CN105106177A - Film-forming agent capable of preventing cow mastitis and preparation method thereof - Google Patents
Film-forming agent capable of preventing cow mastitis and preparation method thereof Download PDFInfo
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- CN105106177A CN105106177A CN201510460221.1A CN201510460221A CN105106177A CN 105106177 A CN105106177 A CN 105106177A CN 201510460221 A CN201510460221 A CN 201510460221A CN 105106177 A CN105106177 A CN 105106177A
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Abstract
The invention relates to a film-forming agent capable of preventing cow mastitis, comprising by weight, 0.6 o 1.2 parts of povidone iodine, 1 to 2 parts of tween 80, 0.2 to 0.6 part of glycerine, 8 to 12 parts of PVA (polyvinyl acetate), and 100 parts of distilled water. The invention further relates to a preparation method of the film-forming agent. The preparation method includes the steps of sterilizing with distilled water, temperature adjusting, adding of the povidone iodine, glycerine, tween 80 and PVA, pH adjusting and the like. The components and production process are further simplified, thus the film forming speed is high and breathability is good, the film-forming agent is nonirritating to skin mucosa. Especially, the film-forming agent and the preparation method thereof have the advantages such as high antibacterial activity, short film-forming time, easiness of eluting or stripping, agent stability, convenience of use and the like.
Description
Technical field
The invention belongs to mammitis of cow prevention technique field, be specifically related to a kind of film former preventing mammitis of cow and preparation method thereof.
Background technology
Mammitis of cow is because mechanical damage (as excessive in milking vacuum pressure or breast in colony house scratch etc.) and cause of disease invade the serial breast inflammation caused, light then cause milk quality comparison, milk is discarded, severe one causes breast red and swollen heat pain, and may cyclomastopathy be developed into, even papillary necrosis etc.Mammitis of cow sickness rate is high, obviously whether can be divided into clinical type and latent mammitis by clinical symptoms, and wherein latent mammitis sickness rate up to more than 30%, can have a strong impact on milk cow health and culture benefit.The main cause causing bovine subclinical mastitis to occur is pathogen infection, and its main infection approach is that 20th-century disease pathogenic microorganism (antibacterial, fungus, virus etc.) is invaded by papillary duct, and a period of time that papillary duct is after being milked opened a business particularly occurs.Therefore, the major measure preventing mastitis from occurring blocks environment cause of disease to invade from papillary duct.
At present, aqueous disinfectant mostly is for what sterilize after milk cow milking, i.e. dipping nipple after milking; this method is simple and quick, but liquid is affected by gravity meeting lower rapidly, acts on of short duration; long period cannot play disinfective action, papillary duct therefore can not be protected not invaded by microorganism.
Summary of the invention
For existing povidone iodine film former, the present invention simplifies composition and production technology further, make that its film forming is fast, good permeability, to skin mucosa nonirritant, especially have that antibacterial activity is strong, film formation time is short, easy eluting or stripping, preparation stabilization, the advantage such as easy to use.
For solving the problem, the present invention is achieved through the following technical solutions:
For the prevention of mammitis of cow, the invasion blocking pathogenic microorganism is particularly important, invades from papillary duct for blocking pathogenic microorganism; good way uses film former; namely after milk cow milking, use film former, make it to form layer protecting film fast, wrap by nipple.As taken Chinese medicine as the film former of main antimicrobial component, its advantage has no side effect, but Chinese medicine antibacterial active constituent content is relatively low, Chinese medicinal formulae prescription is complicated simultaneously, need by technique effective component extractings such as decocting, reflux, distill, be concentrated, complex manufacturing, with high costs, be difficult in production promote.For this reason, through long-term experimental study, it take povidone iodine as the film former of the prevention mammitis of cow of main antimicrobial component that the present invention have developed a kind of, and it comprises the raw material of following weight portion:
Povidone iodine 0.6 ~ 1.2 part, Tween 80 1 ~ 2 part, glycerol 0.2 ~ 0.6 part, PVA8 ~ 12 part, distilled water 100 parts.
Preferably, described film former comprises the raw material of following weight portion: povidone iodine 0.7 ~ 1.0 part, Tween 80 1 ~ 2 part, glycerol 0.3 ~ 0.5 part, PVA8 ~ 10 part, distilled water 100 parts.
The preparation method of the film former of above-mentioned prevention mammitis of cow, comprises the following steps:
(1) by described distilled water sterilizing, and control at 75 ~ 85 DEG C;
(2) described povidone iodine is added in distilled water, be stirred to and dissolve completely;
(3) add described glycerol and Tween 80, stir;
(4) add described PVA, make it fully dissolve;
(5) set up pH value to pH7.0, obtain film former of the present invention.
positive beneficial effect of the present invention:
In film former of the present invention each COMPONENTS COMPATIBILITY good, can synergism be divided, killing action is had to various bacteria, brood cell, virus, fungus etc., its mechanism of action is mainly: spread upon after on breast, povidone iodine wherein can discharge free-iodine and play antimicrobial effect, and povidone iodine is little to Skin and mucosa irritation, be applicable to skin of breast sterilization; Contained glycerin components has thickness moisturizing, promotes the effect of antimicrobial component diffusion and infiltration, and cow breast can be kept moistening, prevents dry and cracked and cold injury in winter; Institute's tween 80 is good emulsifying agent, easily forms glue under uniform temperature, film forming when therefore contributing to using, and Tween 80 also has the effect with povidone iodine Synergistic antimicrobial simultaneously; Contained PVA(polyvinyl alcohol) there is excellent adhering, the easy film forming of its solution, and the resistance to water that there is after film forming unique strong adherence, epithelium pliability, flatness, solvent resistance, protecting colloid, wearability and have through special handling.
Film former of the present invention is mainly used in the sterilization of milk cow milking rear udder attachment, said preparation can rapid film formation in 3 ~ 5min, block microorganism to invade from papillary duct, avoid liquid disinfectant to drip rapidly, thus long-acting disinfection effect can be played, and it is wide to microbial action spectrum, antibacterial, antiviral activity is strong, and to skin, mucosa nonirritant, clinical prophylactic performance is satisfied, and it has no side effect, can not pollute milk dairy products.In addition, the features such as this method has produces simply, easy to use, efficient.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with specific embodiment, the present invention is described in more detail.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
embodiment 1
Prevent a film former for mammitis of cow, be made up of the raw material of following weight portion: povidone iodine 0.7 part, Tween 80 1 part, glycerol 0.3 part, PVA8 part, distilled water 100 parts.
Preparation method is as follows
(1) by described distilled water sterilizing, and control at 80 DEG C;
(2) described povidone iodine is added in distilled water, be stirred to and dissolve completely;
(3) add described glycerol and Tween 80, stir;
(4) add described PVA, make it fully dissolve;
(5) set up pH value to pH7.0, obtain film former of the present invention.
embodiment 2
Prevent a film former for mammitis of cow, be made up of the raw material of following weight portion: povidone iodine 0.9 part, Tween 80 2 parts, glycerol 0.5 part, PVA9 part, distilled water 100 parts.
Preparation method is identical with embodiment 1.
embodiment 3
Prevent a film former for mammitis of cow, be made up of the raw material of following weight portion: povidone iodine 1 part, Tween 80 2 parts, glycerol 0.4 part, PVA10 part, distilled water 100 parts.
Preparation method is identical with embodiment 1.
The film former of mammitis of cow is prevented to carry out clinical effectiveness experiment to the present invention below:
1. experimental technique:
Using embodiment 1 gained film former as experimental group, use this film former to carry out dipping after milch cow is milked at every turn, matched group uses the dipping of routine disinfection liquid, keeps milch cow to stand after dipping 5 minutes.Before discarding during milking within the Lactation of Dairy Cow phase, 3 milk later, collects back segment milk and do C.M.T inspection, observe the sickness rate of recessive mastitis according to its somatic cell situation.Observe acute mammitis of cow incidence in Lactation of Dairy Cow phase whole process simultaneously.
2. mastitis criterion:
(1) recessive mastitis:
According to C.M.T check result, somatic cell quantity is 5 × 10
5individual/more than mL time, can mastitis be judged to;
(2) dominant mastitis:
Cow breast appearance is red, swollen, hot, bitterly, lump appears in breast, and milk is containing curdling block or floccule, and milk color becomes yellow and even occurs the abnormal colors such as color.
3. effect judges:
Record whole milk cow in lactation period recessiveness, dominant mastitis incidence, and calculate its sickness rate (sickness rate=morbidity milch cow number/milch cow sum × 100%) respectively
Case one: each 186 of matched group, experimental group lactating cow sum, Comparison of clinical effect is in table 1.
Table 1 case one Comparison of clinical effect table
。
Case two: each 243 of matched group, experimental group lactating cow sum, Comparison of clinical effect is in table 2.
Table 2 case two Comparison of clinical effect table
。
Claims (3)
1. prevent a film former for mammitis of cow, it is characterized in that, comprise the raw material of following weight portion: povidone iodine 0.6 ~ 1.2 part, Tween 80 1 ~ 2 part, glycerol 0.2 ~ 0.6 part, PVA8 ~ 12 part, distilled water 100 parts.
2. prevent the film former of mammitis of cow according to claim 1, it is characterized in that, described film former comprises the raw material of following weight portion: povidone iodine 0.7 ~ 1.0 part, Tween 80 1 ~ 2 part, glycerol 0.3 ~ 0.5 part, PVA8 ~ 10 part, distilled water 100 parts.
3. prevent a preparation method for the film former of mammitis of cow, it is characterized in that, comprise the following steps:
(1) raw material is equipped with by claim 1;
(2) by described distilled water sterilizing, and control at 75 ~ 85 DEG C;
(3) described povidone iodine is added in distilled water, be stirred to and dissolve completely;
(4) add described glycerol and Tween 80, stir;
(5) add described PVA, make it fully dissolve;
(6) pH value is set up to pH7.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510460221.1A CN105106177A (en) | 2015-07-31 | 2015-07-31 | Film-forming agent capable of preventing cow mastitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510460221.1A CN105106177A (en) | 2015-07-31 | 2015-07-31 | Film-forming agent capable of preventing cow mastitis and preparation method thereof |
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| CN105106177A true CN105106177A (en) | 2015-12-02 |
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| CN201510460221.1A Pending CN105106177A (en) | 2015-07-31 | 2015-07-31 | Film-forming agent capable of preventing cow mastitis and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596235A (en) * | 2016-01-11 | 2016-05-25 | 西安汉隆化工科技有限公司 | Novel milk cow nipple medicated bath solution and preparing method thereof |
| CN107456461A (en) * | 2017-07-06 | 2017-12-12 | 内蒙古新开元动物药业发展有限公司 | Elemental sulfur, iodine mixture and preparation method thereof |
| CN108836951A (en) * | 2018-06-20 | 2018-11-20 | 中山万汉制药有限公司 | A kind of povidone iodine slow-release medicine-membrane and preparation method thereof |
| CN110538221A (en) * | 2019-09-09 | 2019-12-06 | 郑州百瑞动物药业有限公司 | Compound film spraying agent for dairy cows and preparation method thereof |
| CN110559313A (en) * | 2019-09-23 | 2019-12-13 | 天津农学院 | Sodium alginate film-forming substrate milk cow nipple medicated bath liquid and preparation method thereof |
| CN112635079A (en) * | 2020-12-14 | 2021-04-09 | 济南深蓝动物保健品有限公司 | Technical research of povidone iodine film-forming infusion for medicated bath of nipples for preventing mastitis of dairy cows |
| CN113509435A (en) * | 2021-07-23 | 2021-10-19 | 天津华源化工有限公司 | Formula for nursing cow nipples and production method thereof |
Citations (2)
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|---|---|---|---|---|
| US4568559A (en) * | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
| CN104622792A (en) * | 2015-03-04 | 2015-05-20 | 扬州大学 | Film-forming papilla medicated bath preparation used for controlling recessive mastitis of dairy cattle |
-
2015
- 2015-07-31 CN CN201510460221.1A patent/CN105106177A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4568559A (en) * | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
| CN104622792A (en) * | 2015-03-04 | 2015-05-20 | 扬州大学 | Film-forming papilla medicated bath preparation used for controlling recessive mastitis of dairy cattle |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596235A (en) * | 2016-01-11 | 2016-05-25 | 西安汉隆化工科技有限公司 | Novel milk cow nipple medicated bath solution and preparing method thereof |
| CN105596235B (en) * | 2016-01-11 | 2019-02-12 | 西安汉隆化工科技有限公司 | A kind of milk cow nipple medicated bath liquid and preparation method thereof |
| CN107456461A (en) * | 2017-07-06 | 2017-12-12 | 内蒙古新开元动物药业发展有限公司 | Elemental sulfur, iodine mixture and preparation method thereof |
| CN108836951A (en) * | 2018-06-20 | 2018-11-20 | 中山万汉制药有限公司 | A kind of povidone iodine slow-release medicine-membrane and preparation method thereof |
| CN110538221A (en) * | 2019-09-09 | 2019-12-06 | 郑州百瑞动物药业有限公司 | Compound film spraying agent for dairy cows and preparation method thereof |
| CN110538221B (en) * | 2019-09-09 | 2021-10-19 | 郑州百瑞动物药业有限公司 | Compound film spraying agent for dairy cows and preparation method thereof |
| CN110559313A (en) * | 2019-09-23 | 2019-12-13 | 天津农学院 | Sodium alginate film-forming substrate milk cow nipple medicated bath liquid and preparation method thereof |
| CN112635079A (en) * | 2020-12-14 | 2021-04-09 | 济南深蓝动物保健品有限公司 | Technical research of povidone iodine film-forming infusion for medicated bath of nipples for preventing mastitis of dairy cows |
| CN113509435A (en) * | 2021-07-23 | 2021-10-19 | 天津华源化工有限公司 | Formula for nursing cow nipples and production method thereof |
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