CN104398534A - Polyhexamethylene guanidine eye drops - Google Patents
Polyhexamethylene guanidine eye drops Download PDFInfo
- Publication number
- CN104398534A CN104398534A CN201410609088.7A CN201410609088A CN104398534A CN 104398534 A CN104398534 A CN 104398534A CN 201410609088 A CN201410609088 A CN 201410609088A CN 104398534 A CN104398534 A CN 104398534A
- Authority
- CN
- China
- Prior art keywords
- polyhexamethylene guanidine
- water
- eye drops
- minutes
- pure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 Polyhexamethylene guanidine Polymers 0.000 title claims abstract description 24
- 239000003889 eye drop Substances 0.000 title claims abstract description 18
- 229940012356 eye drops Drugs 0.000 title abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 14
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 claims abstract description 7
- 239000011780 sodium chloride Substances 0.000 claims abstract description 7
- 239000008118 PEG 6000 Substances 0.000 claims abstract description 6
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims abstract description 6
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims abstract description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 6
- 229940046009 vitamin E Drugs 0.000 claims abstract description 6
- 239000011709 vitamin E Substances 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000010008 shearing Methods 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 208000001860 Eye Infections Diseases 0.000 abstract description 4
- 206010067268 Post procedural infection Diseases 0.000 abstract description 4
- 201000007032 bacterial conjunctivitis Diseases 0.000 abstract description 4
- 206010023332 keratitis Diseases 0.000 abstract description 4
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 206010011844 Dacryocystitis Diseases 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 231100000344 non-irritating Toxicity 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 244000005700 microbiome Species 0.000 description 4
- 206010064996 Ulcerative keratitis Diseases 0.000 description 3
- 201000007717 corneal ulcer Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 206010015946 Eye irritation Diseases 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 231100000921 acute inhalation toxicity Toxicity 0.000 description 2
- 231100000460 acute oral toxicity Toxicity 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 231100000013 eye irritation Toxicity 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000456 subacute toxicity Toxicity 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 206010048768 Dermatosis Diseases 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 208000003464 asthenopia Diseases 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000005494 xerophthalmia Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Polyhexamethylene guanidine eye drops relate to the technical field of eye drops, and comprise the following components by mass: 0.01%-0.1% of polyhexamethylene guanidine hydrochloride, 0.01% of a synergist, 0.1% of pharmaceutical grade hydroxy propyl methyl cellulose, 0.05% of PEG200 (polyethylene glycol), 0.05% of PEG6000, 0.05% of water soluble vitamin E, 0.01% of water-soluble mint, 0.1% of pure sodium chloride, and 99.53%-99.62% of pure water. Polyhexamethylene guanidine is used in the eye drops, and the polyhexamethylene guanidine eye drops are suitable for bacterial conjunctivitis, keratitis, keratohelcosis, dacryocystitis, postoperative infection and other external ocular infections, and is good in sterilization effect, mild in nature, and non-irritating.
Description
Technical field:
The present invention relates to eye drop technical field, be specifically related to a kind of polyhexamethylene guanidine eye drop.
Background technology:
Collyrium is one of the most frequently used pharmaceutical dosage form of ophthalmic diseases, and for much oculopathy, collyrium has directly, therapeutical effect efficiently.Along with the life style of people and the change of working condition, get more and more with the time of eye, such as see computer for a long time, see TV, operate video games etc., be easy to suffer from visual fatigue disease and xerophthalmia.These two kinds of diseases all with the dry and astringent discomfort of eyes for main manifestations, so collyrium becomes daily " required medicines " by a lot of people.
Environment-friendly type macromolecule polymer bactericide---polyhexamethylene guanidine, has broad-spectrum; Valid density is low; Speed of action is fast; Stable in properties; Premium properties soluble in water; Can use at normal temperatures; For a long time antibacterial, have no side effect; Non-corrosiveness; Colourless, odorless; Nontoxic; Do not fire, not quick-fried, use safety; Moderate; Convenient transportation, can be described as best antibacterial.In fact, this product is a kind of environment-friendly multipurpose new polymers, in industrial, agriculture, medical and daily life, have purposes extremely widely.
Polyhexamethylene guanidine is widely used in aquaculture, pasteurization towelette, skin wound disinfectant, pudendum washing liquid, public place sterilization purification agent, palm disinfectant, textile industry and sanitary towel, beriberi, dermatosis, articles for washing, beverage and food-processing industry, does not also occur that polyhexamethylene guanidine is applied to the product of eye drop at present on the market.
Summary of the invention:
The object of this invention is to provide a kind of polyhexamethylene guanidine eye drop, polyhexamethylene guanidine is applied to eye drop by it, and be applicable to the external ocular infections such as bacterial conjunctivitis, keratitis, corneal ulcer, dacryocystisis, postoperative infection, bactericidal effect is good, and character is gentle, non-stimulated.
In order to solve the problem existing for background technology, the present invention is by the following technical solutions: its quality consists of than formula: Polyhaxemethylenguanidine Hydrochloride 0.01%-0.1%, synergist 0.01%, pharmaceutical grade hydroxypropyl emthylcellulose 0.1%, PEG200 0.05%, PEG60000.05%, water soluble vitamin E 0.05%, water-soluble Herba Menthae 0.01%, pure sodium chloride 0.1%, pure water 99.53%-99.62%.
Preparation method of the present invention is:
(1), according to aforementioned proportion, hydroxypropyl emthylcellulose, PEG6000 are added in a small amount of pure water, high-speed shearing machine stirs 10 minutes, obtain solution A;
(2), according to aforementioned proportion, join in a small amount of pure water by water soluble vitamin E, water-soluble Herba Menthae, PEG200, pure sodium chloride successively when stirring, addition sequence is: after a kind of adjuvant dissolves, then add another adjuvant, then stir 10 minutes, obtain solution B;
(3), according to aforementioned proportion, Polyhaxemethylenguanidine Hydrochloride, synergist are added in pure water, stir after 30 minutes, then solution A and solution B added successively and stir 10 minutes, obtaining polyhexamethylene guanidine eye drop.
Active ingredient of the present invention becomes electropositive, be easy to by electronegative each bacterioid, fungus, virus adsorb and be wound around, thus suppress the splitting function of pathogenic bacteria, make antibacterial lose fertility, add the respiration channel plugging microorganism, microorganism is choked to death rapidly.Stimulate and a damaged skin experiment through Eye irritation, repeatedly intact skin, belong to nonirritant; All belong to nontoxic through acute oral toxicity, acute inhalation toxicity, Skin Irritation Test, subacute toxicity test, micronucleus test.
Polyhexamethylene guanidine is applied to eye drop by the present invention, and be applicable to the external ocular infections such as bacterial conjunctivitis, keratitis, corneal ulcer, dacryocystisis, postoperative infection, bactericidal effect is good, and character is gentle, non-stimulated.
Detailed description of the invention:
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with detailed description of the invention, the present invention is further elaborated.Should be appreciated that detailed description of the invention described herein only in order to explain the present invention, be not intended to limit the present invention.
This detailed description of the invention is by the following technical solutions: its quality consists of than formula: Polyhaxemethylenguanidine Hydrochloride 0.01%-0.1%, synergist 0.01%, pharmaceutical grade hydroxypropyl emthylcellulose 0.1%, PEG200 0.05%, PEG6000 0.05%, water soluble vitamin E 0.05%, water-soluble Herba Menthae 0.01%, pure sodium chloride 0.1%, pure water 99.53%-99.62%.
The preparation method of this detailed description of the invention is:
(1), according to aforementioned proportion, hydroxypropyl emthylcellulose, PEG6000 are added in a small amount of pure water, high-speed shearing machine stirs 10 minutes, obtain solution A;
(2), according to aforementioned proportion, join in a small amount of pure water by water soluble vitamin E, water-soluble Herba Menthae, PEG200, pure sodium chloride successively when stirring, addition sequence is: after a kind of adjuvant dissolves, then add another adjuvant, then stir 10 minutes, obtain solution B;
(3), according to aforementioned proportion, Polyhaxemethylenguanidine Hydrochloride, synergist are added in pure water, stir after 30 minutes, then solution A and solution B added successively and stir 10 minutes, obtaining polyhexamethylene guanidine eye drop.
The active ingredient of this detailed description of the invention becomes electropositive, be easy to by electronegative each bacterioid, fungus, virus adsorb and be wound around, thus suppress the splitting function of pathogenic bacteria, make antibacterial lose fertility, add the respiration channel plugging microorganism, microorganism is choked to death rapidly.Stimulate and a damaged skin experiment through Eye irritation, repeatedly intact skin, belong to nonirritant; All belong to nontoxic through acute oral toxicity, acute inhalation toxicity, Skin Irritation Test, subacute toxicity test, micronucleus test.
Polyhexamethylene guanidine is applied to eye drop by this detailed description of the invention, and be applicable to the external ocular infections such as bacterial conjunctivitis, keratitis, corneal ulcer, dacryocystisis, postoperative infection, bactericidal effect is good, and character is gentle, non-stimulated.
The above is only in order to illustrate technical scheme of the present invention and unrestricted, other amendment that those of ordinary skill in the art make technical scheme of the present invention or equivalently to replace, only otherwise depart from the spirit and scope of technical solution of the present invention, all should be encompassed in the middle of right of the present invention.
Claims (2)
1. polyhexamethylene guanidine eye drop, is characterized in that its quality consists of than formula: Polyhaxemethylenguanidine Hydrochloride 0.01%-0.1%, synergist 0.01%, pharmaceutical grade hydroxypropyl emthylcellulose 0.1%, PEG200 0.05%, PEG6000 0.05%, water soluble vitamin E0.05%, water-soluble Herba Menthae 0.01%, pure sodium chloride 0.1%, pure water 99.53%-99.62%.
2. polyhexamethylene guanidine eye drop, is characterized in that its preparation method is:
(1), according to aforementioned proportion, hydroxypropyl emthylcellulose, PEG6000 are added in a small amount of pure water, high-speed shearing machine stirs 10 minutes, obtain solution A;
(2), according to aforementioned proportion, join in a small amount of pure water by water soluble vitamin E, water-soluble Herba Menthae, PEG200, pure sodium chloride successively when stirring, addition sequence is: after a kind of adjuvant dissolves, then add another adjuvant, then stir 10 minutes, obtain solution B;
(3), according to aforementioned proportion, Polyhaxemethylenguanidine Hydrochloride, synergist are added in pure water, stir after 30 minutes, then solution A and solution B added successively and stir 10 minutes, obtaining polyhexamethylene guanidine eye drop.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410609088.7A CN104398534A (en) | 2014-11-04 | 2014-11-04 | Polyhexamethylene guanidine eye drops |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410609088.7A CN104398534A (en) | 2014-11-04 | 2014-11-04 | Polyhexamethylene guanidine eye drops |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104398534A true CN104398534A (en) | 2015-03-11 |
Family
ID=52636243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410609088.7A Pending CN104398534A (en) | 2014-11-04 | 2014-11-04 | Polyhexamethylene guanidine eye drops |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104398534A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232456A (en) * | 2015-11-06 | 2016-01-13 | 卫国刚 | Polyhexamethylene guanidine propionate eye drop |
| CN107281557A (en) * | 2017-06-21 | 2017-10-24 | 江苏天眼医药科技股份有限公司 | A kind of production technology of contact lenses lubricating fluid |
| CN110123832A (en) * | 2019-05-13 | 2019-08-16 | 东南大学 | A kind of ophthalmic composition containing no drug resistance fungicide |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997000076A1 (en) * | 1995-06-16 | 1997-01-03 | Moorfields Eye Hospital | Compositions containing poly(hexamethylene biguanide) salts and uses thereof |
| CN101455635A (en) * | 2009-01-06 | 2009-06-17 | 河北科技大学 | Cromoglyn sodium eye drops without bacteria inhibitor and preparation method thereof |
| CN102100665A (en) * | 2011-01-14 | 2011-06-22 | 华南理工大学 | Eye drops containing vitamin E derivatives and preparation method thereof |
| RU2513997C1 (en) * | 2012-12-21 | 2014-04-27 | Станислав Анатольевич Кедик | Combined ophthalmic preparation presented in form of eye drops and containing polyhexamethylene guanidine and taurine |
-
2014
- 2014-11-04 CN CN201410609088.7A patent/CN104398534A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997000076A1 (en) * | 1995-06-16 | 1997-01-03 | Moorfields Eye Hospital | Compositions containing poly(hexamethylene biguanide) salts and uses thereof |
| CN101455635A (en) * | 2009-01-06 | 2009-06-17 | 河北科技大学 | Cromoglyn sodium eye drops without bacteria inhibitor and preparation method thereof |
| CN102100665A (en) * | 2011-01-14 | 2011-06-22 | 华南理工大学 | Eye drops containing vitamin E derivatives and preparation method thereof |
| RU2513997C1 (en) * | 2012-12-21 | 2014-04-27 | Станислав Анатольевич Кедик | Combined ophthalmic preparation presented in form of eye drops and containing polyhexamethylene guanidine and taurine |
Non-Patent Citations (4)
| Title |
|---|
| 孙旭光等: "致病性自生生活阿米巴性角膜炎", 《眼科》 * |
| 李杨等: "聚六亚甲基双胍盐酸盐的合成及应用", 《精细化工原料及中间体》 * |
| 薛大权等: "《聚乙二醇在医药学领域的应用与技术》", 30 April 2011, 华中科技大学出版社 * |
| 顾其胜: "《玻璃酸钠生产与临床应用》", 31 May 2012, 上海科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232456A (en) * | 2015-11-06 | 2016-01-13 | 卫国刚 | Polyhexamethylene guanidine propionate eye drop |
| CN107281557A (en) * | 2017-06-21 | 2017-10-24 | 江苏天眼医药科技股份有限公司 | A kind of production technology of contact lenses lubricating fluid |
| CN110123832A (en) * | 2019-05-13 | 2019-08-16 | 东南大学 | A kind of ophthalmic composition containing no drug resistance fungicide |
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Application publication date: 20150311 |
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| RJ01 | Rejection of invention patent application after publication |