KR20140116325A - Improved tear strength hydrogel composition and a method for manufacturing the same - Google Patents

Abstract

The present invention relates to a hydrogel composition and, more specifically, to an elastic hydrogel composition, which includes a natural polymeric material to increase braking strength of hydrogel and not to include a molded object, comprising: 0.1-3 wt% of cassia gum, which is a natural polymeric material, with respect to the total weight of the composition; 0.1-2 wt% of one selected among carrageenan gum and xanthan gum or a mixture thereof; 5-30 wt% of polyhydric alcohols as a plasticizer; 0.5-2 wt% of electrolyte; 0.1-10 wt% of a functional cosmetic compound, which gives skin care function; 0.001-0.5 wt% of preservative; and the remainder, which is made up of a solvent including water. The hydrogel composition, according to the present invention, is in a liquid phase at room temperature and turns into a gel phase when being heated, so the present invention provides a composition to prepare hydrogel without a process which can be exposed to source of pollution, since the composition does not need to go through extra forming step.

Description

TECHNICAL FIELD The present invention relates to a hydrogel composition having improved tear strength and an improved tear strength hydrogel composition and a method for manufacturing the same.

The present invention relates to a hydrogel composition, and more particularly, to a hydrogel composition comprising a natural polymer material having improved tear strength.

Hydrogel has a high water content, which can contain 20 to 90% of water. Therefore, application fields such as contact lenses, drug delivery media, implants and the like are becoming diverse in medicine and pharmaceutical fields. In the field of cosmetics, hydrogels can be used for moisturizing effect, and various functional cosmetic ingredients and moisturizers that give other skin cosmetic functions can be added to improve wrinkles, skin whitening, ultraviolet shielding, nutrition, skin elasticity, moisturizing Can be delivered to the skin.

In the case of a hydrogel containing a natural polymer, the hydrogel has weak tear strength and is generally used as a hydrogel containing a molded body that wraps a rayon mesh fabric as a support, thereby weakening the tear strength. Hydrogel cosmetic products, including molded products, are manufactured through various processes such as liquid injection molding, processing, and packaging. Due to the nature of the hydrogel containing high water content, it is exposed to pollutants such as microorganisms, There is a concern about. Therefore, there is a demand for a hydrogel that can maintain the tear strength without using a molded body in a hydrogel containing a natural polymer.

SUMMARY OF THE INVENTION Accordingly, the present invention has been made to solve the above problems and to provide an elastic hydrogel composition which does not contain a molded article by increasing the fracture strength of the hydrogel.

More particularly, it is an object of the present invention to provide a hydrogel material containing a mixture of natural high-molecular substances including Cassia gum or Cassia gum, which has a high tear strength, The present invention provides a hydrogel composition which is liquid at room temperature but changes into a gel when heated so that the hydrogel composition can be prepared without being subjected to a separate molding step and exposed to a contamination source.

In order to achieve the above object, the present invention provides a hydrogel composition comprising a mixture of natural macromolecules including Cassia gum or Cassia gum.

Hereinafter, the present invention will be described in detail.

The present invention relates to a composition comprising 0.1 to 3% by weight of a natural polymeric material, Cassia Gum, based on the total weight of the composition; 0.1 to 2% by weight of one or a mixture thereof selected from carrageenan gum or xanthan gum; 5 to 30% by weight of a polyhydric alcohol as a plasticizer, 0.5 to 2% by weight of an electrolyte; From 0.1 to 10% by weight of a functional cosmetic ingredient or a mixture thereof, which imparts a skin cosmetic function; 0.001 to 0.5% by weight of an antiseptic and the remainder is water.

The hydrogel composition according to one embodiment of the present invention is characterized in that the content ratio of the natural polymer material composed of Cassia gum and Carrageenan gum or Xanthan gum is higher than that of cassia gum and carrageenan gum Carrageenan Gum in a ratio of 4: 6 to 6: 4 and Cassia Gum and Xanthan Gum in a ratio of 3: 7 to 5: 5 is preferable for improving the tear strength.

It is more preferable to improve the tearing strength when the composition is prepared by mixing the mixture ratio of Cassia gum and Carrageenan gum or Xanthan gum at a ratio of 0.9: 0.6: 0.6.

Cassia gum is a galactomannan structure with a 1: 5 ratio of galactose side chains in Mannos main chain. When used with carrageenan gum or xanthan gum, Compared to natural polymers with galactomannan structure, they form thermoplastic and viscoelastic gels, which improves tear strength.

The plasticizer according to an embodiment of the present invention plays a key role in lowering the temperature during processing and inhibiting hydrogen bonding between chains and maintaining the molecular chain spacing. The plasticizer to be used may be a polyhydric alcohol and may be one or two selected from glycerin, ethylene glycol, polyethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, and butylene glycol More than species can be used. It is preferable that the plasticizer is used in an amount of 5 to 30% by weight based on the composition. If the plasticizer is out of the above range, the viscosity of the solution is high and the film is not easily manufactured.

The electrolyte according to an embodiment of the present invention serves to improve the tear strength and crosslinks with the natural polymer material. At this time, at least one selected from the group consisting of potassium chloride, sodium chloride, magnesium chloride, and calcium chloride may be used. In particular, 0.5 to 1.5% by weight of potassium chloride KCl) is preferably used.

The hydrogel composition according to one embodiment of the present invention preferably has a pH in the range of 4.0 to 8.0, and more preferably has a pH of about 7.0.

The active ingredient of the hydrogel composition to be delivered according to the present invention may include a functional cosmetic ingredient. Examples of the ingredient having a function of improving wrinkles, skin whitening, ultraviolet screening, water supply, nutrient supply and skin elasticity maintenance include hyaluronic acid , Marine collagen, horseradish extract, arbutin, kojic acid, soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate, niacinamide, ethyl ascorbyl ether, alpha-bisabolol, ascorbyl tetraisopalmitate, adenosine, But are not limited to, one or more selected from the group consisting of niacin, palmitate, retinol, polyethoxylated retinamide, and coenzyme quetin.

The hydrogel composition according to the present invention comprises a thermoplastic gel containing one or two kinds of Cassia gum, Carrageenan gum or Xanthan gum, and adding a plasticizer and potassium chloride as an electrolyte There is an advantage that the tear strength at the time of producing the film with the hydrogel composition increases.

The hydrogel of the composition as described above has a weak fracture strength of the conventional hydrogel, so that the hydrogel is not destroyed without the molding method by avoiding the molding method of inserting the molded body, and the tear strength Has the advantage that the improved hydrogel can be manufactured without a separate molding step.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a view showing the tear strength according to the ratio of cassis gum / carrageenan gum, cacia gum / xanthan gum in accordance with the embodiment of the present invention.
2 is a view showing the tear strength of an electrolyte and a hydrogel according to an embodiment of the present invention.
FIG. 3 is a graph showing the tear strength of a hydrogel according to an embodiment of the present invention. FIG.
4 is a view showing a patch of the hydrogel composition film according to the embodiment.

Hereinafter, the configuration and operation of the present invention will be described in more detail with reference to preferred embodiments of the present invention.

Example  1 to 6 and Comparative Example  1 to 10

In Example 1, a liquid hydrogel composition was prepared by mixing 0.6 wt% of Cassia gum, 0.4 wt% of Carrageenan gum, and 0.5 wt% of potassium chloride (KCl) for 30 minutes in purified water at room temperature.

The tear strength of the hydrogel composition was measured according to the sheet's tear test method in accordance with JIS K6401.

Specifically, the tear strength test was carried out at 23 ± 2 ° C and 50 ± 5% relative humidity. The tear strength test specimen was measured at three locations at the center and at equidistance. The width was measured with a precision of 1 mm or more, and the thickness was measured with a precision of 0.1 mm. The pulling speed was 200 mm / min, and the measuring instrument was a SHIMADZU UTM (Universal Testing Machine) AGS-500D. A total of three specimens were measured and the results were averaged.

Example  2 to 3

In Examples 2 to 3, a hydrogel composition was prepared in the same manner as in Example 1, except that the mixing ratio of Cassia gum and Carrageenan gum was changed.

Comparative Example  1-5

In Examples 1 to 5, tearing strength was measured in the same manner as in Example 1 while changing the mixing ratio of Cassia gum and Carrageenan gum.

Example  4 to 6

In Examples 4 to 6, a hydrogel composition was prepared by mixing xanthan gum and carrageenan gum, and the hydrogel composition was prepared in the same manner as in Example 1 except that xanthan gum was used. .

Comparative Example  6 to 10

In Comparative Examples 6 to 10, tearing strength was measured in the same manner as in Example 1 while changing the mixing ratio of xanthan gum and carrageenan gum.

As shown in Table 1, when the cassia gum is selected as a natural polymer material, the tear strength is improved. When the cassia gum, carrageenan gum or xanthan gum are used, It is understood that the tear strength is improved.

As can be seen in Examples 1 to 3 and Comparative Examples 1 to 5, in the production of a hydrogel composition by mixing Cassia gum and Carrageenan gum, as in Comparative Examples 1 to 5 as shown in Table 1, When the hydrogel composition was prepared by mixing Cassia gum and Carrageenan gum in the mixing ratios of Examples 1 to 3 at a ratio of 4: 6 to 6: 4, the tear strength was improved .

As can be seen from Examples 4 to 6 and Comparative Examples 6 to 10, in the production of a hydrogel composition by mixing Cassia gum and Xanthan gum, in Comparative Examples 6 to 10 as shown in Table 1, When the hydrogel composition was prepared by mixing Cassia Gum and Xanthan Gum in the mixing ratios of Examples 4 to 6 at a mixing ratio of 3: 7 to 5: 5, the tear strength was improved .

Example 7

In Example 7, a sample for measuring the tear strength of the electrolyte and the hydrogel composition was prepared. 0.5 wt% of each of Cassia gum and Carrageenan gum and 0.5 to 1.5 wt% of an electrolyte (potassium chloride, sodium chloride, magnesium chloride, and calcium chloride) were stirred for 30 minutes at room temperature to obtain liquid hydrocarbons After the gel composition was prepared, tearing strength was measured in the same manner as in Example 1.

As shown in Table 2, when the hydrogel composition including the electrolyte was prepared, it was found that the tear strength was improved. The hydrogel composition was prepared by using 0.5 to 1.5% by weight of potassium chloride (KCl) in the electrolyte of Example 7 It can be seen that the tearing strength is improved to 1200 to 1500 g / cm < ² >

Example 8

In order to compare the influence of the tear strength of the hydrogel composition with the respective natural polymeric materials according to the pH change, Example 8 was conducted in the same manner as in Example 8 except that 0.5% by weight of potassium chloride (KCl) 0.5% by weight of gum (Cassia Gum) and 99% by weight of purified water were mixed and the pH was adjusted to 3 to 8 by adding HCl and 10% KOH to measure the tearing strength in the same manner as in Example 1. [

As shown in Table 3, it can be seen that the hydrogel composition containing the natural polymer substance has a high tear strength at pH 4 to 8, and preferably the hydrogel composition prepared with Cassia Gum at pH 7 The highest tear strength is obtained.

Examples 9 to 14

In Examples 9 to 14, films were produced using the liquid-phase hydrogel compositions.

(a) EDTA-2Na, hyaluronic acid solution, marine collagen, extract of marigold, and purified water are put in a 1 L beaker in this order, heated at 1000 to 1200 rpm while stirring, and maintained at a temperature of 70 to 90 ° C for 15 minutes;

(b) KCl is completely dissolved in low-temperature purified water in a separate container and placed in a 1 L beaker of (a);

(c) To a separate beaker was added KOH, glycerin, 1,3-butylene glycol, Cassia gum, CGN, konjak mannan, LBG, Gellan Gum, xanthan gum, methyl paraoxybenzoate and propyl p-hydroxybenzoate were added and completely dispersed at 800 to 1000 rpm for 10 minutes. Then, the mixture was placed in a 1 L beaker of (a) and homogenized at 70 to 90 ° C for 20 minutes. Or using a dispersing machine while stirring;

(d) Solubilize the fragrance, tocopherol acetate or cosmetic ingredients with a solubilizer in a separate beaker, slowly add the mixture to a 1 L beaker at 70 to 90 ° C, and keep stirring for 10 minutes.

The obtained hydrogel composition is poured into a sheet form at 80 ° C., molded and cooled to room temperature to prepare a state-change hydrogel sheet, which can be used for skin delivery by controlled release of cosmetic agent for skin care Resulting in a hydrogel composition film.

When the temperature of the hydrogel composition film having the above composition was 75 ° C, the respective viscosities were measured according to a rotating viscometer (Brookfield Viscometer). The tear strength test was carried out in accordance with JIS K6401 Lt; / RTI >

Specifically, the tear strength test was performed at 23 ± 2 ° C and a relative humidity of 50 ± 5%. The thickness of the tear strength specimen was measured at 1 center and 3 at the equidistance, and the thickness was measured with a precision of 1 mm or more and a thickness of 0.1 mm. The pulling speed was 200 mm / min, and the measuring instrument was a SHIMADZU UTM (Universal Testing Machine) AGS-500D. A total of three specimens were measured and the results were averaged.

Comparative Example  11-14

Except that the film was a hydrogel composition film containing other natural high molecular materials besides Cassia gum, carrageenan gum CGN and Xanthan gum. A hydrogel composition film was prepared and viscosity and tear strength were measured.

As shown in Table 4, in the case of Examples 9 to 14, as shown in Examples 9 to 14 and Comparative Examples 11 to 14, the measured viscosity showed a value of around 2,000 cps and was within a range suitable for use as a cosmetic mask or the like 800 to 3,000 cps. By maintaining such a viscosity, when the composition is poured into a mold, a molded article having a smooth surface with a good spreadability and a uniform thickness can be produced. On the other hand, in the case of Comparative Examples 11 to 12, it was confirmed that the measured viscosity showed a value of 3,000 cps or more, and that a gel having a poor shape and a hard shape was formed.

Further, when the hydrogel composition film was prepared by mixing 0.9% by weight of Cassia gum, 0.6% by weight of carrageenan gum (CGN) and 0.6% by weight of Xanthan gum, It was confirmed that the hydrogel mask composition film can be produced because the tearing strength is high and the film has elasticity even when the molded article is not used.

Claims (6)

0.1 to 3% by weight of Cassia gum, which is a natural high molecular substance, based on the total weight of the composition;
0.1 to 2% by weight of one or a mixture thereof selected from carrageenan gum or xanthan gum;
5 to 30% by weight of a polyhydric alcohol as a plasticizer;
0.5 to 2% by weight of electrolyte;
From 0.1 to 10% by weight of a functional cosmetic ingredient which imparts a skin cosmetic function;
0.001 to 0.5% by weight of an antiseptic;
And the remainder is a composition comprising a solvent including water,
Wherein the mixing ratio of the natural polymer material is as follows.
a) a hydrogel composition wherein the content ratio of a natural high molecular substance composed of Cassia gum and Carrageenan gum is 4: 6 to 6: 4.
b) a hydrogel composition having a content ratio of natural polymeric material consisting of Cassia gum and Xanthan gum of 3: 7 to 5: 5.
c) a hydrogel composition wherein the content ratio of a mixture of Cassia gum and Carrageenan gum or Xanthan gum is 0.9: 0.6: 0.6. The method according to claim 1,
Wherein the plasticizer is one or more polyhydric alcohols selected from glycerin, ethylene glycol, polyethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol and butylene glycol,
Wherein the electrolyte is at least one electrolyte selected from the group consisting of potassium chloride, sodium chloride, magnesium chloride, and calcium chloride. 3. The method of claim 2,
Wherein the electrolyte is 0.5-1.5 wt.% Potassium chloride (KCl). The method according to claim 1,
Wherein the functional cosmetic ingredient is at least one substance having a skin cosmetic function including wrinkle improvement, skin whitening, ultraviolet screening, moisture supply, nutrient supply and skin elasticity. The method of claim 1,
Wherein the pH of the hydrogel composition is in the range of 4.0 to 8.0. (a) mixing a liquid natural polymer material with a plasticizer, an electrolyte, a functional cosmetic ingredient, an antiseptic, and water in a ratio according to claim 1;
(b) heating the composition to a temperature of 70 to 90 DEG C to form a gel-like hydrogel composition;
(c) preparing a gel-like hydrogel molding by placing the heated composition in a mold;
≪ / RTI >

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