CN102697786A - Urotropine composite skin disinfectant and preparation method thereof - Google Patents
Urotropine composite skin disinfectant and preparation method thereof Download PDFInfo
- Publication number
- CN102697786A CN102697786A CN2012101817025A CN201210181702A CN102697786A CN 102697786 A CN102697786 A CN 102697786A CN 2012101817025 A CN2012101817025 A CN 2012101817025A CN 201210181702 A CN201210181702 A CN 201210181702A CN 102697786 A CN102697786 A CN 102697786A
- Authority
- CN
- China
- Prior art keywords
- hexamethylenamine
- water
- compound
- disinfectant solution
- percent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a urotropine composite skin disinfectant and a preparation method thereof. The preparation method comprises the following steps of: heating an appropriate amount of purified water to 60 DEG C, preserving heat, and stirring 0.5-2.0 percent of a nonionic surfactant and 0.2-1.0 percent of a water-soluble high molecular compound for dissolving completely; adding 0.5-2.0 percent of urotropine and 0.1-1.0 percent of benzethonium chloride, and stirring for dissolving; adding 0.1-2.0 percent of a pH buffering agent for fully dissolving; and stopping heating, lowering the temperature of a material body in a reaction kettle to 40 DEG C, adding 10-20 percent of ethanol and 1.0-5.0 percent of dimethicone, and stirring uniformly. The sterilizing activity of the disinfectant is raised, and the sterilizing spectrum is expanded; and a plurality of skin moistening components are used simultaneously, so that the irritation of the disinfectant on the skin is lowered.
Description
Technical field
The present invention relates to disinfectant liquid for skin, relate in particular to hexamethylenamine class disinfectant liquid for skin and preparation method thereof.
Background technology
Though skin antiseptic kind in the market is many, but still have various defectives, like the most frequently used skin antiseptic iodine tincture, penetration is strong, thus fabulous bactericidal effect is arranged, because of zest is used not extensive greatly; The disinfecting gel that contains compound alcohol also is a kind of skin antiseptic of using always, but bactericidal effect is not good; The skin antiseptic of making antibacterial with chlorhexidine is quite a few, but allergic phenomena constantly occurs, and simple hexamethylenamine class disinfectant solution is to skin allergy also report to some extent, and therefore researching and developing ideal skin antiseptic is the eternal demand in market.
Summary of the invention
The present invention is intended to address the aforementioned drawbacks, and a kind of hexamethylenamine compound skin disinfectant solution and preparation method thereof is provided.Disinfectant Disinfection Effect of the present invention is good, and zest is low, skin protection is good.
For addressing the above problem, the present invention is achieved in that a kind of hexamethylenamine compound skin disinfectant solution, and it comprises following percentage by weight:
Hexamethylenamine 0.5-2.0 %
Benzethonium chloride 0.1-1.0 %
Ethanol 10 – 20 %
Non-ionic surface active agent 0.5-2.0 %
Dimethicone 1.0-5.0 %
Water-soluble high-molecular compound 0.2 – 1.0 %
PH buffer agent 0.1-2.0 %
Its amount is purified water;
Said water-soluble high-molecular compound is that in hyaluronate sodium, arabic gum, HANSHENGJIAO, Tragacanth, polyvinyl alcohol, Polyethylene Glycol, hydroxyethyl-cellulose, hydroxypropyl cellulose, methylcellulose, the polyvinylpyrrolidone one or more mix;
The pH buffer agent is phosphate, boric acid or Borax.
Described nonionic surfactant is alkanolamide class, ethers and/or esters surface active agent.
Described hexamethylenamine compound skin disinfectant solution, said nonionic surfactant is for being selected from cocos nucifera oil diglycollic amide, cetyl, spermol, polyoxyethylene (3) ether, the polyoxyethylene lauryl ether one or more.
Described hexamethylenamine compound skin disinfectant solution, it also comprises 0.01-0.1% essence.
The method for preparing of said arbitrary hexamethylenamine compound skin disinfectant solution, it comprises: according to formula ratio, purified water is heated to 60 ℃ and maintenance, non-ionic surface active agent and water-soluble high-molecular compound are stirred to dissolving fully then; Add hexamethylenamine and benzethonium chloride again, stir and make its dissolving; Add the pH buffer agent again and be stirred to dissolving fully; Stop heating, the material temperature is reduced in 40 ℃ in the question response still, and adding ethanol, dimethicone and essence stir and gets final product.
The method for preparing of described hexamethylenamine compound skin disinfectant solution, it comprises according to formula ratio, and purified water is heated to 60 ℃ and maintenance, non-ionic surface active agent and water-soluble high-molecular compound are stirred to dissolving fully then; Add hexamethylenamine and benzethonium chloride again, stir and make its dissolving; Add the pH buffer agent again and be stirred to dissolving fully; Stop heating, the material temperature is reduced in 40 ℃ in the question response still, adds ethanol, dimethicone and essence, and stirring gets final product.
The invention is characterized in composite through hexamethylenamine and benzethonium chloride, add an amount of ethanol, thereby improved disinfectant solution bactericidal activity, enlarged fungicidal spectrum; Multiple Safflower Oil uses simultaneously, has reduced the zest of disinfectant solution to skin.
One of bactericidal active ingredient that is adopted among the present invention is a hexamethylenamine, and its chemical name is a hexamethylenetetramine, and chemical molecular formula is C
6H
12N
4, character is colourless glossiness crystallization or white crystalline powder, almost odorless, the just sweet back of flavor hardship.Soluble in water, be dissolved in ethanol, be dissolved in ether hardly.Hexamethylenamine has antibacterial, convergence, anti-hidropoiesis, is Cidex-7.External can be controlled tinea, hidroschesis, control bromhidrosis.Back for oral administration is met acid decomposition and is produced formaldehyde and play bactericidal action, is used for slight urinary tract infection, but also intravenous injection.
Another bactericidal active ingredient that is adopted among the present invention is a benzethonium chloride, and American Pharmacopeia is called Phenyl chloride again, and it is a kind of quaternary ammonium compound of uniqueness; Compare with traditional quaternary ammonium compound, benzethonium chloride purity is high, and antibiotic property is strong; Gentle to skin; Zest is low, is a kind of very effective antiseptic, can kill a large amount of gram-negative micro-organisms and gram-negative micro-organism effectively short time of contact.
This shows; It is good to the invention provides a kind of Disinfection Effect; The disinfectant liquid for skin that zest is low, skin protection is good can be used for the quick sterilization of skin, mucosa, surgery hands, can kill escherichia coli, staphylococcus aureus, bacillus pyocyaneus and Candida albicans effectively; Reach hospital disinfection health request of national standard, and repeated multiple times is used non-stimulated to skin.
The specific embodiment
Below, in conjunction with specific embodiment, further specify the present invention: a kind of hexamethylenamine compound skin disinfectant solution, it comprises following percentage by weight:
Hexamethylenamine 0.5-2.0 %
Benzethonium chloride 0.1-1.0 %
Ethanol 10 – 20 %
Non-ionic surface active agent 0.5-2.0 %
Dimethicone 1.0-5.0 %
Water-soluble high-molecular compound 0.2 – 1.0 %
PH buffer agent 0.1-2.0 %
Its amount is purified water;
Said water-soluble high-molecular compound is that in hyaluronate sodium, arabic gum, HANSHENGJIAO, Tragacanth, polyvinyl alcohol, Polyethylene Glycol, hydroxyethyl-cellulose, hydroxypropyl cellulose, methylcellulose, the polyvinylpyrrolidone one or more mix;
The pH buffer agent is phosphate, boric acid or Borax.
Described nonionic surfactant is alkanolamide class, ethers and/or esters surface active agent.
Described hexamethylenamine compound skin disinfectant solution, said nonionic surfactant is for being selected from cocos nucifera oil diglycollic amide, cetyl, spermol, polyoxyethylene (3) ether, the polyoxyethylene lauryl ether one or more.
Described hexamethylenamine compound skin disinfectant solution, it also comprises 0.01-0.1% essence.
The method for preparing of described hexamethylenamine compound skin disinfectant solution, it comprises according to formula ratio, and purified water is heated to 60 ℃ and maintenance, non-ionic surface active agent and water-soluble high-molecular compound are stirred to dissolving fully then; Add hexamethylenamine and benzethonium chloride again, stir and make its dissolving; Add the pH buffer agent again and be stirred to dissolving fully; Stop heating, the material temperature is reduced in 40 ℃ in the question response still, adds ethanol, dimethicone, can also add essence, and stirring gets final product.
Embodiment 1
Hexamethylenamine 0.5, benzethonium chloride 0.8, ethanol 10, cocos nucifera oil diglycollic amide 1.0, water-soluble dimethyl silicone oil 1.0, polyvinylpyrrolidone 0.5, potassium dihydrogen phosphate 0.68, sodium hydroxide 0.07, essence 0.02, all the other are purified water.
Embodiment 2
Hexamethylenamine 1.0, benzethonium chloride 0.5, ethanol 10, spermol polyoxyethylene (3) ether 1.0, water-soluble dimethyl silicone oil 1.0, polyvinylpyrrolidone 0.5, potassium dihydrogen phosphate 0.68, sodium hydroxide 0.07, essence 0.02, all the other are purified water.
Embodiment 3
Hexamethylenamine 1.5, benzethonium chloride 0.3, ethanol 15, polyoxyethylene lauryl ether 1.0, water-soluble dimethyl silicone oil 1.0, hydroxyethyl-cellulose 0.5, potassium dihydrogen phosphate 0.68, sodium hydroxide 0.07, essence 0.02, all the other are purified water.
Embodiment 4
Hexamethylenamine 0.8, benzethonium chloride 0.6, ethanol 15, spermol polyoxyethylene (3) ether 1.0, hyaluronate sodium 0.2, water-soluble dimethyl silicone oil 1.0, hydroxyethyl-cellulose 0.3, boric acid 1.6, Borax 0.16, essence 0.02, all the other are purified water.
More than among each embodiment content for being weight percentage.
Above-mentioned prescription is configured compound skin disinfectant solution of the present invention according to method for preparing, and the disinfectant solution that other disposes hexamethylenamine, benzethonium chloride list effective ingredient compares BA, and the result sees table 1.
Table 1: hexamethylenamine and benzethonium chloride compound preparation and folk prescription BA effect thereof
Result of the test shows, though folk prescription hexamethylenamine and benzethonium chloride have bactericidal action to escherichia coli, staphylococcus aureus etc., the Disinfection Effect of both compound preparations obviously is superior to folk prescription.
Claims (5)
1. a hexamethylenamine compound skin disinfectant solution is characterized in that, it comprises following percentage by weight:
Hexamethylenamine 0.5-2.0 %
Benzethonium chloride 0.1-1.0 %
Ethanol 10 – 20 %
Non-ionic surface active agent 0.5-2.0 %
Dimethicone 1.0-5.0 %
Water-soluble high-molecular compound 0.2 – 1.0 %
PH buffer agent 0.1-2.0 %
Its amount is purified water;
Said water-soluble high-molecular compound is that in hyaluronate sodium, arabic gum, HANSHENGJIAO, Tragacanth, polyvinyl alcohol, Polyethylene Glycol, hydroxyethyl-cellulose, hydroxypropyl cellulose, methylcellulose, the polyvinylpyrrolidone one or more mix;
The pH buffer agent is phosphate, boric acid or Borax;
Described nonionic surfactant is alkanolamide class, ethers and/or esters surface active agent.
2. hexamethylenamine compound skin disinfectant solution according to claim 1; It is characterized in that said nonionic surfactant is for being selected from cocos nucifera oil diglycollic amide, cetyl, spermol, polyoxyethylene (3) ether, the polyoxyethylene lauryl ether one or more.
3. hexamethylenamine compound skin disinfectant solution according to claim 1 is characterized in that it also comprises 0.01-0.1% essence.
4. according to the method for preparing of the said arbitrary hexamethylenamine compound skin disinfectant solution of claim 1 to 3; It is characterized in that it comprises:, purified water is heated to 60 ℃ and maintenance according to formula ratio; Non-ionic surface active agent and water-soluble high-molecular compound are stirred to dissolving fully then; Add hexamethylenamine and benzethonium chloride again, stir and make its dissolving; Add the pH buffer agent again and be stirred to dissolving fully; Stop heating, the material temperature is reduced in 40 ℃ in the question response still, and adding ethanol, dimethicone and essence stir and gets final product.
5. the method for preparing of hexamethylenamine compound skin disinfectant solution according to claim 4; It is characterized in that it comprises according to formula ratio, and purified water is heated to 60 ℃ and maintenance; Non-ionic surface active agent and water-soluble high-molecular compound are stirred to dissolving fully then; Add hexamethylenamine and benzethonium chloride again, stir and make its dissolving; Add the pH buffer agent again and be stirred to dissolving fully; Stop heating, the material temperature is reduced in 40 ℃ in the question response still, adds ethanol, dimethicone and essence, and stirring gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101817025A CN102697786A (en) | 2012-06-05 | 2012-06-05 | Urotropine composite skin disinfectant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101817025A CN102697786A (en) | 2012-06-05 | 2012-06-05 | Urotropine composite skin disinfectant and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102697786A true CN102697786A (en) | 2012-10-03 |
Family
ID=46891034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101817025A Pending CN102697786A (en) | 2012-06-05 | 2012-06-05 | Urotropine composite skin disinfectant and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102697786A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109288720A (en) * | 2017-07-24 | 2019-02-01 | 刘崇庆 | Deodorant compositions and preparation method thereof |
| CN111840103A (en) * | 2020-08-10 | 2020-10-30 | 黑龙江天龙药业有限公司 | Long-acting film agent for armpit and preparation method thereof |
| CN113142203A (en) * | 2021-01-31 | 2021-07-23 | 康圣医疗科技(温州)有限公司 | Preparation method of quaternary ammonium salt antibacterial adhesion polymer long-acting disinfectant |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1668191A (en) * | 2002-05-20 | 2005-09-14 | 威廉·O·克林 | Skin cleanser compositions and methods of use |
| CN101292653A (en) * | 2007-04-27 | 2008-10-29 | 上海利康消毒高科技有限公司 | Compound hexamethylene tetramine disinfectant liquid and its preparation |
-
2012
- 2012-06-05 CN CN2012101817025A patent/CN102697786A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1668191A (en) * | 2002-05-20 | 2005-09-14 | 威廉·O·克林 | Skin cleanser compositions and methods of use |
| CN101292653A (en) * | 2007-04-27 | 2008-10-29 | 上海利康消毒高科技有限公司 | Compound hexamethylene tetramine disinfectant liquid and its preparation |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109288720A (en) * | 2017-07-24 | 2019-02-01 | 刘崇庆 | Deodorant compositions and preparation method thereof |
| CN111840103A (en) * | 2020-08-10 | 2020-10-30 | 黑龙江天龙药业有限公司 | Long-acting film agent for armpit and preparation method thereof |
| CN113142203A (en) * | 2021-01-31 | 2021-07-23 | 康圣医疗科技(温州)有限公司 | Preparation method of quaternary ammonium salt antibacterial adhesion polymer long-acting disinfectant |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105148253B (en) | Skin and mucosa bactericidal composition | |
| EP2588117B1 (en) | Stable antiseptic compositions and methods | |
| EP2937101A1 (en) | Semi-fluidic composition for lubricating, moisture retaining, disinfecting, sterilizing and method using the same | |
| JP7470449B2 (en) | Bisphosphosin gel preparations and their uses | |
| CN105055642A (en) | Compound guanidine disinfectant and preparation method of compound guanidine disinfectant | |
| CN109316536A (en) | A kind of skin mucosa disinfecting agent and preparation method thereof | |
| DK3035915T3 (en) | Composition, in particular in the form of a gel, and its use | |
| CN105055304A (en) | Leave-on skin care and disinfection gel containing composite sterilization component, and preparation method thereof | |
| CN103356738A (en) | Skin disinfection gel and its application | |
| CN109771315A (en) | A kind of disposable hand-wrist bones gel of environment-friendly type and preparation method thereof | |
| CN105079858B (en) | Liquid dressing and its preparation method are repaired in a kind of wound sterilization | |
| KR20170036058A (en) | Cineole-containing composition for nasal application | |
| CN105168238A (en) | Hyaluronic temperature-sensitive gel and preparation method and application thereof | |
| CN102697786A (en) | Urotropine composite skin disinfectant and preparation method thereof | |
| WO2009123207A1 (en) | Oral rinse composition | |
| WO2008104076A1 (en) | Electrocolloidal silver and echinacea root antimicrobial formulation | |
| CN102872160A (en) | Nano-silver foaming agent used for sterilizing wounds of scalds and burns and ulcer wounds | |
| CN109157505A (en) | Anti-bacteria wet keeping gel and preparation method thereof | |
| CN112515989B (en) | Compound low-alcohol disinfectant and preparation method thereof | |
| CN101310702B (en) | Emulsion type gel preparation containing chlorhexidine and alcohol | |
| KR102241761B1 (en) | A composition having a fast-acting sterilizing effect at room temperature | |
| CN103230386B (en) | Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof | |
| CN105560166A (en) | Gynecological external antibacterial gel with silver ions and method for preparing gynecological external antibacterial gel | |
| JP2017078029A (en) | Sterilization method and sterilization composition | |
| CN102961331A (en) | Iodine-chitosan solution formula and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20121003 |