component, and the like, but is not limited thereto.

Skin active ingredients that may be included in the viscous hydrogel composition of the present invention include, for example, arbutin, niacinamide, vitamin C, vitamin B5, vitamin E, retinol, coenzyme Q10, adenosine, elastin, collagen, hyaluronic acid, chitosan, Extract, and the like, but the present invention is not limited thereto.

The natural extract may be selected from the group consisting of aloe, green tea, ginseng, red ginseng, vinegar, ginkgo leaf, propolis, mulberry leaf, silkworm, snail mucilage, kakaduplum, camucam, yashiyaki, squalane, caviar, broccoli, , Acerola, Chlorella, Mangosteen, Guava, Mountain Demand, Carrots, Caffeine, Hamamelis, Spirulina, Salmon roe, Gamut, Giant kelp, Packo, Matsushiro, Parake, Mugwort, Mulberry root, Raspberry, Raspberry, It is preferably at least one selected from the group consisting of egg yolk, edelweiss, chamomile, lavender, peppermint, eucalyptus, lemon balm, oregano, tea tree, golden oyster, alder tree, citron, albumin and egg yolk protein.

The skin active ingredient may be added in an amount of 0.1 to 15% by weight, more preferably 0.15 to 5% by weight, based on the total adhesive hydrogel composition of the present invention. When the skin active ingredient is added in an amount of less than 0.1% by weight, the skin-affinity is poor and the effect of improving skin is insufficient. When the skin active ingredient is added in an amount exceeding 15% by weight, skin irritation may occur, There is a problem that the coloring and discoloration occurs.

The polyhydric alcohol contained in the skin sticking composition of the present invention has a moisturizing function and is, for example, a polyhydric alcohol which is composed of glycerin, ethylene glycol, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol and xylitol But it is not limited thereto. More preferably, glycerin

Is used.

The polyhydric alcohol is preferably added in an amount of 5 to 35% by weight, more preferably 10 to 30% by weight based on the total adhesive hydrogel composition of the present invention. When the amount of the polyhydric alcohol is less than 5% by weight, the moisture in the composition tends to be volatilized when adhering to the skin, resulting in deterioration of the adhesive strength. When the content is more than 35% by weight, stickiness, there is a problem.

The hydrophilic polymer is added for gelation, and any polymer capable of being gelled by water may be added. For example, gelatin, polyacrylate or a salt thereof, polymethacrylic acid, carboxyvinyl polymer, polyvinyl alcohol, But is not limited to, at least one member selected from the group consisting of polyacrylamide, polyethylene oxide, polyethyleneimine, polyvinylpyrrolidone, methylcellulose, cellulose, carboxymethylcellulose, and hydroxyethylcellulose , And the salt of the polyacrylate is preferably a metal salt such as lithium, sodium or potassium.

The hydrophilic polymer may be contained in an amount of 0.5 to 10% by weight, more preferably 1 to 5% by weight based on the total adhesive hydrogel composition of the present invention. When the hydrophilic polymer is contained in an amount of less than 0.5% by weight, the pressure-sensitive adhesive hydrogel composition of the present invention tends not to maintain sufficient strength. When the hydrophilic polymer is contained in an amount of more than 10% by weight, the viscosity becomes high, There is a problem that the workability is insufficient due to high viscosity at the time of use.

The crosslinking agent is preferably a polyvalent metal salt, and examples thereof include aluminum hydroxide, aluminum hydroxide gel, hydrated aluminum silicate, kaolin, aluminum acetate, aluminum lactate, aluminum stearate, calcium chloride, magnesium chloride, magnesium aluminum metasilicate , And magnesium aluminosilicate, but the present invention is not limited thereto. Most preferably aluminum hydroxide can be used.

The crosslinking agent is preferably 0.01 to 5% by weight, more preferably 0.05 to 3% by weight, most preferably 0.05 to 0.2% by weight based on the total adhesive hydrogel composition of the present invention.

When the amount of the crosslinking agent is less than 0.01% by weight, the crosslinking reaction does not sufficiently proceed and the gel strength tends to become insufficient. When the amount of the crosslinking agent is more than 5% by weight, the crosslinking reaction speed is excessively accelerated during the production of the adhesive- The strength of the viscous hydrogel composition becomes strong and the workability tends to become insufficient.

At this time, the gelling rate controlling agent may be, for example, an organic acid such as EDTA, acetic acid, lactic acid, oxalic acid, citric acid or tartaric acid having a chelating action with respect to metal ion, an organic acid such as EDTA-2 sodium, calcium citrate, sodium citrate or sodium nitrate , And an organic base. However, the present invention is not limited thereto.

On the other hand, the solvent of the present invention preferably uses water but is not limited thereto. The solvent is added in an amount of 100% by weight of the solvent, and more preferably 45 to 80% by weight of the solvent.

Further, other additives such as preservatives, perfumes, surfactants, thickeners and the like may be added to the adhesive hydrogel composition of the present invention, and the other additives are not particularly limited.

For example, the preservative added to the present invention may be selected from the group consisting of capryl glycols, paraoxybenzoic acid alkyl esters, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, phenoxyethanol, parabens, pentanediol, benzoic acid, salicylic acid, Its salt, ethylhexyl glycerin, 1,2-hexanediol, capryl glycol tropolone, p-oxybenzoic acid ester, 3-trifluoromethyl-4,4'-dichlorocarbabanilide, - trichloro-2-hydroxydiphenyl ether, but the present invention is not limited thereto.

According to the present invention, there is provided a process for producing a sticky hydrogel sheet, comprising mixing the gelled polymer, the skin active ingredient and the solvent at a temperature of 60 to 80 캜; Preparing a gel by adding a hydrophilic polymer, a polyhydric alcohol, a gelation rate regulator, and a crosslinking agent; And coating the gel on a support.

The components and content of the adhesive hydrogel composition used for producing the adhesive hydrogel sheet of the present invention are as described above.

The mixing at the temperature of 60 to 80 ° C may be carried out by adding other additives if necessary.

If the mixing step is carried out at a temperature of less than 60 캜, sufficient gelation is not achieved. If the mixing step is performed at a temperature higher than 80 캜, the stability of the skin active ingredient is reduced.

In the mixing step, a hydrophilic polymer, a polyhydric alcohol, a crosslinking agent and a gelation rate controlling agent are added to prepare a gel. Further, the adhesive hydrogel composition of the present invention may further contain preservatives, perfumes, surfactants, Other such additives may be added to the appropriate step, and the other additives are not particularly limited.

In the step of coating the gel on a support, the coating may be carried out using any coating method well known in the art, for example, by coating with a roller and a film coater , A melt-extrusion method in which a film is obtained by extrusion, or by making the cosmetic film composition into a dope,

A solution casting method in which a film is obtained by casting can be used. In the coating step, the support may be paper, a nonwoven fabric, or a base material or a release film of various materials. Examples of the support include polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, polyethylene, polypropylene, polybutadiene, Ethylene-vinyl acetate copolymer, polyvinyl chloride film, and the like.

On the other hand, if necessary, the coated back surface may be coated with a nonwoven fabric, a paper, a film or the like on which the peeling treatment has been performed to prevent evaporation of moisture and the like.

The viscous hydrogel sheet of the present invention is preferably manufactured to a thickness of 0.05 to 0.3 cm, more preferably 0.1 to 0.2 μm. At this time, it is preferable that the coating is uniform in all areas.

If the thickness of the viscous adhesive hydrogel sheet is less than 0.05 cm, it is difficult to handle due to the thin film. If the thickness exceeds 0.3 cm, adhesion to the curved skin is deteriorated.

Subsequently, the adhesive hydrogel sheet provided according to the present invention can be manufactured in a form capable of applying any specific part of the skin, and can be manufactured in any desired shape and size depending on the application site and application.

Generally, in the case of a skin patch with a hydrophilic polymer, sufficient crosslinking is not performed, and the physical properties of the gel are poor and sticky, so that it is difficult to form the gel directly without aging. Therefore, It is necessary to perform aging for about one day to two days. However, in the case where a hydrophilic polymer is contained together with the gelled polymer as in the present invention, a sticky hydrogel composition which can be formed immediately without such an aging step can be produced.

Further, according to the present invention, there is provided the adhesive hydrogel sheet produced by the above method.

Hereinafter, the present invention will be described more specifically by way of specific examples. The following examples are given for the purpose of helping to understand the present invention, but the scope of the present invention is not limited thereto.

Example  1 to 3

In the following Table 1, the components 1, 2, 5 to 10 were mixed at a temperature of 75 캜, and then the components 3, 4, 11 to 18 were added to prepare a gel.

The gel was coated on a PET film support and molded into the desired shape without further aging.

Example  4 to 6

In the following Table 2, the components 1, 2, 5 to 10 were mixed at a temperature of 75 캜, and then the components 3, 4, 11 to 18 were added to prepare a gel.

The gel was coated on a PET film support and molded into the desired shape without further aging.

Test Example  1: Evaluation of stickiness

The sticky hydrogel sheets prepared according to Examples 1 and 2 and the sheet of Comparative Example 1 were attached to the upper arm portions of 20 subjects of healthy male and female subjects for 10 hours each, and sensory examination was performed.

The adhesion index is as shown in Table 3 below.

The degree of exfoliation was measured, and the degree of exfoliation was calculated by dividing the number of subjects by the number of subjects. As a result, most of the embodiments have a value of 4.0 or more.

Claims (8)

A tacky hydrogel composition comprising a gelled polymer, a skin active ingredient, a polyhydric alcohol, a hydrophilic polymer, a cross-linking agent, a gelation rate regulator, and a solvent.
The method according to claim 1,
The adhesive hydrogel composition comprises 0.1 to 10 wt% of a gelled polymer, 0.1 to 15 wt% of a skin active ingredient, 5 to 35 wt% of a polyhydric alcohol, 0.5 to 10 wt% of a hydrophilic polymer, 0.01 to 5 wt% of a crosslinking agent, 0.01 By weight to 5% by weight of a solvent and 45 to 80% by weight of a solvent.
The method according to claim 1,
Wherein the gelled polymer is at least one selected from the group consisting of galactomannan, glucomannan, guar gum, locust bean gum, pluronic, agar, algin, carrageenan, xanthan, and gellan.
The method according to claim 1,
Wherein the skin active ingredient is at least one selected from the group consisting of arbutin, niacinamide, vitamin C, vitamin B5, vitamin E, retinol, coenzyme Q10, adenosine, elastin, collagen, hyaluronic acid, chitosan, Gel composition.
5. The method of claim 4,
The natural extract may be selected from the group consisting of aloe, green tea, ginseng, red ginseng, vinegar, ginkgo leaf, propolis, mulberry leaf, silkworm, snail mucilage, kakaduplum, camucam, yashiyaki, squalane, caviar, broccoli, , Acerola, Chlorella, Mangosteen, Guava, Mountain Demand, Carrots, Caffeine, Hamamelis, Spirulina, Salmon roe, Gamut, Giant kelp, Packo, Matsushiro, Parake, Mugwort, Mulberry root, Raspberry, Raspberry, Wherein the composition is at least one selected from the group consisting of atorvastatin, chamomile, lavender, peppermint, eucalyptus, lemon balm, oregano, tea tree, golden fish, alpinus, citronellum, albumin and egg yolk protein.
The method according to claim 1,
Wherein the polyhydric alcohol is at least one selected from the group consisting of glycerin, ethylene glycol, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol, and xylitol.
The method according to claim 1,
Wherein the hydrophilic polymer is selected from the group consisting of gelatin, polyacrylate or a salt thereof, polymethacrylic acid, carboxyvinyl polymer, polyvinyl alcohol, polyacrylamide, polyethylene oxide, polyethyleneimine, polyvinylpyrrolidone, methylcellulose, cellulose. Carboxymethylcellulose, and hydroxyethylcellulose. ≪ RTI ID = 0.0 > 1. < / RTI >
The method according to claim 1,
Wherein the gelling rate modifier is at least one selected from the group consisting of EDTA, acetic acid, lactic acid, oxalic acid, citric acid, tartaric acid, EDTA-2 sodium, calcium citrate, sodium citrate and sodium nitrate.