CN113142203A - Preparation method of quaternary ammonium salt antibacterial adhesion polymer long-acting disinfectant - Google Patents
Preparation method of quaternary ammonium salt antibacterial adhesion polymer long-acting disinfectant Download PDFInfo
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 39
- 229920000642 polymer Polymers 0.000 title claims abstract description 24
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 21
- 150000003242 quaternary ammonium salts Chemical class 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 25
- 229960002233 benzalkonium bromide Drugs 0.000 claims abstract description 13
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims abstract description 13
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 claims abstract description 13
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 12
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000008367 deionised water Substances 0.000 claims description 17
- 229910021641 deionized water Inorganic materials 0.000 claims description 17
- 238000003756 stirring Methods 0.000 claims description 17
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 10
- 230000001954 sterilising effect Effects 0.000 claims description 10
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 9
- 229940041616 menthol Drugs 0.000 claims description 9
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 9
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 9
- 238000011049 filling Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- -1 etc.) 0.1-5% Chemical compound 0.000 claims description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 229960003237 betaine Drugs 0.000 claims description 4
- 230000004791 biological behavior Effects 0.000 claims description 3
- 241001529459 Enterovirus A71 Species 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 235000010299 hexamethylene tetramine Nutrition 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract description 12
- 241000700605 Viruses Species 0.000 abstract description 7
- CEXQWAAGPPNOQF-UHFFFAOYSA-N 2-phenoxyethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOC1=CC=CC=C1 CEXQWAAGPPNOQF-UHFFFAOYSA-N 0.000 abstract description 4
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 230000007797 corrosion Effects 0.000 abstract description 2
- 238000005260 corrosion Methods 0.000 abstract description 2
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000010069 protein adhesion Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 description 2
- 238000002485 combustion reaction Methods 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- HPMVBVNXFPHBLR-UHFFFAOYSA-N [Br-].[NH4+].C(CCCCCCCCCCCCC)C=1C(=NC=CC1)C Chemical compound [Br-].[NH4+].C(CCCCCCCCCCCCC)C=1C(=NC=CC1)C HPMVBVNXFPHBLR-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 102000006362 catalytic activity proteins Human genes 0.000 description 1
- 108040011022 catalytic activity proteins Proteins 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/06—Unsaturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/04—Sulfonic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a disinfectant based on an antibacterial non-specific adhesion polymer and a plurality of quaternary ammonium salts and a preparation method thereof. Can be used for air disinfection, daily article surface and long-acting disinfection of medical appliance surface. Mainly comprises polyethylene glycol (PEG) or zwitterionic polymer (such as phenoxyethyl methacrylate) with anti-protein adhesion capability and various quaternary ammonium salts with bactericidal function, and comprises the following components: dodecyl trimethyl ammonium chloride and benzalkonium bromide. Different compound preparation methods are adopted according to different purposes. The quaternary ammonium salt component kills bacteria through strong interaction of amino and the surfaces of the bacteria, and the polymer component prevents various bacteria and viruses from adhering to the mechanical surfaces again through excellent film forming property and protein adhesion resistance property to achieve the aim of long-acting antibiosis. Has no harm or irritation to human body, convenient use, and no corrosion to various equipments.
Description
Technical Field
The invention relates to a disinfectant, which can be used for personal cleaning, object surface disinfection, air disinfection and medical instrument surface disinfection and belongs to the field of long-acting disinfectants.
Background
The disinfectant is used for killing pathogenic microorganisms on a medium to make the medium achieve the harmless requirement. In recent years, increased attention has been paid to public and personal care. The disinfection and sterilization become almost necessary work in daily work and life, and the supply of disinfectant products is insufficient. Generally, the method can be divided into a plurality of application occasions such as air disinfection, skin disinfection, object surface disinfection, medical instrument disinfection and the like. The quaternary ammonium salt disinfectant is one of the most commonly used main components of the current disinfectant, can be adsorbed on the surface of bacteria or viruses, and the hydrophobic part of the disinfectant permeates into the rice lipid layer of bacteria or virus cells, so that the permeability of cell walls and cell membranes of the disinfectant is changed, the activity of enzyme activity protein is inhibited, and the metabolic process of the cells is influenced. Quaternary ammonium salt disinfectants have been derived from 7 generations at present, and the mature quaternary ammonium salt disinfectants in the market of China mainly comprise alkyl dimethyl benzyl chloride/ammonium bromide containing benzyl, alkyl trimethyl chloride/ammonium bromide or tetradecyl-2-methylpyridine ammonium bromide containing pyridine. However, researches show that the sterilizing effect of a single quaternary ammonium salt disinfectant in some environments is greatly limited, in recent years, various compound quaternary ammonium salt disinfectants show more excellent sterilizing and disinfecting effects, the antibacterial effect of the compound quaternary ammonium salt disinfectants can be improved by 4-20 times, and the compound quaternary ammonium salt disinfectants have good prospects in the current disinfectant development. However, there are some problems to be raised, most notably that the antibacterial time efficiency is short, the sterilization capability for a long-term sterilization environment can be kept insufficient, and the biocompatibility needs to be further improved.
To achieve long-term disinfection, the main approach is to kill bacteria or viruses on the surface of the article, and to prevent the adhesion of bacteria and viruses on the surface, so as to prevent the continuous proliferation of living bacteria with very small adhesion with the passage of time. In recent years, antibacterial adhesive materials have been rapidly developed. Among them, many polymers and neutral natural polysaccharides can also achieve the effect of binding water molecules through hydrogen bond receptors such as hydroxyl groups, such as polyethylene glycol (PEG), which has excellent hydrophilicity and can bind a large amount of water, forming a 'space exclusion' and hydration layer by surrounding molecular chain hydrogen bonds to resist the adhesion of bacteria and viruses, achieving the effect of prolonged disinfection. In addition, the zwitterionic polymer also has the characteristics of extremely strong hydrophilicity, excellent thermal and chemical stability, excellent biocompatibility, good pollution resistance and the like. Meanwhile, the polymers have good biocompatibility, and have potential application prospects in the aspect of long-acting disinfection.
Disclosure of Invention
The invention aims to disclose a quaternary ammonium salt/antibacterial adhesion polymer long-acting disinfectant, which overcomes the defects of the prior quaternary ammonium salt disinfectant and simple mixed disinfectant, improves the disinfection effect, prolongs the disinfection time, and provides a disinfectant which is safe, nontoxic, harmless and non-irritant to human bodies; no corrosion to equipment; long-acting disinfectant without environmental pollution.
The disinfectant disclosed by the invention is mainly characterized by comprising the following components: the solvent is deionized water, and comprises 0.1-5 wt% of antibacterial nonspecific polymer (polyethylene glycol, polysulfonic acid betaine methacrylate, etc.), 0.1-1 wt% of dodecyl trimethyl ammonium chloride, 0.05-0.5 wt% of benzalkonium bromide, and 0.5-3.8 wt% of urotropine. The balance being auxiliary additives such as: fatty alcohol-polyoxyethylene ether, menthol and the like, and the content of the fatty alcohol-polyoxyethylene ether and the menthol is less than 0.2 percent.
The preparation method of the quaternary ammonium salt/antibacterial adhesion polymer long-acting disinfectant comprises the following steps:
(1) 0.5L of antibacterial nonspecific polymer (polyethylene glycol and polysulfonate betaine methacrylate) with mass concentration of 0.2-6% is prepared for later use.
(2) 0.4-4 percent of dodecyl trimethyl ammonium chloride, 0.05-0.5 percent of benzalkonium bromide and 0.25L of 2-14.2 percent of urotropine solution are prepared for later use.
(3) And (3) mixing the solutions in the step (1) and the step (2), and uniformly stirring. Then, an appropriate amount of auxiliary additives is added as required.
(4) And (4) fixing the volume of the mixed solution obtained in the step (3) to 1L, stirring, and filling to obtain the long-acting disinfectant.
Compared with the prior art, the invention has the following beneficial effects: the disinfectant with long acting and different application environments is obtained by combining the polymer with the non-specific adhesion of bacteria and viruses and quaternary ammonium salt with the disinfection function through different compatibility. The average sterilization rate of the compound on influenza A virus H1N1 is more than 99.99%, the average sterilization rate on enterovirus-71 is more than 81.43%, and the biological behavior of normal cells is not influenced. Meanwhile, the polymer with the function of resisting bacteria adhesion prevents bacteria adhesion, effectively prolongs the disinfection effect and improves the biocompatibility of the quaternary ammonium salt disinfectant.
Drawings
Fig. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a sectional view of the structure of the protective box of the present invention;
FIG. 3 is an enlarged view of area A of FIG. 2;
fig. 4 is a partial cross-sectional view of the combustion chamber of the present invention.
Reference numerals: 1. a combustion chamber; 11. an air outlet pipe; 12. a second valve; 2. a protective case; 21. A drive motor; 22. a straight bevel gear; 23. a rotating shaft; 231. an external thread; 232. a ball bearing; 24. a bevel gear; 25. a threaded rod; 26. a fixing plate; 261. a threaded hole; 3. an air pump; 31. an air inlet pipe; 32. a first valve; 4. a support plate; 41. a bearing seat; 42. a return spring; 43. a cushion pad; 5. a power source; 51. a positive electrode electrifying block; 52. a negative electrode energizing block; 6. an ignition mechanism.
Detailed Description
The technical scheme of the invention is further explained by combining specific examples. The reagents used in the following examples include mainly the following: polyethylene glycol, phenoxyethyl methacrylate, dodecyl trimethyl ammonium chloride, benzalkonium bromide, urotropine, fatty alcohol-polyoxyethylene ether, menthol, deionized water and the like.
Example 1:
(1) 30g of PEG (molecular weight 1000) is dissolved in 500ml of deionized water, and the mixture is stirred at normal temperature to obtain a PSB solution with the mass concentration of 6% for later use.
(2) 1g of dodecyltrimethylammonium chloride, 5g of urotropine and 0.125g of benzalkonium bromide are weighed, added into 250ml of deionized water, stirred and fully dissolved.
(3) And (3) mixing the solutions in the step (1) and the step (2), and uniformly stirring. Adding 1g of fatty alcohol-polyoxyethylene ether and 0.5g of menthol, and stirring and mixing uniformly.
(4) And (4) adding deionized water into the mixed solution obtained in the step (3), fixing the volume to 1L, stirring, and filling to obtain the long-acting disinfectant.
Example 2:
(1) 30g of phenoxyethyl methacrylate (PSB) is dissolved in 500ml of deionized water, and stirred at normal temperature to obtain a PSB solution with the mass concentration of 6% for later use.
(2) 1g of dodecyltrimethylammonium chloride, 5g of urotropine and 0.125g of benzalkonium bromide are weighed, added into 250ml of deionized water, stirred and fully dissolved.
(3) And (3) mixing the solutions in the step (1) and the step (2), and uniformly stirring. Adding 1g of fatty alcohol-polyoxyethylene ether and 0.5g of menthol, and stirring and mixing uniformly.
(4) And (4) adding deionized water into the mixed solution obtained in the step (3), fixing the volume to 1L, stirring, and filling to obtain the long-acting disinfectant.
Example 3:
(1) 10g of phenoxyethyl methacrylate (PSB) is dissolved in 500ml of deionized water, and stirred at normal temperature to obtain a PSB solution with the mass concentration of 2% for later use.
(2) 2g of dodecyltrimethylammonium chloride, 10g of urotropine and 0.25g of benzalkonium bromide are weighed, added into 250ml of deionized water, stirred and fully dissolved.
(3) And (3) mixing the solutions in the step (1) and the step (2), and uniformly stirring. Adding 1g of fatty alcohol-polyoxyethylene ether and 0.5g of menthol, and stirring and mixing uniformly.
(4) And (4) adding deionized water into the mixed solution obtained in the step (3), fixing the volume to 1L, stirring, and filling to obtain the long-acting disinfectant.
Example 4:
(1) 3g of dodecyltrimethylammonium chloride, 15g of urotropine and 0.75g of benzalkonium bromide are weighed, added into 750ml of deionized water, stirred and fully dissolved.
(2) Adding deionized water, diluting to a constant volume of 1L, stirring, and filling to obtain the long-acting disinfectant.
Example 5:
(1) 20g of polyethylene glycol (with the weight of 200) is dissolved in 500ml of deionized water, and the mixture is stirred at the normal temperature environment to obtain a PEG solution with the mass concentration of 4% for later use.
(2) 2g of dodecyltrimethylammonium chloride, 10g of urotropine and 0.25g of benzalkonium bromide are weighed, added into 250ml of deionized water, stirred and fully dissolved.
(3) And (3) mixing the solutions in the step (1) and the step (2), and uniformly stirring. Adding 1g of fatty alcohol-polyoxyethylene ether and 0.5g of menthol, and stirring and mixing uniformly.
(4) And (4) adding deionized water into the mixed solution obtained in the step (3), fixing the volume to 1L, stirring, and filling to obtain the long-acting disinfectant.
Claims (5)
1. A preparation method of a quaternary ammonium salt antibacterial adhesion polymer long-acting disinfectant; the method is characterized by comprising the following main components: the solvent is deionized water, and comprises antibacterial nonspecific polymer (polyethylene glycol, polysulfonate betaine methacrylate, etc.) 0.1-5%, dodecyl trimethyl ammonium chloride 0.1-1%, benzalkonium bromide 0.05-0.5%, and urotropine 0.5-3.8%. The balance being auxiliary additives such as: fatty alcohol-polyoxyethylene ether, menthol and the like, and the content of the fatty alcohol-polyoxyethylene ether and the menthol is less than 0.2 percent.
2. The method of preparing a long acting disinfectant of quaternary ammonium salt anti-bacterial adhesion polymer according to claim 1, characterized by the steps of:
(1) 0.5L of antibacterial nonspecific polymer (polyethylene glycol, polysulfonic acid betaine methacrylate) with mass concentration of 0.2-6% is prepared for later use.
(2) 0.4-4 percent of dodecyl trimethyl ammonium chloride, 0.05-0.5 percent of benzalkonium bromide and 0.25L of 2-14.2 percent of urotropine solution are prepared for later use.
(3) And (3) mixing the solutions in the step (1) and the step (2), and uniformly stirring. Then, an appropriate amount of auxiliary additives is added as needed.
(4) And (4) fixing the volume of the mixed solution obtained in the step (3) to 1L, stirring, and filling to obtain the long-acting disinfectant.
3. The method for preparing a quaternary ammonium salt anti-bacterial adhesion polymer long-acting disinfectant according to claim 1, wherein the formula is different according to different applications. The final concentration of the antibacterial non-specific polymer is 0.1-0.2% during air sterilization; the rest components are unchanged; when the skin surface is disinfected, the concentration of dodecyl trimethyl ammonium chloride is 0.1-0.2%, the concentration of benzalkonium bromide is 0.05-0.2%, the concentration of urotropin is 0.1-1.8%, the final concentration of the antibacterial nonspecific polymer is 1-5%, and the rest concentrations are unchanged. When the articles are disinfected, the concentration of dodecyl trimethyl ammonium chloride is 0.5-1.0%, the concentration of benzalkonium bromide is 0.3-0.5%, the concentration of urotropin is 1.6-3.8%, the final concentration of the antibacterial nonspecific polymer is 2-3%, and the rest concentrations are unchanged.
4. The method of claim 2 wherein said quaternary ammonium salt anti-bacterial adhesion polymer long acting disinfectant has an average sterilization rate of greater than 99.99% for influenza a virus H1N 1; and simultaneously does not influence the biological behavior of normal cells.
5. The method of claim 2 wherein said quaternary ammonium salt anti-bacterial adhesion polymer long acting disinfectant has an average sterilization rate of greater than 81.43% for enterovirus type 71 without affecting the biological behavior of normal cells.
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| CN104521959A (en) * | 2014-12-23 | 2015-04-22 | 广东环凯微生物科技有限公司 | Novel disinfectant prepared from quaternary ammonium salt and alcohol |
| CN106750445A (en) * | 2016-12-12 | 2017-05-31 | 东南大学 | A kind of processing method of the anti-albumen adhesion of aquagel membrane material surface |
| CN109420196A (en) * | 2017-08-31 | 2019-03-05 | 鸿富锦精密工业（深圳）有限公司 | Wound dressing and its minimizing technology |
| CN211575146U (en) * | 2020-02-14 | 2020-09-25 | 辽宁索能环保能源科技有限公司 | External automatic ignition device of organic waste |
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| CN102697786A (en) * | 2012-06-05 | 2012-10-03 | 上海利康消毒高科技有限公司 | Urotropine composite skin disinfectant and preparation method thereof |
| CN104521959A (en) * | 2014-12-23 | 2015-04-22 | 广东环凯微生物科技有限公司 | Novel disinfectant prepared from quaternary ammonium salt and alcohol |
| CN106750445A (en) * | 2016-12-12 | 2017-05-31 | 东南大学 | A kind of processing method of the anti-albumen adhesion of aquagel membrane material surface |
| CN109420196A (en) * | 2017-08-31 | 2019-03-05 | 鸿富锦精密工业（深圳）有限公司 | Wound dressing and its minimizing technology |
| CN211575146U (en) * | 2020-02-14 | 2020-09-25 | 辽宁索能环保能源科技有限公司 | External automatic ignition device of organic waste |
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Application publication date: 20210723 |