CN106474053B - A kind of composite high-molecular colloid surface of a wound thimerosal and its preparation method containing amino acid - Google Patents
A kind of composite high-molecular colloid surface of a wound thimerosal and its preparation method containing amino acid Download PDFInfo
- Publication number
- CN106474053B CN106474053B CN201510536140.5A CN201510536140A CN106474053B CN 106474053 B CN106474053 B CN 106474053B CN 201510536140 A CN201510536140 A CN 201510536140A CN 106474053 B CN106474053 B CN 106474053B
- Authority
- CN
- China
- Prior art keywords
- stirring
- preparation
- amino acid
- wound
- composite high
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of composite high-molecular colloid surface of a wound thimerosal and its preparation method containing amino acid, the composite high-molecular colloid surface of a wound thimerosal is using polyvinylpyrrolidone and poloxamer as emulsifier and solubilizer, with poly hexamethylene biguanide, epsilon-polylysine, Phenoxyethanol and deacetylation are greater than 80%, viscosity average molecular weigh is fungicide active ingredient in 100000 or more water-insoluble chitosan, with aspartic acid, glutamic acid and cysteine mixture are regulator and reinforcing agent, composite high-molecular colloid surface of a wound thimerosal of the invention has sterilizing ability strong, work fast, stability is good, safety and the function that wound repair can be promoted.Composite high-molecular colloid surface of a wound thimerosal preparation method of the invention includes the preparation of chitosan solution, four steps of the preparation of poly hexamethylene biguanide emulsion, the preparation of Phenoxyethanol solution and compounding.
Description
Technical field
The present invention relates to medical drugs, disappear furthermore, it is understood that being related to a kind of composite high-molecular colloid surface of a wound containing amino acid
Venom and its preparation method.
Technical background
Ideal thimerosal should have wide sterilization spectrum, sterilizing ability are strong, work fast, stability are good, it is nontoxic, without residual
The features such as staying, be corrosion-free, is non-stimulated, is soluble easily in water, is safe to humans and animals and cheap and easy to get, environmental pollution degree is low, and
For surface of a wound thimerosal, it is also necessary to facilitate the healing of the surface of a wound.
In the prior art, thimerosal can be divided into 9 major class on the whole, be class containing chlorine, peroxide, aldehyde respectively
Class, alcohols, class containing iodine, phenols, ethylene oxide, biguanides and quaternary ammonium salt.At present it is respective all to there is its in this 9 class disinfectant
Disadvantage, what is had toxic irritating, harmful to body, the easy failure having, some sterilizing abilities are poor.Disinfection in the prior art
This nothing of liquid-based actively promotes the function of wound repair.
Therefore, the prior art fail to provide a kind of sterilizing ability is strong, work fast, stability are good, nontoxic, noresidue,
It is corrosion-free, non-stimulated, soluble easily in water, to humans and animals safety, with promoting wound repair and excellent disinfection cheap and easy to get
Liquid.
Amino acid is the basic building unit of protein, constitutes a total of 20 variety classes of amino acid of protein,
In to have 8 kinds be that human body can not be synthesized, be called essential amino acid.They be respectively histidine, isoleucine, leucine,
Lysine, methionine, threonine, tryptophan, valine, every kind of amino acid all play very important physiological action, especially
For surface of a wound tissue around, amino acid it is in liberal supply whether directly affect the speed of wound healing.In this 20 kinds of amino acid,
There are also seldom a part of amino acid can play preferable bacteria resistance function, they are aspartic acid, glutamic acid and cysteine (Chen Yue
It opens, Xu Jun etc. " the antibacterial research of amino acid ", Chinese biochemical drug magazine, the 1st phases of volume 22 in 2001).
Chitosan is the large biological molecule that de-acetyl chitin generates, and chitin is that the second largest natural biology abundant is more
Aggressiveness.Chitosan is the condensate of about 20%N- acetylglucosamine and 80% dextran amine residue.Chitosan is nontoxic, non-stimulated
Property, without challeng, be a kind of good biomaterial of histocompatbility.Due to having a large amount of free amino in its molecule,
Chitosan has natural bacteriostatic activity, has to leather Lan Shi positive bacteria, leather Lan Shi negative bacterium and Candida albicans obvious antibacterial
Effect.In addition, chitosan can promote the formation of granulation and tissue, it is beneficial to the wound of animal large area opening；It can also enhance
Mononuclear macrophage function, cellular immune function and NK cell activity.
Poly hexamethylene biguanide (PHMB) has broad-spectrum, sterilization mechanism are as follows: ionization can be generated in aqueous solution,
Strong electropositive is contained in its hydrophilic group part, and absorption is usually in electronegative all kinds of bacteriums, virus, into cell membrane, suppression
It is film-made the synthesis of lactones plastid, causes thallus apoptosis.Poly hexamethylene biguanide has low effective concentration, work fast, property steady
Fixed, excellent performance soluble easily in water；It can use at normal temperature；It can be long-term antibacterial, without side-effects；It is non-corrosive；It is colourless, odorless；
It is nontoxic；It is non-ignitable, not quick-fried, using safe, be a kind of optimal environment-friendly type macromolecule polymer disinfection sanitizer.The substance is answered extensively
For industrial, agriculture, various aspects in medical and daily life antibacterial or sterilization.
Epsilon-polylysine is by single lysine molecule in the poly that a- hydroxyl and epsilon-amino form amido bond and connect into
Body straight chain has a large amount of free amino on straight chain, has obviously to gram-positive bacteria and negative bacterium, yeast, mould, virus etc.
Inhibiting effect.Its Antibacterial Mechanism is its molecule in high polymerization polyvalent cation state, it can destroy the cell membrane knot of microorganism
Structure causes the substance, energy and information of cell to transmit and interrupts, moreover it is possible to influence the conjunction of large biological molecule in conjunction with ribosomes intracellular
At eventually leading to cell death.And the decomposition product of epsilon-polylysine is lysine, is essential amino acid, it can be by
It makes full use of.
Phenoxyethanol is the colourless oily liquids of one kind as made of ethylene glycol and menthylphenoxypolyethoxy ethanol, belongs to a kind of alcohols disinfection
Antiseptic has stronger killing effect to Pseudomonas aeruginosa, weaker to other gramnegative bacteriums and positive bacteria effect.
Relate to the use of in the prior art chitosan, polyhexamethylene guanide etc. prepare environmental protection disinfectant technology be Liang Xizong,
Liu Xia etc. " modern preventive medicine " the 17th phase of volume 36 in 2009 deliver " development of novel biochemical efficient environmental protection disinfectant and
Detection ".The natural component hyaluronic acid-like chitosan and amino-acid salt kinases of the choice of technology natural marine organism kind, ocean are raw
Object cerebroysin enzyme and polyhexamethylene guanide are developed into novel biochemical efficient environmental protection disinfectant, and preparation method is related to bioactivity packet
Quilt, polymerization reaction and emulsion reaction.But the preparation method of the technology is more complicated, needs specific consersion unit.
Therefore, that there is no preparation methods in the prior art is simple, do not need special installation and can by poly hexamethylene biguanide,
Epsilon-polylysine and this three big antimicrobial macromolecule of chitosan and high molecular alcohol substance Phenoxyethanol are by emulsifier and solubilising
The technology that agent is compounded with specific amino acid.
Summary of the invention
The present invention will solve the above problems for the disinfection of the surface of a wound, and amino acid is applied to the polymer colloid surface of a wound for the first time
The preparation of thimerosal.
The present invention with polyvinylpyrrolidone and poloxamer collectively as emulsifier and solubilizer, it is double with polyhexamethylene
Guanidine, epsilon-polylysine, Phenoxyethanol and deacetylation are greater than 80%, water-insoluble shell of the viscosity average molecular weigh 100000 or more
Glycan collectively as bactericidal activity part, using aspartic acid, glutamic acid and cysteine mixture as regulator and reinforcing agent from
And provide that a kind of sterilizing ability is strong, work fast, stability are good, safety and has the excellent disinfection for promoting wound repair function
Liquid and preparation method thereof.
In order to achieve the above objectives, the technical scheme of the present invention is realized as follows:
The invention discloses a kind of composite high-molecular colloid surface of a wound thimerosal containing amino acid, it is with polyvinylpyrrolidone
It is emulsifier and solubilizer with poloxamer, is greater than with poly hexamethylene biguanide, epsilon-polylysine, Phenoxyethanol and deacetylation
80%, viscosity average molecular weigh 100000 or more water-insoluble chitosan be fungicide active ingredient, with aspartic acid, glutamic acid and
Cysteine mixture is regulator and reinforcing agent, and composition quality formula is as follows:
A kind of preparation method of the composite high-molecular colloid surface of a wound thimerosal containing amino acid, comprising the following steps:
(1) aspartic acid, glutamic acid and cysteine mixture and epsilon-polylysine are put into purifying jointly at room temperature
In water, chitosan is added after stirring and dissolving is complete, stirring dissolves mixture after heating pressurization, and natural cooling obtains chitosan
Solution for standby；
Poly hexamethylene biguanide is put into purified water at room temperature, after stirring and dissolving is complete, poloxamer is added and stirs
Emulsification pretreatment is carried out, it is spare to obtain poly hexamethylene biguanide emulsion after mixing；
Polyvinylpyrrolidone is put into purified water at room temperature, after stirring and dissolving is complete, Phenoxyethanol is added, after stirring
Sealing is by obtaining Phenoxyethanol solution for standby after heating water bath hydrotropy；
Without sequencing between above three step；
(2) above-mentioned poly hexamethylene biguanide cream is added in Phenoxyethanol solution not yet cooling after above-mentioned preparation while stirring
Change in liquid, above-mentioned chitosan solution is added thereto again compound up to the composite high-molecular glue containing amino acid after mixing
Body surface of a wound thimerosal.
Optionally, the aspartic acid, glutamic acid and cysteine mixture are with aspartic acid, glutamic acid and half Guang ammonia
Acid mixes in mass ratio for 1:1:2.
Optionally, the composite high-molecular colloid surface of a wound thimerosal quality formula containing amino acid is as follows:
The preparation method of the invention also discloses a kind of composite high-molecular colloid surface of a wound thimerosal containing amino acid, this method
Include:
(1) aspartic acid, glutamic acid and cysteine mixture and epsilon-polylysine are put into purifying jointly at room temperature
In water, chitosan is added after stirring and dissolving is complete, stirring dissolves mixture after heating pressurization, and natural cooling obtains chitosan
Solution for standby；
Poly hexamethylene biguanide is put into purified water at room temperature, after stirring and dissolving is complete, poloxamer is added and stirs
Emulsification pretreatment is carried out, it is spare to obtain poly hexamethylene biguanide emulsion after mixing；
Polyvinylpyrrolidone is put into purified water at room temperature, after stirring and dissolving is complete, Phenoxyethanol is added, after stirring
Sealing is by obtaining Phenoxyethanol solution for standby after heating water bath hydrotropy；
Without sequencing between above three step；
(2) above-mentioned poly hexamethylene biguanide cream is added in Phenoxyethanol solution not yet cooling after above-mentioned preparation while stirring
Change in liquid, above-mentioned chitosan solution is added thereto again compound up to the composite high-molecular glue containing amino acid after mixing
Body surface of a wound thimerosal.
Optionally, chitosan, the work that stirring dissolves mixture after heating pressurization are added after the stirring and dissolving is complete
Skill condition are as follows: chitosan is added after stirring and dissolving is complete, heating pressurization makes mixture temperature reach 105 DEG C and continues 10 minutes
More than, it is stirred for dissolving mixture.
Optionally, described that poloxamer is added and stirs the process conditions for carrying out emulsification pretreatment are as follows: poloxamer is added simultaneously
Emulsification pretreatment is carried out with the stirring rate not less than 2000 revs/min.
Optionally, the addition Phenoxyethanol, sealing passes through the process conditions of heating water bath hydrotropy after stirring are as follows: benzene is added
Oxyethanol passes through 80 DEG C of heating water bath hydrotropies with sealing after the rate stirring not less than 500 revs/min.
Optionally, described that above-mentioned poly- six methylene is added in Phenoxyethanol solution not yet cooling after above-mentioned preparation while stirring
Process conditions in base biguanides emulsion are as follows:, will be not yet cold after above-mentioned preparation under the stirring condition not less than 2000 revs/min
But Phenoxyethanol solution is added in above-mentioned poly hexamethylene biguanide emulsion.
From the foregoing, it can be seen that the present invention it is this with polyvinylpyrrolidone and poloxamer collectively as emulsifier and solubilising
Agent is greater than 80% with poly hexamethylene biguanide, epsilon-polylysine, Phenoxyethanol and deacetylation, and viscosity average molecular weigh is 100000
Above water-insoluble chitosan is fungicide active ingredient, using aspartic acid, glutamic acid and cysteine mixture as regulator
Have that sterilizing ability is strong, work fast, stability with the composite high-molecular colloid surface of a wound thimerosal containing amino acid of reinforcing agent
Good, safety and the function that wound repair can be promoted.Preparation including chitosan solution of the invention, poly hexamethylene biguanide emulsification
The preparation method of four steps of preparation, the preparation of Phenoxyethanol solution and compounding of liquid is capable of providing the composite high-molecular glue containing amino acid
Body surface of a wound thimerosal.
Specific embodiment
Core of the invention thought is: using technology of the invention, passes through the preparation of chitosan solution, poly- six methylene
Four steps of preparation, the preparation of Phenoxyethanol solution and compounding of base biguanides emulsion, it is common with polyvinylpyrrolidone and poloxamer
It, will be originally difficult by regulator and reinforcing agent of aspartic acid, glutamic acid and cysteine mixture as emulsifier and solubilizer
It is greater than 80% with the poly hexamethylene biguanide, epsilon-polylysine, Phenoxyethanol and the deacetylation that coexist in same system, glues
Average molecular weight is re-dubbed the composite high-molecular colloid surface of a wound thimerosal containing amino acid in 100000 or more water-insoluble chitosan,
A kind of composite high-molecular colloid surface of a wound thimerosal containing amino acid of the invention can retain the original characteristic of each component, so that this
A kind of composite high-molecular colloid surface of a wound thimerosal containing amino acid of invention strong, work fast, stability with sterilizing ability
Good, safety and the multi-efficiency that wound repair can be promoted.
To make the object, technical solutions and advantages of the present invention clearer, the present invention will be implemented by embodiment below
Mode is described in further detail.
The present invention is prepared according to the formula of table one (formula that table one is 1-3 of the embodiment of the present invention) by following technique to implement
The composite high-molecular colloid surface of a wound thimerosal containing amino acid of example 1-3:
(1) under room temperature, aspartic acid, glutamic acid and cysteine mixture and epsilon-polylysine are put into jointly
In purified water, chitosan is added after stirring and dissolving is complete, stirring dissolves mixture after heating pressurization, in the present invention, excellent
The heating pressure processing conditions of choosing are that heating pressurization makes mixture temperature reach 105 DEG C and continues 10 minutes or more.Then natural
It is spare that cooling obtains chitosan solution；
(2) poly hexamethylene biguanide is put into purified water, after stirring and dissolving is complete, be added poloxamer after and stir into
Row emulsification pretreatment, in the present invention, it is preferred to stirring to carry out the process conditions of emulsification pretreatment be with not less than 2000 revs/min
Rate high speed shearing emulsification.Then it is uniformly mixed that obtain poly hexamethylene biguanide emulsion spare；
(3) at room temperature, polyvinylpyrrolidone is put into purified water, after stirring and dissolving is complete, Phenoxyethanol is added, stirs
Sealing passes through heating water bath hydrotropy after mixing.In the present invention, it is preferred to stirring after sealing pass through the technique item of heating water bath hydrotropy
Part is after being vigorously stirred with the rate not less than 500 revs/min, and sealing carries out 80 DEG C of heating water bath hydrotropies.Then benzene oxygen is obtained
Ethanol solution is spare；
Above without sequencing between (1) (2) (3) step.
(4) above-mentioned poly hexamethylene biguanide cream is added in Phenoxyethanol solution not yet cooling after above-mentioned preparation while stirring
Change in liquid, in the present invention, it is preferred to Phenoxyethanol solution not yet cooling after above-mentioned preparation is added while stirring it is above-mentioned poly-
Process conditions in hexamethylene biguan-ide emulsion are under the rate high-speed stirred not less than 2000r/min, by above-mentioned preparation
Not yet cooling Phenoxyethanol solution is added in above-mentioned poly hexamethylene biguanide emulsion afterwards, after mixing again gathers above-mentioned shell
Sugar juice, which is added thereto, to be compounded, after mixing the composite high-molecular colloid surface of a wound disinfection up to of the invention containing amino acid
Liquid.
In the present invention in embodiment 1-3, the mixed proportion of aspartic acid, glutamic acid and cysteine mixture is preferably
It is mixed in mass ratio for 1:1:2 with aspartic acid, glutamic acid and cysteine.Aspartic acid, glutamic acid and cysteine
It is both the ion of colloidal solution and acidity regulator can enhance the local nutrition supply of the surface of a wound again.
In 1-3 of the embodiment of the present invention, water-insoluble chitosan and amino acid energy wound healing effect；It is non-aqueous
Property chitosan and poly hexamethylene biguanide, epsilon-polylysine and Phenoxyethanol collective effect, play effective biocidal efficacies, this
The composite high-molecular colloid surface of a wound thimerosal containing amino acid of invention can be used in the disinfection of body surface, mucous membrane and the surface of a wound.
[table one]
The formula of 1-3 of the embodiment of the present invention
By the composite high-molecular colloid surface of a wound thimerosal containing amino acid prepared in 1-3 of the embodiment of the present invention, according to state
" sterile products Hygienic safety evaluation provides (2014 editions) " and " disinfection technology standard (2008 that hygienic State Family Planning Commission, family promulgates
Version) " test requirements document, carry out skin of hand sterilizing test, Suspension quantitative bactericidal test and rabbit vaginal mucosa irritation test, examination
It tests result statistics and is shown in Table two, table three, table four.
[table two]
Skin of hand disinfection test result
[table three]
Suspension quantitative bactericidal test result
[table four]
Rabbit vaginal mucosa irritation test result
From result it can be concluded that the composite high-molecular colloid surface of a wound thimerosal Disinfection Effect of the invention containing amino acid is preferable,
To common staphylococcus aureus at 4 minutes, the killing logarithm of pseudomonas aeruginosa, Escherichia coli, Candida albicans etc. is equal
It is nonirritant to rabbit vagina mucosa greater than 5, the disinfection suitable for wound tissue.
In conclusion the present invention it is this with polyvinylpyrrolidone and poloxamer collectively as emulsifier and solubilizer,
With poly hexamethylene biguanide, epsilon-polylysine, Phenoxyethanol and deacetylation be greater than 80%, viscosity average molecular weigh 100000 with
On water-insoluble chitosan collectively as bactericidal activity part, be to adjust with aspartic acid, glutamic acid and cysteine mixture
The composite high-molecular colloid surface of a wound thimerosal containing amino acid that section agent and reinforcing agent are constituted strong, speed of action with sterilizing ability
Fastly, stability it is good, safety and have the function of promotion wound repair.The composite high-molecular colloid surface of a wound i.e. of the invention containing amino acid
Thimerosal had not only been able to achieve the compatible of each component, but also maintained the original function of each component.It includes that chitosan is molten that of the invention, which includes,
The preparation of liquid, the preparation of poly hexamethylene biguanide emulsion, Phenoxyethanol solution prepares and the preparation method of four steps of compounding is capable of providing
The composite high-molecular colloid surface of a wound thimerosal containing amino acid.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the scope of the present invention.It is all
Any modification, equivalent replacement, improvement and so within the spirit and principles in the present invention, are all contained in protection scope of the present invention
It is interior.
Claims (8)
1. a kind of composite high-molecular colloid surface of a wound thimerosal containing amino acid, it is characterised in that the thimerosal is with polyvinyl pyrrole
Alkanone and poloxamer are emulsifier and solubilizer, with poly hexamethylene biguanide, epsilon-polylysine, Phenoxyethanol and deacetylation
Greater than 80%, viscosity average molecular weigh is fungicide active ingredient in 100000 or more water-insoluble chitosan, with aspartic acid, paddy ammonia
Acid and cysteine mixture are regulator and reinforcing agent, and composition quality formula is as follows:
A kind of preparation method of the composite high-molecular colloid surface of a wound thimerosal containing amino acid, comprising the following steps:
(1) aspartic acid, glutamic acid and cysteine mixture and epsilon-polylysine are put into purified water jointly at room temperature,
Water-insoluble chitosan is added after stirring and dissolving is complete, stirring dissolves mixture after heating pressurization, and natural cooling obtains shell
Glycan solution for standby；
Poly hexamethylene biguanide is put into purified water at room temperature, after stirring and dissolving is complete, poloxamer is added and stirs progress
It is spare to obtain poly hexamethylene biguanide emulsion after mixing for emulsification pretreatment；
Polyvinylpyrrolidone is put into purified water at room temperature, after stirring and dissolving is complete, Phenoxyethanol is added, is sealed after stirring
By obtaining Phenoxyethanol solution for standby after heating water bath hydrotropy；
Without sequencing between above three step；
(2) above-mentioned poly hexamethylene biguanide emulsion is added in Phenoxyethanol solution not yet cooling after above-mentioned preparation while stirring
In, above-mentioned chitosan solution is added thereto again compound up to the composite high-molecular colloid wound containing amino acid after mixing
Face thimerosal.
2. a kind of composite high-molecular colloid surface of a wound thimerosal containing amino acid as described in claim 1, it is characterised in that described
Aspartic acid, glutamic acid and cysteine mixture are mixed for 1:1:2 in mass ratio with aspartic acid, glutamic acid and cysteine
It closes.
3. a kind of composite high-molecular colloid surface of a wound thimerosal containing amino acid as described in claim 1, it is characterised in that quality
It is formulated as follows:
4. such as the preparation method of any one composite high-molecular colloid surface of a wound thimerosal containing amino acid in claim 1-3,
It is characterized in that the preparation method includes:
(1) aspartic acid, glutamic acid and cysteine mixture and epsilon-polylysine are put into purified water jointly at room temperature,
Water-insoluble chitosan is added after stirring and dissolving is complete, stirring dissolves mixture after heating pressurization, and natural cooling obtains shell
Glycan solution for standby；
Poly hexamethylene biguanide is put into purified water at room temperature, after stirring and dissolving is complete, poloxamer is added and stirs progress
It is spare to obtain poly hexamethylene biguanide emulsion after mixing for emulsification pretreatment；
Polyvinylpyrrolidone is put into purified water at room temperature, after stirring and dissolving is complete, Phenoxyethanol is added, is sealed after stirring
By obtaining Phenoxyethanol solution for standby after heating water bath hydrotropy；
Without sequencing between above three step；
(2) above-mentioned poly hexamethylene biguanide emulsion is added in Phenoxyethanol solution not yet cooling after above-mentioned preparation while stirring
In, above-mentioned chitosan solution is added thereto again compound up to the composite high-molecular colloid wound containing amino acid after mixing
Face thimerosal.
5. a kind of preparation method of the composite high-molecular colloid surface of a wound thimerosal containing amino acid as claimed in claim 4, special
Sign is to add water-insoluble chitosan, the technique that stirring dissolves mixture after heating pressurization after the stirring and dissolving is complete
Condition are as follows: water-insoluble chitosan is added after stirring and dissolving is complete, heating pressurization makes mixture temperature reach 105 DEG C and continues
It 10 minutes or more, is stirred for dissolving mixture.
6. a kind of preparation method of the composite high-molecular colloid surface of a wound thimerosal containing amino acid as claimed in claim 4, special
Sign is the addition poloxamer and stirs the process conditions for carrying out emulsification pretreatment are as follows: poloxamer is added and to be not less than
2000 revs/min of stirring rate carries out emulsification pretreatment.
7. a kind of preparation method of the composite high-molecular colloid surface of a wound thimerosal containing amino acid as claimed in claim 4, special
Sign is the addition Phenoxyethanol, and sealing passes through the process conditions of heating water bath hydrotropy after stirring are as follows: Phenoxyethanol is added, with
Sealing passes through 80 DEG C of heating water bath hydrotropies after rate stirring not less than 500 revs/min.
8. a kind of preparation method of the composite high-molecular colloid surface of a wound thimerosal containing amino acid as claimed in claim 4, special
Sign is described while stirring by the above-mentioned poly hexamethylene biguanide cream of Phenoxyethanol solution not yet cooling after above-mentioned preparation addition
Change the process conditions in liquid are as follows: under the stirring condition not less than 2000 revs/min, by benzene oxygen not yet cooling after above-mentioned preparation
Ethanol solution is added in above-mentioned poly hexamethylene biguanide emulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510536140.5A CN106474053B (en) | 2015-08-28 | 2015-08-28 | A kind of composite high-molecular colloid surface of a wound thimerosal and its preparation method containing amino acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510536140.5A CN106474053B (en) | 2015-08-28 | 2015-08-28 | A kind of composite high-molecular colloid surface of a wound thimerosal and its preparation method containing amino acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106474053A CN106474053A (en) | 2017-03-08 |
| CN106474053B true CN106474053B (en) | 2019-11-05 |
Family
ID=58234272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510536140.5A Active CN106474053B (en) | 2015-08-28 | 2015-08-28 | A kind of composite high-molecular colloid surface of a wound thimerosal and its preparation method containing amino acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106474053B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108949748B (en) * | 2018-07-30 | 2021-05-28 | 浙江今复康生物科技有限公司 | Sputum liquefaction and nucleic acid protection reagent |
| CN111388500B (en) * | 2020-05-22 | 2021-08-24 | 陕西恒远生物科技有限公司 | Pharmaceutical composition for oral mucosa ulcer inflammatory pain and bacteriostasis, gel and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933062A (en) * | 2014-03-12 | 2014-07-23 | 贵州扬生医用器材有限公司 | Polyglycosaminoglycan polypeptide complex iodine composite system solution and preparation method thereof |
-
2015
- 2015-08-28 CN CN201510536140.5A patent/CN106474053B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933062A (en) * | 2014-03-12 | 2014-07-23 | 贵州扬生医用器材有限公司 | Polyglycosaminoglycan polypeptide complex iodine composite system solution and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 氨基酸的抑菌作用研究;陈月开等;《中国生化药物杂志》;20011231;第22卷(第1期);29-30 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106474053A (en) | 2017-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH07330505A (en) | Antimicrobial composition | |
| CN113491709B (en) | Multifunctional high-efficiency compound disinfectant and preparation method thereof | |
| CN105079858B (en) | Liquid dressing and its preparation method are repaired in a kind of wound sterilization | |
| CN105963147A (en) | Hand-washing-free lipidosome disinfecting gel and preparation method thereof | |
| CN108904315A (en) | A kind of foam type hand sanitizing fluid and preparation method thereof | |
| CN106474053B (en) | A kind of composite high-molecular colloid surface of a wound thimerosal and its preparation method containing amino acid | |
| CN103933062B (en) | Poly-aminopolysaccharide polypeptide chelated iodine compound system solution and method for making thereof | |
| CN111150705A (en) | Alcohol hyaluronic acid disinfectant and preparation method thereof | |
| CN101023753A (en) | Oxidation-type disinfecting sterilizing agent and preparing method | |
| CN110876684A (en) | Preparation method of washing-free polyhexamethylene guanidine hydrochloride disinfectant | |
| DK2170081T3 (en) | Antimicrobial preparations | |
| EP1349457B1 (en) | Liquid antimicrobial compositions | |
| CN1565635A (en) | Chemical disinfectant with broad spectrum sterilization | |
| CN112716820A (en) | Antibacterial skin-care lotion and preparation method thereof | |
| CN102961331A (en) | Iodine-chitosan solution formula and preparation method thereof | |
| CN102846489B (en) | Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof | |
| CN106832267B (en) | A kind of guanidine copolymer and preparation method thereof | |
| CN102488885A (en) | Marine organism bacteria-removing liquid for pet | |
| CN103110976A (en) | Skin antimicrobial gel recipe and preparation method thereof | |
| US20130209442A1 (en) | Wound cleaning chemical composition and method for manufacturing | |
| CN117100729B (en) | Private part antibacterial composition, private part nursing product, and preparation methods and applications thereof | |
| RU2560674C1 (en) | All-purpose antibacterial agent | |
| US20230284627A1 (en) | Antimicrobial compositions and methods of use and for making same | |
| RU2706115C1 (en) | Antifungal and antimicrobial agent of complex action | |
| CN115152790A (en) | MOFs antibacterial material-quaternary ammonium salt composite disinfectant and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A composite polymer colloid wound disinfectant containing amino acid and its preparation method Effective date of registration: 20230110 Granted publication date: 20191105 Pledgee: Bank of Guiyang Limited by Share Ltd. directly under the sub branch Pledgor: GUIZHOU YANGSHENG MEDICAL INSTRUMENT Co.,Ltd. Registration number: Y2019520000014 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |