CN111150705A - Alcohol hyaluronic acid disinfectant and preparation method thereof - Google Patents
Alcohol hyaluronic acid disinfectant and preparation method thereof Download PDFInfo
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- CN111150705A CN111150705A CN202010131323.XA CN202010131323A CN111150705A CN 111150705 A CN111150705 A CN 111150705A CN 202010131323 A CN202010131323 A CN 202010131323A CN 111150705 A CN111150705 A CN 111150705A
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- solution
- hyaluronic acid
- disinfectant
- ethanol
- sodium hyaluronate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The invention relates to an alcohol hyaluronic acid disinfectant and a preparation method thereof. The effective disinfection and sterilization component of the invention is ethanol, and the content of the ethanol is 60 to 80 percent. Firstly, dissolving sodium hyaluronate in purified water to form solution A, and mixing ethanol and cosurfactant according to a certain proportion to form solution B. And then mixing the solution A and the solution B, adding a pH value regulator, regulating the pH value to 6.0-8.0, supplementing purified water until the content of ethanol reaches 60-80%, and uniformly stirring. The disinfectant has no oil phase component, and has the advantages of practicality, simplicity, high safety, good stability, low irritation, disinfection, no washing, no stickiness, and skin moistening and comfort.
Description
Technical Field
The invention belongs to the technical field of disinfection and sterilization, and particularly relates to an alcohol hyaluronic acid disinfectant and a preparation method thereof.
Background
Along with the improvement of the living standard of people while the economic development, the disinfection consciousness of residents is rapidly improved, so that the demand of people on disinfection products is gradually increased. Disinfectants are widely used in agriculture/livestock husbandry, food and diet industry and medical industry, and are increasingly used by families and individuals. The skin is the first barrier for the human body to contact with the outside, and as people come in and go out of various places, the skin becomes an important medium for the transmission of various pathogens, and if infection is caused, the health of people is affected, and even the life safety is threatened. Therefore, frequent disinfection of the skin effectively prevents the transmission of pathogens. There is a need for a disinfectant solution that can be used for a long period of time, is not harmful or irritating to the skin.
At present, skin disinfectants commonly used at home and abroad mainly comprise: (1) single ethanol, iodine tincture and the like, and the disinfectant has unobvious lasting effect and large irritation, generates anaphylactic reaction after being used by a small number of people, and is not suitable for long-term use of skin/hands; (2) the disinfectant is a compound disinfectant of chemical reagents and ethanol, and the disinfectant has the phenomena of dryness, chap, rash and the like on the skin/hands after use due to the overhigh concentration of the ethanol, so the protection and wetting effects on the skin are to be improved. Ethanol is a widely used disinfectant, and has rapid action and low cost. Ethanol is a disinfectant with good effect, and can kill pathogenic microorganisms. The virus/bacteria propagules can be killed by soaking or wiping with 60-90% ethanol water solution, but the protein can be denatured by taking 60-80% as the optimal concentration, so that the effects of disinfection and sterilization are achieved. The ethanol solution can be used as a daily-used disinfection medicament in hospitals and families and is mainly used for hand and skin disinfection.
The main effective disinfecting and sterilizing component of the alcohol hyaluronic acid disinfectant is ethanol, the content of the ethanol is 60% -80%, sodium hyaluronate and cosurfactant are added, after purified water is added, a low-viscosity and uniform transparent/semitransparent dispersion system is formed according to a certain proportion, the cosurfactant can reduce the surface tension of an interfacial film, so that the disinfecting effective component can reach a proper concentration under the system, and a strong killing effect on pathogenic microorganisms is achieved.
Disclosure of Invention
The invention aims to solve the technical problem of providing an alcohol hyaluronic acid disinfectant and a preparation method thereof aiming at the defects in the prior art in the market. The invention takes ethanol with the content of 60-80 percent as a main effective disinfection and sterilization component, and sodium hyaluronate and cosurfactant are used as auxiliary materials. The disinfectant has the advantages of high safety, good stability, low irritation, disinfection, no washing, no stickiness, and good skin moistening and comfort.
The invention is realized by the following technical scheme: the alcohol hyaluronic acid disinfectant is characterized by comprising the following components in percentage by mass:
60 to 80 percent of ethanol
0.02 to 1.0 percent of sodium hyaluronate
0.1 to 5.0 percent of cosurfactant
The balance of pH value regulator and purified water.
The ethanol content is 60-80%.
The content of the sodium hyaluronate is 0.02-1.0%.
The molecular weight of the sodium hyaluronate is 5000Da to 100 ten thousand Da.
The content of the cosurfactant is 0.1-5.0%.
The cosurfactant is one or more of propylene glycol, glycerol, n-butanol, isobutanol, 1-octanol, 2-octanol, n-propanol, isopropanol, n-pentanol, isoamylol, 1-hexanol and 2-hexanol.
The pH value regulator is one or more of triethanolamine, sodium hydroxide solution, ammonia water solution, hydrochloric acid solution, sulfuric acid solution and glacial acetic acid solution.
The concentration of the pH value regulator is 0.001 mol/L-5.0 mol/L. .
The method for preparing an alcohol hyaluronic acid disinfectant according to claim 1, wherein the method comprises the following steps: the method comprises the following steps:
(1) adding a certain amount of sodium hyaluronate into purified water, fully stirring, standing for 1-12 h, fully swelling the sodium hyaluronate in the water, and making the solution uniform to obtain solution A;
(2) mixing a certain amount of ethanol and cosurfactant, and uniformly stirring to obtain solution B;
(3) and mixing the solution A and the solution B, stirring for a certain time to fully and uniformly mix the solution A and the solution B, adding a pH value regulator, and regulating the pH value to 6.0-8.0. Adding the rest purified water until the content of the ethanol is 60-80%, and fully stirring to form a uniform, transparent/semitransparent solution.
Detailed Description
The invention is further illustrated by the following specific examples, which are not to be construed as limiting the invention.
Example 1
The alcohol hyaluronic acid disinfectant comprises the following raw and auxiliary materials in parts by mass: 60% of ethanol, 5.0% of glycerol, 0.02% of sodium hyaluronate with the molecular weight of 100 ten thousand Da, and the balance of pH value regulator and purified water.
The preparation method of the alcohol hyaluronic acid disinfectant can be carried out according to the following steps:
(1) weighing the components according to the mass ratio of the raw materials and the auxiliary materials, slowly adding sodium hyaluronate which is 0.02 percent of the total mass of the disinfectant into purified water which is 20 percent of the total mass of the disinfectant, fully stirring, and then standing for 1-12 hours to fully swell the sodium hyaluronate in the water to obtain uniform solution A;
(2) mixing ethanol with the total mass of 60% of the disinfectant and glycerol with the total mass of 5.0%, and uniformly stirring to obtain solution B;
(3) and mixing the prepared solution A and the prepared solution B, stirring for a certain time to fully and uniformly mix the solutions, adding a pH value regulator, and regulating the pH value to 6.0-8.0. Adding the rest purified water, and fully stirring and uniformly mixing to form a uniform, transparent/semitransparent solution.
Example 2
The alcohol hyaluronic acid disinfectant comprises the following raw and auxiliary materials in parts by mass: 80% of ethanol, 0.1% of propylene glycol, 0.02% of sodium hyaluronate with the molecular weight of 5000Da, and the balance of pH value regulator and purified water.
The preparation method of the alcohol hyaluronic acid disinfectant can be carried out according to the following steps:
(1) weighing the components according to the mass ratio of the raw materials and the auxiliary materials, slowly adding sodium hyaluronate which is 0.02 percent of the total mass of the disinfectant into purified water which is 10 percent of the total mass of the disinfectant, fully stirring, and then standing for 1-12 hours to ensure that the sodium hyaluronate is fully swelled in the water to obtain uniform solution A;
(2) mixing ethanol with the total mass of 80% of the disinfectant and 0.1% of propylene glycol, and uniformly stirring to obtain solution B;
(3) and mixing the prepared solution A and the prepared solution B, stirring for a certain time to fully and uniformly mix the solutions, adding a pH value regulator, and regulating the pH value to 6.0-8.0. Adding the rest purified water, and fully stirring and uniformly mixing to form a uniform, transparent/semitransparent solution.
Example 3
The alcohol hyaluronic acid disinfectant comprises the following raw and auxiliary materials in parts by mass: 75% of ethanol, 3.0% of glycerol, 0.1% of sodium hyaluronate with the molecular weight of 10 ten thousand Da, and the balance of pH value regulator and purified water.
The preparation method of the alcohol hyaluronic acid disinfectant can be carried out according to the following steps:
(1) weighing the components according to the mass ratio of the raw materials and the auxiliary materials, slowly adding sodium hyaluronate which is 0.1 percent of the total mass of the disinfectant into purified water which is 15 percent of the total mass of the disinfectant, fully stirring, and standing for 1-12 hours to fully swell the sodium hyaluronate in the water to obtain uniform solution A;
(2) mixing ethanol with the total mass of 75% of the disinfectant and glycerol with the total mass of 3.0%, and uniformly stirring to obtain solution B;
(3) and mixing the prepared solution A and the prepared solution B, stirring for a certain time to fully and uniformly mix the solutions, adding a pH value regulator, and regulating the pH value to 6.0-8.0. Adding the rest purified water, and fully stirring and uniformly mixing to form a uniform, transparent/semitransparent solution.
Example 4
The alcohol hyaluronic acid disinfectant comprises the following raw and auxiliary materials in parts by mass: 70% of ethanol, 2.0% of propylene glycol, 1.0% of sodium hyaluronate with the molecular weight of 1 ten thousand Da, and the balance of pH value regulator and purified water.
The preparation method of the alcohol hyaluronic acid disinfectant can be carried out according to the following steps:
(1) weighing the components according to the mass ratio of the raw materials and the auxiliary materials, slowly adding sodium hyaluronate which is 0.5 percent of the total mass of the disinfectant into purified water which is 15 percent of the total mass of the disinfectant, fully stirring, and standing for 1-12 hours to fully swell the sodium hyaluronate in the water to obtain uniform solution A;
(2) mixing ethanol accounting for 70% of the total mass of the disinfectant with propylene glycol accounting for 2.0%, and uniformly stirring to prepare a solution B;
(3) and mixing the prepared solution A and the prepared solution B, stirring for a certain time to fully and uniformly mix the solutions, adding a pH value regulator, and regulating the pH value to 6.0-8.0. Adding the rest purified water, and fully stirring and uniformly mixing to form a uniform, transparent/semitransparent solution.
Example 5
The alcohol hyaluronic acid disinfectant comprises the following raw and auxiliary materials in parts by mass: 77% of ethanol, 1.0% of glycerol, 0.05% of sodium hyaluronate with the molecular weight of 2 ten thousand Da, and the balance of pH value regulator and purified water.
The preparation method of the alcohol hyaluronic acid disinfectant can be carried out according to the following steps:
(1) weighing the components according to the mass ratio of the raw materials and the auxiliary materials, slowly adding sodium hyaluronate which is 0.05 percent of the total mass of the disinfectant into purified water which is 15 percent of the total mass of the disinfectant, fully stirring, and standing for 1-12 hours to fully swell the sodium hyaluronate in the water to obtain uniform solution A;
(2) mixing 77% ethanol and 1.0% glycerol, and stirring to obtain solution B;
(3) and mixing the prepared solution A and the prepared solution B, stirring for a certain time to fully and uniformly mix the solutions, adding a pH value regulator, and regulating the pH value to 6.0-8.0. Adding the rest purified water, and fully stirring and uniformly mixing to form a uniform, transparent/semitransparent solution.
Example 6
The alcohol hyaluronic acid disinfectant comprises the following raw and auxiliary materials in parts by mass: 73% of ethanol, 0.2% of propylene glycol, 0.2% of sodium hyaluronate with the molecular weight of 5000Da, and the balance of pH value regulator and purified water.
The preparation method of the alcohol hyaluronic acid disinfectant can be carried out according to the following steps:
(1) weighing the components according to the mass ratio of the raw materials and the auxiliary materials, slowly adding sodium hyaluronate which is 0.2 percent of the total mass of the disinfectant into purified water which is 10 percent of the total mass of the disinfectant, fully stirring, and then standing for 1-12 hours to fully swell the sodium hyaluronate in the water to obtain uniform solution A;
(2) mixing 73% of ethanol and 0.2% of propylene glycol by the total mass of the disinfectant, and uniformly stirring to prepare a solution B;
(3) and mixing the prepared solution A and the prepared solution B, stirring for a certain time to fully and uniformly mix the solutions, adding a pH value regulator, and regulating the pH value to 6.0-8.0. Adding the rest purified water, and fully stirring and uniformly mixing to form a uniform, transparent/semitransparent solution.
Evaluation of Performance
1. Skin/hand moisturization comparative evaluation:
the alcohol hyaluronic acid disinfectant prepared in the patent embodiment and the single-component ethanol solution with corresponding concentration are respectively and uniformly applied to the skin/hands, so that the skin/hands moisture retention is compared and evaluated. The specific experimental results are as follows:
TABLE 1 comparative evaluation of skin/hand moisturization
2. And (3) evaluation of disinfection and sterilization performance:
the evaluation of the disinfecting and sterilizing properties was intended to confirm that the disinfecting solution of the present invention can kill bacteria/viruses in suspension or on a carrier. The disinfection and sterilization experimental results are as follows: disinfectant liquid was prepared according to this example and compared with single ethanol solution of the corresponding concentration. Staphylococcus aureus (ATCC6538), Escherichia coli (8099), Candida albicans (ATCC10231), Pseudomonas aeruginosa (ATCC15442) and Bacillus subtilis were selected as test strains to prepare suspensions for disinfection and sterilization experiments. The process is carried out according to the requirements of the Disinfection Specification (2002 edition) and is not described in detail here. The results of the experiment are as follows:
TABLE 2 Disinfection and Sterilization Effect as the kill rate of 20 seconds
TABLE 3 Disinfection and Sterilization Effect as the kill rate of 40 seconds
Claims (9)
1. An alcohol hyaluronic acid disinfectant and a preparation method thereof, which is characterized in that: the disinfectant is an alcohol hyaluronic acid disinfectant prepared by taking 60-80% of ethanol as an effective disinfecting and sterilizing component, and sodium hyaluronate, a cosurfactant, a pH value regulator and purified water as auxiliary materials according to a certain proportion, and comprises the following components in percentage by mass:
60 to 80 percent of ethanol
0.02 to 1.0 percent of sodium hyaluronate
0.1 to 5.0 percent of cosurfactant
The balance of pH value regulator and purified water.
2. The alcohol hyaluronic acid disinfectant as set forth in claim 1, wherein: the ethanol content is 60-80%.
3. The alcohol hyaluronic acid disinfectant as set forth in claim 1, wherein: the content of the sodium hyaluronate is 0.02-1.0%.
4. The alcohol hyaluronic acid disinfectant as set forth in claim 1, wherein: the molecular weight of the sodium hyaluronate is 5000Da to 100 ten thousand Da.
5. The alcohol hyaluronic acid disinfectant as set forth in claim 1, wherein: the content of the cosurfactant is 0.1-5.0%.
6. The alcohol hyaluronic acid disinfectant as set forth in claim 1, wherein: the cosurfactant is one or more of propylene glycol, glycerol, n-butanol, isobutanol, 1-octanol, 2-octanol, n-propanol, isopropanol, n-pentanol, isoamylol, 1-hexanol and 2-hexanol.
7. The alcohol hyaluronic acid disinfectant as set forth in claim 1, wherein: the pH value regulator is one or more of triethanolamine, sodium hydroxide solution, ammonia water solution, hydrochloric acid solution, sulfuric acid solution and glacial acetic acid solution.
8. The alcohol hyaluronic acid disinfectant liquid according to claim 6, wherein: the concentration of the pH value regulator is 0.001 mol/L-5.0 mol/L.
9. The method for preparing an alcohol hyaluronic acid disinfectant according to claim 1, wherein the method comprises the following steps: the method comprises the following steps:
(1) adding a certain amount of transparent/semitransparent sodium hyaluronate into purified water, fully stirring, standing for 1-12 h, fully swelling the sodium hyaluronate in the water, and making the solution uniform to obtain solution A;
(2) mixing a certain amount of ethanol and cosurfactant, and uniformly stirring to obtain solution B;
(3) and mixing the solution A and the solution B, stirring for a certain time to fully and uniformly mix the solution A and the solution B, adding a pH value regulator, and regulating the pH value to 6.0-8.0. Adding the rest purified water until the content of the ethanol is 60-80%, and fully stirring to form a uniform, transparent/semitransparent solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010131323.XA CN111150705A (en) | 2020-02-28 | 2020-02-28 | Alcohol hyaluronic acid disinfectant and preparation method thereof |
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| CN202010131323.XA CN111150705A (en) | 2020-02-28 | 2020-02-28 | Alcohol hyaluronic acid disinfectant and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113648326A (en) * | 2021-08-01 | 2021-11-16 | 杭州氢源素生物科技有限公司 | Disinfectant containing nano particles and capable of inactivating viruses and preparation method thereof |
| CN114767712A (en) * | 2022-04-25 | 2022-07-22 | 杭州西子卫生消毒药械有限公司 | Low-volatility disinfectant and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1245012A (en) * | 1998-08-14 | 2000-02-23 | 凌沛学 | Disinfecting gel containing transparent sodium phytate and its preparing process |
-
2020
- 2020-02-28 CN CN202010131323.XA patent/CN111150705A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1245012A (en) * | 1998-08-14 | 2000-02-23 | 凌沛学 | Disinfecting gel containing transparent sodium phytate and its preparing process |
Non-Patent Citations (1)
| Title |
|---|
| WESTOCK: "日本人手一瓶的洗手液，10秒手上细菌全搓光，双手还能又滑又嫩！", 《微信公众号：新鲜日本》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113648326A (en) * | 2021-08-01 | 2021-11-16 | 杭州氢源素生物科技有限公司 | Disinfectant containing nano particles and capable of inactivating viruses and preparation method thereof |
| CN113648326B (en) * | 2021-08-01 | 2023-11-07 | 武汉启航科技发展有限公司 | Nanoparticle-containing virus-inactivated disinfectant and preparation method thereof |
| CN114767712A (en) * | 2022-04-25 | 2022-07-22 | 杭州西子卫生消毒药械有限公司 | Low-volatility disinfectant and preparation method thereof |
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